Aβ oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine

Journal of Biological Chemistry

Volumn 282, Issue 15, 2007, Pages 11590-11601

  De Felice, Fernanda G ^a,b   Velasco, Pauline T ^a   Lambert, Mary P ^a   Viola, Kirsten ^a   Fernandez, Sara J ^a   Ferreira, Sergio T ^b   Klein, William L ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CELL CULTURE; OLIGOMERS; OXIDATIVE STRESS; PATHOLOGY; TISSUE;

ALZHEIMER DISEASE (AD) PATHOLOGY; BRAIN TISSUE; HIPPOCAMPAL NEURONAL CULTURES;

DISEASES;

MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT; OLIGOMER; REACTIVE OXYGEN METABOLITE; AMYLOID BETA PROTEIN; ANTIBODY; CALCIUM;

ALZHEIMER DISEASE; ARTICLE; BRAIN DYSFUNCTION; BRAIN SYNAPTOSOME; COGNITIVE DEFECT; HUMAN; IMMUNOPRECIPITATION; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; ANIMAL; CELL DIFFERENTIATION; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; HIPPOCAMPUS; IMMUNOLOGY; METABOLISM; MOUSE; NERVE CELL; PROTEIN BINDING;

AMYLOID BETA-PROTEIN; ANIMALS; ANTIBODIES; CALCIUM; CELL DIFFERENTIATION; HIPPOCAMPUS; MEMANTINE; MICE; NEURONS; OXIDATIVE STRESS; PROTEIN BINDING; REACTIVE OXYGEN SPECIES; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 34249672242     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M607483200     Document Type: Article

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