Amyloid-β dynamics are regulated by orexin and the sleep-wake cycle

Science

Volumn 326, Issue 5955, 2009, Pages 1005-1007

  Kang, Jae Eun ^a   Lim, Miranda M ^a   Bateman, Randall J ^a   Lee, James J ^a   Smyth, Liam P ^a   Cirrito, John R ^a   Fujiki, Nobuhiro ^b   Nishino, Seiji ^b   Holtzman, David M ^a,c  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

^c WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; OREXIN; PROTEIN INHIBITOR;

ANTAGONISM; CARBOHYDRATE; FLUID; GENETICALLY MODIFIED ORGANISM; NERVOUS SYSTEM DISORDER; PATHOGENICITY; PROTEIN; RODENT; SLEEP;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; HUMAN; INTERSTITIAL FLUID; MALE; MOUSE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; SENILE PLAQUE; SLEEP DEPRIVATION; SLEEP WAKING CYCLE; WAKEFULNESS;

ACETAMIDES; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; ANTIGENS, SURFACE; CIRCADIAN RHYTHM; DISEASE MODELS, ANIMAL; EXTRACELLULAR FLUID; FEMALE; HIPPOCAMPUS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ISOQUINOLINES; LIGHT; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEUROPEPTIDES; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; SIGNAL TRANSDUCTION; SLEEP; SLEEP DEPRIVATION; WAKEFULNESS;

MUS; MUS MUSCULUS;

EID: 72449161215     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1180962     Document Type: Article

References (15)

1. D. J. Selkoe, Nat. Cell Biol. 6, 1054 (2004).
2. F. Kamenetz et al., Neuron 37, 925 (2003).
3. J. R. Cirrito et al., Neuron 48, 913 (2005).
4. K. Hsiao et al., Science 274, 99 (1996).
5. J. E. Kang, J. R. Cirrito, H. Dong, J. G. Csernansky, D. M. Holtzman, Proc. Natl. Acad. Sci. U.S.A. 104, 10673 (2007).
6. T. S. Kilduff et al., J. Neurosci. 28, 11814 (2008).
7. Y. Yoshida et al., Eur. J. Neurosci. 14, 1075 (2001).
8. C. Peyron et al., J. Neurosci. 18, 9996 (1998).
9. Z. L. Huang et al., Proc. Natl. Acad. Sci. U.S.A. 98, 9965 (2001).
10. V. V. Vyazovskiy, C. Cirelli, M. Pfister-Genskow, U. Faraguna, G. Tononi, Nat. Neurosci. 11, 200 (2008).
11. G. F. Gilestro, G. Tononi, C. Cirelli, Science 324, 109 (2009).
12. J. M. Donlea, N. Ramanan, P. J. Shaw, Science 324, 105 (2009).
13. P. Yan et al., J. Neurosci. 29, 10706 (2009).
14. J. F. Gagnon, D. Petit, V. Latreille, J. Montplaisir, Curr. Pharm. Des. 14, 3430 (2008).
15. We thank E. D. Herzog and G. M. Freeman Jr. for assistance and P. J. Shaw for discussion. This work was supported by NIH grants AG025824, AG030946, NS065667, AG029524, and MH072525; Neuroscience Blueprint Center Core Grant P30 NS057105; Cure Alzheimer's Fund; Alzheimer's Association Zenith Award; and Eli Lilly.