메뉴 건너뛰기




Volumn 105, Issue 4, 2003, Pages 381-392

Role of protein kinase B in Alzheimer's neurofibrillary pathology

Author keywords

Alzheimer's disease; Glycogen synthase kinase 3; Microtubule associated protein tau; Neurofibrillary tangle; Protein kinase B

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN ANTIBODY; PROTEIN KINASE B; TAU PROTEIN; ISOENZYME; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE;

EID: 0038100358     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-002-0657-y     Document Type: Review
Times cited : (150)

References (67)
  • 1
    • 0031913246 scopus 로고    scopus 로고
    • Mechanism of activation and function of protein kinase B
    • Alessi DR, Cohen P (1998) Mechanism of activation and function of protein kinase B. Curr Opin Genet Dev 8:55-62
    • (1998) Curr. Opin. Genet. Dev. , vol.8 , pp. 55-62
    • Alessi, D.R.1    Cohen, P.2
  • 2
    • 0029999787 scopus 로고    scopus 로고
    • Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filament and disassembles microtubules
    • Alonso A del C, Grundke-Iqbal I, Iqbal K (1996) Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filament and disassembles microtubules. Nat Med 2:783-787
    • (1996) Nat. Med. , vol.2 , pp. 783-787
    • Alonso, A.1    del, C.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 3
    • 0031012497 scopus 로고    scopus 로고
    • Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: Sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau
    • Alonso A del C, Grundke-Iqbal I, Barra HS, Iqbal K (1997) Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau. Proc Natl Acad Sci USA 94: 298-303
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 298-303
    • Alonso, A.1    del, C.2    Grundke-Iqbal, I.3    Barra, H.S.4    Iqbal, K.5
  • 4
    • 0035811050 scopus 로고    scopus 로고
    • Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments
    • Alonso A del C, Zaidi T, Novak M, Grundke-Iqbal I, Iqbal K (2001) Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments. Proc Natl Acad Sci USA 98:6923-6928
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 6923-6928
    • Alonso, A.1    del, C.2    Zaidi, T.3    Novak, M.4    Grundke-Iqbal, I.5    Iqbal, K.6
  • 5
    • 0035208849 scopus 로고    scopus 로고
    • Activation of the JNK/p38 pathway occurs in diseases characterized by tau protein pathology and is related to tau phosphorylation but not to apoptosis
    • Atzori C, Ghetti B, Piva R, Srinivasan AN, Zolo P, Delisle MB, Mirra SS, Migheli A (2001) Activation of the JNK/p38 pathway occurs in diseases characterized by tau protein pathology and is related to tau phosphorylation but not to apoptosis. J Neuropathol Exp Neurol 60:1190-1197
    • (2001) J. Neuropathol. Exp. Neurol. , vol.60 , pp. 1190-1197
    • Atzori, C.1    Ghetti, B.2    Piva, R.3    Srinivasan, A.N.4    Zolo, P.5    Delisle, M.B.6    Mirra, S.S.7    Migheli, A.8
  • 6
    • 0034718421 scopus 로고    scopus 로고
    • Regulation and localization of tyrosine216 phosphorylation of glycogen synthase kinase-3beta in cellular and animal models of neuronal degeneration
    • Bhat RV, Shanley J, Correll MP, Fieles WE, Keith RA, Scott CW, Lee CM (2000) Regulation and localization of tyrosine216 phosphorylation of glycogen synthase kinase-3beta in cellular and animal models of neuronal degeneration. Proc Natl Acad Sci USA 97:11074-11079
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 11074-11079
    • Bhat, R.V.1    Shanley, J.2    Correll, M.P.3    Fieles, W.E.4    Keith, R.A.5    Scott, C.W.6    Lee, C.M.7
  • 7
    • 0025863618 scopus 로고
    • Neuropathological staging of Alzheimer-related changes
    • Braak E, Braak H (1991) Neuropathological staging of Alzheimer-related changes. Acta Neuropathol 82:239-259
    • (1991) Acta Neuropathol. , vol.82 , pp. 239-259
    • Braak, E.1    Braak, H.2
  • 8
    • 0026101978 scopus 로고
    • Parvalbumin immunoreactive structures in the hippocampus of the human adult
    • Braak E, Strotkamp B, Braak H (1991) Parvalbumin immunoreactive structures in the hippocampus of the human adult. Cell Tissue Res 264:33-48
    • (1991) Cell Tissue Res. , vol.264 , pp. 33-48
    • Braak, E.1    Strotkamp, B.2    Braak, H.3
  • 9
    • 0028362458 scopus 로고
    • A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads
    • Braak E, Braak H, Mandelkow EM (1994) A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads. Acta Neuropathol 87:554-567
    • (1994) Acta Neuropathol. , vol.87 , pp. 554-567
    • Braak, E.1    Braak, H.2    Mandelkow, E.M.3
  • 10
    • 84907130484 scopus 로고
    • Silver impregnation of Alzheimer's neurofibrillary changes counterstained for basophilic material and lipofuscin pigment
    • Braak H, Braak E, Ohm T, Bohl J (1988) Silver impregnation of Alzheimer's neurofibrillary changes counterstained for basophilic material and lipofuscin pigment. Stain Technol 63: 197-200
    • (1988) Stain. Technol. , vol.63 , pp. 197-200
    • Braak, H.1    Braak, E.2    Ohm, T.3    Bohl, J.4
  • 12
    • 0000276080 scopus 로고
    • Alzheimer's plaques and tangles: A controlled and enhanced silver-staining method
    • Campbell SK, Switzer RC, Martin TL (1987) Alzheimer's plaques and tangles: a controlled and enhanced silver-staining method. Soc Neurosci Abstr 13:H678
    • (1987) Soc. Neurosci. Abstr. , vol.13
    • Campbell, S.K.1    Switzer, R.C.2    Martin, T.L.3
  • 15
    • 0030841793 scopus 로고    scopus 로고
    • PDK1, one of the missing links in insulin signal transduction
    • Cohen P, Alessi DR, Cross DAE (1997) PDK1, one of the missing links in insulin signal transduction. FEBS Lett 410:3-10
    • (1997) FEBS Lett. , vol.410 , pp. 3-10
    • Cohen, P.1    Alessi, D.R.2    Cross, D.A.E.3
  • 16
    • 0027978816 scopus 로고
    • The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: Evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf
    • Cross DA, Alessi DR, Vandenheede JR, McDowell HE, Hundal HS, Cohen P (1994) The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf. Biochem J 303:21-26
    • (1994) Biochem. J. , vol.303 , pp. 21-26
    • Cross, D.A.1    Alessi, D.R.2    Vandenheede, J.R.3    McDowell, H.E.4    Hundal, H.S.5    Cohen, P.6
  • 17
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings B (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378:785-789
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.A.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.5
  • 18
    • 0027184141 scopus 로고
    • p42 mitogen-activated protein kinase in brain: Prominent localization in neuronal cell bodies and dendrites
    • Fiore RS, Bayer VE, Pelech SL, Posada J, Cooper JA, Baraban JM (1993) p42 mitogen-activated protein kinase in brain: prominent localization in neuronal cell bodies and dendrites. Neuroscience 55:463-472
    • (1993) Neuroscience , vol.55 , pp. 463-472
    • Fiore, R.S.1    Bayer, V.E.2    Pelech, S.L.3    Posada, J.4    Cooper, J.A.5    Baraban, J.M.6
  • 19
    • 0015168149 scopus 로고
    • Silver staining of Alzheimer's neurofibrillary changes by means of physical development
    • Gallyas F (1971) Silver staining of Alzheimer's neurofibrillary changes by means of physical development. Acta Morphol Acad Sci Hung 19:1-8
    • (1971) Acta Morphol. Acad. Sci. Hung. , vol.19 , pp. 1-8
    • Gallyas, F.1
  • 20
    • 0027214404 scopus 로고
    • Phosphoprotein phosphatase activities in Alzheimer's disease brain
    • Gong C-X, Singh TJ, Grundke-Iqbal I, Iqbal K (1993) Phosphoprotein phosphatase activities in Alzheimer's disease brain. J Neurochem 61:921-927
    • (1993) J. Neurochem. , vol.61 , pp. 921-927
    • Gong, C.-X.1    Singh, T.J.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 21
    • 0029113874 scopus 로고
    • Phosphatase activity toward abnormally phosphorylated τ: Decrease in Alzheimer disease brain
    • Gong C-X, Shaikh S, Wang J-Z, Zaidi T, Grundke-Iqbal I, Iqbal K (1995) Phosphatase activity toward abnormally phosphorylated τ: decrease in Alzheimer disease brain. J Neurochem 65:732-738
    • (1995) J. Neurochem. , vol.65 , pp. 732-738
    • Gong, C.-X.1    Shaikh, S.2    Wang, J.-Z.3    Zaidi, T.4    Grundke-Iqbal, I.5    Iqbal, K.6
  • 24
    • 0026487365 scopus 로고
    • Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired filament epitopes and neuronal localisation of the kinase
    • Hanger D, Hughes K, Woodgett JR, Brion J-P, Anderton BH (1992) Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired filament epitopes and neuronal localisation of the kinase. Neurosci Lett 147:58-62
    • (1992) Neurosci. Lett. , vol.147 , pp. 58-62
    • Hanger, D.1    Hughes, K.2    Woodgett, J.R.3    Brion, J.-P.4    Anderton, B.H.5
  • 25
    • 0027475421 scopus 로고
    • Modulation of glycogen synthase kinase-3 family by tyrosine phosphorylation
    • Hughes K, Nikolakaki E, Plyte SE, Totty NF, Woodgett JR (1993) Modulation of glycogen synthase kinase-3 family by tyrosine phosphorylation. EMBO J 12:803-808
    • (1993) EMBO J. , vol.12 , pp. 803-808
    • Hughes, K.1    Nikolakaki, E.2    Plyte, S.E.3    Totty, N.F.4    Woodgett, J.R.5
  • 26
    • 0026298636 scopus 로고
    • Ubiquitination and abnormal phosphorylation of paired helical filaments in Alzheimer's disease
    • Iqbal K, Grundke-Iqbal I (1992) Ubiquitination and abnormal phosphorylation of paired helical filaments in Alzheimer's disease. Mol Neurobiol 5:399-410
    • (1992) Mol. Neurobiol. , vol.5 , pp. 399-410
    • Iqbal, K.1    Grundke-Iqbal, I.2
  • 28
    • 0023675999 scopus 로고
    • A novel tubulin-dependent protein kinase forming a paired helical filament epitope on tau
    • Ishiguro K, Ihara Y, Uchida T, Imahori K (1988) A novel tubulin-dependent protein kinase forming a paired helical filament epitope on tau. J Biochem (Tokyo) 104:319-321
    • (1988) J. Biochem. (Tokyo) , vol.104 , pp. 319-321
    • Ishiguro, K.1    Ihara, Y.2    Uchida, T.3    Imahori, K.4
  • 29
    • 0026694783 scopus 로고
    • Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: A radioimmuno-slot-blot assay for nanograms of the protein
    • Khatoon S, Grundke-Iqbal I, Iqbal K (1992) Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein. J Neurochem 59:750-753
    • (1992) J. Neurochem. , vol.59 , pp. 750-753
    • Khatoon, S.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 30
    • 0028095224 scopus 로고
    • Levels of normal and abnormally phosphorylated tau in different cellular and regional compartments of Alzheimer disease and control brains
    • Khatoon S, Grundke-Iqbal I, Iqbal K (1994) Levels of normal and abnormally phosphorylated tau in different cellular and regional compartments of Alzheimer disease and control brains. FEBS Lett 351:80-84
    • (1994) FEBS Lett. , vol.351 , pp. 80-84
    • Khatoon, S.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 33
    • 0027361281 scopus 로고
    • Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease
    • Köpke E, Tung Y-C, Shaikh S, Alonso A del C, Iqbal K, Grundke-Iqbal I (1993) Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease. J Biol Chem 268:24374-24384
    • (1993) J. Biol. Chem. , vol.268 , pp. 24374-24384
    • Köpke, E.1    Tung, Y.-C.2    Shaikh, S.3    Alonso, A.4    del, C.5    Iqbal, K.6    Grundke-Iqbal, I.7
  • 34
    • 0032955426 scopus 로고    scopus 로고
    • Insulin transiently increases tau phosphorylation: Involvement of glycogen synthase kinase-3β and fyn tyrosine kinase
    • Lesort M, Jope RS, Johnson GVW (1999) Insulin transiently increases tau phosphorylation: involvement of glycogen synthase kinase-3β and fyn tyrosine kinase. J Neurochem 72:576-584
    • (1999) J. Neurochem. , vol.72 , pp. 576-584
    • Lesort, M.1    Jope, R.S.2    Johnson, G.V.W.3
  • 37
    • 0034839145 scopus 로고    scopus 로고
    • Effect of the Alzheimer amyloid fragment Abeta (25-35) on Akt/PKB kinase and survival of PC12 cells
    • Martin D, Salinas M, Lopez-Valdaliso R, Serrano E, Recuero M, Cuadrado A (2001) Effect of the Alzheimer amyloid fragment Abeta (25-35) on Akt/PKB kinase and survival of PC12 cells. J Neurochem 78:1000-1008
    • (2001) J. Neurochem. , vol.78 , pp. 1000-1008
    • Martin, D.1    Salinas, M.2    Lopez-Valdaliso, R.3    Serrano, E.4    Recuero, M.5    Cuadrado, A.6
  • 38
    • 0031025743 scopus 로고    scopus 로고
    • Protein phosphatase-2A association with microtubules and its role in restricting the invasiveness of human head and neck squamous cell carcinoma cells
    • Meisinger J, Patel S, Vellody K, Bergstrom R, Benefield J, Lozano Y, Young MR (1997) Protein phosphatase-2A association with microtubules and its role in restricting the invasiveness of human head and neck squamous cell carcinoma cells. Cancer Lett 111: 87-95
    • (1997) Cancer Lett. , vol.111 , pp. 87-95
    • Meisinger, J.1    Patel, S.2    Vellody, K.3    Bergstrom, R.4    Benefield, J.5    Lozano, Y.6    Young, M.R.7
  • 39
    • 16944366762 scopus 로고    scopus 로고
    • Regulation of protein kinase B and glycogen synthase kinase-3 by insulin and β-adrenergic agonists in rat epididymal fat cells
    • Moule SK, Welsh GI, Edgell NJ, Foulstone EJ, Pround CG, Denton RM (1997) Regulation of protein kinase B and glycogen synthase kinase-3 by insulin and β-adrenergic agonists in rat epididymal fat cells. J Biol Chem 272:7713-7719
    • (1997) J. Biol. Chem. , vol.272 , pp. 7713-7719
    • Moule, S.K.1    Welsh, G.I.2    Edgell, N.J.3    Foulstone, E.J.4    Pround, C.G.5    Denton, R.M.6
  • 40
    • 0030603104 scopus 로고    scopus 로고
    • Tyrosine dephosphorylation of glycogen synthase kinase-3 is involved in its extra-cellular signal-dependent inactivation
    • Murai H, Okazaki M, Kikuchi A (1996) Tyrosine dephosphorylation of glycogen synthase kinase-3 is involved in its extra-cellular signal-dependent inactivation. FEBS Lett 392:153-160
    • (1996) FEBS Lett. , vol.392 , pp. 153-160
    • Murai, H.1    Okazaki, M.2    Kikuchi, A.3
  • 41
    • 0031471277 scopus 로고    scopus 로고
    • Apoptosis-related protein expression in the hippocampus in Alzheimer's disease
    • Nagy ZS, Esiri MM (1997) Apoptosis-related protein expression in the hippocampus in Alzheimer's disease. Neurobiol Aging 18:565-571
    • (1997) Neurobiol. Aging , vol.18 , pp. 565-571
    • Nagy, Z.S.1    Esiri, M.M.2
  • 42
    • 0035476408 scopus 로고    scopus 로고
    • Tumor necrosis factor-α activation of protein kinase B in WEHI-164 is accompanied by increased phosphorylation of Ser473, but not Thr308
    • O'Toole A, Moule SK, Lockyer PJ, Halestrap AP (2001) Tumor necrosis factor-α activation of protein kinase B in WEHI-164 is accompanied by increased phosphorylation of Ser473, but not Thr308. Biochem J 259:119-127
    • (2001) Biochem. J. , vol.259 , pp. 119-127
    • O'Toole, A.1    Moule, S.K.2    Lockyer, P.J.3    Halestrap, A.P.4
  • 43
    • 0031196773 scopus 로고    scopus 로고
    • Expression of mRNA for Akt, serine-threonine protein kinase, in the brain during development and its transient enhancement following axotomy of hypoglossal nerve
    • Owada Y, Utsunomiya A, Yoshimoto T, Kondo H (1997) Expression of mRNA for Akt, serine-threonine protein kinase, in the brain during development and its transient enhancement following axotomy of hypoglossal nerve. J Mol Neurosci 9: 27-33
    • (1997) J. Mol. Neurosci. , vol.9 , pp. 27-33
    • Owada, Y.1    Utsunomiya, A.2    Yoshimoto, T.3    Kondo, H.4
  • 44
    • 0030692829 scopus 로고    scopus 로고
    • Phosphorylation by neuronal cdc2-like protein kinase promotes dimerization of tau protein in vitro
    • Paudel HK (1997) Phosphorylation by neuronal cdc2-like protein kinase promotes dimerization of tau protein in vitro. J Biol Chem 272:28328-28334
    • (1997) J. Biol. Chem. , vol.272 , pp. 28328-28334
    • Paudel, H.K.1
  • 45
    • 0037894159 scopus 로고    scopus 로고
    • An WL The stress-activated C-jun amino-terminal kinase (JNK) in Alzheimer disease neurofibrillary degeneration
    • Pei J-J, An WL (2002) The stress-activated C-jun amino-terminal kinase (JNK) in Alzheimer disease neurofibrillary degeneration. Brain Aging 2:26-33
    • (2002) Brain Aging , vol.2 , pp. 26-33
    • Pei, J.-J.1
  • 47
    • 0032578024 scopus 로고    scopus 로고
    • Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration
    • Pei J-J, Grundke-Iqbal I, Iqbal K, Bogdanovic N, Winblad B, Cowburn RF (1998) Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration. Brain Res 797:267-277
    • (1998) Brain Res. , vol.797 , pp. 267-277
    • Pei, J.-J.1    Grundke-Iqbal, I.2    Iqbal, K.3    Bogdanovic, N.4    Winblad, B.5    Cowburn, R.F.6
  • 48
    • 0032850599 scopus 로고    scopus 로고
    • Distribution of active glycogen synthase kinase 3β (GSK-3β) in brains staged for Alzheimer disease neurofibrillary changes
    • Pei J-J, Braak E, Braak H., Grundke-Iqbal I., Iqbal K, Winblad B., Cowburn RF (1999) Distribution of active glycogen synthase kinase 3β (GSK-3β) in brains staged for Alzheimer disease neurofibrillary changes. J Neuropathol Exp Neurol 58: 1010-1019
    • (1999) J. Neuropathol. Exp. Neurol. , vol.58 , pp. 1010-1019
    • Pei, J.-J.1    Braak, E.2    Braak, H.3    Grundke-Iqbal, I.4    Iqbal, K.5    Winblad, B.6    Cowburn, R.F.7
  • 49
    • 0035087703 scopus 로고    scopus 로고
    • Distribution of active forms of C-jun kinase (JNK) and p38 kinase in brains staged with Alzheimer's disease neurofibrillary changes
    • Pei J-J, Braak E, Braak H, Grundke-Iqbal I, Iqbal K, Winblad B, Cowburn RF (2001) Distribution of active forms of C-jun kinase (JNK) and p38 kinase in brains staged with Alzheimer's disease neurofibrillary changes. J Alzheimer's Dis 3:41-48
    • (2001) J. Alzheimer's Dis. , vol.3 , pp. 41-48
    • Pei, J.-J.1    Braak, E.2    Braak, H.3    Grundke-Iqbal, I.4    Iqbal, K.5    Winblad, B.6    Cowburn, R.F.7
  • 50
    • 0036938381 scopus 로고    scopus 로고
    • Up-regulation of cell division cycle (cdc2) in neurons with early stage Alzheimer's disease neurofibrillary changes
    • Pei J-J, Braak H, Gong C-X, Grundke-Iqbal I, Iqbal K, Winblad B, Cowburn RF (2002) Up-regulation of cell division cycle (cdc2) in neurons with early stage Alzheimer's disease neurofibrillary changes. Acta Neuropathol 104:369-376
    • (2002) Acta Neuropathol. , vol.104 , pp. 369-376
    • Pei, J.-J.1    Braak, H.2    Gong, C.-X.3    Grundke-Iqbal, I.4    Iqbal, K.5    Winblad, B.6    Cowburn, R.F.7
  • 51
    • 0038570457 scopus 로고    scopus 로고
    • Up-regulation of mitogen activated protein kinase kinase and mitogen activated protein kinase is associated with the progression of Alzheimer's disease neurofibrillary degeneration
    • in press
    • Pei J-J, Braak H, An WL, Winblad B, Cowburn RF, Grundke-Iqbal I, Iqbal K, (in press) Up-regulation of mitogen activated protein kinase kinase and mitogen activated protein kinase is associated with the progression of Alzheimer's disease neurofibrillary degeneration. Mol Brain Res
    • Mol. Brain Res.
    • Pei, J.-J.1    Braak, H.2    An, W.L.3    Winblad, B.4    Cowburn, R.F.5    Grundke-Iqbal, I.6    Iqbal, K.7
  • 52
    • 0031039081 scopus 로고    scopus 로고
    • Analysis of the expression, distribution and function of cyclin dependent kinase 5 (cdk5) in developing cerebellar macroneurons
    • Pigino G, Paglini G, Ulloa L, Avila J, Caceres A (1997) Analysis of the expression, distribution and function of cyclin dependent kinase 5 (cdk5) in developing cerebellar macroneurons. J Cell Sci 110:257-270
    • (1997) J. Cell Sci. , vol.110 , pp. 257-270
    • Pigino, G.1    Paglini, G.2    Ulloa, L.3    Avila, J.4    Caceres, A.5
  • 53
    • 0035793574 scopus 로고    scopus 로고
    • p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils
    • Rane MJ, Coxon PY, Powell DW, Webster R, Klein JB, Pierce W, Ping P, McLeish KR (2001) p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils. J Biol Chem 276:3517-3523
    • (2001) J. Biol. Chem. , vol.276 , pp. 3517-3523
    • Rane, M.J.1    Coxon, P.Y.2    Powell, D.W.3    Webster, R.4    Klein, J.B.5    Pierce, W.6    Ping, P.7    McLeish, K.R.8
  • 55
    • 0037104720 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 is activated in neuronal cells by Galpha12 and Galpha13 by Rho-independent and Rho-dependent mechanisms
    • Sayas CL, Avila J, Wandosell F (2002) Glycogen synthase kinase-3 is activated in neuronal cells by Galpha12 and Galpha13 by Rho-independent and Rho-dependent mechanisms. J Neurosci 22:6863-6875
    • (2002) J. Neurosci. , vol.22 , pp. 6863-6875
    • Sayas, C.L.1    Avila, J.2    Wandosell, F.3
  • 56
    • 0030712317 scopus 로고    scopus 로고
    • Further evidence that the inhibition of glycogen synthase kinase-3β by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216
    • Shaw M, Cohen P, Alessi DR (1997) Further evidence that the inhibition of glycogen synthase kinase-3β by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216. FEBS Lett 416:307-311
    • (1997) FEBS Lett. , vol.416 , pp. 307-311
    • Shaw, M.1    Cohen, P.2    Alessi, D.R.3
  • 57
    • 0027447602 scopus 로고
    • The protein tyrosine kinase, fyn, in Alzheimer's disease pathology
    • Shirazi SK, Wood JG (1993) The protein tyrosine kinase, fyn, in Alzheimer's disease pathology. NeuroReport 4:435-437
    • (1993) NeuroReport , vol.4 , pp. 435-437
    • Shirazi, S.K.1    Wood, J.G.2
  • 58
    • 0028924295 scopus 로고
    • A novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell-cycle
    • Sontag E, Nunbhakdi-Craig V, Bloom GS, Mumby MC (1995) A novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell-cycle. J Cell Biol: 1131-1144
    • (1995) J. Cell Biol. , pp. 1131-1144
    • Sontag, E.1    Nunbhakdi-Craig, V.2    Bloom, G.S.3    Mumby, M.C.4
  • 59
    • 0030461275 scopus 로고    scopus 로고
    • Regulation of the phosphorylation state and microtubule-binding activity of tau by protein phosphatase 2A
    • Sontag E, Nunbhakdi-Craig V, Lee G, Bloom GS, Mumby MC (1996) Regulation of the phosphorylation state and microtubule-binding activity of tau by protein phosphatase 2A. Neuron 17:1201-1207
    • (1996) Neuron , vol.17 , pp. 1201-1207
    • Sontag, E.1    Nunbhakdi-Craig, V.2    Lee, G.3    Bloom, G.S.4    Mumby, M.C.5
  • 60
    • 0036759157 scopus 로고    scopus 로고
    • Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activtion of cell survival pathways
    • Stein TD, Johnson JA (2002) Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activtion of cell survival pathways. J Neurosci 22:7380-7388
    • (2002) J. Neurosci. , vol.22 , pp. 7380-7388
    • Stein, T.D.1    Johnson, J.A.2
  • 61
    • 0030638139 scopus 로고    scopus 로고
    • Bax protein expression is increased in Alzheimer's brain: Correlations with DNA damage, Bcl-2 expression, and brain pathology
    • Su JH, Deng G, Cotman CW (1997) Bax protein expression is increased in Alzheimer's brain: correlations with DNA damage, Bcl-2 expression, and brain pathology. J Neuropathol Exp Neurol 56:86-93
    • (1997) J. Neuropathol. Exp. Neurol. , vol.56 , pp. 86-93
    • Su, J.H.1    Deng, G.2    Cotman, C.W.3
  • 62
    • 0034598963 scopus 로고    scopus 로고
    • Inactivation of glycogen synthase kinase-3 by protein kinase C delta: Implications for regulation of tau phosphorylation
    • Tsujio I, Tanaka T, Kudo T, Nishikawa T, Shinozaki K, Grundke-Iqbal I, Iqbal K, Takeda M (2000) Inactivation of glycogen synthase kinase-3 by protein kinase C delta: implications for regulation of tau phosphorylation. FEBS Lett 469: 111-117
    • (2000) FEBS Lett. , vol.469 , pp. 111-117
    • Tsujio, I.1    Tanaka, T.2    Kudo, T.3    Nishikawa, T.4    Shinozaki, K.5    Grundke-Iqbal, I.6    Iqbal, K.7    Takeda, M.8
  • 63
    • 0034653608 scopus 로고    scopus 로고
    • The P13K-PDK1 connection: More than just a road to PKB
    • Vanhaesebroeck A, Alessi DR (2000) The P13K-PDK1 connection: more than just a road to PKB. Biochem J 346:561-576
    • (2000) Biochem. J. , vol.346 , pp. 561-576
    • Vanhaesebroeck, A.1    Alessi, D.R.2
  • 64
    • 0025286104 scopus 로고
    • Molecular cloning and expression of glycogen synthase kinase-3/Factor A
    • Woodgett JR (1990) Molecular cloning and expression of glycogen synthase kinase-3/Factor A. EMBO J 9:2431-2438
    • (1990) EMBO J. , vol.9 , pp. 2431-2438
    • Woodgett, J.R.1
  • 65
    • 0029737421 scopus 로고    scopus 로고
    • Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPKI) glycogen synthase kinase-3β and cyclin-dependent kinase 5, a component of TPK II
    • Yamaguchi H, Ishiguro K, Uchida T, Takashima A, Lemere CA, Imahori K (1996) Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPKI) glycogen synthase kinase-3β and cyclin-dependent kinase 5, a component of TPK II. Acta Neuropathol 92:232-241
    • (1996) Acta Neuropathol. , vol.92 , pp. 232-241
    • Yamaguchi, H.1    Ishiguro, K.2    Uchida, T.3    Takashima, A.4    Lemere, C.A.5    Imahori, K.6
  • 67
    • 0033776498 scopus 로고    scopus 로고
    • Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1
    • York RD, Molliver DC, Grewal SS, Stenberg PE, McCleskey EW, Stork PJ (2000) Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1. Mol Cell Biol 20:8069-8083
    • (2000) Mol. Cell Biol. , vol.20 , pp. 8069-8083
    • York, R.D.1    Molliver, D.C.2    Grewal, S.S.3    Stenberg, P.E.4    McCleskey, E.W.5    Stork, P.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.