Mitochondria dysfunction of Alzheimer's disease cybrids enhances Aβ toxicity

Journal of Neurochemistry

Volumn 89, Issue 6, 2004, Pages 1417-1426

  Cardoso, Sandra M ^a   Santana, Isabel ^b   Swerdlow, Russell H ^c   Oliveira, Catarina R ^a  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b CENTRO HOSPITALAR E UNIVERSITÁRIO DE COIMBRA   (Portugal)

^c UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Alzheimer's disease; Beta amyloid; Cell death; Cybrids; Mitochondria

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; CASPASE 3; CYTOCHROME C; CYTOCHROME C OXIDASE; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN MITOCHONDRION; CELL MEMBRANE DEPOLARIZATION; CELL STRAIN; CELL STRAIN NT2; CONTROLLED STUDY; CYBRID; HUMAN; HUMAN CELL; MITOCHONDRIAL DNA DISORDER; MITOCHONDRIAL DYSFUNCTION; MITOCHONDRIAL MEMBRANE; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; OXIDATIVE STRESS; PRIORITY JOURNAL; TERATOCARCINOMA;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; CASPASES; CELL LINE, TUMOR; DNA, MITOCHONDRIAL; ELECTRON TRANSPORT; ELECTRON TRANSPORT COMPLEX IV; HUMANS; HYBRID CELLS; LIPID METABOLISM; MEMBRANE POTENTIALS; MITOCHONDRIA; OXIDATION-REDUCTION; OXIDATIVE STRESS; PEPTIDE FRAGMENTS; PHOSPHATIDYLSERINES; PROTEINS; REACTIVE OXYGEN SPECIES; TERATOCARCINOMA;

EID: 3042513691     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2004.02438.x     Document Type: Article

References (44)

1. Agid Y. (1995) Aging, disease and nerve cell death. Bull. Acad. Natl Med. 179, 1193-1207.
2. Allen J. W., Eldadah B. A., Huang X., Knoblach S. M. and Faden A. I. (2001) Multiple caspases are involved in beta-amyloid-induced neuronal apoptosis. J. Neurosci. Res. 65, 45-53.
3. Bass D. A., Parce J. W., Dechatelet L. R., Szejda P., Seeds M. C. and Thomas M. (1983) Flow cytometric studies of oxidative product formation by neutrophils: a grade response to membrane stimulation. J. Immunol. 130, 1910-1917.
4. Beal M. F. (1992) Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses? Ann. Neurol. 31, 119-130,
5. Beal M. F. (1995) Aging, energy, and oxidative stress in neurodegenerative diseases. Ann. Neurol. 38, 357-366.
6. Berg L. (1988) Clinical dementia rating (CDR). Psychopharmacol. Bull. 24, 637-639.
7. Cardoso S. M., Santos S., Swerdlow R. H. and Oliveira C. R. (2001) Functional mitochondria are required for amyloid β-mediated neurotoxicity. FASEB J. 15, 1439-1441.
8. Cardoso S. M., Swerdlow R. H. and Oliveira C. R. (2002) Induction of cytochrome c-mediated apoptosis by amyloid β 25-35 requires functional mitochondria. Brain Res. 931, 117-125.
9. Cardoso S. M., Proença T., Santos S., Santana I. and Oliveira C. R. (2004) A possible mechanism for the decrease of cytochrome c oxidase activity in Alzheimer's disease. Neurobiol. Aging 25, 105-110.
10. Cassarino D. S., Swerdlow R. H., Parks J. K., Parker W. D. Jr and Bennett J. P. Jr (1998) Cyclosporin A increases resting mitochondrial membrane potential in SY5Y cells and reverses the depressed mitochondrial membrane potential of Alzheimer's disease cybrids. Biochem, Biophys. Res. Commun. 248, 168-173.
11. Coore H. G., Denton R. M., Martin B. R. and Randle P. J. (1971) Regulation of adipose tissue pyruvate dehydrogenase by insulin and others hormones. Biochem. J. 125, 115-127.
12. Cregan S. P., MacLaurin J. G., Craig C. G., Robertson G. S., Nicholson D. W., Park D. S. and Slack R. S. (1999) Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons. J. Neurosci. 19, 7860-7869.
13. +: implications for neurodegeneration. J. Neurochem. 63, 584-591.
14. Ernster L. and Nordenbrand K. (1967) Microsomal lipid peroxidation, in Methods in Enzymology (Colowick, S. P., Koplan, N. O., eds), pp. 574-580. Academic Press, New York.
15. Fernandes-Alnemri T., Litwack G. and Alnemri E. S. (1995) Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family. Cancer Res. 55, 2737-2742.
16. Foltein M. F., Folstein S. E. and McHugh P. R. (1975) Mini-Mental State: a practical method for grading the cognitive state of patients for the clinician. J. Psychiat. Res. 12, 189-198.
17. Gabuzda D., Busciglio J., Chen L. B., Matsudaira P. and Yankner B. A. (1994) Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative. J Biol. Chem. 269, 13623-13628.
18. Ghosh S. S., Swerdlow R. H., Miller S. W., Sheeman B., Parker W. D. Jr and Davis R. E. (1999) Use of cytoplasmic hybrid cell lines for elucidating the role of mitochondrial dysfunction in Alzheimer's disease and Parkinson's disease. Ann. N. Y. Acad. Sci. 893, 176-191.
19. Ito S., Ohta S., Nishimaki K., Kagawa Y., Soma R., Kumo S. Y., Kumatsuzaki Y., Mizusawa H. and Hayashi Y. (1999) Functional integrity of mitochondial genomes in human platelets and autopsied brain tissues from elderly patients with Alzheimer's disease. Proc. Natl Acad. Sci. 96, 2099-2103.
20. Khan S. M., Cassarino D. S., Abramova N. N. et al. (2000) Alzheimer's disease cybrids replicate beta-amyloid abnormalities through cell death pathways. Ann. Neurol. 48, 148-155.
21. King M. P. and Attardi G. (1989) Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation. Science 246, 500-503.
22. Levine R. L., Garland D., Oliver C. N., Amici A., Climent I., Lenz A. G., Ahn B.-W., Shaltiel S. and Stadtman E. R. (1990) Determination of carbonyl content in oxidative modified proteins. Meth. Enzymol. 186, 464-478.
23. Liu X., Kim C. N., Yang J., Jemmerson R. and Wang X. (1996) Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome C. Cell 86, 147-157.
24. Lovell M. A., Ehmann W. D., Butler S. M. and Markesbery W. R. (1995) Elevated thiobarbituric acid-reactive substances and antioxidant enzymes activity in the brain in Alzheimer's disease. Neurology 45, 1594-1601.
25. Mark R. J., Blanc E. M. and Mattson M. P. (1996) Amyloid beta-peptide and oxidative cellular injury in Alzheimer's disease. Mol. Neurobiol. 12, 211-224.
26. Markesbery W. R. (1997) Oxidative stress hypothesis in Alzheimer's disease. Free Radic. Biol. Med. 23, 134-147.
27. McKhann G., Drachman D., Folstein M., Katzman R., Price D. and Stadlan E. M. (1994) Clinical Diagnosis of Alzheimer's Disease. Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 4, 939-944.
28. Mecocci P., MacGarvey U. and Beal M. F. (1994) Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Ann. Neurol. 36, 747-751.
29. Mignotte B. and Vayssiere J. L. (1998) Mitochondria and apoptosis. Eur. J. Biochem. 252, 1-15.
30. Miller S. W., Trimmer P. A., Parker W. D. Jr and Davis R. E. (1996) Creation and characterization of mitochondrial DNA-depleted cell lines with 'neuronal-like' properties. J. Neurochem. 67, 1897-1907.
31. Nakagawa T., Zhu H., Morishima N., Li E., Xu J., Yankner B. A. and Yuan J. (2000) Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 403, 98-103.
32. Selkoe D. J. (1990) Deciphering Alzheimer's disease: the amyloid precursor protein yields new clues. Science 248, 1058-1060.
33. Sheehan J. P., Swerdlow R. H., Miller S. W., Davis R. E., Parks J. K., Parker W. D. and Tuttle J. B. (1997) Calcium homeostasis and reactive oxygen species production in cells transformed by mitochondria from individuals with sporadic Alzheimer's disease. J. Neurosci. 17, 4612-4622.
34. Smith M. A. (1998) Alzheimer disease. Int. Rev. Neurobiol. 42, 1-54.
35. Smith C. D., Carney J. M., Starke-Reed P. E., Oliver C. N., Stadtman E. R., Floyd R. A. and Markesbery W. R. (1991) Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease. Proc. Natl Acad. Sci. USA 88, 10540-10543.
36. Stocchi V., Cucchiarini L., Chiarantini L., Palma P. and Crescentini G. (1985) Simultaneous extration and reverse-phase high-performance liquid chromatografic determination of adenine and pyridine nucleotides in human red blood cells. Anal. Biochem. 46, 118-124.
37. Swerdlow R. H. and Kish S. J. (2002) Mitochondria in Alzheimer's disease. Int. Rev. Neurobiol. 53, 341-385.
38. Swerdlow R. H., Parks J. K., Miller S. W., Tuttle J. B., Trimmer P. A., Sheehan J. P., Bennett J. P. Jr, Davis R. E. and Parker W. D. Jr (1996) Origin and functional consequences of the complex I defect in Parkinson's disease. Ann. Neurol. 40, 663-671.
39. Swerdlow R. H., Parks J. K., Cassarino D. S., Maguire D. J., Maguire R. S., Bennett J. P. Jr, Davis R. E. and Parker W. D. Jr (1997) Cybrids in Alzheimer's disease: a cellular model of the disease? Neurology 49, 918-925.
40. Trimmer P. A., Swerdlow R. H., Parks J. K., Keeney P., Bennett J. P. Jr, Miller S. W., Davis R. E. and Parker W. D. Jr (2000) Abnormal mitochondrial morphology in sporadic Parkinson's and Alzheimer's disease cybrid cell lines. Exp. Neurol. 162, 37-50.
41. Troy C. M., Rabacchi S. A., Friedman W. J., Frappier T. F., Brown K. and Shelanski M. L. (2000) Caspase-2 mediates neuronal cell death induced by beta-amyloid. J. Neurosci. 20, 1386-1392.
42. Wharton D. C. and Tzagoloff A. (1967) Cytochrome oxidase from beef heart mitochondria. Meth. Enzymol. 10, 245-250.
43. Xu J., Chen S., Ku G., Ahmed S. H., Xu J., Chen H. Hsu C. Y. (2001) Amyloid beta peptide-induced cerebral endothelial cell death involves mitochondrial dysfunction and caspase activation. J. Cereb. Blood Flow Metab. 21, 702-710.
44. Zou H., Liu X. and Wang X. (1999) An APAF-1 cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J. Biol. Chem. 274, 11549-11556.