Metabolomics-driven approach for the improvement of Chinese hamster ovary cell growth: Overexpression of malate dehydrogenase II

Journal of Biotechnology

Volumn 147, Issue 2, 2010, Pages 116-121

  Chong, William P K ^a,b   Reddy, Satty G ^a   Yusufi, Faraaz N K ^a   Lee, Dong Yup ^a,c   Wong, Niki S C ^a   Heng, Chew Kiat ^b   Yap, Miranda G S ^a,c   Ho, Ying Swan ^a  

^a AGENCY FOR SCIENCE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Aspartate; Chinese hamster ovary; Liquid chromatography mass spectrometry (LC MS); Malate dehydrogenase II; Metabolic engineering; Metabolomics

Indexed keywords

ASPARTATES; CHINESE HAMSTER OVARY; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; MALATE DEHYDROGENASE; METABOLIC ENGINEERING; METABOLOMICS;

BATCH REACTORS; CELL CULTURE; ENZYME ACTIVITY; GROWTH KINETICS; LIQUIDS; MASS SPECTROMETRY; METABOLISM; METABOLITES;

LIQUID CHROMATOGRAPHY;

ADENOSINE TRIPHOSPHATE; ASPARTIC ACID; MALATE DEHYDROGENASE; MALATE DEHYDROGENASE II; MALIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL COUNT; CELL GROWTH; CELL VIABILITY; CHO CELL; CITRIC ACID CYCLE; FED BATCH REACTOR; GENE OVEREXPRESSION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLIC ENGINEERING; METABOLITE; METABOLOMICS; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ASPARTIC ACID; CELL COUNT; CELL CULTURE TECHNIQUES; CELL GROWTH PROCESSES; CHO CELLS; CHROMATOGRAPHY, LIQUID; CRICETINAE; CRICETULUS; MALATE DEHYDROGENASE; MALATES; MASS SPECTROMETRY; METABOLIC NETWORKS AND PATHWAYS; METABOLOMICS;

CRICETULUS GRISEUS;

EID: 77952585767     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2010.03.018     Document Type: Article

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