Modes of Aβ toxicity in Alzheimer's disease

Cellular and Molecular Life Sciences

Volumn 68, Issue 20, 2011, Pages 3359-3375

  Götz, Jürgen ^a   Eckert, Anne ^b   Matamales, Miriam ^a   Ittner, Lars M ^a   Liu, Xin ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Alzheimer; Amyloid; Frontotemporal dementia; Fyn; miRNA; Mitochondria; Oligomer; Proteomic; Tau; Transgenic

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; CD36 ANTIGEN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MICRORNA; MUTANT PROTEIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROTROPHIN RECEPTOR P75; TAU PROTEIN;

ALZHEIMER DISEASE; AMYLOID PLAQUE; CLINICAL FEATURE; COGNITIVE DEFECT; COMPLEX FORMATION; DIAGNOSTIC ACCURACY; DIFFERENTIAL DIAGNOSIS; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EXCITOTOXICITY; FRONTOTEMPORAL DEMENTIA; GENE EXPRESSION; GENE MUTATION; GENETIC REGULATION; GENETIC VARIABILITY; HISTOPATHOLOGY; HUMAN; LONG TERM POTENTIATION; MITOCHONDRIAL RESPIRATION; MOLECULAR PATHOLOGY; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; REVIEW; SIGNAL TRANSDUCTION; TRANSGENIC ANIMAL;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; MICE;

ANIMALIA;

EID: 80054761710     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-011-0750-2     Document Type: Review

References (197)

1. NR Graff-Radford BK Woodruff 2007 Frontotemporal dementia Semin Neurol 27 48 57 17226741 10.1055/s-2006-956755 (Pubitemid 46239039)
2. KR Daffner 2010 Promoting successful cognitive aging: a comprehensive review J Alzheimers Dis 19 1101 1122 20308777
3. MB Graeber 1999 No man alone: the rediscovery of Alois Alzheimer's original cases Brain Pathol 9 237 240 10219740 1:STN:280:DyaK1M3jsFWntA%3D%3D 10.1111/j.1750-3639.1999.tb00221.x
4. A Alzheimer RA Stelzmann HN Schnitzlein FR Murtagh 1995 An English translation of Alzheimer's 1907 paper, "Uber eine eigenartige Erkankung der Hirnrinde" Clin Anat 8 429 431 8713166 1:STN:280:DyaK28zkvVWktg%3D%3D 10.1002/ca.980080612
5. M Goedert 2009 Oskar Fischer and the study of dementia Brain 132 1102 1111 18952676 10.1093/brain/awn256
6. DJ Selkoe 2002 Alzheimer's disease is a synaptic failure Science 298 789 791 12399581 1:CAS:528:DC%2BD38XotFSnur0%3D 10.1126/science.1074069 (Pubitemid 35231524)
7. GG Glenner CW Wong 1984 Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein Biochem Biophys Res Commun 120 885 890 6375662 1:CAS:528:DyaL2cXitVOntLw%3D 10.1016/S0006-291X(84)80190-4 (Pubitemid 14104991)
8. CL Masters G Simms NA Weinman G Multhaup BL McDonald K Beyreuther 1985 Amyloid plaque core protein in Alzheimer disease and Down syndrome Proc Natl Acad Sci USA 82 4245 4249 3159021 1:CAS:528:DyaL2MXktlGltr0%3D 10.1073/pnas.82.12.4245 (Pubitemid 15053619)
9. R Vassar BD Bennett S Babu-Khan S Kahn EA Mendiaz P Denis DB Teplow S Ross P Amarante R Loeloff Y Luo S Fisher J Fuller S Edenson J Lile MA Jarosinski AL Biere E Curran T Burgess JC Louis F Collins J Treanor G Rogers M Citron 1999 Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE Science 286 735 741 10531052 1:CAS:528:DyaK1MXntFWit74%3D 10.1126/science.286.5440.735 (Pubitemid 29505878)
10. D Edbauer E Winkler JT Regula B Pesold H Steiner C Haass 2003 Reconstitution of gamma-secretase activity Nat Cell Biol 5 486 488 12679784 1:CAS:528:DC%2BD3sXjtlamu70%3D 10.1038/ncb960 (Pubitemid 36592274)
11. J Gotz LM Ittner 2008 Animal models of Alzheimer's disease and frontotemporal dementia Nat Rev Neurosci 9 532 544 18568014 10.1038/nrn2420 1:CAS:528:DC%2BD1cXnsFCgsrw%3D (Pubitemid 351873467)
12. VM Lee M Goedert JQ Trojanowski 2001 Neurodegenerative tauopathies Annu Rev Neurosci 24 1121 1159 11520930 1:CAS:528:DC%2BD3MXls1Shsbo%3D 10.1146/annurev.neuro.24.1.1121 (Pubitemid 32695256)
13. I Grundke-Iqbal K Iqbal YC Tung M Quinlan HM Wisniewski LI Binder 1986 Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology Proc Natl Acad Sci USA 83 4913 4917 3088567 1:CAS:528:DyaL28XksFyqtrg%3D 10.1073/pnas.83.13.4913
14. M Goedert CM Wischik RA Crowther JE Walker A Klug 1988 Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau Proc Natl Acad Sci USA 85 4051 4055 3131773 1:CAS:528:DyaL1MXhvFah 10.1073/pnas.85.11.4051
15. A Matus 1990 Microtubule-associated proteins and the determination of neuronal form J Physiol (Paris) 84 134 137 1:CAS:528:DyaK3MXhs1Whtro%3D (Pubitemid 20177940)
16. LM Ittner YD Ke F Delerue M Bi A Gladbach J van Eersel H Wolfing BC Chieng MJ Christie IA Napier A Eckert M Staufenbiel E Hardeman J Gotz 2010 Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models Cell 142 387 397 20655099 1:CAS:528:DC%2BC3cXpvFKrtr4%3D 10.1016/j.cell.2010.06.036
17. F Chen D David A Ferrari J Gotz 2004 Posttranslational modifications of tau-role in human tauopathies and modeling in transgenic animals Curr Drug Targets 5 503 515 15270197 1:CAS:528:DC%2BD2cXlslWjtrw%3D 10.2174/ 1389450043345236 (Pubitemid 39004425)
18. E Kopke YC Tung S Shaikh AC Alonso K Iqbal I Grundke-Iqbal 1993 Microtubule-associated protein tau abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease J Biol Chem 268 24374 24384 8226987 1:CAS:528:DyaK3sXmtVWisro%3D (Pubitemid 23335430)
19. GA Jicha R Bowser IG Kazam P Davies 1997 Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau J Neurosci Res 48 128 132 9130141 1:CAS:528:DyaK2sXivVGqur4%3D 10.1002/(SICI)1097-4547(19970415)48:2<128::AID- JNR5>3.0.CO;2-E (Pubitemid 27181338)
20. JD Harper PT Lansbury Jr 1997 Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins Annu Rev Biochem 66 385 407 9242912 1:CAS:528:DyaK2sXktFOhsrc%3D 10.1146/annurev.biochem.66.1.385 (Pubitemid 27274662)
21. P Hortschansky V Schroeckh T Christopeit G Zandomeneghi M Fandrich 2005 The aggregation kinetics of Alzheimer's beta-amyloid peptide is controlled by stochastic nucleation Protein Sci 14 1753 1759 15937275 1:CAS:528: DC%2BD2MXmtVejtr4%3D 10.1110/ps.041266605 (Pubitemid 40994145)
22. R Pellarin A Caflisch 2006 Interpreting the aggregation kinetics of amyloid peptides J Mol Biol 360 882 892 16797587 1:CAS:528:DC%2BD28XmslKjsbg%3D 10.1016/j.jmb.2006.05.033
23. J Gotz LM Ittner M Fandrich N Schonrock 2008 Is tau aggregation toxic or protective: a sensible question in the absence of sensitive methods? J Alzheimers Dis 14 423 429 18688093
24. J Gotz 2001 Tau and transgenic animal models Brain Res Brain Res Rev 35 266 286 11423157 1:CAS:528:DC%2BD3MXksVGmu7o%3D 10.1016/S0165-0173(01)00055-8 (Pubitemid 32566200)
25. P Kurosinski J Gotz 2002 Glial cells under physiologic and pathological conditions Arch Neurol 59 1524 1528 12374489 10.1001/archneur.59.10.1524
26. SE Arnold BT Hyman J Flory AR Damasio GW Van Hoesen 1991 The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease Cereb Cortex 1 103 116 1822725 1:STN:280:DyaK38zltlGmsw%3D%3D 10.1093/cercor/1.1.103
27. H Braak E Braak 1991 Neuropathological stageing of Alzheimer-related changes Acta Neuropathol (Berl) 82 239 259 1:STN:280:DyaK387gtFOiug%3D%3D 10.1007/BF00308809
28. H Braak E Braak 1995 Staging of Alzheimer's disease-related neurofibrillary changes Neurobiol Aging 16 271 278 7566337 1:STN:280: DyaK28%2FjsVynsg%3D%3D 10.1016/0197-4580(95)00021-6 (discussion 278-284)
29. A Delacourte N Sergeant D Champain A Wattez CA Maurage F Lebert F Pasquier JP David 2002 Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer's disease Neurology 59 398 407 12177374 1:CAS:528: DC%2BD38XmvVarurc%3D (Pubitemid 34857933)
30. L Bertram RE Tanzi 2008 Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses Nat Rev Neurosci 9 768 778 18802446 1:CAS:528:DC%2BD1cXhtFeit7fL 10.1038/nrn2494
31. JC Lambert S Heath G Even D Campion K Sleegers M Hiltunen O Combarros D Zelenika MJ Bullido B Tavernier L Letenneur K Bettens C Berr F Pasquier N Fievet P Barberger-Gateau S Engelborghs P De Deyn I Mateo A Franck S Helisalmi E Porcellini O Hanon MM de Pancorbo C Lendon C Dufouil C Jaillard T Leveillard V Alvarez P Bosco M Mancuso F Panza B Nacmias P Bossu P Piccardi G Annoni D Seripa D Galimberti D Hannequin F Licastro H Soininen K Ritchie H Blanche JF Dartigues C Tzourio I Gut C Van Broeckhoven A Alperovitch M Lathrop P Amouyel 2009 Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease Nat Genet 41 1094 1099 19734903 1:CAS:528: DC%2BD1MXhtV2gsb%2FK 10.1038/ng.439
32. D Harold R Abraham P Hollingworth R Sims A Gerrish ML Hamshere JS Pahwa V Moskvina K Dowzell A Williams N Jones C Thomas A Stretton AR Morgan S Lovestone J Powell P Proitsi MK Lupton C Brayne DC Rubinsztein M Gill B Lawlor A Lynch K Morgan KS Brown PA Passmore D Craig B McGuinness S Todd C Holmes D Mann AD Smith S Love PG Kehoe J Hardy S Mead N Fox M Rossor J Collinge W Maier F Jessen B Schurmann H van den Bussche I Heuser J Kornhuber J Wiltfang M Dichgans L Frolich H Hampel M Hull D Rujescu AM Goate JS Kauwe C Cruchaga P Nowotny JC Morris K Mayo K Sleegers K Bettens S Engelborghs PP De Deyn C Van Broeckhoven G Livingston NJ Bass H Gurling A McQuillin R Gwilliam P Deloukas A Al-Chalabi CE Shaw M Tsolaki AB Singleton R Guerreiro TW Muhleisen MM Nothen S Moebus KH Jockel N Klopp HE Wichmann MM Carrasquillo VS Pankratz SG Younkin PA Holmans M O'Donovan MJ Owen J Williams 2009 Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease Nat Genet 41 1088 1093 19734902 1:CAS:528:DC%2BD1MXhtV2gsbrM 10.1038/ng.440
33. G Jun AC Naj GW Beecham LS Wang J Buros PJ Gallins JD Buxbaum N Ertekin-Taner MD Fallin R Friedland R Inzelberg P Kramer E Rogaeva P St George-Hyslop LB Cantwell BA Dombroski AJ Saykin EM Reiman DA Bennett JC Morris KL Lunetta ER Martin TJ Montine AM Goate D Blacker DW Tsuang D Beekly LA Cupples H Hakonarson W Kukull TM Foroud J Haines R Mayeux LA Farrer MA Pericak-Vance GD Schellenberg 2010 Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes Arch Neurol 67 1473 1484 20697030 10.1001/archneurol.2010.201
34. JR Hodges RR Davies JH Xuereb B Casey M Broe TH Bak JJ Kril GM Halliday 2004 Clinicopathological correlates in frontotemporal dementia Ann Neurol 56 399 406 15349867 10.1002/ana.20203 (Pubitemid 39166559)
35. M Hutton CL Lendon P Rizzu M Baker S Froelich H Houlden S Pickering-Brown S Chakraverty A Isaacs A Grover J Hackett J Adamson S Lincoln D Dickson P Davies RC Petersen M Stevens E de Graaff E Wauters J van Baren M Hillebrand M Joosse JM Kwon P Nowotny P Heutink, et al. 1998 Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17 Nature 393 702 705 9641683 1:CAS:528:DyaK1cXktVyqsr0%3D 10.1038/31508 (Pubitemid 28289662)
36. P Poorkaj TD Bird E Wijsman E Nemens RM Garruto L Anderson A Andreadis WC Wiederholt M Raskind GD Schellenberg 1998 Tau is a candidate gene for chromosome 17 frontotemporal dementia Ann Neurol 43 815 825 9629852 1:CAS:528:DyaK1cXktVSjsL8%3D 10.1002/ana.410430617 (Pubitemid 28280226)
37. MG Spillantini JR Murrell M Goedert MR Farlow A Klug B Ghetti 1998 Mutation in the tau gene in familial multiple system tauopathy with presenile dementia Proc Natl Acad Sci USA 95 7737 7741 9636220 1:CAS:528: DyaK1cXktFCgs7c%3D 10.1073/pnas.95.13.7737 (Pubitemid 28293323)
38. M Baker IR Mackenzie SM Pickering-Brown J Gass R Rademakers C Lindholm J Snowden J Adamson AD Sadovnick S Rollinson A Cannon E Dwosh D Neary S Melquist A Richardson D Dickson Z Berger J Eriksen T Robinson C Zehr CA Dickey R Crook E McGowan D Mann B Boeve H Feldman M Hutton 2006 Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17 Nature 442 916 919 16862116 1:CAS:528:DC%2BD28XosVOgurc%3D 10.1038/nature05016 (Pubitemid 44285946)
39. M Cruts I Gijselinck J van der Zee S Engelborghs H Wils D Pirici R Rademakers R Vandenberghe B Dermaut JJ Martin C van Duijn K Peeters R Sciot P Santens T De Pooter M Mattheijssens M Van den Broeck I Cuijt K Vennekens PP De Deyn S Kumar-Singh C Van Broeckhoven 2006 Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21 Nature 442 920 924 16862115 1:CAS:528:DC%2BD28XosVOgu74%3D 10.1038/nature05017 (Pubitemid 44285947)
40. M Neumann DM Sampathu LK Kwong AC Truax MC Micsenyi TT Chou J Bruce T Schuck M Grossman CM Clark LF McCluskey BL Miller E Masliah IR Mackenzie H Feldman W Feiden HA Kretzschmar JQ Trojanowski VM Lee 2006 Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis Science 314 130 133 17023659 1:CAS:528:DC%2BD28XhtVCiurrL 10.1126/science.1134108 (Pubitemid 44547757)
41. IR Mackenzie R Rademakers M Neumann 2010 TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia Lancet Neurol 9 995 1007 20864052 1:CAS:528:DC%2BC3cXhtFOntbjN 10.1016/S1474-4422(10)70195-2
42. M Cruts C Van Broeckhoven 2008 Loss of progranulin function in frontotemporal lobar degeneration Trends Genet 24 4 186 194 18328591 1:CAS:528:DC%2BD1cXktVKhtbs%3D 10.1016/j.tig.2008.01.004
43. JL Mathias K Morphett 2010 Neurobehavioral differences between Alzheimer's disease and frontotemporal dementia: a meta-analysis J Clin Exp Neuropsychol 32 682 698 20063255 10.1080/13803390903427414
44. VL Villemagne KE Pike G Chetelat KA Ellis RS Mulligan P Bourgeat U Ackermann G Jones C Szoeke O Salvado R Martins G O'Keefe CA Mathis WE Klunk D Ames CL Masters CC Rowe 2011 Longitudinal assessment of abeta and cognition in aging and Alzheimer disease Ann Neurol 69 181 192 21280088 1:CAS:528: DC%2BC3MXisVCisLs%3D 10.1002/ana.22248
45. LM Ittner J Gotz 2011 Amyloid-beta and tau-a toxic pas de deux in Alzheimer's disease Nat Rev Neurosci 12 65 72 21193853 1:CAS:528:DC%2BC3MXjvFeq 10.1038/nrn2967
46. F Assal JL Cummings 2002 Neuropsychiatric symptoms in the dementias Curr Opin Neurol 15 445 450 12151841 10.1097/00019052-200208000-00007 (Pubitemid 34828121)
47. D Neary JS Snowden L Gustafson U Passant D Stuss S Black M Freedman A Kertesz PH Robert M Albert K Boone BL Miller J Cummings DF Benson 1998 Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria [see comments] Neurology 51 1546 1554 9855500 1:STN:280:DyaK1M%2FntFWnsA%3D%3D
48. AJ Walker S Meares PS Sachdev H Brodaty 2005 The differentiation of mild frontotemporal dementia from Alzheimer's disease and healthy aging by neuropsychological tests Int Psychogeriatr 17 57 68 15945591 10.1017/S1041610204000778 (Pubitemid 40593647)
49. JS Snowden D Bathgate A Varma A Blackshaw ZC Gibbons D Neary 2001 Distinct behavioural profiles in frontotemporal dementia and semantic dementia J Neurol Neurosurg Psychiatry 70 323 332 11181853 1:STN:280: DC%2BD3M3gsFWltQ%3D%3D 10.1136/jnnp.70.3.323 (Pubitemid 32250888)
50. ND Weder R Aziz K Wilkins RR Tampi 2007 Frontotemporal dementias: a review Ann Gen Psychiatry 6 15 17565679 10.1186/1744-859X-6-15 (Pubitemid 47054709)
51. J Gotz N Deters A Doldissen L Bokhari Y Ke A Wiesner N Schonrock LM Ittner 2007 A decade of tau transgenic animal models and beyond Brain Pathol 17 91 103 17493043 1:CAS:528:DC%2BD2sXkvFShsrw%3D 10.1111/j.1750-3639.2007.00051.x
52. D Games D Adams R Alessandrini R Barbour P Berthelette C Blackwell T Carr J Clemens T Donaldson F Gillespie, et al. 1995 Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein Nature 373 523 527 7845465 1:CAS:528:DyaK2MXjs1Wns7w%3D 10.1038/373523a0 (see comments)
53. K Hsiao P Chapman S Nilsen C Eckman Y Harigaya S Younkin F Yang G Cole 1996 Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice Science 274 99 102 8810256 1:CAS:528:DyaK28XmtVyns7c%3D 10.1126/science.274.5284.99 (see comments) (Pubitemid 26332733)
54. C Sturchler-Pierrat D Abramowski M Duke KH Wiederhold C Mistl S Rothacher B Ledermann K Burki P Frey PA Paganetti C Waridel ME Calhoun M Jucker A Probst M Staufenbiel B Sommer 1997 Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology Proc Natl Acad Sci USA 94 13287 13292 9371838 1:CAS:528:DyaK2sXnvFamtLs%3D 10.1073/pnas.94.24.13287 (Pubitemid 27518514)
55. M Stalder A Phinney A Probst B Sommer M Staufenbiel M Jucker 1999 Association of microglia with amyloid plaques in brains of APP23 transgenic mice Am J Pathol 154 1673 1684 10362792 1:STN:280:DyaK1M3ptlSisQ%3D%3D 10.1016/S0002-9440(10)65423-5 (Pubitemid 29262849)
56. C Janus J Pearson J McLaurin PM Mathews Y Jiang SD Schmidt MA Chishti P Horne D Heslin J French HT Mount RA Nixon M Mercken C Bergeron PE Fraser P St George-Hyslop D Westaway 2000 A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease Nature 408 979 982 11140685 1:CAS:528:DC%2BD3MXhslWitg%3D%3D 10.1038/35050110 (Pubitemid 32101644)
57. L Mucke E Masliah GQ Yu M Mallory EM Rockenstein G Tatsuno K Hu D Kholodenko K Johnson-Wood L McConlogue 2000 High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation J Neurosci 20 4050 4058 10818140 1:CAS:528:DC%2BD3cXjsFeltbg%3D (Pubitemid 30365675)
58. J Gotz A Probst MG Spillantini T Schafer R Jakes K Burki M Goedert 1995 Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform EMBO J 14 1304 1313 7729409 1:STN:280:DyaK2M3ks1OhsQ%3D%3D
59. T Ishihara M Hong B Zhang Y Nakagawa MK Lee JQ Trojanowski VM Lee 1999 Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform Neuron 24 751 762 10595524 1:CAS:528:DyaK1MXnvFyjsrg%3D 10.1016/S0896-6273(00)81127-7
60. K Spittaels C Van den Haute J Van Dorpe K Bruynseels K Vandezande I Laenen H Geerts M Mercken R Sciot A Van Lommel R Loos F Van Leuven 1999 Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein Am J Pathol 155 2153 2165 10595944 1:CAS:528:DC%2BD3cXit1KntQ%3D%3D 10.1016/S0002-9440(10)65533-2
61. A Probst J Gotz KH Wiederhold M Tolnay C Mistl AL Jaton M Hong T Ishihara VM Lee JQ Trojanowski R Jakes RA Crowther MG Spillantini K Burki M Goedert 2000 Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein Acta Neuropathol (Berl) 99 469 481 1:CAS:528:DC%2BD3cXhvF2murk%3D 10.1007/s004010051148 (Pubitemid 30201307)
62. J Gotz RM Nitsch 2001 Compartmentalized tau hyperphosphorylation and increased levels of kinases in transgenic mice Neuroreport 12 2007 2016 11435938 1:CAS:528:DC%2BD3MXltFajs78%3D 10.1097/00001756-200107030-00045 (Pubitemid 32553723)
63. J Gotz M Tolnay R Barmettler F Chen A Probst RM Nitsch 2001 Oligodendroglial tau filament formation in transgenic mice expressing G272V tau Eur J Neurosci 13 2131 2140 11422454 1:STN:280:DC%2BD3Mzmt1Wqsw%3D%3D 10.1046/j.0953-816x.2001.01604.x (Pubitemid 32578799)
64. J Gotz F Chen R Barmettler RM Nitsch 2001 Tau filament formation in transgenic mice expressing P301L tau J Biol Chem 276 529 534 11013246 1:CAS:528:DC%2BD3MXmtFSqtg%3D%3D 10.1074/jbc.M006531200 (Pubitemid 32050347)
65. J Gotz F Chen J van Dorpe RM Nitsch 2001 Formation of neurofibrillary tangles in P301L tau transgenic mice induced by Abeta 42 fibrils Science 293 1491 1495 11520988 1:STN:280:DC%2BD3MvnslKjsA%3D%3D 10.1126/science.1062097 (Pubitemid 32807681)
66. L Kulic P Kurosinski F Chen J Tracy MH Mohajeri H Li RM Nitsch J Gotz 2005 Active immunization trial in Abeta(42)-injected P301L tau transgenic mice Neurobiol Dis 22 50 56 16289870 10.1016/j.nbd.2005.10.002 1:CAS:528: DC%2BD28XivVOjtb8%3D
67. N Deters LM Ittner J Gotz 2008 Divergent phosphorylation pattern of tau in P301L tau transgenic mice Eur J Neurosci 28 137 147 18662339 10.1111/j.1460-9568.2008.06318.x
68. M Hundelt T Fath K Selle K Oesterwind J Jordan C Schultz J Gotz J von Engelhardt H Monyer L Lewejohann N Sachser L Bakota R Brandt 2009 Altered phosphorylation but no neurodegeneration in a mouse model of tau hyperphosphorylation Neurobiol Aging 32 991 1006 19660835 10.1016/j. neurobiolaging.2009.06.007 1:CAS:528:DC%2BC3MXmsVGhsr8%3D
69. L Pennanen H Welzl P D'Adamo RM Nitsch J Gotz 2004 Accelerated extinction of conditioned taste aversion in P301L tau transgenic mice Neurobiol Dis 15 500 509 15056457 1:CAS:528:DC%2BD2cXivVKnu70%3D 10.1016/j.nbd.2003.11.020 (Pubitemid 38435342)
70. L Pennanen DP Wolfer RM Nitsch J Gotz 2006 Impaired spatial reference memory and increased exploratory behavior in P301L tau transgenic mice Genes Brain Behav 5 369 379 16879631 1:CAS:528:DC%2BD28XptVamsbg%3D 10.1111/j.1601-183X.2005.00165.x (Pubitemid 44000922)
71. N Deters LM Ittner J Gotz 2009 Substrate-specific reduction of PP2A activity exaggerates tau pathology Biochem Biophys Res Commun 379 400 405 19126401 1:CAS:528:DC%2BD1MXotl2jug%3D%3D 10.1016/j.bbrc.2008.12.140
72. LM Ittner T Fath YD Ke M Bi J van Eersel KM Li P Gunning J Gotz 2008 Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia Proc Natl Acad Sci USA 105 15997 16002 18832465 1:CAS:528: DC%2BD1cXht1Ors7nL 10.1073/pnas.0808084105
73. LM Ittner YD Ke J Gotz 2009 Phosphorylated Tau Interacts with c-Jun N-terminal Kinase-interacting Protein 1 (JIP1) in Alzheimer disease J Biol Chem 284 20909 20916 19491104 1:CAS:528:DC%2BD1MXovFWrtLg%3D 10.1074/jbc.M109.014472
74. S Oddo A Caccamo JD Shepherd MP Murphy TE Golde R Kayed R Metherate MP Mattson Y Akbari FM LaFerla 2003 Triple-transgenic model of Alzheimer's disease with plaques and tangles. Intracellular abeta and synaptic dysfunction Neuron 39 409 421 12895417 1:CAS:528:DC%2BD3sXmsFOksro%3D 10.1016/S0896-6273(03)00434-3 (Pubitemid 36937044)
75. S Oddo L Billings JP Kesslak DH Cribbs FM LaFerla 2004 Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome Neuron 43 321 332 15294141 1:CAS:528: DC%2BD2cXmvFOisLk%3D 10.1016/j.neuron.2004.07.003 (Pubitemid 39061125)
76. M Blurton-Jones M Kitazawa H Martinez-Coria NA Castello FJ Muller JF Loring TR Yamasaki WW Poon KN Green FM LaFerla 2009 Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease Proc Natl Acad Sci USA 106 13594 13599 19633196 1:CAS:528:DC%2BD1MXovFKgtrk%3D 10.1073/pnas.0901402106
77. F Grueninger B Bohrmann C Czech TM Ballard JR Frey C Weidensteiner M von Kienlin L Ozmen 2010 Phosphorylation of Tau at S422 is enhanced by Abeta in TauPS2APP triple transgenic mice Neurobiol Dis 37 294 306 19781645 1:CAS:528:DC%2BC3cXos1eq 10.1016/j.nbd.2009.09.004
78. V Rhein X Song A Wiesner LM Ittner G Baysang F Meier L Ozmen H Bluethmann S Drose U Brandt E Savaskan C Czech J Gotz A Eckert 2009 Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice Proc Natl Acad Sci USA 106 20057 20062 19897719 1:CAS:528:DC%2BD1MXhsFGjtLvE
79. J Hardy DJ Selkoe 2002 The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science 297 353 356 12130773 1:CAS:528:DC%2BD38Xls1Cju7s%3D 10.1126/science.1072994 (Pubitemid 34790756)
80. J Gotz A Schild F Hoerndli L Pennanen 2004 Amyloid-induced neurofibrillary tangle formation in Alzheimer's disease: insight from transgenic mouse and tissue-culture models Int J Dev Neurosci 22 453 465 15465275 10.1016/j.ijdevneu.2004.07.013 1:CAS:528:DC%2BD2cXotF2gsL4%3D (Pubitemid 39311434)
81. J Lewis DW Dickson W-L Lin L Chisholm A Corral G Jones S-H Yen N Sahara L Skipper D Yager C Eckman J Hardy M Hutton E McGowan 2001 Enhanced neurofibrillary degeneration in transgenic mice expressing mutant Tau and APP Science 293 1487 1491 11520987 1:CAS:528:DC%2BD3MXmsVeru7Y%3D 10.1126/science.1058189 (Pubitemid 32801551)
82. A Ferrari F Hoerndli T Baechi RM Nitsch J Gotz 2003 Beta-amyloid induces PHF-like tau filaments in tissue culture J Biol Chem 278 40162 40168 12893817 1:CAS:528:DC%2BD3sXnvFamsbY%3D 10.1074/jbc.M308243200 (Pubitemid 37248584)
83. L Pennanen J Gotz 2005 Different tau epitopes define Abeta(42)-mediated tau insolubility Biochem Biophys Res Commun 337 1097 1101 16226718 1:CAS:528:DC%2BD2MXhtFKhs7nJ 10.1016/j.bbrc.2005.09.168 (Pubitemid 41505239)
84. T Bolmont F Clavaguera M Meyer-Luehmann MC Herzig R Radde M Staufenbiel J Lewis M Hutton M Tolnay M Jucker 2007 Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP × Tau transgenic mice Am J Pathol 171 2012 2020 18055549 1:CAS:528:DC%2BD1cXntlartw%3D%3D 10.2353/ajpath.2007.070403
85. M Rapoport HN Dawson LI Binder MP Vitek A Ferreira 2002 Tau is essential to beta -amyloid-induced neurotoxicity Proc Natl Acad Sci USA 99 6364 6369 11959919 1:CAS:528:DC%2BD38XjslWnt74%3D 10.1073/pnas.092136199 (Pubitemid 34493317)
86. ED Roberson K Scearce-Levie JJ Palop F Yan IH Cheng T Wu H Gerstein GQ Yu L Mucke 2007 Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model Science 316 750 754 17478722 1:CAS:528:DC%2BD2sXkvVWrtrw%3D 10.1126/science.1141736 (Pubitemid 46717684)
87. GM Shankar S Li TH Mehta A Garcia-Munoz NE Shepardson I Smith FM Brett MA Farrell MJ Rowan CA Lemere CM Regan DM Walsh BL Sabatini DJ Selkoe 2008 Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory Nat Med 14 837 842 18568035 1:CAS:528: DC%2BD1cXptlKltb0%3D 10.1038/nm1782
88. JJ Palop L Mucke 2009 Epilepsy and cognitive impairments in Alzheimer disease Arch Neurol 66 435 440 19204149 10.1001/archneurol.2009.15
89. DH Small D Maksel ML Kerr J Ng X Hou C Chu H Mehrani S Unabia MF Azari R Loiacono MI Aguilar M Chebib 2007 The beta-amyloid protein of Alzheimer's disease binds to membrane lipids but does not bind to the alpha7 nicotinic acetylcholine receptor J Neurochem 101 1527 1538 17286584 1:CAS:528: DC%2BD2sXnvVantL4%3D 10.1111/j.1471-4159.2006.04444.x (Pubitemid 46848846)
90. HW Kessels LN Nguyen S Nabavi R Malinow 2010 The prion protein as a receptor for amyloid-beta Nature 466 E3 E4 20703260 1:CAS:528:DC%2BC3cXhtVSmu77E 10.1038/nature09217 (discussion E4-E5)
91. Z Gu T Nakamura SA Lipton 2010 Redox reactions induced by nitrosative stress mediate protein misfolding and mitochondrial dysfunction in neurodegenerative diseases Mol Neurobiol 41 55 72 20333559 1:CAS:528: DC%2BC3cXmsFSqsbo%3D 10.1007/s12035-010-8113-9
92. A Nikolaev T McLaughlin DD O'Leary M Tessier-Lavigne 2009 APP binds DR6 to trigger axon pruning and neuron death via distinct caspases Nature 457 981 989 19225519 1:CAS:528:DC%2BD1MXitFKlu7k%3D 10.1038/nature07767
93. M D'Amelio V Cavallucci S Middei C Marchetti S Pacioni A Ferri A Diamantini D De Zio P Carrara L Battistini S Moreno A Bacci M Ammassari-Teule H Marie F Cecconi 2011 Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease Nat Neurosci 14 69 76 21151119 10.1038/nn.2709 1:CAS:528:DC%2BC3cXhsFGgtrnL
94. SL Budd L Tenneti T Lishnak SA Lipton 2000 Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons Proc Natl Acad Sci USA 97 6161 6166 10811898 1:CAS:528:DC%2BD3cXjvFaru70%3D 10.1073/pnas.100121097 (Pubitemid 30367540)
95. C Haass E Mandelkow 2010 Fyn-tau-amyloid: a toxic triad Cell 142 356 358 20691893 1:CAS:528:DC%2BC3cXpvFKrsLY%3D 10.1016/j.cell.2010.07.032
96. MW Salter LV Kalia 2004 Src kinases: a hub for NMDA receptor regulation Nat Rev Neurosci 5 317 328 15034556 1:CAS:528:DC%2BD2cXit12nu7k%3D 10.1038/nrn1368 (Pubitemid 38478658)
97. M Aarts Y Liu L Liu S Besshoh M Arundine JW Gurd YT Wang MW Salter M Tymianski 2002 Treatment of ischemic brain damage by perturbing NMDA receptor-PSD-95 protein interactions Science 298 846 850 12399596 1:CAS:528:DC%2BD38XotFSntbk%3D 10.1126/science.1072873 (Pubitemid 35231541)
98. KA Vossel K Zhang J Brodbeck AC Daub P Sharma S Finkbeiner B Cui L Mucke 2010 Tau reduction prevents Abeta-induced defects in axonal transport Science 330 198 20829454 1:CAS:528:DC%2BC3cXht1CgtrfN 10.1126/science.1194653
99. JA Harris N Devidze L Verret K Ho B Halabisky MT Thwin D Kim P Hamto I Lo GQ Yu JJ Palop E Masliah L Mucke 2010 Transsynaptic progression of amyloid-beta-induced neuronal dysfunction within the entorhinal-hippocampal network Neuron 68 428 441 21040845 1:CAS:528:DC%2BC3cXhtlKkt7vK 10.1016/j.neuron.2010.10.020
100. R Cappai KJ Barnham 2008 Delineating the mechanism of Alzheimer's disease Abeta peptide neurotoxicity Neurochem Res 33 526 532 17762917 1:CAS:528:DC%2BD1cXhs1ahsLk%3D 10.1007/s11064-007-9469-8 (Pubitemid 351230455)
101. YA Lim LM Ittner YL Lim J Gotz 2008 Human but not rat amylin shares neurotoxic properties with Abeta42 in long-term hippocampal and cortical cultures FEBS Lett 582 2188 2194 18486611 1:CAS:528:DC%2BD1cXnt1Ogurw%3D 10.1016/j.febslet.2008.05.006
102. J Gotz LM Ittner YA Lim 2009 Common features between diabetes mellitus and Alzheimer's disease Cell Mol Life Sci 66 1321 1325 19266159 1:CAS:528:DC%2BD1MXksFGhtb8%3D 10.1007/s00018-009-9070-1
103. R Bhatia H Lin R Lal 2000 Fresh and globular amyloid beta protein (1-42) induces rapid cellular degeneration: evidence for AbetaP channel-mediated cellular toxicity FASEB J 14 1233 1243 10834945 1:CAS:528:DC%2BD3cXjvFyjt7c%3D (Pubitemid 30350405)
104. EE Ambroggio DH Kim F Separovic CJ Barrow KJ Barnham LA Bagatolli GD Fidelio 2005 Surface behavior and lipid interaction of Alzheimer beta-amyloid peptide 1-42: a membrane-disrupting peptide Biophys J 88 2706 2713 15681641 1:CAS:528:DC%2BD2MXjtFCjtr0%3D 10.1529/biophysj.104.055582 (Pubitemid 40976137)
105. TL Lau EE Ambroggio DJ Tew R Cappai CL Masters GD Fidelio KJ Barnham F Separovic 2006 Amyloid-beta peptide disruption of lipid membranes and the effect of metal ions J Mol Biol 356 759 770 16403524 1:CAS:528:DC%2BD28XotVKqtw%3D%3D 10.1016/j.jmb.2005.11.091 (Pubitemid 43139335)
106. N Arispe E Rojas HB Pollard 1993 Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum Proc Natl Acad Sci USA 90 567 571 8380642 1:CAS:528: DyaK3sXpvFKitQ%3D%3D 10.1073/pnas.90.2.567 (Pubitemid 23028904)
107. HB Pollard N Arispe E Rojas 1995 Ion channel hypothesis for Alzheimer amyloid peptide neurotoxicity Cell Mol Neurobiol 15 513 526 8719038 1:CAS:528:DyaK28Xht12gtb8%3D 10.1007/BF02071314 (Pubitemid 26023380)
108. C Holscher 1998 Possible causes of Alzheimer's disease: amyloid fragments, free radicals, and calcium homeostasis Neurobiol Dis 5 129 141 9848086 1:CAS:528:DyaK1cXnsFGrsro%3D 10.1006/nbdi.1998.0193 (Pubitemid 28520948)
109. H Lin R Bhatia R Lal 2001 Amyloid beta protein forms ion channels: implications for Alzheimer's disease pathophysiology FASEB J 15 2433 2444 11689468 1:CAS:528:DC%2BD3MXoslSisrs%3D 10.1096/fj.01-0377com (Pubitemid 33063171)
110. A Demuro E Mina R Kayed SC Milton I Parker CG Glabe 2005 Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers J Biol Chem 280 17294 17300 15722360 1:CAS:528:DC%2BD2MXjsFOguro%3D 10.1074/jbc.M500997200 (Pubitemid 41389198)
111. GE Hardingham H Bading 2010 Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders Nat Rev Neurosci 11 682 696 20842175 1:CAS:528:DC%2BC3cXhtFGntL7P 10.1038/nrn2911
112. DH Small SS Mok JC Bornstein 2001 Alzheimer's disease and Abeta toxicity: from top to bottom Nat Rev Neurosci 2 595 598 11484003 1:CAS:528: DC%2BD3MXmtVaqur4%3D 10.1038/35086072 (Pubitemid 33679833)
113. Q Wang DM Walsh MJ Rowan DJ Selkoe R Anwyl 2004 Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5 J Neurosci 24 3370 3378 15056716 1:CAS:528:DC%2BD2cXjt1yhsL0%3D 10.1523/JNEUROSCI.1633-03.2004 (Pubitemid 38451902)
114. AM Minogue AW Schmid MP Fogarty AC Moore VA Campbell CE Herron MA Lynch 2003 Activation of the c-Jun N-terminal kinase signaling cascade mediates the effect of amyloid-beta on long term potentiation and cell death in hippocampus: a role for interleukin-1beta? J Biol Chem 278 27971 27980 12738769 1:CAS:528:DC%2BD3sXlsFKku7o%3D 10.1074/jbc.M302530200 (Pubitemid 36899992)
115. S Kins A Crameri DR Evans BA Hemmings RM Nitsch J Gotz 2001 Reduced PP2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice J Biol Chem 276 38193 38200 11473109 1:CAS:528: DC%2BD3MXotFOru7g%3D
116. S Kins P Kurosinski RM Nitsch J Gotz 2003 Activation of the ERK and JNK signaling pathways caused by neuron specific inhibition of PP2A in transgenic mice Am J Pathol 163 833 843 12937125 1:CAS:528:DC%2BD3sXnsVCjurw%3D 10.1016/S0002-9440(10)63444-X (Pubitemid 37040120)
117. YH Chong YJ Shin EO Lee R Kayed CG Glabe AJ Tenner 2006 ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures J Biol Chem 281 20315 20325 16714296 1:CAS:528:DC%2BD28XmvFeqtL0%3D 10.1074/jbc.M601016200 (Pubitemid 44065806)
118. G Lee ST Newman DL Gard H Band G Panchamoorthy 1998 Tau interacts with src-family non-receptor tyrosine kinases J Cell Sci 111 3167 3177 9763511 1:CAS:528:DyaK1cXnvFOqtrc%3D (Pubitemid 28532427)
119. G Lee R Thangavel VM Sharma JM Litersky K Bhaskar SM Fang LH Do A Andreadis G Van Hoesen H Ksiezak-Reding 2004 Phosphorylation of tau by fyn: implications for Alzheimer's disease J Neurosci 24 2304 2312 14999081 1:CAS:528:DC%2BD2cXitlCrur0%3D 10.1523/JNEUROSCI.4162-03.2004 (Pubitemid 38314562)
120. MP Lambert AK Barlow BA Chromy C Edwards R Freed M Liosatos TE Morgan I Rozovsky B Trommer KL Viola P Wals C Zhang CE Finch GA Krafft WL Klein 1998 Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins Proc Natl Acad Sci USA 95 6448 6453 9600986 1:STN:280:DyaK1c3mtlektQ%3D%3D 10.1073/pnas.95.11.6448 (Pubitemid 28249033)
121. J Chin JJ Palop GQ Yu N Kojima E Masliah L Mucke 2004 Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice J Neurosci 24 4692 4697 15140940 1:CAS:528:DC%2BD2cXksFCqu74%3D 10.1523/JNEUROSCI.0277-04.2004 (Pubitemid 38656624)
122. J Chin JJ Palop J Puolivali C Massaro N Bien-Ly H Gerstein K Scearce-Levie E Masliah L Mucke 2005 Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease J Neurosci 25 9694 9703 16237174 1:CAS:528:DC%2BD2MXht1WqsrnF 10.1523/JNEUROSCI.2980-05.2005 (Pubitemid 41510910)
123. SP Braithwaite S Paul AC Nairn PJ Lombroso 2006 Synaptic plasticity: one STEP at a time Trends Neurosci 29 452 458 16806510 1:CAS:528: DC%2BD28Xns1Slurg%3D 10.1016/j.tins.2006.06.007 (Pubitemid 44118442)
124. ED Roberson B Halabisky JW Yoo J Yao J Chin F Yan T Wu P Hamto N Devidze GQ Yu JJ Palop JL Noebels L Mucke 2011 Amyloid-beta/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease J Neurosci 31 700 711 21228179 1:CAS:528: DC%2BC3MXht1arsrk%3D 10.1523/JNEUROSCI.4152-10.2011
125. EM Snyder Y Nong CG Almeida S Paul T Moran EY Choi AC Nairn MW Salter PJ Lombroso GK Gouras P Greengard 2005 Regulation of NMDA receptor trafficking by amyloid-beta Nat Neurosci 8 1051 1058 16025111 1:CAS:528:DC%2BD2MXmsFWmtL8%3D 10.1038/nn1503 (Pubitemid 41061516)
126. AY Abramov L Canevari MR Duchen 2004 Calcium signals induced by amyloid beta peptide and their consequences in neurons and astrocytes in culture Biochim Biophys Acta 1742 81 87 15590058 1:CAS:528:DC%2BD2cXhtVKktrzL 10.1016/j.bbamcr.2004.09.006 (Pubitemid 39601768)
127. DM Hartley DM Walsh CP Ye T Diehl S Vasquez PM Vassilev DB Teplow DJ Selkoe 1999 Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons J Neurosci 19 8876 8884 10516307 1:CAS:528:DyaK1MXms1ahtb0%3D (Pubitemid 30226709)
128. M Necula R Kayed S Milton CG Glabe 2007 Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct J Biol Chem 282 10311 10324 17284452 1:CAS:528:DC%2BD2sXjs1Sitb4%3D 10.1074/jbc.M608207200 (Pubitemid 47093410)
129. BA Yankner LK Duffy DA Kirschner 1990 Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides Science 250 279 282 2218531 1:CAS:528:DyaK3MXlslansg%3D%3D 10.1126/science.2218531
130. CJ Pike AJ Walencewicz CG Glabe CW Cotman 1991 In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity Brain Res 563 311 314 1786545 1:CAS:528:DyaK38Xks1al 10.1016/0006-8993(91)91553-D
131. CJ Pike AJ Walencewicz CG Glabe CW Cotman 1991 Aggregation-related toxicity of synthetic beta-amyloid protein in hippocampal cultures Eur J Pharmacol 207 367 368 1783006 1:CAS:528:DyaK3MXlvVSksrY%3D 10.1016/0922-4106(91) 90014-9
132. CJ Pike D Burdick AJ Walencewicz CG Glabe CW Cotman 1993 Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state J Neurosci 13 1676 1687 8463843 1:CAS:528:DyaK3sXks12murw%3D (Pubitemid 23095409)
133. DM Walsh I Klyubin JV Fadeeva WK Cullen R Anwyl MS Wolfe MJ Rowan DJ Selkoe 2002 Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo Nature 416 535 539 11932745 1:CAS:528:DC%2BD38XivVOntL8%3D 10.1038/416535a (Pubitemid 34288854)
134. 2+ induced aggregation and dityrosine formation of the Alzheimer's disease amyloid-beta peptide Biochemistry 46 2881 2891 17297919 1:CAS:528:DC%2BD2sXhsFOlurg%3D 10.1021/bi0620961 (Pubitemid 46417926)
135. CG Glabe 2008 Structural classification of toxic amyloid oligomers J Biol Chem 283 29639 29643 18723507 1:CAS:528:DC%2BD1cXht1ynt7rK 10.1074/jbc. R800016200
136. S Barghorn V Nimmrich A Striebinger C Krantz P Keller B Janson M Bahr M Schmidt RS Bitner J Harlan E Barlow U Ebert H Hillen 2005 Globular amyloid beta-peptide oligomer-a homogenous and stable neuropathological protein in Alzheimer's disease J Neurochem 95 834 847 16135089 1:CAS:528:DC%2BD2MXht1SitbjJ 10.1111/j.1471-4159.2005.03407.x (Pubitemid 41567174)
137. S Lesne MT Koh L Kotilinek R Kayed CG Glabe A Yang M Gallagher KH Ashe 2006 A specific amyloid-beta protein assembly in the brain impairs memory Nature 440 352 357 16541076 1:CAS:528:DC%2BD28XitlKgurg%3D 10.1038/nature04533
138. M Ahmed J Davis D Aucoin T Sato S Ahuja S Aimoto JI Elliott WE Van Nostrand SO Smith 2010 Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils Nat Struct Mol Biol 17 561 567 20383142 1:CAS:528:DC%2BC3cXksFalurY%3D 10.1038/nsmb.1799
139. G Habicht C Haupt RP Friedrich P Hortschansky C Sachse J Meinhardt K Wieligmann GP Gellermann M Brodhun J Gotz KJ Halbhuber C Rocken U Horn M Fandrich 2007 Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Abeta protofibrils Proc Natl Acad Sci USA 104 19232 19237 18042730 1:CAS:528:DC%2BD1cXisVKrug%3D%3D 10.1073/pnas.0703793104
140. I Klyubin DM Walsh CA Lemere WK Cullen GM Shankar V Betts ET Spooner L Jiang R Anwyl DJ Selkoe MJ Rowan 2005 Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo Nat Med 11 556 561 15834427 1:CAS:528:DC%2BD2MXjvVOls74%3D 10.1038/nm1234 (Pubitemid 40685979)
141. BL Trommer C Shah SH Yun G Gamkrelidze ES Pasternak WB Stine A Manelli P Sullivan JF Pasternak MJ LaDu 2005 ApoE isoform-specific effects on LTP: blockade by oligomeric amyloid-beta1-42 Neurobiol Dis 18 75 82 15649697 1:CAS:528:DC%2BD2MXkslOhtQ%3D%3D 10.1016/j.nbd.2004.08.011 (Pubitemid 40092897)
142. JP Cleary DM Walsh JJ Hofmeister GM Shankar MA Kuskowski DJ Selkoe KH Ashe 2005 Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function Nat Neurosci 8 79 84 15608634 1:CAS:528: DC%2BD2MXhtFWmsw%3D%3D 10.1038/nn1372 (Pubitemid 41236735)
143. DM Walsh I Klyubin GM Shankar M Townsend JV Fadeeva V Betts MB Podlisny JP Cleary KH Ashe MJ Rowan DJ Selkoe 2005 The role of cell-derived oligomers of Abeta in Alzheimer's disease and avenues for therapeutic intervention Biochem Soc Trans 33 1087 1090 16246051 1:CAS:528:DC%2BD2MXhtFCqs7nO 10.1042/BST20051087 (Pubitemid 41659119)
144. WB Stine Jr KN Dahlgren GA Krafft MJ LaDu 2003 In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis J Biol Chem 278 11612 11622 12499373 1:CAS:528:DC%2BD3sXit1Kgtbs%3D 10.1074/jbc.M210207200 (Pubitemid 36792723)
145. JA White AM Manelli KH Holmberg LJ Van Eldik MJ Ladu 2005 Differential effects of oligomeric and fibrillar amyloid-beta 1-42 on astrocyte-mediated inflammation Neurobiol Dis 18 459 465 15755672 1:CAS:528:DC%2BD2MXhvFygu7Y%3D 10.1016/j.nbd.2004.12.013 (Pubitemid 40332705)
146. M Jin N Shepardson T Yang G Chen D Walsh DJ Selkoe 2011 Soluble amyloid {beta}-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration Proc Natl Acad Sci USA 108 5819 5824 21421841 1:CAS:528:DC%2BC3MXkvVCnu7o%3D 10.1073/pnas.1017033108
147. K Iijima HP Liu AS Chiang SA Hearn M Konsolaki Y Zhong 2004 Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease Proc Natl Acad Sci USA 101 6623 6628 15069204 1:CAS:528:DC%2BD2cXjvVyiu70%3D 10.1073/pnas.0400895101 (Pubitemid 38586024)
148. LM Luheshi GG Tartaglia AC Brorsson AP Pawar IE Watson F Chiti M Vendruscolo DA Lomas CM Dobson DC Crowther 2007 Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity PLoS Biol 5 e290 17973577 10.1371/journal.pbio.0050290 1:CAS:528:DC%2BD2sXhsVersr7I (Pubitemid 350276925)
149. Y Yan C Wang 2007 Abeta40 protects non-toxic Abeta42 monomer from aggregation J Mol Biol 369 909 916 17481654 1:CAS:528:DC%2BD2sXls1Sjt7s%3D 10.1016/j.jmb.2007.04.014 (Pubitemid 46754070)
150. Y Verdier M Zarandi B Penke 2004 Amyloid beta-peptide interactions with neuronal and glial cell plasma membrane: binding sites and implications for Alzheimer's disease J Pept Sci 10 229 248 15160835 1:CAS:528: DC%2BD2cXkt1ChsLY%3D 10.1002/psc.573 (Pubitemid 38594184)
151. M Shibata S Yamada SR Kumar M Calero J Bading B Frangione DM Holtzman CA Miller DK Strickland J Ghiso BV Zlokovic 2000 Clearance of Alzheimer's amyloid-beta(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier J Clin Invest 106 1489 1499 11120756 1:CAS:528: DC%2BD3cXovFagtbs%3D 10.1172/JCI10498 (Pubitemid 32038587)
152. R Deane Z Wu A Sagare J Davis S Du Yan K Hamm F Xu M Parisi B LaRue HW Hu P Spijkers H Guo X Song PJ Lenting WE Van Nostrand BV Zlokovic 2004 LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms Neuron 43 333 344 15294142 1:CAS:528:DC%2BD2cXmvFOisLY%3D 10.1016/j.neuron.2004. 07.017 (Pubitemid 39061126)
153. KG Mawuenyega W Sigurdson V Ovod L Munsell T Kasten JC Morris KE Yarasheski RJ Bateman 2010 Decreased clearance of CNS beta-amyloid in Alzheimer's disease Science 330 1774 21148344 1:CAS:528:DC%2BC3cXhsF2jtbrF 10.1126/science.1197623
154. RJ Ellis JM Olichney LJ Thal SS Mirra JC Morris D Beekly A Heyman 1996 Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: the CERAD experience, Part XV Neurology 46 1592 1596 8649554 1:STN:280:DyaK283kvV2ksQ%3D%3D (Pubitemid 26185777)
155. EJ Coulson 2006 Does the p75 neurotrophin receptor mediate Abeta-induced toxicity in Alzheimer's disease? J Neurochem 98 654 660 16893414 1:CAS:528:DC%2BD28XovFGhsL8%3D 10.1111/j.1471-4159.2006.03905.x (Pubitemid 44051267)
156. A Sotthibundhu AM Sykes B Fox CK Underwood W Thangnipon EJ Coulson 2008 Beta-amyloid(1-42) induces neuronal death through the p75 neurotrophin receptor J Neurosci 28 3941 3946 18400893 1:CAS:528:DC%2BD1cXkvV2hsbY%3D 10.1523/JNEUROSCI.0350-08.2008
157. Y Zhang Y Hong Y Bounhar M Blacker X Roucou O Tounekti E Vereker WJ Bowers HJ Federoff CG Goodyer A LeBlanc 2003 p75 Neurotrophin receptor protects primary cultures of human neurons against extracellular amyloid beta peptide cytotoxicity J Neurosci 23 7385 7394 12917374 1:CAS:528:DC%2BD3sXms1WntrY%3D (Pubitemid 36999530)
158. G Perini V Della-Bianca V Politi G Della Valle I Dal-Pra F Rossi U Armato 2002 Role of p75 neurotrophin receptor in the neurotoxicity by beta-amyloid peptides and synergistic effect of inflammatory cytokines J Exp Med 195 907 918 11927634 1:CAS:528:DC%2BD38Xis1OltbY%3D 10.1084/jem.20011797 (Pubitemid 34286761)
159. FG De Felice PT Velasco MP Lambert K Viola SJ Fernandez ST Ferreira WL Klein 2007 Abeta oligomers induce neuronal oxidative stress through an N-methyl-d-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine J Biol Chem 282 11590 11601 17308309 10.1074/jbc.M607483200 1:CAS:528:DC%2BD2sXjvFagtbc%3D (Pubitemid 47100810)
160. JW Lustbader M Cirilli C Lin HW Xu K Takuma N Wang C Caspersen X Chen S Pollak M Chaney F Trinchese S Liu F Gunn-Moore LF Lue DG Walker P Kuppusamy ZL Zewier O Arancio D Stern SS Yan H Wu 2004 ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease Science 304 448 452 15087549 1:CAS:528:DC%2BD2cXjtVWksrg%3D 10.1126/science.1091230 (Pubitemid 38495942)
161. PJ Crouch R Blake JA Duce GD Ciccotosto QX Li KJ Barnham CC Curtain RA Cherny R Cappai T Dyrks CL Masters IA Trounce 2005 Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42 J Neurosci 25 672 679 15659604 1:CAS:528:DC%2BD2MXhtFOktLg%3D 10.1523/JNEUROSCI. 4276-04.2005
162. C Caspersen N Wang J Yao A Sosunov X Chen JW Lustbader HW Xu D Stern G McKhann SD Yan 2005 Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease FASEB J 19 2040 2041 16210396 1:CAS:528:DC%2BD2MXhtlSmu7fN (Pubitemid 41759758)
163. L Devi BM Prabhu DF Galati NG Avadhani HK Anandatheerthavarada 2006 Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction J Neurosci 26 9057 9068 16943564 1:CAS:528:DC%2BD28Xpt1aqu70%3D 10.1523/JNEUROSCI.1469-06.2006 (Pubitemid 44319397)
164. M Manczak TS Anekonda E Henson BS Park J Quinn PH Reddy 2006 Mitochondria are a direct site of Abeta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression Hum Mol Genet 15 1437 1449 16551656 1:CAS:528:DC%2BD28XjslGhsLs%3D 10.1093/hmg/ddl066
165. U Keil A Bonert CA Marques I Scherping J Weyermann JB Strosznajder F Muller-Spahn C Haass C Czech L Pradier WE Muller A Eckert 2004 Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis J Biol Chem 279 50310 50320 15371443 1:CAS:528:DC%2BD2cXhtVWjs7bN 10.1074/jbc.M405600200 (Pubitemid 39577847)
166. DC David S Hauptmann I Scherping K Schuessel U Keil P Rizzu R Ravid S Dröse U Brandt WE Müller E Eckert J Gotz 2005 Proteomic and functional analysis reveal a mitochondrial dysfunction in P301L tau transgenic mice J Biol Chem 280 23802 23814 15831501 1:CAS:528:DC%2BD2MXltlKhs78%3D 10.1074/jbc.M500356200 (Pubitemid 40884866)
167. A Eckert S Hauptmann I Scherping J Meinhardt V Rhein S Drose U Brandt M Fandrich WE Muller J Gotz 2008 Oligomeric and fibrillar species of β-amyloid (Aβ42) both impair mitochondrial function in P301L tau transgenic mice J Mol Med 86 1255 1267 18709343 1:CAS:528:DC%2BD1cXht1Kns7rP 10.1007/s00109-008-0391-6
168. A Eckert S Hauptmann I Scherping V Rhein F Muller-Spahn J Gotz WE Muller 2008 Soluble beta-amyloid leads to mitochondrial defects in amyloid precursor protein and tau transgenic mice Neurodegener Dis 5 157 159 18322377 1:CAS:528:DC%2BD1cXjs1Wht70%3D 10.1159/000113689 (Pubitemid 351347837)
169. A Eckert KL Schulz V Rhein J Gotz 2010 Convergence of amyloid-beta and tau pathologies on mitochondria in vivo Mol Neurobiol 41 107 114 20217279 1:CAS:528:DC%2BC3cXmsFSqtrk%3D 10.1007/s12035-010-8109-5
170. FJ Hoerndli S Pelech A Papassotiropoulos J Götz 2007 Abeta treatment and P301L tau expression in an Alzheimer's disease tissue culture model act synergistically to promote aberrant cell cycle re-entry Eur J Neurosci 26 60 72 17587323 10.1111/j.1460-9568.2007.05618.x (Pubitemid 47035431)
171. HK Anandatheerthavarada G Biswas MA Robin NG Avadhani 2003 Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells J Cell Biol 161 41 54 12695498 1:CAS:528:DC%2BD3sXjtVaitrY%3D 10.1083/jcb.200207030 (Pubitemid 36459078)
172. K Takuma J Yao J Huang H Xu X Chen J Luddy AC Trillat DM Stern O Arancio SS Yan 2005 ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction FASEB J 19 597 598 15665036 1:CAS:528:DC%2BD2MXjtFaksrk%3D (Pubitemid 40471256)
173. Y Yan Y Liu M Sorci G Belfort JW Lustbader SS Yan C Wang 2007 Surface plasmon resonance and nuclear magnetic resonance studies of ABAD-Abeta interaction Biochemistry 46 1724 1731 17253767 1:CAS:528:DC%2BD2sXot1Wqsg%3D%3D 10.1021/bi061314n
174. KJ Ivins ET Bui CW Cotman 1998 Beta-amyloid induces local neurite degeneration in cultured hippocampal neurons: evidence for neuritic apoptosis Neurobiol Dis 5 365 378 10069579 1:CAS:528:DyaK1MXjvFyisQ%3D%3D 10.1006/nbdi.1998.0228 (Pubitemid 29037288)
175. AR White R Guirguis MW Brazier MF Jobling AF Hill K Beyreuther CJ Barrow CL Masters SJ Collins R Cappai 2001 Sublethal concentrations of prion peptide PrP106-126 or the amyloid beta peptide of Alzheimer's disease activates expression of proapoptotic markers in primary cortical neurons Neurobiol Dis 8 299 316 11300725 1:CAS:528:DC%2BD3MXis1Sis7w%3D 10.1006/nbdi.2001.0386 (Pubitemid 32382483)
176. C Casas N Sergeant JM Itier V Blanchard O Wirths N van der Kolk V Vingtdeux E van de Steeg G Ret T Canton H Drobecq A Clark B Bonici A Delacourte J Benavides C Schmitz G Tremp TA Bayer P Benoit L Pradier 2004 Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model Am J Pathol 165 1289 1300 15466394 1:CAS:528:DC%2BD2cXptFSmtbc%3D 10.1016/S0002-9440(10)63388-3 (Pubitemid 39297734)
177. P Gomez-Ramos M Asuncion Moran 2007 Ultrastructural localization of intraneuronal Abeta-peptide in Alzheimer disease brains J Alzheimers Dis 11 53 59 17361035 1:CAS:528:DC%2BD2sXisVGju7o%3D (Pubitemid 46376709)
178. J Wegiel I Kuchna K Nowicki J Frackowiak B Mazur-Kolecka H Imaki J Wegiel PD Mehta WP Silverman B Reisberg M Deleon T Wisniewski T Pirttilla H Frey T Lehtimaki T Kivimaki FE Visser W Kamphorst A Potempska D Bolton JR Currie DL Miller 2007 Intraneuronal Abeta immunoreactivity is not a predictor of brain amyloidosis-beta or neurofibrillary degeneration Acta Neuropathol 113 389 402 17237937 1:CAS:528:DC%2BD2sXjtVSqt74%3D 10.1007/s00401-006-0191-4 (Pubitemid 46421628)
179. A Eckert K Schmitt J Gotz 2011 Mitochondrial dysfunction-the beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-beta toxicity Alzheimers Res Ther 3 15 21545753 1:CAS:528: DC%2BC3MXmtFWhtbY%3D 10.1186/alzrt74
180. F Hoerndli D David J Gotz 2005 Functional genomics meets neurodegenerative disorders. Part II: application and data integration Prog Neurobiol 76 169 188 16169146 1:CAS:528:DC%2BD2MXhtVehsrfO 10.1016/j.pneurobio. 2005.07.002 (Pubitemid 41377165)
181. RA Sowell JB Owen DA Butterfield 2009 Proteomics in animal models of Alzheimer's and Parkinson's diseases Ageing Res Rev 8 1 17 18703168 1:CAS:528:DC%2BD1MXitlCnsbY%3D 10.1016/j.arr.2008.07.003
182. F Chen MA Wollmer F Hoerndli G Münch B Kuhla EI Rogaev M Tsolaki A Papassotiropoulos J Gotz 2004 Role for glyoxalase I in Alzheimer's disease Proc Natl Acad Sci USA 101 7687 7692 15128939 1:CAS:528:DC%2BD2cXktlOlurw%3D 10.1073/pnas.0402338101 (Pubitemid 38658090)
183. FJ Hoerndli M Toigo A Schild J Gotz PJ Day 2004 Reference genes identified in SH-SY5Y cells using custom-made gene arrays with validation by quantitative polymerase chain reaction Anal Biochem 335 30 41 15519568 1:CAS:528:DC%2BD2cXpt1Sqt70%3D 10.1016/j.ab.2004.08.028 (Pubitemid 39446227)
184. DC David LM Ittner P Gehrig D Nergenau C Shepherd G Halliday J Gotz 2006 β-Amyloid treatment of two complementary P301L tau-expressing Alzheimer's disease models reveals similar deregulated cellular processes Proteomics 6 6566 6577 17111439 1:CAS:528:DC%2BD2sXms1KitA%3D%3D 10.1002/pmic.200600634 (Pubitemid 46048395)
185. N Schonrock YD Ke D Humphreys M Staufenbiel LM Ittner T Preiss J Gotz 2010 Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-beta PLoS ONE 5 e11070 20552018 10.1371/journal.pone.0011070 1:CAS:528:DC%2BC3cXnvVChtrw%3D
186. SS Hebert B De Strooper 2009 Alterations of the microRNA network cause neurodegenerative disease Trends Neurosci 32 199 206 19268374 1:CAS:528:DC%2BD1MXkt1Skt7k%3D 10.1016/j.tins.2008.12.003
187. WX Wang BR Wilfred SK Madathil G Tang Y Hu J Dimayuga AJ Stromberg Q Huang KE Saatman PT Nelson 2010 miR-107 Regulates granulin/progranulin with implications for traumatic brain injury and neurodegenerative disease Am J Pathol 177 334 345 20489155 1:CAS:528:DC%2BC3cXpslCrs7Y%3D 10.2353/ajpath.2010. 091202
188. E Vilardo C Barbato M Ciotti C Cogoni F Ruberti 2010 MicroRNA-101 regulates amyloid precursor protein expression in hippocampal neurons J Biol Chem 285 18344 18351 20395292 1:CAS:528:DC%2BC3cXmvFaqsr8%3D 10.1074/jbc.M110.112664
189. H Siomi MC Siomi 2010 Posttranscriptional regulation of microRNA biogenesis in animals Mol Cell 38 323 332 20471939 1:CAS:528: DC%2BC3cXms1alsLk%3D 10.1016/j.molcel.2010.03.013
190. MR Fabian N Sonenberg W Filipowicz 2010 Regulation of mRNA translation and stability by microRNAs Annu Rev Biochem 79 351 379 20533884 1:CAS:528:DC%2BC3cXpslShtro%3D 10.1146/annurev-biochem-060308-103103
191. WX Wang BW Rajeev AJ Stromberg N Ren G Tang Q Huang I Rigoutsos PT Nelson 2008 The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1 J Neurosci 28 1213 1223 18234899 10.1523/JNEUROSCI.5065-07.2008 1:CAS:528:DC%2BD1cXhvVSksbs%3D (Pubitemid 351186356)
192. SS Hebert K Horre L Nicolai AS Papadopoulou W Mandemakers AN Silahtaroglu S Kauppinen A Delacourte B De Strooper 2008 Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression Proc Natl Acad Sci USA 105 6415 6420 18434550 1:CAS:528:DC%2BD1cXlsFGktrw%3D 10.1073/pnas.0710263105 (Pubitemid 351758360)
193. JP Cogswell J Ward IA Taylor M Waters Y Shi B Cannon K Kelnar J Kemppainen D Brown C Chen RK Prinjha JC Richardson AM Saunders AD Roses CA Richards 2008 Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways J Alzheimers Dis 14 27 41 18525125 1:CAS:528:DC%2BD1cXmtlygt78%3D (Pubitemid 352039013)
194. V Boissonneault I Plante S Rivest P Provost 2009 MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1 J Biol Chem 284 1971 1981 18986979 1:CAS:528:DC%2BD1MXlvFaksw%3D%3D 10.1074/jbc.M807530200
195. M Kapsimali WP Kloosterman E de Bruijn F Rosa RH Plasterk SW Wilson 2007 MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system Genome Biol 8 R173 17711588 10.1186/gb-2007-8-8- r173 1:CAS:528:DC%2BD2sXhtVOms7%2FP (Pubitemid 351891464)
196. JS Mattick IV Makunin 2005 Small regulatory RNAs in mammals Hum Mol Genet 14 1 R121 R132 15809264 1:CAS:528:DC%2BD2MXjsFeksbY%3D 10.1093/hmg/ddi101 (Pubitemid 40542628)
197. J Lu G Getz EA Miska E Alvarez-Saavedra J Lamb D Peck A Sweet-Cordero BL Ebert RH Mak AA Ferrando JR Downing T Jacks HR Horvitz TR Golub 2005 MicroRNA expression profiles classify human cancers Nature 435 834 838 15944708 1:CAS:528:DC%2BD2MXkvVGgsLc%3D 10.1038/nature03702 (Pubitemid 40839735)