Enhancement of cell proliferation in various mammalian cell lines by gene insertion of a cyclin-dependent kinase homolog

BMC Biotechnology

Volumn 7, Issue , 2007, Pages

  Jaluria, Pratik ^a,b   Betenbaugh, Michael ^a   Konstantopoulos, Konstantinos ^a   Shiloach, Joseph ^b  

^a Johns Hopkins University   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROFILERATION; CYCLIN-DEPENDENT KINASE HOMOLOG; DNA MICROARRAYS; MAMMALIAN CELL;

BIOCHEMISTRY; BIOTECHNOLOGY; DNA; FLOW CYTOMETRY; GENES; MICROARRAYS; PHASE TRANSITIONS; PROTEINS;

CELLS;

ADIPONECTIN; CYCLIN DEPENDENT KINASE 3; CYTOCHROME C OXIDASE; CYTOCHROME C OXIDASE 15; OXYGEN RADICAL; UNCLASSIFIED DRUG; CDKL3 PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE; PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL COUNT; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL GROWTH; CELL PROLIFERATION; CELL SECRETION; CELL STRAIN HEK293; CELL SUSPENSION; CELL VIABILITY; CHO CELL; CONTROLLED STUDY; DNA MICROARRAY; FLOW CYTOMETRY; GENE EXPRESSION; GENE INSERTION; GENETIC ENGINEERING; HELA CELL; HUMAN; HUMAN CELL; MAMMAL CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE PHOSPHORYLATION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; SEQUENCE HOMOLOGY; UPREGULATION; ANIMAL; BIOSYNTHESIS; CELL ADHESION; CELL SURVIVAL; COMPARATIVE STUDY; CONTACT INHIBITION; CRICETULUS; FEMALE; GENE EXPRESSION PROFILING; GENETICS; HAMSTER; INTERPHASE; METABOLISM; PHENOTYPE; PHYSIOLOGY; STANDARD;

CRICETULUS GRISEUS; MAMMALIA;

ANIMALS; CELL ADHESION; CELL COUNT; CELL PROLIFERATION; CELL SURVIVAL; CHO CELLS; CONTACT INHIBITION; CRICETINAE; CRICETULUS; CYCLIN-DEPENDENT KINASES; ELECTRON TRANSPORT COMPLEX IV; FEMALE; GENE EXPRESSION PROFILING; HELA CELLS; HUMANS; INTERPHASE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; PROTEIN-SERINE-THREONINE KINASES; UP-REGULATION;

EID: 37549016345     PISSN: None     EISSN: 14726750     Source Type: Journal    
DOI: 10.1186/1472-6750-7-71     Document Type: Article

References (46)

1. Seth G Hossler P Yee JC Hu WS Engineering cells for cell culture bioprocessing-physiological fundamentals Adv Biochem Eng Biotechnol 2006, 101:119-164. 16989260
2. Fussenegger M Bailey JE Molecular regulation of cell-cycle progression and apoptosis in mammalian cells: Implications for biotechnology Biotechnol Prog 1998, 14:807-833. 10.1021/bp9800891 9841643
3. Bailey JE Sburlati A Hatzimanikatis V Lee K Renner WA Tsai PS Inverse metabolic engineering: A strategy for directed genetic engineering of useful phenotypes Biotechnol Bioeng 2002, 79:568-579. 10.1002/bit.10441 12209828
4. Barnes LM Moy N Dickson AJ Phenotypic variation during cloning procedures: Analysis of the growth behavior of clonal cell lines Biotechnol Bioeng 2006, 94:530-537. 10.1002/bit.20856 16496399
5. Bohm E Voglauer R Steinfellner W Kunert R Borth N Katinger H Screening for improved cell performance: Selection of subclones with altered production kinetics or improved stability by cell sorting Biotechnol Bioeng 2004, 88:699-706. 10.1002/bit.20271 15532061
6. Merrill GV Cell synchronization Methods Cell Biol 1998, 57:229-249. 9648108
7. Hatzimanikatis V Lee KH Bailey JE A mathematical description of regulation of the G1-S transition of the mammalian cell cycle Biotechnol Bioeng 1999, 65:631-637. 10.1002/ (SICI)1097-0290(19991220)65:6<631::AID-BIT3>3.0.CO;2-7 10550769
8. Ifandi V Al-Rubeai M Stable transfection of CHO cells with the c-myc gene results in increased proliferation rates, reduces serum dependency, and induces anchorage independence Cytotechnology 2003, 41:1-10. 10.1023/ A:1024203518501
9. Davis PK Ho A Dowdy SF Biological methods for cell-cycle synchronization of mammalian cells Biotechniques 2001, 30:1322-1326. 11414226
10. Pollard TD Earnshaw WC Cell Biology Philadelphia: Saunders 2004. 15573095
11. Masters JR HeLa cells 50 years on: The good, the bad and the ugly Nat Rev Cancer 2002, 2:315-319. 10.1038/nrc775 12001993
12. Jaluria P Betenbaugh M Konstantopoulos K Frank B Shiloach J Application of microarrays to identify and characterize genes involved in attachment dependence in HeLa cells Metab Eng 2007, 9:241-251. 10.1016/ j.ymben.2006.12.001 17240181
13. Burke HB Discovering Patterns in Microarray Data Mol Diagn 2000, 5:349-357. 10.1054/modi.2000.19562 11172499
14. Quackenbush J Computational Analysis of Microarray Data Nat Rev Genet 2001, 2:418-427. 10.1038/35076576 11389458
15. Simon R Radmacher MD Dobbin K Design of studies using DNA microarrays Genet Epidemiol 2002, 23:21-26. 10.1002/gepi.202 12112246
16. Harvester http://harvester.fzk.de/harvester/
17. GenBank http://www.ncbi.nlm.nih.gov/
18. Racher AJ Moreira JL Alves PM Wirth M Weidle UH Hauser H Carrondo MJ Griffiths JB Expression of recombinant antibody and secreted alkaline phosphatase in mammalian cell. Influence of cell line and culture system upon production kinetics Appl Microbiol Biotechnol 1994, 40:851-856. 10.1007/s002530050079 7764571
19. Robertson JS An overview of host cell selection Dev Biol Stand 1999, 98:7-11. 10494955
20. Yee KW Moore SJ Midmer M Zanke BW Tong F Hedley D Minden MD NKIAMRE, a novel conserved CDC2-related kinase with features of both mitogen-activated protein kinases and cyclin-dependent kinases Biochem Biophys Res Commun 2003, 308:784-792. 10.1016/S0006-291X(03)01475-X 12927787
21. Oquendo CE Antonicka H Shoubridge EA Reardon W Brown GK Functional and genetic studies demonstrate that mutation in the COX15 gene can cause Leigh syndrome J Med Genet 2004, 41:540-544. 10.1136/jmg.2003.017426 15235026
22. Midmer M Haq R Squire JA Zanke BW Identification of NKIAMRE, the human homologue to the mitogen-activated protein kinase-/cyclin-dependent kinase-related protein kinase NKIATRE, and its loss in leukemic blasts with chromosome arm 5q deletion Cancer Res 1999, 59:4069-4074. 10463609
23. Haq R Randall S Midmer M Yee K Zanke B NKIATRE is a novel conserved cdc2-related kinase Genomics 2001, 71:131-141. 10.1006/geno.2000.6424 11161806
24. Hanks SK Quinn AM Hunter T The protein kinase family: Conserved features and deduced phylogeny of the catalytic domains Science 1988, 241:42-52. 10.1126/science.3291115 3291115
25. Miyata Y Nishida E Distantly related cousins of MAP kinase: Biochemical properties and possible physiological functions Biochem Biophys Res Commun 1999, 266:291-295. 10.1006/bbrc.1999.1705 10600495
26. Hofmann F Livingston DM Differential effects of cdk2 and cdk3 on the control of pBb and E2F function during G1 exit Genes Dev 1996, 10:851-861. 10.1101/gad.10.7.851 8846921
27. Thompson MA Stumph J Henrickson SE Rosenwald A Wang Q Olson S Brandt SJ Roberts J Zhang X Shyr Y Kinney MC Differential gene expression in anaplastic lymphoma kinase-positive and anaplastic lymphoma kinase-negative anaplastic large cell lymphomas Hum Pathol 2005, 36:494-504. 10.1016/j.humpath.2005.03.004 15948116
28. Matsuoka M Matsuura Y Semba K Nishimoto I Molecular cloning of a cyclin-like protein associated with cyclin-dependent kinase 3 (cdk 3) in vivo Biochem Biophys Res Commun 2000, 273:442-447. 10.1006/ bbrc.2000.2965 10873625
29. Braun K Holzl G Soucek T Geisen C Moroy T Hengstschlager M Investigation of the cell cycle regulation of cdk3-associated kinase activity and the role of cdk3 in proliferation and transformation Oncogene 1998, 17:2259-2269. 10.1038/sj.onc.1202145 9811456
30. Ren S Rollins BJ Cyclin C/cdk3 promotes Rb-dependent G0 exit Cell 2004, 117:239-251. 10.1016/S0092-8674(04)00300-9 15084261
31. Petruzzella V Tiranti V Fernandez P Ianna P Carrozzo R Zeviani M Identification and characterization of human cDNAs specific to BCS1, PET112, SCO1, COX15, and COX11, five genes involved in the formation and function of the mitochondrial respiratory chain Genomics 1998, 54:494-504. 10.1006/geno.1998.5580 9878253
32. Antonicka H Mattman A Carlson CG Glerum DM Hoffbuhr KC Leary SC Kennaway NG Shoubridge EA Mutations in COX15 produce a defect in the mitochondrial heme biosynthetic pathway, causing early-onset fatal hypertrophic cardiomyopathy Am J Hum Genet 2003, 72:101-114. 378614 12474143 10.1086/345489
33. Glerum DM Muroff I Jin C Tzagoloff A COX15 codes for a mitochondrial protein essential for the assembly of yeast cytochrome oxidase J Biol Chem 1997, 272:19088-19094. 10.1074/jbc.272.30.19088 9228094
34. Bugiani M Tiranti V Farina L Uziel G Zeviani M Novel mutations in COX15 in a long surviving Leigh syndrome patient with cytochrome c oxidase deficiency J Med Genet 2005, 42:e28. 10.1136/jmg.2004.029926 15863660
35. Pecina P Houstkova H Hansikova H Zeman J Houstek J Genetic defects of cytochrome c oxidase assembly Physiol Res 2004, 53(Suppl 1):S213-S223. 15119951
36. Groen AK Wanders RJ Westerhoff HV van der Meer R Tager JM Quantification of the contribution of various steps to the control of mitochondrial respiration J Biol Chem 1982, 257:2754-2757. 7061448
37. Zhuang J Reddi AR Wang Z Khodaverdian B Hegg EL Gibney BR Evaluating the roles of the heme a side chains in cytochrome c oxidase using designed heme proteins Biochemistry 2006, 45:12530-12538. 10.1021/bi060565t 17029408
38. Barros MH Carlson CG Glerum DM Tzagoloff A Involvement of mitochondrial ferredoxin and Cox15p in hydroxylation of heme O FEBS Lett 2001, 492:133-138. 10.1016/S0014-5793(01)02249-9 11248251
39. Van Houten B Woshner V Santos JH Role of mitochondrial DNA in toxic responses to oxidative stress DNA Repair (Amst) 2006, 5:145-152. 10.1016/ j.dnarep.2005.03.002 15878696
40. Kumar S Bandyopadhyay U Free heme toxicity and its detoxification systems in human Toxicol Lett 2005, 157:175-188. 10.1016/ j.toxlet.2005.03.004 15917143
41. Bleckwenn NA Bentley WE Shiloach J Evaluation of production parameters with the vaccinia virus expression system using microcarrier attached HeLa cells Biotechnol Prog 2005, 21:554-561. 10.1021/bp0498443 15801798
42. Bleckwenn NA Golding H Bentley WE Shiloach J Production of recombinant proteins by vaccinia virus in a microcarrier based mammalian cell perfusion bioreactor Biotechnol Bioeng 2005, 90:663-674. 10.1002/ bit.20423 15858791
43. Hegde P Qi R Abernathy K Gay C Dharap S Gaspard R Hughes JE Snesrud E Lee N Quackenbush J A concise guide to cDNA microarray analysis Biotechniques 2000, 29(548):550-556. passim 10997270
44. Mancia F Patel SD Rajala MW Scherer PE Nemes A Schieren I Hendrickson WA Shapiro L Optimization of protein production in mammalian cells with a coexpressed fluorescent marker Structure 2004, 12:1355-1360. 10.1016/ j.str.2004.06.012 15296729
45. Berg AH Combs TP Du X Brownlee M Scherer PE The adipocyte-secreted protein Acrp30 enhances hepatic insulin action Nat Med 2001, 7:947-953. 10.1038/90992 11479628
46. Darzynkiewicz Z Juan G Unit 7.5 DNA content measurement for DNA ploidy and cell cycle analysis Current Protocols in Cytometry 1997.