Is mitochondrial DNA depletion involved in Alzheimer's disease?

European Journal of Human Genetics

Volumn 9, Issue 4, 2001, Pages 279-285

  Rodríguez Santiago, Benjamín ^a   Casademont, Jordi ^b   Nunes, Virginia ^a  

^a Institut de Recerca Oncologica   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Alzheimer's disease; Brain; Depletion; Mitochondria; MtDNA

Indexed keywords

MITOCHONDRIAL DNA;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; AUTOPSY; BLOOD SAMPLING; BRAIN REGION; CEREBELLUM; CLINICAL ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; DNA MODIFICATION; FRONTAL CORTEX; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; CEREBELLUM; DNA, MITOCHONDRIAL; FRONTAL LOBE; HIPPOCAMPUS; HUMANS; MIDDLE AGED;

EID: 0035058647     PISSN: 10184813     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ejhg.5200629     Document Type: Article

References (30)

1. The cause of neuronal degeneration in Alzheimer's disease
2. The pathogenesis of senile plaques
3. Molecular pathogenesis of sporadic and familial forms of Alzheimer's disease
4. Oxidative stress and Alzheimer disease
5. Electron transport chain defects in Alzheimer's disease brain
6. Cortical cytochrome oxidase activity is reduced in Alzheimer's disease
7. Abnormal substrate levels that depend upon mitochondrial function in cerebrospinal fluid from Alzheimer patients
8. Association of the mitochondrial tRNA(A4336G) mutation with Alzheimer's and Parkinson's diseases
9. A mitochondrial DNA clone is associated with increased risk for Alzheimer disease
10. Marked changes in mitochondrial DNA deletion levels in Alzheimer brains
11. Elevated levels of the Kearns-Sayre syndrome mitochondrial DNA deletion in temporal cortex of Alzheimer's patients
12. The expression of several mitochondrial and nuclear genes encoding the subunits of electron transport chain enzyme complexes, cytochrome c oxidase, and NADH dehydrogenase, in different brain regions in Alzheimer's disease
13. Decreased expression of nuclear and mitochondrial DNA-encoded genes of oxidative phosphorylation in association neocortex in Alzheimer disease
14. Calcium homeostasis and reactive oxygen species production in cells transformed by mitochondria from individuals with sporadic Alzheimer's disease
15. Mitochondrial regulation of cell death: Mitochondria are essential for procaspase 3-p21 complex formation to resist Fas-mediated cell death
16. Bcl-2 facilitates recovery from DNA damage after oxidative stress
17. mtDNA depletion with variable tissue expression: A novel genetic abnormality in mitochondrial diseases
18. Disorders associated with depletion of mitochondrial DNA
19. Variation in mitochondrial DNA levels in muscle from normal controls. Is depletion of mtDNA in patients with mitochondrial myopathy a distinct clinical syndrome
20. The effect of zidovudine on skeletal muscle mtDNA in HIV-1 infected patients with mild or no muscle dysfunction
21. Mitochondrial myopathy caused by long-term zidovudine therapy
22. Clinical manifestations of mitochondrial DNA depletion
23. Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy
24. Clinical heterogeneity associated with mitochondrial DNA depletion in muscle
25. Cytochrome oxidase deficiency in Alzheimer's disease
26. Oxidative damage to DNA in lymphocytes from AD patients
27. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
28. Quantification of low-copy transcripts by continuous SYBR Green I monitoring during amplification
29. Product differentiation by analysis of DNA melting curves during the polymerase chain reaction
30. Reduced steady-state levels of mitochondrial RNA and increased mitochondrial DNA amount in human brain with aging