Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice

Journal of Neuroscience

Volumn 24, Issue 19, 2004, Pages 4692-4697

  Chin, Jeannie ^a   Palop, Jorge J ^a   Yu, Gui Qiu ^a   Kojima, Nobuhiko ^b   Masliah, Eliezer ^c   Mucke, Lennart ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d GLADSTONE INSTITUTE OF NEUROLOGICAL DISEASE   (United States)

Author keywords

Alzheimer's disease; Amyloid ; Fyn kinase; GAP 43; Neurodegeneration; Signaling; Sprouting; Synaptic deficits

Indexed keywords

AMYLOID PRECURSOR PROTEIN; PROTEIN KINASE FYN;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE OVEREXPRESSION; HIPPOCAMPUS; HUMAN; IMMUNOREACTIVITY; MOUSE; NERVE CELL PLASTICITY; NERVE DEGENERATION; NERVE ENDING; NERVE FIBER GROWTH; NERVE SPROUTING; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; SYNAPSE; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; GAP-43 PROTEIN; HUMANS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PRESYNAPTIC TERMINALS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-FYN; SYNAPSES; SYNAPTOPHYSIN;

EID: 2442711560     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0277-04.2004     Document Type: Article

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