Protein disulfide isomerase does not control recombinant IgG4 productivity in mammalian cell lines

Biotechnology and Bioengineering

Volumn 105, Issue 4, 2010, Pages 770-779

  Hayes, N V L ^a   Smales, C M ^a   Klappa, P ^a  

^a UNIVERSITY OF KENT   (United Kingdom)

Author keywords

Control; Disulfide bonds; Mammalian cells; Monoclonal antibody productivity; Protein disulfide isomerase

Indexed keywords

CHINESE HAMSTER OVARY CELLS; DISULFIDE BOND FORMATION; DISULFIDE BONDS; ENDOPLASMIC RETICULUM; FOLDED PROTEINS; INTRACELLULAR LEVELS; MAMMALIAN CELL LINES; MAMMALIAN CELLS; MAMMALIAN PROTEINS; MRNA LEVEL; OVER-EXPRESSION; PROTEIN DISULFIDE ISOMERASES; RATE LIMITING; RECOMBINANT MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN PRODUCTIONS;

CELL CULTURE; ENZYME ACTIVITY; MAMMALS; MONOCLONAL ANTIBODIES; PRODUCTIVITY; SURFACE PLASMON RESONANCE;

PROTEINS;

IMMUNOGLOBULIN G4; MESSENGER RNA; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CB72.3; PROTEIN DISULFIDE ISOMERASE; PROTEIN DISULFIDE ISOMERASE ERP72; UNCLASSIFIED DRUG; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; DISULFIDE BOND; ENDOPLASMIC RETICULUM; GENE EXPRESSION; GENE SILENCING; IMMUNOGLOBULIN PRODUCTION; MOUSE; NONHUMAN; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; ANIMAL; BIOSYNTHESIS; CELL LINE; CHO CELL; CRICETULUS; GENETICS; HAMSTER; METABOLISM; PROTEIN FOLDING;

CRICETULUS GRISEUS; MAMMALIA;

ANIMALS; CELL LINE; CHO CELLS; CRICETINAE; CRICETULUS; GENE SILENCING; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; PROTEIN DISULFIDE-ISOMERASES; PROTEIN FOLDING; RECOMBINANT PROTEINS; RNA, MESSENGER;

EID: 77449115254     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22587     Document Type: Article

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