Redox reactions induced by nitrosative stress mediate protein misfolding and mitochondrial dysfunction in neurodegenerative diseases

Molecular Neurobiology

Volumn 41, Issue 2-3, 2010, Pages 55-72

  Gu, Zezong ^a,b   Nakamura, Tomohiro ^b   Lipton, Stuart A ^b,c  

^a University of Missouri   (United States)

^b BURNHAM INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Mitochondrial fission; Molecular chaperone; Neurodegeneration; Protein misfolding; S Nitrosylation; Ubiquitin proteasome system

Indexed keywords

ADAMANTANE; AMANTADINE; AMYLOID BETA PROTEIN; ANTIPARKINSON AGENT; CALCIMYCIN; CALCIUM ION; DOPAMINE; DYNAMIN; DYNAMIN I; FREE RADICAL; GLUTAMIC ACID; GLYCERYL TRINITRATE; HEAT SHOCK PROTEIN; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NITRIC OXIDE; NITROMEMANTINE; PARKIN; PROTEASOME; PROTEIN; PROTEIN DISULFIDE ISOMERASE; PROTEIN PDI; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; UBIQUITIN; UNCLASSIFIED DRUG; CALCIUM; NERVE PROTEIN; UBIQUITIN PROTEIN LIGASE;

ALZHEIMER DISEASE; CALCIUM TRANSPORT; CELL DEATH; CLINICAL TRIAL; CONFERENCE PAPER; DEGENERATIVE DISEASE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG EFFICACY; DRUG INHIBITION; DRUG TOLERABILITY; ENDOPLASMIC RETICULUM; EXCITOTOXICITY; FRAGMENTATION REACTION; HISTOPATHOLOGY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INFLUENZA; MITOCHONDRION; NERVE CELL; NERVE CELL LESION; NEUROPROTECTION; NEUROTOXICITY; NEUROTRANSMISSION; NITROSATIVE STRESS; NITROSYLATION; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PARKINSON DISEASE; PARKINSONISM; POINT MUTATION; PROTEIN AGGREGATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEOMICS; SIGNAL TRANSDUCTION; STROKE; UBIQUITINATION; ANIMAL; CHEMISTRY; GENETICS; METABOLISM; NEURODEGENERATIVE DISEASES; PATHOPHYSIOLOGY; PHYSIOLOGICAL STRESS; PHYSIOLOGY;

ANIMALS; CALCIUM; CELL DEATH; DYNAMINS; GLUTAMIC ACID; HUMANS; MITOCHONDRIA; NERVE TISSUE PROTEINS; NEURODEGENERATIVE DISEASES; NITRIC OXIDE; OXIDATION-REDUCTION; PROTEIN DISULFIDE-ISOMERASES; PROTEIN FOLDING; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; RECEPTORS, N-METHYL-D-ASPARTATE; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; UBIQUITIN-PROTEIN LIGASES;

EID: 77955085868     PISSN: 08937648     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12035-010-8113-9     Document Type: Conference Paper

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