Neurotrophin receptors and selective loss of cholinergic neurons in Alzheimer disease

Molecular and Chemical Neuropathology

Volumn 28, Issue 1-3, 1996, Pages 219-223

  Boissière, Florence ^a   Lehéricy, Stéphane ^a   Strada, Ornella ^a   Agid, Yves ^a   Hirsch, Etienne C ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

Alzheimer disease; choline acetyltransferase; nerve growth factor; neurotrophin receptors; nucleus basalis of Meynert; striatum

Indexed keywords

NERVE GROWTH FACTOR; NEUROTROPHIN RECEPTOR; PROTEIN TYROSINE KINASE;

ALZHEIMER DISEASE; BRAIN REGION; CHOLINERGIC NERVE CELL; CONFERENCE PAPER; HUMAN; HUMAN TISSUE; NERVE CELL DEGENERATION; OLIVARY NUCLEUS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RECEPTOR DENSITY; RECEPTOR UPREGULATION;

EID: 0029790619     PISSN: 10447393     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02815225     Document Type: Conference Paper

References (14)

1. Bertrand P., Roger O., Houlgatte R., Javoy-Agid F., Brandel J. P., Doble A., and Blanchard J. C. (1992) Measurement of nerve growth factor-like immunoreactivity in the human brain using an anti-mouse-NGF enzyme immunoassay. Neurochem. Int., 20, 215-218.
2. Boissiere F., Hunot S., Faucheux B., Mouatt-Prigent A., Agid Y., and Hirsch E. C. (1994) High affinity neurotrophin receptors in cholinergic neurons in the human brain. C. R. Acad. Sci. Paris, Sci. de la vie/Life Sci. 318, 997-1003.
3. Brandel J. P., Hirsch E., Malessa S., Duyckaerts C., Cervera P., and Agid Y. (1991) Differential vulnerability of cholinergic projections to the mediodorsal nucleus of the thalamus in senile dementia of Alzheimer type and progressive supranuclear palsy. Neuroscience, 41, 25-31.
4. Dreyfus C. F. (1989) Effects of nerve growth factor on cholinergic brain neurons. Trends Pharmacol. Sci. 10, 145-149.
5. Ernfors P., Lindefors N., Chan-Palay V., and Persson H. (1990) Cholinergic neurons of the nucleus basalis express elevated levels of nerve growth factor receptor mRNA in senile dementia of the Alzheimer's type. Dementia 1, 138-145.
6. Goedert M., Fine A., Hunt S. P., and Ullrich A. (1986) Nerve growth factor mRNA in the peripheral and central rat tissues and in human central nervous system: lesion effects in the rat brain and levels in Alzheimer's disease. Mol. Brain Res. 1, 85-92.
7. Goedert M., Fine A., Dawbarn D., Wilcock G. K., and Chao M. V. (1989) Nerve growth factor receptor mRNA distribution in human brain: normal levels in basal forebrain in Alzheimer's disease. Mol. Brain. Res. 5, 1-7.
8. Hefti F. and Mash D. C. (1989) Localization of nerve growth factor receptors in the normal human brain and in Alzheimer's disease. Neurobiol. Aging 10, 75-87.
9. Ip N. Y., and Yancopoulos G. D. (1994) Neurotrophic factors and their receptors. Ann. Neurol. 35, S13-S16.
10. Lehéricy S., Hirsch E. C., Cervera P., Hersh L. B., Hauw J. J., Ruberg M., and Agid Y. (1989) Selective loss of cholinergic neurons in the ventral striatum of patients with Alzheimer's disease. Proc. Natl. Acad. Sci. USA 86, 8580-8584.
11. Lehéricy S., Hirsch E. C., Cervera-Piérot P., Hersh L. B., Bakchine S., Piette F., Duyckaerts C., Hauw J. J., Javoy-Agid F. and Agid Y. (1993) Heterogeneity and selectivity of the degeneration of cholinergic neurons in the basal forebrain of patients with Alzheimer's disease. J. Comp. Neurol 330, 15-31.
12. Mufson E. J., Bothwell M., Hersh L. B., and Kordower H. J. (1989a) Nerve growth factor receptor in the normal, aged human basal forebrain: colocalization with cholinergic neurons. J. Comp. Neurol. 285, 196-217.
13. Mufson E. J., Bothwell M., and Kordower J. H. (1989b) Loss of nerve growth factor receptor-containing neurons in Alzheimer's disease: a quantitative analysis across subregions of the basal forebrain. Exp. Neurol. 105, 221-232.
14. 3H vesamicol binding in the temporal cortex of patients with Alzheimer's disease, Parkinson's disease, and rats with basal forebrain lesions. Neuroscience, 35, 327-333.