메뉴 건너뛰기




Volumn 14, Issue 1, 2008, Pages 27-41

Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways

Author keywords

Alzheimer's disease; Inflammation; Insulin signaling; MicroRNA; Neurogenesis

Indexed keywords

MICRORNA;

EID: 47849124269     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2008-14103     Document Type: Article
Times cited : (795)

References (72)
  • 1
    • 26844498125 scopus 로고    scopus 로고
    • J.F. Abelson, K.Y. Kwan, B.J. O'Roak, D.Y. Baek, A.A. Stillman, T.M. Morgan, C.A. Mathews, D.L. Pauls, M.-R. Rasin, M. Gunel, J.A. Spertus, J.F. Leckman, L.S. Dure, R. Kurlan, H.S. Singer, D.L. Gilbert, A. Farhi, A. Louvi, R.P. Lifton, N. Sestan and M.W. State. Sequence variants in SLITRK1 are associated with Tourette's syndrome, Science 310 (2005), 317-320.
    • J.F. Abelson, K.Y. Kwan, B.J. O'Roak, D.Y. Baek, A.A. Stillman, T.M. Morgan, C.A. Mathews, D.L. Pauls, M.-R. Rasin, M. Gunel, J.A. Spertus, J.F. Leckman, L.S. Dure, R. Kurlan, H.S. Singer, D.L. Gilbert, A. Farhi, A. Louvi, R.P. Lifton, N. Sestan and M.W. State. Sequence variants in SLITRK1 are associated with Tourette's syndrome, Science 310 (2005), 317-320.
  • 2
    • 0032971621 scopus 로고    scopus 로고
    • The expression of several mitochondrial and nuclear genes encoding the subunit of electron transport chain complexes, cytochrome c oxidase, and NADH dehydrogenase, in different brain regions in alzheimer's disease
    • M.Y. Aksenov, H.M. Tucker, P. Nair, M.V. Aksenova, D.A. Butterfield, E. Estus and W.R. Markesbury, The expression of several mitochondrial and nuclear genes encoding the subunit of electron transport chain complexes, cytochrome c oxidase, and NADH dehydrogenase, in different brain regions in alzheimer's disease, Neurochem Res 24 (1999), 767-774.
    • (1999) Neurochem Res , vol.24 , pp. 767-774
    • Aksenov, M.Y.1    Tucker, H.M.2    Nair, P.3    Aksenova, M.V.4    Butterfield, D.A.5    Estus, E.6    Markesbury, W.R.7
  • 3
    • 0036592758 scopus 로고    scopus 로고
    • The role of the metabolic lesion in Alzheimer's disease
    • J.P. Blass, G.E. Gibson and S. Hoyer, The role of the metabolic lesion in Alzheimer's disease, J Alzheimers Dis 4 (2002), 225-232.
    • (2002) J Alzheimers Dis , vol.4 , pp. 225-232
    • Blass, J.P.1    Gibson, G.E.2    Hoyer, S.3
  • 4
    • 0025863618 scopus 로고    scopus 로고
    • Neuropathological staging of Alzheimer's related changes
    • H. Braak and E. Braak, Neuropathological staging of Alzheimer's related changes, Acta Neuropathol 82 (2004), 239-259.
    • (2004) Acta Neuropathol , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 5
    • 34147162708 scopus 로고    scopus 로고
    • Immune cells may fend off Alzheimer disease
    • M. Britschgi and T. Wyss-Coray, Immune cells may fend off Alzheimer disease, Nat Med 13 (2007), 408-409.
    • (2007) Nat Med , vol.13 , pp. 408-409
    • Britschgi, M.1    Wyss-Coray, T.2
  • 7
    • 0036841178 scopus 로고    scopus 로고
    • Broad expression of Toll-like receptors in the human central nervous system
    • M. Bsibsi, R. Ravid, D. Gveric and J.M. van Noort, Broad expression of Toll-like receptors in the human central nervous system, J Neuropathol Exp Neurol 61 (2002), 1013-1021.
    • (2002) J Neuropathol Exp Neurol , vol.61 , pp. 1013-1021
    • Bsibsi, M.1    Ravid, R.2    Gveric, D.3    van Noort, J.M.4
  • 8
    • 18244390483 scopus 로고    scopus 로고
    • Mitochondrial abnormalities in Alzheimer brain: Mechanistic implications
    • P. Bubber, V. Haroutunian, G. Fisch, J.P. Blass and G.E. Gibson, Mitochondrial abnormalities in Alzheimer brain: Mechanistic implications, Ann Neurol 57 (2005), 695-703.
    • (2005) Ann Neurol , vol.57 , pp. 695-703
    • Bubber, P.1    Haroutunian, V.2    Fisch, G.3    Blass, J.P.4    Gibson, G.E.5
  • 9
    • 29444436680 scopus 로고    scopus 로고
    • Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity
    • S. Chang, T.R. Ma, D. Miranda, M.E. Balestra, R.W. Mahley and Y. Huang, Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity, Proc Natl Acad Sci USA 102 (2005), 18694-18699.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 18694-18699
    • Chang, S.1    Ma, T.R.2    Miranda, D.3    Balestra, M.E.4    Mahley, R.W.5    Huang, Y.6
  • 10
    • 0346727524 scopus 로고    scopus 로고
    • MicroRNAs modulate hematopoietic lineage differentiation
    • C.-Z. Chen, L. Li, H.F. Lodish and D.P. Bartel. MicroRNAs modulate hematopoietic lineage differentiation, Science 303 (2004), 83-86.
    • (2004) Science , vol.303 , pp. 83-86
    • Chen, C.-Z.1    Li, L.2    Lodish, H.F.3    Bartel, D.P.4
  • 12
    • 33845468713 scopus 로고    scopus 로고
    • Insulin resistance syndrome and Alzheimer disease: Pathophysiologic mechanisms and therapeutic implications
    • S. Craft, Insulin resistance syndrome and Alzheimer disease: pathophysiologic mechanisms and therapeutic implications, Alzheimer Dis Assoc Disord 20 (2006), 298-301.
    • (2006) Alzheimer Dis Assoc Disord , vol.20 , pp. 298-301
    • Craft, S.1
  • 13
    • 85036936850 scopus 로고    scopus 로고
    • A. Culhane, Multivariate analyses of microarray data using Ade4, Bioconductor v2.1, http://bioconductor.org/packages/bioc/html/made4.html, Posted 8 October 2007, Accessed January 30, 2008.
    • A. Culhane, Multivariate analyses of microarray data using Ade4, Bioconductor v2.1, http://bioconductor.org/packages/bioc/html/made4.html, Posted 8 October 2007, Accessed January 30, 2008.
  • 14
    • 33748310866 scopus 로고    scopus 로고
    • Detection of mammalian microRNA expression by in situ hybridization with RNA oligonucleotides
    • M. Deo, J.-Y. Yu, K.-H., Chung, M. Tippens and D.L. Turner, Detection of mammalian microRNA expression by in situ hybridization with RNA oligonucleotides, Dev Dynamics 235 (2006), 2538-2548.
    • (2006) Dev Dynamics , vol.235 , pp. 2538-2548
    • Deo, M.1    Yu, J.-Y.2    Chung, K.-H.3    Tippens, M.4    Turner, D.L.5
  • 15
    • 33947201115 scopus 로고    scopus 로고
    • Loss-of-function presenilin mutations in Alzheimer disease. Talking point on the role of presenilin mutations in Alzheimer disease,
    • B. De Strooper, Loss-of-function presenilin mutations in Alzheimer disease. Talking point on the role of presenilin mutations in Alzheimer disease, EMBO Reports 8 (2007), 141-146.
    • (2007) EMBO Reports , vol.8 , pp. 141-146
    • De Strooper, B.1
  • 16
    • 23044447002 scopus 로고    scopus 로고
    • Evidence from a case-control study
    • Association between dementia and infectious disease
    • M.D.M. Dunn, M. Mullee, V.H. Perry and C. Holmes, Association between dementia and infectious disease: Evidence from a case-control study, Alzheimer Dis Assoc Disord 19 (2005), 91-94.
    • (2005) Alzheimer Dis Assoc Disord , vol.19 , pp. 91-94
    • Dunn, M.D.M.1    Mullee, M.2    Perry, V.H.3    Holmes, C.4
  • 17
    • 33646922314 scopus 로고    scopus 로고
    • Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3
    • T. Engel, F. Hernandez, J. Avila and J.J. Lucas, Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3, J Neurosci 26 (2006), 5083-5090.
    • (2006) J Neurosci , vol.26 , pp. 5083-5090
    • Engel, T.1    Hernandez, F.2    Avila, J.3    Lucas, J.J.4
  • 19
    • 33645294070 scopus 로고    scopus 로고
    • Oncomirs - microRNAs with a role in cancer
    • A. Esquela-Kerscher and F.J. Slack, Oncomirs - microRNAs with a role in cancer, Nat Rev Cancer 6 (2006), 259-269.
    • (2006) Nat Rev Cancer , vol.6 , pp. 259-269
    • Esquela-Kerscher, A.1    Slack, F.J.2
  • 21
    • 1842455649 scopus 로고    scopus 로고
    • Reduction of glutamate uptake into cerebral cortex of developing rats by the branched-chain alpha-keto acids accumulating in maple syrup urine disease
    • C. Funchal, A.M. Rosa, M. Wajner, S. Wofchuk and R.P. Pureur, Reduction of glutamate uptake into cerebral cortex of developing rats by the branched-chain alpha-keto acids accumulating in maple syrup urine disease, Neurochem Res 29 (2004), 747-753.
    • (2004) Neurochem Res , vol.29 , pp. 747-753
    • Funchal, C.1    Rosa, A.M.2    Wajner, M.3    Wofchuk, S.4    Pureur, R.P.5
  • 23
    • 33750705653 scopus 로고    scopus 로고
    • A century of Alzheimer's disease
    • M. Goedert and G. Spillantani, A century of Alzheimer's disease, Science 314 (2006), 777-781.
    • (2006) Science , vol.314 , pp. 777-781
    • Goedert, M.1    Spillantani, G.2
  • 24
    • 0346096686 scopus 로고    scopus 로고
    • Neurogenesis and brain injury: Managing a renewable resource for repair
    • A.F. Hallbergson, C. Gnatenco and D.A. Peterson, Neurogenesis and brain injury: managing a renewable resource for repair, J Clin Invest 112 (2003), 1128-1133.
    • (2003) J Clin Invest , vol.112 , pp. 1128-1133
    • Hallbergson, A.F.1    Gnatenco, C.2    Peterson, D.A.3
  • 25
    • 35649011441 scopus 로고    scopus 로고
    • Overexpression of miR-29, highly upregulated in diabetic rats, leads to insulin resistance in 3T3-L1 adipocytes
    • doi:10.1210/me.2007 0167
    • A. He, L. Zhu, N, Gupta, Y. Chang and F. Fang, Overexpression of miR-29, highly upregulated in diabetic rats, leads to insulin resistance in 3T3-L1 adipocytes, Mol Endocrinol 21 (2007), 2785-2794, doi:10.1210/me.2007 0167.
    • (2007) Mol Endocrinol , vol.21 , pp. 2785-2794
    • He, A.1    Zhu, L.2    Gupta, N.3    Chang, Y.4    Fang, F.5
  • 27
    • 0035844289 scopus 로고    scopus 로고
    • S.-H. Jo, M.-K. Son H.-J. Koh, S.-M. Lee, I.-H. Song, Y.-O. Kim, Y.-S. Lee, K.-S., Jeong, W.B. Kim, J.-W. Park, B.-J. Song and T.-L. Huh, Control of mitochondrial redox balance and cellular defense against oxidative damage by mitochondrial NADP+-dependent isocitrate dehydrogenase (IDPm), J Biol Chem 276 (2001), 16168-16176.
    • S.-H. Jo, M.-K. Son H.-J. Koh, S.-M. Lee, I.-H. Song, Y.-O. Kim, Y.-S. Lee, K.-S., Jeong, W.B. Kim, J.-W. Park, B.-J. Song and T.-L. Huh, Control of mitochondrial redox balance and cellular defense against oxidative damage by mitochondrial NADP+-dependent isocitrate dehydrogenase (IDPm), J Biol Chem 276 (2001), 16168-16176.
  • 29
    • 84949501486 scopus 로고    scopus 로고
    • N. Johnson, A. Kemp, A. and S. Kotz, Univariate Discrete Distributions, Second Edition, John Wiley and Sons, New York, 1992.
    • N. Johnson, A. Kemp, A. and S. Kotz, Univariate Discrete Distributions, Second Edition, John Wiley and Sons, New York, 1992.
  • 30
    • 0034108632 scopus 로고    scopus 로고
    • Branched chain amino acids induce apoptosis in neural cells without mitochondrial membrane depolarization or cytochrome c release: Implications for neurological impairment associated with maple syrup urine disease
    • P. Jouvet, P. Rustin, D.L. Taylor, J.M. Pocock, U. Felderhoof-Mueser, N.D. Mazarakis, C. Sarrat, U. Joashi, M. Kozma, K. Greenwood, A.D. Edwards and H. Mehmet, 2000, Branched chain amino acids induce apoptosis in neural cells without mitochondrial membrane depolarization or cytochrome c release: Implications for neurological impairment associated with maple syrup urine disease, Mol Biol Cell 11 (2005), 1919-1932.
    • (2000) Mol Biol Cell , vol.11 , pp. 1919-1932
    • Jouvet, P.1    Rustin, P.2    Taylor, D.L.3    Pocock, J.M.4    Felderhoof-Mueser, U.5    Mazarakis, N.D.6    Sarrat, C.7    Joashi, U.8    Kozma, M.9    Greenwood, K.10    Edwards, A.D.11    Mehmet, H.12
  • 31
    • 85036951059 scopus 로고    scopus 로고
    • J. Kemppainen, J. Shelton, K. Kelnar, S. Volz, H. Peltier, A. Szafranska, D. Ovcharenko, T. Illmer, M. Labourier, G. Latham and D. Brown, microRNAs as biomarkers in blood and other biofluids, http://www.asuragen.com/pdfs/posters/ biomarkers.pdf, Accessed January 30, 2008.
    • J. Kemppainen, J. Shelton, K. Kelnar, S. Volz, H. Peltier, A. Szafranska, D. Ovcharenko, T. Illmer, M. Labourier, G. Latham and D. Brown, microRNAs as biomarkers in blood and other biofluids, http://www.asuragen.com/pdfs/posters/ biomarkers.pdf, Accessed January 30, 2008.
  • 33
    • 25644456097 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced inflammation exacerbates Tau Pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease
    • M. Kitazawa, S. Oddo, T.R. Yamasaki, K.M. Green and F.M. LaFerla, Lipopolysaccharide-induced inflammation exacerbates Tau Pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease, J Neurosci 25 (2005), 8843-8853.
    • (2005) J Neurosci , vol.25 , pp. 8843-8853
    • Kitazawa, M.1    Oddo, S.2    Yamasaki, T.R.3    Green, K.M.4    LaFerla, F.M.5
  • 34
    • 36448969801 scopus 로고    scopus 로고
    • Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA
    • doi:10.1038/nn2010
    • M.E. Klein, D.T. Lioy, L. Ma, S. Impey, G. Mandel and R.H. Goodman, Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA, Nat Neurosci (2007), doi:10.1038/nn2010.
    • (2007) Nat Neurosci
    • Klein, M.E.1    Lioy, D.T.2    Ma, L.3    Impey, S.4    Mandel, G.5    Goodman, R.H.6
  • 35
    • 24644437266 scopus 로고    scopus 로고
    • The Elegance of the MicroRNAs: A Neuronal Perspective
    • K.S. Kosik and A.M. Krichevsky, The Elegance of the MicroRNAs: A Neuronal Perspective, Neuron 47 (2005), 779-782.
    • (2005) Neuron , vol.47 , pp. 779-782
    • Kosik, K.S.1    Krichevsky, A.M.2
  • 37
    • 33745480963 scopus 로고    scopus 로고
    • Specific microRNAs modulate embryonic stem cell-derived neurogenesis
    • A.M. Krichevsky, K.-C. Sonntag, O. Isacson and K. Kosik, Specific microRNAs modulate embryonic stem cell-derived neurogenesis, Stem Cells 24 (2006), 857-864.
    • (2006) Stem Cells , vol.24 , pp. 857-864
    • Krichevsky, A.M.1    Sonntag, K.-C.2    Isacson, O.3    Kosik, K.4
  • 41
    • 33750347347 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
    • M.T. Lin and M.F. Beal. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases, Nature 443 (2006), 787-795.
    • (2006) Nature , vol.443 , pp. 787-795
    • Lin, M.T.1    Beal, M.F.2
  • 43
    • 22244456028 scopus 로고    scopus 로고
    • Amyloid beta peptide 1-40 enhances the action of Toll-like receptor-2 and -4 agonists but antagonizes Toll-like receptor-9-induced inflammation in primary mouse microglial cell cultures
    • M. Lotz, S. Ebert, H. Esselmann, A.I. Iliev, M. Prinz, N, Wiazewicz, J. Wiltfang, J. Gerber and R. Nau, Amyloid beta peptide 1-40 enhances the action of Toll-like receptor-2 and -4 agonists but antagonizes Toll-like receptor-9-induced inflammation in primary mouse microglial cell cultures, J Neurochem 94 (2005), 289-298.
    • (2005) J Neurochem , vol.94 , pp. 289-298
    • Lotz, M.1    Ebert, S.2    Esselmann, H.3    Iliev, A.I.4    Prinz, M.5    Wiazewicz, N.6    Wiltfang, J.7    Gerber, J.8    Nau, R.9
  • 44
    • 33847203593 scopus 로고    scopus 로고
    • Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus
    • W. Lukiw, Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus, Mol Neurosci 18 (2007), 297-300.
    • (2007) Mol Neurosci , vol.18 , pp. 297-300
    • Lukiw, W.1
  • 45
    • 36048992118 scopus 로고    scopus 로고
    • T cell activation by TLRs: A role to TLRs in the adaptive immune response
    • pe48
    • H. MacLeod and L.M. Wetzler, T cell activation by TLRs: A role to TLRs in the adaptive immune response, Science STKE (2007), 402, pe48.
    • (2007) Science STKE , vol.402
    • MacLeod, H.1    Wetzler, L.M.2
  • 46
    • 34250162541 scopus 로고    scopus 로고
    • Alzheimer's disease: A new take on tau
    • J. Marx, Alzheimer's disease: A new take on tau, Science 316 (2007), 1416-1417.
    • (2007) Science , vol.316 , pp. 1416-1417
    • Marx, J.1
  • 47
    • 27944480498 scopus 로고    scopus 로고
    • Human microRNA (miR29b) expression controls the amount of branched chain a-ketoacid dehydrogenase complex in a cell
    • B.D. Mersey, P. Jin and D.J. Danner, Human microRNA (miR29b) expression controls the amount of branched chain a-ketoacid dehydrogenase complex in a cell, Hum Mol Genet 14 (2005), 3371-3377.
    • (2005) Hum Mol Genet , vol.14 , pp. 3371-3377
    • Mersey, B.D.1    Jin, P.2    Danner, D.J.3
  • 48
    • 34547774686 scopus 로고    scopus 로고
    • Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induce inflammation but not in the anti-inflammatory action of glucocorticoids
    • S.A. Moschos, A.E. Williams, M.M. Perry, M.A. Birrell, M.G. Belvisi and M.A. Lindsay, Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induce inflammation but not in the anti-inflammatory action of glucocorticoids, BMC Genomics 8 (2007), 240.
    • (2007) BMC Genomics , vol.8 , pp. 240
    • Moschos, S.A.1    Williams, A.E.2    Perry, M.M.3    Birrell, M.A.4    Belvisi, M.G.5    Lindsay, M.A.6
  • 49
    • 33947104955 scopus 로고    scopus 로고
    • Dynamic regulation of miRNA expression in ordered stages of cellular development
    • J.R. Neilson, G.X. Zheng, C.B. Burge and P.A. Sharp, Dynamic regulation of miRNA expression in ordered stages of cellular development, Genes Dev 21 (2007), 578-589.
    • (2007) Genes Dev , vol.21 , pp. 578-589
    • Neilson, J.R.1    Zheng, G.X.2    Burge, C.B.3    Sharp, P.A.4
  • 50
    • 21844473275 scopus 로고    scopus 로고
    • High-throughput RNAi screening in vitro: From cell lines to primary cells
    • D. Ovcharenko, S. Hunicke-Smith, K. Kelnar, D. Brown and R. Jarvis, High-throughput RNAi screening in vitro: From cell lines to primary cells, RNA 11 (2005), 985-993.
    • (2005) RNA , vol.11 , pp. 985-993
    • Ovcharenko, D.1    Hunicke-Smith, S.2    Kelnar, K.3    Brown, D.4    Jarvis, R.5
  • 51
    • 0035116513 scopus 로고    scopus 로고
    • Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation
    • G. Pigino, A. Pelsman, H. Mori and J. Busciglio, Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation, J Neurosci 21 (2001), 834-842.
    • (2001) J Neurosci , vol.21 , pp. 834-842
    • Pigino, G.1    Pelsman, A.2    Mori, H.3    Busciglio, J.4
  • 52
    • 28344440823 scopus 로고    scopus 로고
    • multiple mechanisms for a tiny RNA?
    • MicroRNA function
    • R.S. Pillai, MicroRNA function: multiple mechanisms for a tiny RNA? RNA-A Publication of the Rna Society 11 (2005), 1753-1761.
    • (2005) RNA-A Publication of the Rna Society , vol.11 , pp. 1753-1761
    • Pillai, R.S.1
  • 53
    • 33750371447 scopus 로고    scopus 로고
    • Chemokines, mononuclear cells and the nervous system: Heaven (or hell) is in the details
    • N. Rebenko-Moll, L. Liu, A. Cardon and R. Ransohoff, Chemokines, mononuclear cells and the nervous system: heaven (or hell) is in the details, Curr Opin Immunol 18 (2006), 683-689.
    • (2006) Curr Opin Immunol , vol.18 , pp. 683-689
    • Rebenko-Moll, N.1    Liu, L.2    Cardon, A.3    Ransohoff, R.4
  • 57
    • 1942494040 scopus 로고    scopus 로고
    • Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation
    • L.F. Sempere, S. Freemantle, I. Pitha-Rowe, E. Moss, E. Dmitrovsky and V. Ambros, Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation, Genome Biol 5 (2004), R13.1-R13.11.
    • (2004) Genome Biol , vol.5
    • Sempere, L.F.1    Freemantle, S.2    Pitha-Rowe, I.3    Moss, E.4    Dmitrovsky, E.5    Ambros, V.6
  • 58
    • 36348994146 scopus 로고    scopus 로고
    • MicroRNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells
    • B. Shi, L. Sepp-Lorenzino, M. Prisco, P. Linsley, T. deAngelis and R. Baserga, MicroRNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells, J Biol Chem 282 (2007), 32582-32590.
    • (2007) J Biol Chem , vol.282 , pp. 32582-32590
    • Shi, B.1    Sepp-Lorenzino, L.2    Prisco, M.3    Linsley, P.4    deAngelis, T.5    Baserga, R.6
  • 59
    • 33644499134 scopus 로고    scopus 로고
    • Cell-type-specific signatures of microRNAs on target mRNA expression
    • P. Sood, A. Kreck, M. Zavolan, G. Macino and N. Rajewsky, Cell-type-specific signatures of microRNAs on target mRNA expression, Proc Natl Acad Sci USA 103 (2006), 2746-2751.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 2746-2751
    • Sood, P.1    Kreck, A.2    Zavolan, M.3    Macino, G.4    Rajewsky, N.5
  • 62
    • 33747608638 scopus 로고    scopus 로고
    • NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
    • K.D. Taganov, M.P. Boldin, K.-J. Chang and D. Baltimore, NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses, Proc Natl Acad Sci USA 103 (2006), 12481-12486.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 12481-12486
    • Taganov, K.D.1    Boldin, M.P.2    Chang, K.-J.3    Baltimore, D.4
  • 63
    • 33750576993 scopus 로고    scopus 로고
    • Role of toll-like receptor signaling in Aβ uptake and clearance
    • K. Tahara, H.-D. Kim, J.-J. Jin, J.A. Maxwell, L. Li and F. Ken-ichiro, Role of toll-like receptor signaling in Aβ uptake and clearance, Brain 129(2006), 3006-3019.
    • (2006) Brain , vol.129 , pp. 3006-3019
    • Tahara, K.1    Kim, H.-D.2    Jin, J.-J.3    Maxwell, J.A.4    Li, L.5    Ken-ichiro, F.6
  • 65
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • H. Valadi, K. Ekstrom, A. Bossios, J. Sjostrand, J.J. Lee and J.O. Lotvall, Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells, Nat Cell Biol 9 (2007), 1-6.
    • (2007) Nat Cell Biol , vol.9 , pp. 1-6
    • Valadi, H.1    Ekstrom, K.2    Bossios, A.3    Sjostrand, J.4    Lee, J.J.5    Lotvall, J.O.6
  • 66
    • 33644768174 scopus 로고    scopus 로고
    • Control of translation and mRNA degradation by miRNAs and siRNAs
    • M.A. Valencia-Sanchez, J. Liu, G.J. Hannon and R. Parker, Control of translation and mRNA degradation by miRNAs and siRNAs, Genes Dev 20 (2006), 515-524.
    • (2006) Genes Dev , vol.20 , pp. 515-524
    • Valencia-Sanchez, M.A.1    Liu, J.2    Hannon, G.J.3    Parker, R.4
  • 69
    • 0036430133 scopus 로고    scopus 로고
    • Lymphocyte development in neonatal and adult c-Kit-deficient (c-KitW/W) mice
    • C. Waskow and H.R. Rodewald, Lymphocyte development in neonatal and adult c-Kit-deficient (c-KitW/W) mice, Adv Exp Med Biol 512 (2002), 1-10.
    • (2002) Adv Exp Med Biol , vol.512 , pp. 1-10
    • Waskow, C.1    Rodewald, H.R.2
  • 70
    • 33646846157 scopus 로고    scopus 로고
    • Insulin resistance, inflammation and cognition in Alzheimer's disease: Lessons for multiple sclerosis
    • G.S. Watson and S. Craft, Insulin resistance, inflammation and cognition in Alzheimer's disease: Lessons for multiple sclerosis, J Neurol Sci 245 (2006), 21-33.
    • (2006) J Neurol Sci , vol.245 , pp. 21-33
    • Watson, G.S.1    Craft, S.2
  • 71
    • 0036710280 scopus 로고    scopus 로고
    • IRS proteins and the common path to diabetes
    • M.F. White, IRS proteins and the common path to diabetes, Am J Physiol Endocrinol Metab 283 (2001), E413-E422.
    • (2001) Am J Physiol Endocrinol Metab , vol.283
    • White, M.F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.