Comparative transcriptome analysis to unveil genes affecting recombinant protein productivity in mammalian cells

Biotechnology and Bioengineering

Volumn 102, Issue 1, 2009, Pages 246-263

  Yee, Joon Chong ^a   Gerdtzen, Ziomara P ^b   Hu, Wei Shou ^a  

^a University of Minnesota   (United States)

^b UNIVERSITY OF CHILE   (Chile)

Author keywords

CDNA microarrays; CHO cells; Hybridoma; Mammalian cell culture; Transcriptome

Indexed keywords

CDNA MICROARRAYS; CHO CELLS; HYBRIDOMA; MAMMALIAN CELL CULTURE; TRANSCRIPTOME;

ANIMAL CELL CULTURE; ANTIBODIES; CELLS; CYTOLOGY; GENES; MAMMALS; PHOSPHORYLATION; PRODUCTIVITY;

CELL CULTURE;

CHAPERONE; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; OXIDOREDUCTASE; RECOMBINANT PROTEIN; TRANSCRIPTOME; ANTIBODY;

ANIMAL CELL; ANTIBODY PRODUCTION; ARTICLE; CELL LINE; CHO CELL; CHOLESTEROL METABOLISM; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; ENERGY METABOLISM; GENE EXPRESSION; GENETIC TRANSCRIPTION; INTERMETHOD COMPARISON; LIPID METABOLISM; LOW TEMPERATURE; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PROTEIN FOLDING; PROTEIN PROCESSING; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; RESPIRATORY CHAIN; RIBOSOME; ANIMAL; BIOSYNTHESIS; COLD; COMPARATIVE STUDY; CRICETULUS; FEMALE; GENE EXPRESSION PROFILING; HAMSTER; METABOLISM; PRODUCTIVITY; TUMOR CELL LINE;

CRICETULUS GRISEUS; MAMMALIA;

ANIMALS; ANTIBODIES; CELL LINE, TUMOR; CHO CELLS; COLD TEMPERATURE; CRICETINAE; CRICETULUS; EFFICIENCY; FEMALE; GENE EXPRESSION PROFILING; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECOMBINANT PROTEINS;

EID: 58149214612     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22039     Document Type: Article

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