Oxidative metabolism in cultured fibroblasts derived from sporadic Alzheimer's disease (AD) patients

Neuroscience Letters

Volumn 236, Issue 1, 1997, Pages 13-16

  Curti, Daniela ^a   Rognoni, Francesca ^a   Gasparini, Laura ^b,c   Cattaneo, Achille ^a   Paolillo, Mayra ^a   Racchi, Marco ^b,c   Zani, Laura ^a   Bianchetti, Angelo ^c   Trabucchi, Marco ^c   Bergamaschi, Stefania ^c   Govoni, Stefano ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b Sacred Heart Hospital FBF   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

Alzheimer's disease; Cytochrome c oxidase; Fibroblasts; Intracellular pH; Oxidative metabolism

Indexed keywords

AZIDE; CYTOCHROME C OXIDASE; OXYGEN; POTASSIUM CYANIDE;

AEROBIC METABOLISM; AGED; ALZHEIMER DISEASE; ARTICLE; CELL CULTURE; CELL PH; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; MALE; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL;

AGED; ALZHEIMER DISEASE; CASE-CONTROL STUDIES; CELLS, CULTURED; ELECTRON TRANSPORT COMPLEX IV; ENERGY METABOLISM; FEMALE; FIBROBLASTS; HUMANS; MALE; MIDDLE AGED; OXIDATION-REDUCTION; OXYGEN CONSUMPTION; PERIODICITY;

EID: 0031585485     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)00741-6     Document Type: Article

References (22)

1. Beal M.F. Aging, energy, and oxidative stress in neurodegenerative diseases. Ann. Neurol. 38:1995;357-366.
2. Benzi G., Moretti A. Are reactive oxygen species involved in Alzheimer's disease? Neurobiol. Aging. 16:1995;661-674.
3. Benzi G., Pastoris O., Marzatico F., Villa R.F., Dagani F., Curti D. The mitochondrial electron transfer alteration as a factor involved in the brain aging. Neurobiol. Aging. 13:1992;361-368.
4. Bergamaschi S., Binetti G., Govoni S., Wetsel W.G., Battaini F., Trabucchi M., Bianchetti A., Racchi M. Defective phorbol ester-stimulated secretion of β-amyloid precursor protein from Alzheimer's disease fibroblasts. Neurosci. Lett. 201:1995;1-4.
5. Boveris A., Chance B. The mitochondrial generation of hydrogen peroxide. Biochem. J. 134:1973;707-716.
6. Chandrasekaran K., Giordano T., Brady D.R., Stoll J., Martin L.J., Rapoport S.P. Impairment in mitochondrial cytochrome oxidase gene expression in AD. Mol. Brain Res. 24:1994;336-340.
7. Curti D., Malaspina A., Facchetti G., Camana C., Mazzini L., Tosca P., Zerbi F., Ceroni M. Amyotrophic lateral sclerosis: oxidative energy metabolism and calcium homeostasis in peripheral blood lymphocytes. Neurology. 47:1996;1060-1064.
8. Davis R.E., Miller S., Herrnstadt C., Ghosh S.S., Fahy E., Shinobu L.A., Galasko D., Thal L.J., Beal M.F., Howell N., Parker W.D. Jr. Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease. Proc. Natl. Acad. Sci. USA. 94:1997;4526-4569.
9. Ferguson-Miller S., Brautigan D.L., Margoliash E. Correlation of the kinetics of electron transfer activity of various eukaryotic cytochromes c with binding to mitochondrial cytochrome c oxidase. J. Biol. Chem. 251:1976;1104-1113.
10. Gabuzda D., Busciglio J., Chen L.B., Matsudaira P., Yankner B.A. Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative. J. Biol. Chem. 269:1994;13623-13628.
11. Gasparini L., Govoni S., Benussi L., Curti D., Bianchetti A., Racchi M. Oxidative metabolism influences amyloid precursor protein secretion in fibroblast from AD patients. Pharmacol. Res. 35(suppl.):1997;62.
12. Govoni S., Bergamaschi S., Racchi M., Battaini F., Binetti G., Bianchetti A., Trabucchi M. Cytosol protein kinase c downregulation in fibroblasts from Alzheimer's disease patients. Neurology. 43:1993;2581-2586.
13. Heiss W.D., Pawlik G., Holthoff V., Kessler J., Szelieks B. PET correlates of normal and impaired memory functions. Cerebral Brain Metab. Rev. 4:1992;1-27.
14. Kish S.J., Bergeron C., Rajput A., Dozic S., Mastrogiacomo F., Chang L.J., Wilson J.M., Di Stefano L.M., Nobrega J.N. Brain cytochrome oxidase in Alzheimer's disease. J. Neurochem. 59:1992;776-779.
15. Mutisya E.M., Bowling A.C., Beal M.F. Cortical cytochrome oxidase activity is reduced in Alzheimer's disease. J. Neurochem. 63:1994;2179-2184.
16. Parker W.D., Mahr M.S., Filley C.M., Parks J.K., Hughes D., Young D.A., Cullum C.M. Reduced platelet cytochrome c oxidase activity in Alzheimer's disease. Neurology. 44:1994;1086-1090.
17. Parker W.D., Parks J., Filley C.M., Kleinschmidt-DeMasters B.K. Electron transport chain defects in Alzheimer's disease brain. Neurology. 44:1994;1090-1096.
18. Partridge R.S., Monroe M.S., Parks J.K., Johnson K., Parker W.D., Eaton G.R., Eaton S.S. Spin trapping of azidyl and hydroxyl radicals in azide-inhibited rat brain submitochondrial particles. Arch. Biochem. Biophys. 310:1994;210-217.
19. Peterson C., Goldman J.E. Alteration in calcium content and biochemical processes in cultured skin fibroblast from aged and Alzheimer donors. Proc. Natl. Acad. Sci. USA. 83:1986;2758-2762.
20. Simonian N.A., Hyman B.T. Functional alterations in Alzheimer's disease: diminution of cytochrome oxidase in the hippocampal formation. J. Neuropathol. Exp. Neurol. 52:1993;580-585.
21. Sims N.R., Finegan J.M., Blass J.P. Altered metabolic properties of cultured skin fibroblasts in Alzheimer's disease. Ann. Neurol. 21:1987;451-457.
22. Whatley S.A., Curti D., Marchbanks R.M. Mitochondrial involvement in schizophrenia and other functional psychoses. Neurochem Res. 21:1996;1001-1010.