메뉴 건너뛰기




Volumn 24, Issue 3, 1999, Pages 751-762

Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform

Author keywords

[No Author keywords available]

Indexed keywords

TAU PROTEIN;

EID: 0033230886     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(00)81127-7     Document Type: Article
Times cited : (509)

References (48)
  • 1
    • 0026488111 scopus 로고
    • Structure and novel exons of the human tau gene
    • Andreadis, A., Brown, W.M., and Kosik, K.S. (1992). Structure and novel exons of the human tau gene. Biochemistry 31, 10626-10633.
    • (1992) Biochemistry , vol.31 , pp. 10626-10633
    • Andreadis, A.1    Brown, W.M.2    Kosik, K.S.3
  • 2
    • 0022365608 scopus 로고
    • The distribution of tau in the mammalian central nervous system
    • Binder, L.I., Frankfurter, A., and Rebhun, L.I. (1985). The distribution of tau in the mammalian central nervous system. J. Cell Biol. 101, 1371-1378.
    • (1985) J. Cell Biol. , vol.101 , pp. 1371-1378
    • Binder, L.I.1    Frankfurter, A.2    Rebhun, L.I.3
  • 4
    • 0026578425 scopus 로고
    • Regions with abundant neurofibrillary pathology in human brain exhibit a selective reduction in levels of binding-competent tau and accumulation of abnormal tau-isoforms (A68 proteins)
    • Bramblett, G.T., Trojanowski, J.Q., and Lee, V.M.-Y. (1992). Regions with abundant neurofibrillary pathology in human brain exhibit a selective reduction in levels of binding-competent tau and accumulation of abnormal tau-isoforms (A68 proteins). Lab. Invest. 66, 212-222.
    • (1992) Lab. Invest. , vol.66 , pp. 212-222
    • Bramblett, G.T.1    Trojanowski, J.Q.2    Lee, V.M.-Y.3
  • 5
    • 0027308924 scopus 로고
    • Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding
    • Bramblett, G.T., Goedert, M., Jakes, R., Merrick, S.E., Trojanowski, J.Q., and Lee, V.M.-Y. (1993). Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding. Neuron 10, 1089-1099.
    • (1993) Neuron , vol.10 , pp. 1089-1099
    • Bramblett, G.T.1    Goedert, M.2    Jakes, R.3    Merrick, S.E.4    Trojanowski, J.Q.5    Lee, V.M.-Y.6
  • 6
    • 0345580607 scopus 로고    scopus 로고
    • Transgenic expression of the shortest human tau affects its compartmentalization and its phosphorylation as in the pretangle stage of Alzheimer's disease
    • Brion, J.-P., Tremp, G., and Octave, J.-N. (1999). Transgenic expression of the shortest human tau affects its compartmentalization and its phosphorylation as in the pretangle stage of Alzheimer's disease. Am. J. Pathol. 154, 255-270.
    • (1999) Am. J. Pathol. , vol.154 , pp. 255-270
    • Brion, J.-P.1    Tremp, G.2    Octave, J.-N.3
  • 7
    • 12644260802 scopus 로고    scopus 로고
    • The structural basis of monoclonal antibody Alz50's selectivity for Alzheimer's disease pathology
    • Carmel, G., Mager, E.M., Binder, L.I., and Kuret, J. (1996). The structural basis of monoclonal antibody Alz50's selectivity for Alzheimer's disease pathology. J. Biol. Chem. 271, 32789-32795.
    • (1996) J. Biol. Chem. , vol.271 , pp. 32789-32795
    • Carmel, G.1    Mager, E.M.2    Binder, L.I.3    Kuret, J.4
  • 9
    • 0027058857 scopus 로고
    • Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau
    • Drechsel, D.N., Hyman, A.A., Cobb, M.H., and Kirschner, M.W. (1992). Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau. Mol. Biol. Cell 3, 1141-1154.
    • (1992) Mol. Biol. Cell , vol.3 , pp. 1141-1154
    • Drechsel, D.N.1    Hyman, A.A.2    Cobb, M.H.3    Kirschner, M.W.4
  • 10
    • 0033545946 scopus 로고    scopus 로고
    • Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism - Chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements
    • D'Souza, I., Poorkaj, P., Hong, M., Nochlin, D., Lee, V.M.-Y., Bird, T.D., and Schellenberg, G.D. (1999). Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism - chromosome 17type, by affecting multiple alternative RNA splicing regulatory elements. Proc. Natl. Acad. Sci. USA 96, 5598-5603.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 5598-5603
    • D'Souza, I.1    Poorkaj, P.2    Hong, M.3    Nochlin, D.4    Lee, V.M.-Y.5    Bird, T.D.6    Schellenberg, G.D.7
  • 11
    • 0025600995 scopus 로고
    • Expression of separate isoforms of human tau protein: Correlation with the tau pattern in brain and effects on tubulin polymerization
    • Goedert, M., and Jakes, R. (1990). Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization. EMBO J. 9, 4225-4230.
    • (1990) EMBO J. , vol.9 , pp. 4225-4230
    • Goedert, M.1    Jakes, R.2
  • 12
    • 0024745894 scopus 로고
    • Multiple isoforms of human microtubule-associated protein tau: Sequences and localization in neurofibrillary tangles of Alzheimer's disease
    • Goedert, M., Spillantini, M.G., Jakes, R., Rutherford, D., and Crowther, R.A. (1989). Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease. Neuron 3, 519-526.
    • (1989) Neuron , vol.3 , pp. 519-526
    • Goedert, M.1    Spillantini, M.G.2    Jakes, R.3    Rutherford, D.4    Crowther, R.A.5
  • 14
    • 0027984739 scopus 로고
    • Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: Identification of phosphorylation sites in tau protein
    • Goedert, M., Jakes, R., Crowther, R.A., Cohen, P., Vanmechelen, E., Vandermeeren, M., and Cras, P. (1994). Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein. Biochem. J. 301, 871-877.
    • (1994) Biochem. J. , vol.301 , pp. 871-877
    • Goedert, M.1    Jakes, R.2    Crowther, R.A.3    Cohen, P.4    Vanmechelen, E.5    Vandermeeren, M.6    Cras, P.7
  • 15
    • 0002941489 scopus 로고    scopus 로고
    • The neurofibrillary pathology of Alzheimer's disease
    • S.B. Prusiner et al., eds. Boston: Butterworth-Heinemann Press
    • Goedert, M., Trojanowski, J.Q., and Lee, V.M.-Y. (1997). The neurofibrillary pathology of Alzheimer's disease. In The Molecular and Genetic Basis of Neurological Diseases. S.B. Prusiner et al., eds. (Boston: Butterworth-Heinemann Press), pp. 613-627.
    • (1997) The Molecular and Genetic Basis of Neurological Diseases , pp. 613-627
    • Goedert, M.1    Trojanowski, J.Q.2    Lee, V.M.-Y.3
  • 16
    • 0028965635 scopus 로고
    • Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform
    • Goetz, J., Probst, A., Spillantini, M.G., Schafer, T., Jakes, R., Buerki, K., and Goedert, M. (1995). Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform. EMBO J. 14, 1304-1313.
    • (1995) EMBO J. , vol.14 , pp. 1304-1313
    • Goetz, J.1    Probst, A.2    Spillantini, M.G.3    Schafer, T.4    Jakes, R.5    Buerki, K.6    Goedert, M.7
  • 17
    • 0025292866 scopus 로고
    • A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by poly-acrylamide gel electrophoresis
    • Greenberg, S.G., and Davies, P. (1990). A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by poly-acrylamide gel electrophoresis. Proc. Natl. Acad. Sci. USA 87, 5827-5831.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 5827-5831
    • Greenberg, S.G.1    Davies, P.2
  • 18
    • 73049132762 scopus 로고
    • Parkinsonism dementia complex: An endemic disease on the island of Guam - Pathological features
    • Hirano, A., Malamud, N., and Kurland, L.T. (1961). Parkinsonism dementia complex: an endemic disease on the island of Guam -pathological features. Brain 84, 642-661.
    • (1961) Brain , vol.84 , pp. 642-661
    • Hirano, A.1    Malamud, N.2    Kurland, L.T.3
  • 19
    • 0030750558 scopus 로고    scopus 로고
    • Unique Alzheimer's disease paired helical filament specific epitopes involve double phosphorylation at specific sites
    • Hoffmann, R., Lee, V.M.-Y., Leight, S., Varga, I., and Otvos, L., Jr. (1997). Unique Alzheimer's disease paired helical filament specific epitopes involve double phosphorylation at specific sites. Biochemistry 36, 8114-8124.
    • (1997) Biochemistry , vol.36 , pp. 8114-8124
    • Hoffmann, R.1    Lee, V.M.-Y.2    Leight, S.3    Varga, I.4    Otvos L., Jr.5
  • 23
    • 0022497390 scopus 로고
    • Spinal cord lesions in progressive supranuclear palsy: Some new observations
    • Kato, T., Hirano, A., Weinberg, M.N., and Jacobs, A.K. (1986). Spinal cord lesions in progressive supranuclear palsy: some new observations. Acta Neuropathologica 71, 11-14.
    • (1986) Acta Neuropathologica , vol.71 , pp. 11-14
    • Kato, T.1    Hirano, A.2    Weinberg, M.N.3    Jacobs, A.K.4
  • 24
    • 0024109687 scopus 로고
    • Epitopes that span the tau molecule are shared with paired helical filaments
    • Kosik, K.S., Orecchio, L.D., Binder, L, Trojanowski, J.Q., Lee, V.M.-Y., and Lee, G. (1988). Epitopes that span the tau molecule are shared with paired helical filaments. Neuron 1, 817-825.
    • (1988) Neuron , vol.1 , pp. 817-825
    • Kosik, K.S.1    Orecchio, L.D.2    Binder, L.3    Trojanowski, J.Q.4    Lee, V.M.-Y.5    Lee, G.6
  • 25
    • 0026611728 scopus 로고
    • Immunological and conformation characterization of a phosphorylated immunodominant epitope on the paired helical filaments found in Alzheimer's disease
    • Lang, E., Szendrei, G.I., Lee, V.M.-Y., and Otvos, L., Jr. (1992). Immunological and conformation characterization of a phosphorylated immunodominant epitope on the paired helical filaments found in Alzheimer's disease. Biochem. Biophys. Res. Commun. 187, 783-790.
    • (1992) Biochem. Biophys. Res. Commun. , vol.187 , pp. 783-790
    • Lang, E.1    Szendrei, G.I.2    Lee, V.M.-Y.3    Otvos L., Jr.4
  • 26
    • 0025904444 scopus 로고
    • A68: A major subunit of paired helical filaments and derivatized forms of normal Tau
    • Lee, V.M.-Y., Balin, B.J., Otvos, L., Jr., and Trojanowski, J.Q. (1991). A68: a major subunit of paired helical filaments and derivatized forms of normal Tau. Science 251, 675-678.
    • (1991) Science , vol.251 , pp. 675-678
    • Lee, V.M.-Y.1    Balin, B.J.2    Otvos L., Jr.3    Trojanowski, J.Q.4
  • 27
    • 0025331812 scopus 로고
    • Spinal cord neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis and parkinsonism-dementia complex: An immunohistochemical study
    • Matsumoto, S., Hirano, A., and Goto, S. (1990). Spinal cord neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis and parkinsonism-dementia complex: an immunohistochemical study. Neurology 40, 975-979.
    • (1990) Neurology , vol.40 , pp. 975-979
    • Matsumoto, S.1    Hirano, A.2    Goto, S.3
  • 28
    • 0027945346 scopus 로고
    • Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau
    • Matsuo, E.S., Shin, R.W., Billingsley, M.L., Van deVoorde, A., O'Connor, M., Trojanowski, J.Q., and Lee, V.M.-Y. (1994). Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau. Neuron 13, 989-1002.
    • (1994) Neuron , vol.13 , pp. 989-1002
    • Matsuo, E.S.1    Shin, R.W.2    Billingsley, M.L.3    Van DeVoorde, A.4    O'Connor, M.5    Trojanowski, J.Q.6    Lee, V.M.-Y.7
  • 29
    • 0021272282 scopus 로고
    • Immunohistochemical localization of neurofilament protein in neuronal degenerations
    • Nakazato, Y., Sasaki, A., Hirato, J., and Ishida, Y. (1984). Immunohistochemical localization of neurofilament protein in neuronal degenerations. Acta Neuropathologica 64, 30-36.
    • (1984) Acta Neuropathologica , vol.64 , pp. 30-36
    • Nakazato, Y.1    Sasaki, A.2    Hirato, J.3    Ishida, Y.4
  • 30
    • 0028593606 scopus 로고
    • Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404
    • Otvos, L., Jr., Feiner, L., Lang, E., Szendrei, G.I., Goedert, M., and Lee, V.M.-Y. (1994). Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404. J. Neurosci. Res. 39, 669-673.
    • (1994) J. Neurosci. Res. , vol.39 , pp. 669-673
    • Otvos L., Jr.1    Feiner, L.2    Lang, E.3    Szendrei, G.I.4    Goedert, M.5    Lee, V.M.-Y.6
  • 31
    • 0345419152 scopus 로고
    • Paired helical filaments from Alzhemier's disease patients contain cytoskeletal components
    • Perry, G., Rizzuto, N., Autilio-Gambetti, L., and Gambetti, P. (1985). Paired helical filaments from Alzhemier's disease patients contain cytoskeletal components. Proc. Natl. Acad. Sci. USA 82, 3916-3920.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 3916-3920
    • Perry, G.1    Rizzuto, N.2    Autilio-Gambetti, L.3    Gambetti, P.4
  • 35
    • 0025345913 scopus 로고
    • Relative abundance of tau and neurofilament epitopes in hippocampal neurofibrillary tangles
    • Schmidt, M.L., Lee, V.M.-Y., and Trojanowski, J.Q. (1990). Relative abundance of tau and neurofilament epitopes in hippocampal neurofibrillary tangles. Am. J. Pathol. 136, 1069-1075.
    • (1990) Am. J. Pathol. , vol.136 , pp. 1069-1075
    • Schmidt, M.L.1    Lee, V.M.-Y.2    Trojanowski, J.Q.3
  • 36
    • 0025905505 scopus 로고
    • Comparative epitope analysis of neuronal cytoskeletal proteins in Alzheimer's disease senile plaque neurites and neuropil threads
    • Schmidt, M.L., Lee, V.M.-Y., and Trojanowski, J.Q. (1991). Comparative epitope analysis of neuronal cytoskeletal proteins in Alzheimer's disease senile plaque neurites and neuropil threads. Lab. Invest. 64, 352-357.
    • (1991) Lab. Invest. , vol.64 , pp. 352-357
    • Schmidt, M.L.1    Lee, V.M.-Y.2    Trojanowski, J.Q.3
  • 38
    • 0024589232 scopus 로고
    • Immunocytochemical characterization of neurofibrillary tangles in amyotrophic lateral sclerosis and parkinsonism-dementia of Guam
    • Shankar, S.K., Yanagihara, R., Garruto, R.M., Grundke-Iqbal, I., Kosik, K.S., and Gajdusek, D.C. (1989). Immunocytochemical characterization of neurofibrillary tangles in amyotrophic lateral sclerosis and parkinsonism-dementia of Guam. Ann. Neurol. 25, 146-151.
    • (1989) Ann. Neurol. , vol.25 , pp. 146-151
    • Shankar, S.K.1    Yanagihara, R.2    Garruto, R.M.3    Grundke-Iqbal, I.4    Kosik, K.S.5    Gajdusek, D.C.6
  • 39
    • 0031949084 scopus 로고    scopus 로고
    • Frontotemporal dementia and Parkinsonism linked to chromosome 17: A new group of tauopathies
    • Spillantini, M.G., Bird, T.D., and Ghetti, B. (1998a). Frontotemporal dementia and Parkinsonism linked to chromosome 17: a new group of tauopathies. Brain Pathol. 8, 387-402.
    • (1998) Brain Pathol. , vol.8 , pp. 387-402
    • Spillantini, M.G.1    Bird, T.D.2    Ghetti, B.3
  • 41
    • 0027388775 scopus 로고
    • Recognition of the minimal epitope of monoclonal antibody Tau-1 depends upon the presence of a phosphate group but not its location
    • Szendrei, G.I., Lee, V.M.-Y., and Otvos, L., Jr. (1993). Recognition of the minimal epitope of monoclonal antibody Tau-1 depends upon the presence of a phosphate group but not its location. J. Neurosci. Res. 34, 243-249.
    • (1993) J. Neurosci. Res. , vol.34 , pp. 243-249
    • Szendrei, G.I.1    Lee, V.M.-Y.2    Otvos L., Jr.3
  • 42
    • 0017581518 scopus 로고
    • Ultrastructure of neurofibrillary tangles in progressive supranuclear palsy
    • Tomonaga, M. (1977). Ultrastructure of neurofibrillary tangles in progressive supranuclear palsy. Acta Neuropathologica 37, 177-181.
    • (1977) Acta Neuropathologica , vol.37 , pp. 177-181
    • Tomonaga, M.1
  • 43
    • 0024529404 scopus 로고
    • Distribution of tau proteins in the normal human central and peripheral nervous system
    • Trojanowski, J.Q., Schuck, T., Schmidt, M.L., and Lee, V.M.-Y. (1989). Distribution of tau proteins in the normal human central and peripheral nervous system. J. Histochem. Cytochem. 37, 209-215.
    • (1989) J. Histochem. Cytochem. , vol.37 , pp. 209-215
    • Trojanowski, J.Q.1    Schuck, T.2    Schmidt, M.L.3    Lee, V.M.-Y.4
  • 44
    • 0029052277 scopus 로고
    • Over-expression of the human NFM subunit in transgenic mice modifies the level of endogenous NFL and the phosphorylation state of NFH subunits
    • Tu, P.H., Elder, G., Lazzarini, R.A., Nelson, D., Trojanowski, J.Q., and Lee, V.M.-Y. (1995). Over-expression of the human NFM subunit in transgenic mice modifies the level of endogenous NFL and the phosphorylation state of NFH subunits. J. Cell Biol. 129, 1629-1640.
    • (1995) J. Cell Biol. , vol.129 , pp. 1629-1640
    • Tu, P.H.1    Elder, G.2    Lazzarini, R.A.3    Nelson, D.4    Trojanowski, J.Q.5    Lee, V.M.-Y.6
  • 45
    • 0030910404 scopus 로고    scopus 로고
    • Oxidative stress, mutant SOD1, and neurofilament pathology in transgenic mouse models of human motor neuron disease
    • Tu, P.H., Gurney, M.E., Julien, J.-P., Lee, V.M.-Y., and Trojanowski, J.Q. (1997). Oxidative stress, mutant SOD1, and neurofilament pathology in transgenic mouse models of human motor neuron disease. Lab. Invest. 76, 441-456.
    • (1997) Lab. Invest. , vol.76 , pp. 441-456
    • Tu, P.H.1    Gurney, M.E.2    Julien, J.-P.3    Lee, V.M.-Y.4    Trojanowski, J.Q.5
  • 47
    • 0027237861 scopus 로고
    • Tau in paired helical filaments is functionally distinct from fetal tau: Assembly incompetence of paired helical filament-tau
    • Yoshida, H., and Ihara, Y. (1993). Tau in paired helical filaments is functionally distinct from fetal tau: assembly incompetence of paired helical filament-tau. J. Neurochem. 61, 1183-1186.
    • (1993) J. Neurochem. , vol.61 , pp. 1183-1186
    • Yoshida, H.1    Ihara, Y.2
  • 48
    • 0030817291 scopus 로고    scopus 로고
    • Neurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation
    • Zhang, B., Tu, P.-H., Abtahian, F., Trojanowski, J.Q., and Lee, V.M.-Y. (1997). Neurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation. J. Cell Biol. 139, 1307-1315.
    • (1997) J. Cell Biol. , vol.139 , pp. 1307-1315
    • Zhang, B.1    Tu, P.-H.2    Abtahian, F.3    Trojanowski, J.Q.4    Lee, V.M.-Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.