Alterations of the microRNA network cause neurodegenerative disease

Trends in Neurosciences

Volumn 32, Issue 4, 2009, Pages 199-206

  Hébert, Sébastien S ^a,b   De Strooper, Bart ^a,b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 20; MICRORNA; PROGRANULIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; DEGENERATIVE DISEASE; DOWN SYNDROME; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION PROFILING; GILLES DE LA TOURETTE SYNDROME; HEART VENTRICLE HYPERTROPHY; HUMAN; MYOPATHY; NERVE CELL DIFFERENTIATION; NEUROBIOLOGY; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; RNA ANALYSIS; RNA BINDING; RNA TRANSLATION; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; GENE REGULATORY NETWORKS; HUMANS; MICRORNAS; MODELS, BIOLOGICAL; NEURODEGENERATIVE DISEASES;

EID: 63349094897     PISSN: 01662236     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tins.2008.12.003     Document Type: Review

References (93)

1. Lee R.C., et al. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75 (1993) 843-854
2. Ma L., and Weinberg R.A. Micromanagers of malignancy: role of microRNAs in regulating metastasis. Trends Genet. 24 (2008) 448-456
3. Care A., et al. MicroRNA-133 controls cardiac hypertrophy. Nat. Med. 13 (2007) 613-618
4. Eisenberg I., et al. Distinctive patterns of microRNA expression in primary muscular disorders. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 17016-17021
5. Yang B., et al. The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2. Nat. Med. 13 (2007) 486-491
6. Abelson J.F., et al. Sequence variants in SLITRK1 are associated with Tourette's syndrome. Science 310 (2005) 317-320
7. Perkins D.O., et al. microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder. Genome Biol. 8 (2007) R27
8. Kuhn D.E., et al. Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts. Biochem. Biophys. Res. Commun. 370 (2008) 473-477
9. Lagos-Quintana M., et al. Identification of novel genes coding for small expressed RNAs. Science 294 (2001) 853-858
10. Lee Y., et al. MicroRNA genes are transcribed by RNA polymerase II. EMBO J. 23 (2004) 4051-4060
11. Borchert G.M., et al. RNA polymerase III transcribes human microRNAs. Nat. Struct. Mol. Biol. 13 (2006) 1097-1101
12. Cai X., et al. Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA 10 (2004) 1957-1966
13. Gregory R.I., et al. The Microprocessor complex mediates the genesis of microRNAs. Nature 432 (2004) 235-240
14. Hutvagner G., et al. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science 293 (2001) 834-838
15. Peters L., and Meister G. Argonaute proteins: mediators of RNA silencing. Mol. Cell 26 (2007) 611-623
16. Eulalio A., et al. Getting to the root of miRNA-mediated gene silencing. Cell 132 (2008) 9-14
17. Meister G. miRNAs get an early start on translational silencing. Cell 131 (2007) 25-28
18. Giraldez A.J., et al. Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs. Science 312 (2006) 75-79
19. Hobert O. Gene regulation by transcription factors and microRNAs. Science 319 (2008) 1785-1786
20. Makeyev E.V., and Maniatis T. Multilevel regulation of gene expression by microRNAs. Science 319 (2008) 1789-1790
21. Sylvestre Y., et al. An E2F/miR-20a autoregulatory feedback loop. J. Biol. Chem. 282 (2007) 2135-2143
22. Kim J., et al. A MicroRNA feedback circuit in midbrain dopamine neurons. Science 317 (2007) 1220-1224
23. Gao F.B. Posttranscriptional control of neuronal development by microRNA networks. Trends Neurosci. 31 (2008) 20-26
24. Miska E.A., et al. Microarray analysis of microRNA expression in the developing mammalian brain. Genome Biol. 5 (2004) R68
25. Sempere L.F., et al. Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation. Genome Biol. 5 (2004) R13
26. Barad O., et al. MicroRNA expression detected by oligonucleotide microarrays: system establishment and expression profiling in human tissues. Genome Res. 14 (2004) 2486-2494
27. Hohjoh H., and Fukushima T. Marked change in microRNA expression during neuronal differentiation of human teratocarcinoma NTera2D1 and mouse embryonal carcinoma P19 cells. Biochem. Biophys. Res. Commun. 362 (2007) 360-367
28. Kapsimali M., et al. MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system. Genome Biol. 8 (2007) R173
29. Giraldez A.J., et al. MicroRNAs regulate brain morphogenesis in zebrafish. Science 308 (2005) 833-838
30. Davis T.H., et al. Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus. J. Neurosci. 28 (2008) 4322-4330
31. Conaco C., et al. Reciprocal actions of REST and a microRNA promote neuronal identity. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 2422-2427
32. Schratt G.M., et al. A brain-specific microRNA regulates dendritic spine development. Nature 439 (2006) 283-289
33. Yu J.Y., et al. MicroRNA miR-124 regulates neurite outgrowth during neuronal differentiation. Exp. Cell Res. 314 (2008) 2618-2633
34. Vo N., et al. A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 16426-16431
35. Selkoe D.J. Alzheimer's disease is a synaptic failure. Science 298 (2002) 789-791
36. Wayman G.A., et al. An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 9093-9098
37. Nelson P.G. Activity-dependent synapse modulation and the pathogenesis of Alzheimer disease. Curr. Alzheimer Res. 2 (2005) 497-506
38. Carleton M., et al. MicroRNAs and cell cycle regulation. Cell Cycle 6 (2007) 2127-2132
39. Xu P., et al. MicroRNAs and the regulation of cell death. Trends Genet. 20 (2004) 617-624
40. Raina A.K., et al. Cyclin' toward dementia: cell cycle abnormalities and abortive oncogenesis in Alzheimer disease. J. Neurosci. Res. 61 (2000) 128-133
41. Perry G., et al. Apoptosis and Alzheimer's disease. Science 282 (1998) 1268-1269
42. Bilen J., et al. MicroRNA pathways modulate polyglutamine-induced neurodegeneration. Mol. Cell 24 (2006) 157-163
43. Karres J.S., et al. The conserved microRNA miR-8 tunes atrophin levels to prevent neurodegeneration in Drosophila. Cell 131 (2007) 136-145
44. Lee Y., et al. miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis. Nat. Neurosci. 11 (2008) 1137-1139
45. Schaefer A., et al. Cerebellar neurodegeneration in the absence of microRNAs. J. Exp. Med. 204 (2007) 1553-1558
46. Tam O.H., et al. Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes. Nature 453 (2008) 534-538
47. Fukagawa T., et al. Dicer is essential for formation of the heterochromatin structure in vertebrate cells. Nat. Cell Biol. 6 (2004) 784-791
48. Cuellar T.L., et al. Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 5614-5619
49. Stark K.L., et al. Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model. Nat. Genet. 40 (2008) 751-760
50. McBride J.L., et al. Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 5868-5873
51. Rovelet-Lecrux A., et al. APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy. Nat. Genet. 38 (2006) 24-26
52. Podlisny M.B., et al. Gene dosage of the amyloid beta precursor protein in Alzheimer's disease. Science 238 (1987) 669-671
53. Singleton A.B., et al. α-Synuclein locus triplication causes Parkinson's disease. Science 302 (2003) 841
54. Chartier-Harlin M.C., et al. α-synuclein locus duplication as a cause of familial Parkinson's disease. Lancet 364 (2004) 1167-1169
55. John B., et al. Human MicroRNA targets. PLoS Biol. 2 (2004) e363
56. Nelson P.T., et al. MicroRNAs (miRNAs) in neurodegenerative diseases. Brain Pathol. 18 (2008) 130-138
57. Patel N., et al. MicroRNAs can regulate human APP levels. Mol. Neurodegener. 3 (2008) 10
58. Hébert, S.S. et al. MicroRNA regulation of Alzheimer's Amyloid precursor protein expression. Neurobiol. Dis. www.sciencedirect.com 10.1016/j.nbd.2008.11.009
59. Niwa R., et al. The expression of the Alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in Caenorhabditis elegans. Dev. Biol. 315 (2008) 418-425
60. Wang G., et al. Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of α-synuclein. Am. J. Hum. Genet. 82 (2008) 283-289
61. Rademakers R., et al. Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia. Hum. Mol. Genet. 17 (2008) 3631-3642
62. Cruts M., and Van Broeckhoven C. Loss of progranulin function in frontotemporal lobar degeneration. Trends Genet. 24 (2008) 186-194
63. Lambert J.C., et al. Association of 3′-UTR polymorphisms of the oxidised LDL receptor 1 (OLR1) gene with Alzheimer's disease. J. Med. Genet. 40 (2003) 424-430
64. Lambert J.C., et al. The transcriptional factor LBP-1c/CP2/LSF gene on chromosome 12 is a genetic determinant of Alzheimer's disease. Hum. Mol. Genet. 9 (2000) 2275-2280
65. Johnson S.M., et al. RAS is regulated by the let-7 microRNA family. Cell 120 (2005) 635-647
66. Cogswell J.P., et al. Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways. J. Alzheimers Dis. 14 (2008) 27-41
67. Wang W.X., et al. The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of β-site amyloid precursor protein-cleaving enzyme 1. J. Neurosci. 28 (2008) 1213-1223
68. Lukiw W.J. Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus. Neuroreport 18 (2007) 297-300
69. Hebert S.S., et al. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 6415-6420
70. Fukumoto H., et al. β-secretase protein and activity are increased in the neocortex in Alzheimer disease. Arch. Neurol. 59 (2002) 1381-1389
71. Holsinger R.M., et al. Increased expression of the amyloid precursor β-secretase in Alzheimer's disease. Ann. Neurol. 51 (2002) 783-786
72. Achard P., et al. Modulation of floral development by a gibberellin-regulated microRNA. Development 131 (2004) 3357-3365
73. Calin G.A., et al. Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas. Cancer Cell 12 (2007) 215-229
74. Mattson M.P., and Shea T.B. Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci. 26 (2003) 137-146
75. Wu J., and Xie X. Comparative sequence analysis reveals an intricate network among REST, CREB and miRNA in mediating neuronal gene expression. Genome Biol. 7 (2006) R85
76. Mortazavi A., et al. Comparative genomics modeling of the NRSF/REST repressor network: from single conserved sites to genome-wide repertoire. Genome Res. 16 (2006) 1208-1221
77. Tsang J., et al. MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammals. Mol. Cell 26 (2007) 753-767
78. Lukiw W.J., et al. An NF-κB-sensitive microRNA-146a-mediated inflammatory circuit in Alzheimer's disease and in stressed human brain cells. J. Biol. Chem. 283 (2008) 31315-31322
79. Johnson R., et al. A microRNA-based gene dysregulation pathway in Huntington's disease. Neurobiol. Dis. 29 (2008) 438-445
80. Gillardon F., et al. MicroRNA and proteome expression profiling in early-symptomatic α-synuclein (A30P)-transgenic mice. Proteomic Clin. Appl. 2 (2008) 697-705
81. Schipper H.M., et al. MicroRNA expression in Alzheimer blood mononuclear cells. Gene Regulation and Systems Biology 1 (2008) 263-274
82. Hebert S.S., and De Strooper B. Molecular biology. miRNAs in neurodegeneration. Science 317 (2007) 1179-1180
83. St George-Hyslop P., and Haass C. Regulatory RNA goes awry in Alzheimer's disease. Nat. Med. 14 (2008) 711-712
84. Nelson P.T., and Keller J.N. RNA in brain disease: no longer just 'the messenger in the middle'. J. Neuropathol. Exp. Neurol. 66 (2007) 461-468
85. Faghihi M.A., et al. Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of β-secretase. Nat. Med. 14 (2008) 723-730
86. Mus E., et al. Dendritic BC200 RNA in aging and in Alzheimer's disease. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 10679-10684
87. Kim D.H., and Rossi J.J. Strategies for silencing human disease using RNA interference. Nat. Rev. Genet. 8 (2007) 173-184
88. Krutzfeldt J., et al. Silencing of microRNAs in vivo with 'antagomirs'. Nature 438 (2005) 685-689
89. Krutzfeldt J., et al. Specificity, duplex degradation and subcellular localization of antagomirs. Nucleic Acids Res. 35 (2007) 2885-2892
90. Boissonneault V., et al. MicroRNA-298 and microRNA-328 regulate expression of mouse β-amyloid precursor protein converting enzyme 1. J. Biol. Chem. 284 (2008) 1971-1981
91. Wang W.X., et al. Focus on RNA isolation: obtaining RNA for microRNA (miRNA) expression profiling analyses of neural tissue. Biochim. Biophys. Acta 1779 (2008) 749-757
92. Hohjoh H., and Fukushima T. Expression profile analysis of microRNA (miRNA) in mouse central nervous system using a new miRNA detection system that examines hybridization signals at every step of washing. Gene 391 (2007) 39-44
93. Smirnova L., et al. Regulation of miRNA expression during neural cell specification. Eur. J. Neurosci. 21 (2005) 1469-1477