Overexpression of bcl-2 inhibits sodium butyrate-induced apoptosis in Chinese hamster ovary cells resulting in enhanced humanized antibody production

Biotechnology and Bioengineering

Volumn 71, Issue 3, 2000, Pages 184-193

  Kim, No Soo ^a   Lee, Gyun Min ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

Apoptosis; bcl 2; Chinese hamster ovary (CHO); Humanized antibody; Sodium butyrate (NaBu)

Indexed keywords

ANTIBODIES; ANTIGENS; CONCENTRATION (PROCESS); PROTEINS; VIRUSES;

CELL GROWTH;

BIOTECHNOLOGY;

ANTIBODY; BUTYRIC ACID; CASPASE 3; HEPATITIS B SURFACE ANTIGEN; PROTEIN BCL 2;

ANIMAL CELL; ANTIBODY PRODUCTION; ANTIGEN ANTIBODY REACTION; APOPTOSIS; ARTICLE; CELL CULTURE; CELL GROWTH; CELL VIABILITY; CHINESE HAMSTER; CONTROLLED STUDY; CYTOTOXICITY; ENZYME INHIBITION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; NONHUMAN; OVARY CELL;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BUTYRIC ACID; CASPASE 3; CASPASES; CELL CYCLE; CELL SURVIVAL; CHO CELLS; CRICETINAE; CULTURE MEDIA; FLOW CYTOMETRY; GENE EXPRESSION; GENES, BCL-2; HEPATITIS B SURFACE ANTIGENS; HUMANS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECOMBINANT FUSION PROTEINS; TRANSFECTION;

CRICETINAE; CRICETULUS GRISEUS; CYTOMEGALOVIRUS; HEPATITIS B VIRUS; MAMMALIA; SIMIAE; SIMIAN VIRUS; SIMIAN VIRUS 40; TRIXIS;

EID: 0001162423     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0290(2000)71:3<184::AID-BIT1008>3.0.CO;2-W     Document Type: Article

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