Sublethal concentrations of prion peptide PrP106-126 or the amyloid beta peptide of Alzheimer's disease activates expression of proapoptotic markers in primary cortical neurons

Neurobiology of Disease

Volumn 8, Issue 2, 2001, Pages 299-316

  White, A R ^a   Guirguis, R ^a   Brazier, M W ^a   Jobling, M F ^a   Hill, A F ^a   Beyreuther, K ^b   Barrow, C J ^c   Masters, C L ^a   Collins, S J ^a   Cappai, R ^a  

^a FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Alzheimer's disease; Amyloid; Apoptosis; Caspase; Mad cow disease; Neurodegeneration; Prions

Indexed keywords

AMYLOID BETA PROTEIN; CASPASE; CASPASE 3; CASPASE 6; LIPOCORTIN 5; PRION PROTEIN;

ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; BRAIN CELL; DISEASE COURSE; DISEASE MARKER; ENZYME ACTIVATION; IN VITRO STUDY; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION;

EID: 0035029801     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1006/nbdi.2001.0386     Document Type: Article

References (59)

1. Both oxidative stress-dependent and independent effects of amyloid beta protein are detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction assay
2. Externalization of phosphatidylserine may not be an early signal of apoptosis in neuronal cells but only the phosphatidylserine-displaying apoptotic cells are phagocytosed by microglia
3. Cross-linking of NCAM receptors on neurons induces programmed cell death
4. Normal host prion protein necessary for scrapie-induced neurotoxicity
5. Mouse cortical cells lacking cellular PrP survive in culture with a neurotoxic PrP fragment
6. Role of microglia and host prion protein in neurotoxicity of a prion protein fragment
7. PrP and beta-amyloid fragments activate different neurotoxic mechanisms in cultured mouse cells
8. Effects of copper on survival of prion protein knockout neurons and glia
9. Poly(ADPribose) immunostaining to detect apoptosis induced by a neurotoxic fragment of prion protein
10. Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of β-amyloid and prion proteins
11. Cross-linking of concanavalin A receptors on cortical neurons induces programmed cell death
12. Structural correlates of cognition in dementia: Quantification and assessment of synapse change
13. Caspase-3 is required for apoptosis-associated DNA fragmentation but not for cell death in neurons deprived of potassium
14. Neuronal apoptosis in fatal familial insomnia
15. Mammalian caspases: Structure, activation, substrates and functions during apoptosis
16. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages
17. Neuroloxicity of a prion protein fragment
18. Role of microglia in neuronal cell death in prion disease
19. Caspase-mediated degradation of AMPA receptor subunits: A mechanism for preventing excitotoxic necrosis and ensuring apoptosis
20. Evidence of neuronal oxidative damage in Alzheimer's disease
21. Neuronal apoptosis in Creutzfeldt-Jakob disease
22. Inhibitors of interleukin-1β-converting enzyme family proteases (caspases) prevent apoptosis without affecting decreased cellular ability to reduce 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide in cerebellar granule neurons
23. Activation of caspase-3 in β-amyloid-induced apoptosis of cultured rat cortical neurons
24. The A beta 3-pyroglutamyl and 11-pyroglutamyl peptides found in senile plaque have greater beta-sheet forming and aggregation propensities in vitro than full-length A beta
25. Cu(II) potentiation of Alzheimer Aβ neurotoxicity: Correlation with cell-free hydrogen peroxide production and metal reduction
26. β-amyloid induces local neurite degeneration in cultured hippocampal neurons: Evidence for neuritic apoptosis
27. Neuronal apoptosis induced by β-amyloid is mediated by caspase-8
28. Synapse loss associated with abnormal PrP precedes neuronal degeneration in the scrapie-infected murine hippocampus
29. The synthesis and spectroscopic analysis of the neurotoxic prion peptide 106-126: Comparative use of manual Boc and Fmoc chemistry
30. The hydrophobic core sequence modulates the neurotoxic and secondary structure properties of the prion peptide 106-126
31. Activation of CPP32 during apoptosis of neurons and astrocytes
32. Caspase-6 role in apoptosis of human neurons, amyloidogenesis and Alzheimer's disease
33. Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease
34. Oxidative alterations in Alzheimer's disease
35. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of bcl-2 and ab1
36. Mechanisms of synaptic dysfunction in Alzheimer's disease
37. Evidence for synaptic apoptosis
38. Amyloid β-peptide induces apoptosis-related events in synapses and dendrites
39. Amyloid fibrils activate tyrosine kinase-dependent signalling and superoxide production in microglia
40. Soluble pool of A beta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
41. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta
42. Caspases: Killer proteases
43. Prions
44. Caspases: Intracellular signalling by proteolysis
45. Caspases as treatment targets in stroke and neurodegenerative diseases
46. Changes in caspase expression in Alzheimer's disease: Comparison with development and aging
47. Widespread peroxynitrite-mediated damage in Alzheimer's disease
48. DNA fragmentation indicates increased neuronal vulnerability but not apoptosis
49. Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease
50. Death-signalling cascade in mouse cerebellar granule neurons
51. Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
52. c
53. Caspases: Enemies within
54. Caspase-2 mediates neuronal cell death induced by β-amyloid
55. The levels of soluble versus insoluble brain A beta distinguish Alzheimer's disease from normal and pathologic aging
56. Survival of cultured neurons from APP knockout mice against Alzheimer's amyloid Aβ toxicity and oxidative stress
57. Prion protein-deficient neurons reveal lower glutathione reductase activity and increased susceptibility to hydrogen peroxide toxicity
58. The Alzheimer's disease amyloid precursor protein modulates copper-induced toxicity and oxidative stress in primary neuronal cultures
59. PrP deposition, microglial activation and neuronal apoptosis in murine scrapie