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Volumn 51, Issue 1, 2006, Pages 21-28

Metabolic characteristics of recombinant Chinese hamster ovary cells expressing glutamine synthetase in presence and absence of glutamine

Author keywords

Animal cell culture; Cell metabolism; Glutamine; Glutamine synthetase; Recombinant CHO cell

Indexed keywords

2 OXOGLUTARIC ACID; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GLUTAMATE AMMONIA LIGASE; GLUTAMATE DEHYDROGENASE; GLUTAMINE; ISOCITRATE DEHYDROGENASE; RECOMBINANT PROTEIN;

EID: 33748109526     PISSN: 09209069     EISSN: 15730778     Source Type: Journal    
DOI: 10.1007/s10616-006-9010-y     Document Type: Article
Times cited : (36)

References (26)
  • 1
    • 0029636676 scopus 로고
    • The effect of ammonia on the O-linked glycosylation of granulocyte colony-stimulating factor produced by Chinese hamster ovary cells
    • Andersen DC, Goochee CF (1995) The effect of ammonia on the O-linked glycosylation of granulocyte colony-stimulating factor produced by Chinese hamster ovary cells. Biotechnol Bioeng 47:96-105
    • (1995) Biotechnol Bioeng , vol.47 , pp. 96-105
    • Andersen, D.C.1    Goochee, C.F.2
  • 5
    • 0033527072 scopus 로고    scopus 로고
    • The adaptation of BHK cells to a non-ammoniagenic glutamate-based culture medium
    • Christie A, Butler M (1999) The adaptation of BHK cells to a non-ammoniagenic glutamate-based culture medium. Biotechnol Bioeng 64:298-309
    • (1999) Biotechnol Bioeng , vol.64 , pp. 298-309
    • Christie, A.1    Butler, M.2
  • 6
    • 0019755991 scopus 로고
    • Membrane cholesterol, tumorigenesis and the biochemical phenotype of neoplasia
    • Coleman PS, Lavietes BB (1981) Membrane cholesterol, tumorigenesis and the biochemical phenotype of neoplasia. CRC Crit Rev Biochem 11:341-393
    • (1981) CRC Crit Rev Biochem , vol.11 , pp. 341-393
    • Coleman, P.S.1    Lavietes, B.B.2
  • 7
    • 11944265249 scopus 로고
    • High level expression of tissue inhibitor of metalloproteinases in Chinese hamster ovary cells using glutamine synthetase gene amplification
    • Cockett MI, Bebbington CR, Yarranton GT (1990) High level expression of tissue inhibitor of metalloproteinases in Chinese hamster ovary cells using glutamine synthetase gene amplification. BioTechnol 8:662-667
    • (1990) BioTechnol , vol.8 , pp. 662-667
    • Cockett, M.I.1    Bebbington, C.R.2    Yarranton, G.T.3
  • 8
    • 0037279450 scopus 로고    scopus 로고
    • Improved fermentation processes for NS0 cell lines expressing human antibodies and glutamine synthetase
    • Dempsey J, Ruddock S, Osborne M, Ridley A, Sturt S, Field R (2003) Improved fermentation processes for NS0 cell lines expressing human antibodies and glutamine synthetase. Biotechnol Prog 19:175-178
    • (2003) Biotechnol Prog , vol.19 , pp. 175-178
    • Dempsey, J.1    Ruddock, S.2    Osborne, M.3    Ridley, A.4    Sturt, S.5    Field, R.6
  • 10
    • 0024349791 scopus 로고
    • Liquid chromatographic analysis of amino acids in protein hydrolysates by post-column derivatization with o-phthaladehyde and 3-mercaptoproropionic acid
    • Fiorina A, Frigo G, Cucchetti E (1989) Liquid chromatographic analysis of amino acids in protein hydrolysates by post-column derivatization with o-phthaladehyde and 3-mercaptoproropionic acid. J Chromatogr 476:83-92
    • (1989) J Chromatogr , vol.476 , pp. 83-92
    • Fiorina, A.1    Frigo, G.2    Cucchetti, E.3
  • 11
    • 0027692808 scopus 로고
    • Glucose and glutamine metabolism of a murine B-lymphocyte hybridoma grown in batch culture
    • Fitzpatrick L, Jenkins HA, Butler M (1993) Glucose and glutamine metabolism of a murine B-lymphocyte hybridoma grown in batch culture. Appl Biochem Biotechnol 43:93-116
    • (1993) Appl Biochem Biotechnol , vol.43 , pp. 93-116
    • Fitzpatrick, L.1    Jenkins, H.A.2    Butler, M.3
  • 12
    • 0025340874 scopus 로고
    • Adaptation to non-ammoniagenic medium and selective substrate feeding leads to enhanced yields in animal cell cultures
    • Hassell T, Butler M (1990) Adaptation to non-ammoniagenic medium and selective substrate feeding leads to enhanced yields in animal cell cultures. J Cell Sci 96:501-508
    • (1990) J Cell Sci , vol.96 , pp. 501-508
    • Hassell, T.1    Butler, M.2
  • 13
    • 0025465312 scopus 로고
    • Growth behavior of Chinese hamster ovary cells in a compact loop bioreactor. 2. Effects of medium components and waste products
    • Kurano N, Leist C, Messi F, Kurano S, Fiechter A (1990) Growth behavior of Chinese hamster ovary cells in a compact loop bioreactor. 2. Effects of medium components and waste products. J Biotechnol 15:113-128
    • (1990) J Biotechnol , vol.15 , pp. 113-128
    • Kurano, N.1    Leist, C.2    Messi, F.3    Kurano, S.4    Fiechter, A.5
  • 14
    • 0028500473 scopus 로고
    • Catabolic control of hybridoma cells by glucose and glutamine limited fed batch cultures
    • Ljunggren J, Häggström L (1994) Catabolic control of hybridoma cells by glucose and glutamine limited fed batch cultures. Biotechnol Bioeng 44:808-818
    • (1994) Biotechnol Bioeng , vol.44 , pp. 808-818
    • Ljunggren, J.1    Häggström, L.2
  • 15
    • 0142092531 scopus 로고    scopus 로고
    • Determination of tricarboxylic acid cycle acids and other related substances in cultured mammalian cells by gradient ion-exchange chromatography with suppressed conductivity detection
    • Lu S, Sun X, Shi C, Zhang Y (2003) Determination of tricarboxylic acid cycle acids and other related substances in cultured mammalian cells by gradient ion-exchange chromatography with suppressed conductivity detection. J Chromatogr A 1012:161-168
    • (2003) J Chromatogr A , vol.1012 , pp. 161-168
    • Lu, S.1    Sun, X.2    Shi, C.3    Zhang, Y.4
  • 16
    • 13844296832 scopus 로고    scopus 로고
    • Insight into metabolism of CHO cells at low glucose concentration on the basis of the determination of intracellular metabolites
    • Lu S, Sun X, Zhang Y (2005) Insight into metabolism of CHO cells at low glucose concentration on the basis of the determination of intracellular metabolites. Process Biochem 40:1917-1921
    • (2005) Process Biochem , vol.40 , pp. 1917-1921
    • Lu, S.1    Sun, X.2    Zhang, Y.3
  • 17
    • 0028484019 scopus 로고
    • Examination of primary metabolic pathways in a murine hybridoma with carbon-13 nuclear magnetic resonance spectroscopy
    • Mancuso A, Sharfstein ST, Tucker SN, Clark DS, Blanch HW (1994) Examination of primary metabolic pathways in a murine hybridoma with carbon-13 nuclear magnetic resonance spectroscopy. Biotechnol Bioeng 44:563-585
    • (1994) Biotechnol Bioeng , vol.44 , pp. 563-585
    • Mancuso, A.1    Sharfstein, S.T.2    Tucker, S.N.3    Clark, D.S.4    Blanch, H.W.5
  • 18
    • 0027303835 scopus 로고
    • Mechanisms of ammonia and ammonium ion toxicity in animal cells: Transport across cell membranes
    • Martinelle K, Häggström L (1993) Mechanisms of ammonia and ammonium ion toxicity in animal cells: transport across cell membranes. J Biotechnol 30:339-350
    • (1993) J Biotechnol , vol.30 , pp. 339-350
    • Martinelle, K.1    Häggström, L.2
  • 20
    • 33748111673 scopus 로고
    • Academic Press, New York
    • Meister A (1985) Methods in enzymology, vol 113. Academic Press, New York, pp 158-199
    • (1985) Methods in Enzymology , vol.113 , pp. 158-199
    • Meister, A.1
  • 21
    • 0028765762 scopus 로고
    • Induction of apoptosis in nutrient-deprived cultures of hybridoma and myeloma cells
    • Mercille S, Massie B (1994) Induction of apoptosis in nutrient-deprived cultures of hybridoma and myeloma cells. Biotechnol Bioeng 44:1140-1154
    • (1994) Biotechnol Bioeng , vol.44 , pp. 1140-1154
    • Mercille, S.1    Massie, B.2
  • 22
    • 0016590734 scopus 로고
    • Immunochemical evidence for glutamine-mediated degradation of glutamine synthetase in cultured Chinese hamster cells
    • Milman G, Portnoff LS, Tiemeier DC (1975) Immunochemical evidence for glutamine-mediated degradation of glutamine synthetase in cultured Chinese hamster cells. J Biol Chem 250:1393-1399
    • (1975) J Biol Chem , vol.250 , pp. 1393-1399
    • Milman, G.1    Portnoff, L.S.2    Tiemeier, D.C.3
  • 23
    • 0027033717 scopus 로고
    • Monitoring hybridoma metabolism in continuous suspension culture at the intracellular level
    • Schmid G, Keller T (1992) Monitoring hybridoma metabolism in continuous suspension culture at the intracellular level. Cytotechnology 9:217-229
    • (1992) Cytotechnology , vol.9 , pp. 217-229
    • Schmid, G.1    Keller, T.2
  • 24
    • 0032486571 scopus 로고    scopus 로고
    • Fluxes and enzyme activities in central metabolism of myeloma cells grown in chemostat culture
    • Vriezen N, van Dijken JP (1998) Fluxes and enzyme activities in central metabolism of myeloma cells grown in chemostat culture. Biotechnol Bioeng 59: 28-39
    • (1998) Biotechnol Bioeng , vol.59 , pp. 28-39
    • Vriezen, N.1    Van Dijken, J.P.2
  • 25
    • 8344271026 scopus 로고    scopus 로고
    • Production of recombinant protein therapeutics in cultivated mammalian cells
    • Wurm FM (2004) Production of recombinant protein therapeutics in cultivated mammalian cells. Nat Biotechnol 22:1393-1398
    • (2004) Nat Biotechnol , vol.22 , pp. 1393-1398
    • Wurm, F.M.1
  • 26
    • 1642460583 scopus 로고    scopus 로고
    • Characterisation of G418-induced metabolic load in recombinant CHO and BHK cells: Effect on the activity and expression of central metabolic enzymes
    • Yallop CA, Nørby PL, Jensen R, Reinbach H, Svendsen I (2003) Characterisation of G418-induced metabolic load in recombinant CHO and BHK cells: effect on the activity and expression of central metabolic enzymes. Cytotechnology 42:87-99
    • (2003) Cytotechnology , vol.42 , pp. 87-99
    • Yallop, C.A.1    Nørby, P.L.2    Jensen, R.3    Reinbach, H.4    Svendsen, I.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.