Systematic in vivo analysis of the intrinsic determinants of amyloid β pathogenicity

PLoS Biology

Volumn 5, Issue 11, 2007, Pages 2493-2500

  Luheshi, Leila M ^a   Tartaglia, Gian Gaetano ^a   Brorsson, Ann Christin ^a   Pawar, Amol P ^a   Watson, Ian E ^a   Chiti, Fabrizio ^b   Vendruscolo, Michele ^a   Lomas, David A ^a,c   Dobson, Christopher M ^a   Crowther, Damian C ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF FLORENCE   (Italy)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); PEPTIDE FRAGMENT; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; CORRELATION ANALYSIS; DEGENERATIVE DISEASE; DROSOPHILA; GENETIC LINKAGE; MATHEMATICAL ANALYSIS; MUTAGENESIS; NONHUMAN; PATHOGENICITY; PROTEIN AGGREGATION; PROTEIN ANALYSIS; QUANTITATIVE ANALYSIS; ANIMAL; DISEASE MODEL; DROSOPHILA MELANOGASTER; GENETICS; LOCOMOTION; LONGEVITY; METABOLISM; MISSENSE MUTATION; PHYSIOLOGY;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; DISEASE MODELS, ANIMAL; DROSOPHILA MELANOGASTER; LOCOMOTION; LONGEVITY; MUTATION, MISSENSE; PEPTIDE FRAGMENTS;

EID: 37249017468     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.0050290     Document Type: Article

References (30)

1. Chiti F, Dobson CM (2006) Protein misfolding, functional amyloid, and human disease. Annu Rev Biochem 75: 333-366.
2. Selkoe DJ (2003) Folding proteins in fatal ways. Nature 426: 900-904.
3. Barnhart MM, Chapman MR (2006) Curli biogenesis and function. Annu Rev Microbiol 60: 131-147.
4. Uptain SM, Lindquist S (2002) Prions as protein-based genetic elements. Annu Rev Microbiol 56: 703-741.
5. Fowler DM, Koulov AV, Alory-Jost C, Marks MS, Balch WE, et al. (2006) Functional amyloid formation within mammalian tissue. PLoS Biol 4: e6.
6. Fandrich M, Dobson CM (2002) The behaviour of polyamino acids reveals an inverse side chain effect in amyloid structure formation. EMBO J 21: 5682-5690.
7. Dobson CM (1999) Protein misfolding, evolution and disease. Trends Biochem Sci 24: 329-332.
8. Chiti F, Stefani M, Taddei N, Ramponi G, Dobson CM (2003) Rationalization of the effects of mutations on peptide and protein aggregation rates. Nature 424: 805-808.
9. Fernandez-Escamilla AM, Rousseau F, Schymkowitz J, Serrano L (2004) Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins. Nat Biotechnol 22: 1302-1306.
10. Pawar AP, Dubay KF, Zurdo J, Chiti F, Vendruscolo M, et al. (2005) Prediction of "aggregation-prone" and "aggregation- susceptible" regions in proteins associated with neurodegenerative diseases. J Mol Biol 350: 379-392.
11. Bukau B, Weissman J, Horwich A (2006) Molecular chaperones and protein quality control. Cell 125: 443-451.
12. Crowther DC, Kinghorn KJ, Miranda E, Page R, Curry JA, et al. (2005) Intraneuronal Ab, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer's disease. Neuroscience 132: 123-135.
13. Finelli A, Kelkar A, Song HJ, Yang H, Konsolaki M (2004) A model for studying Alzheimer's Abeta42-induced toxicity in Drosophila melanogaster. Mol Cell Neurosci 26: 365-375.
14. Iijima K, Liu HP, Chiang AS, Hearn SA, Konsolaki M, et al. (2004) Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: A potential model for Alzheimer's disease. Proc Natl Acad Sci U S A 101: 6623-6628.
15. Bilen J, Bonini NM (2005) Drosophila as a model for human neurodegenerative disease. Annu Rev Genet 39: 153-171.
16. Gidalevitz T, Ben-Zvi A, Ho KH, Brignull HR, Morimoto RI (2006) Progressive disruption of cellular protein folding in models of polyglutamine diseases. Science 311: 1471-1474.
17. Kim J, Onstead L, Randle S, Price R, Smithson L, et al. (2007) Abeta40 inhibits amyloid deposition In vivo. J Neurosci 27: 627-633.
18. Ida N, Hartmann T, Pantel J, Schroder J, Zerfass R, et al. (1996) Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay. J Biol Chem 271: 22908-22914.
19. Buchanan RL, Benzer S (1993) Defective glia in the drosophila brain degeneration mutant drop-dead. Neuron 10: 839-850.
20. Westerman MA, Cooper-Blacketer D, Mariash A, Kotilinek L, Kawarabayashi T, et al. (2002) The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease. J Neurosci 22: 1858-1867.
21. Dodart JC, Bales KR, Gannon KS, Greene SJ, DeMattos RB, et al. (2002) Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model. Nat Neurosci 5: 452-457.
22. Cleary JP, Walsh DM, Hofmeister JJ, Shankar GM, Kuskowski MA, et al. (2005) Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function. Nat Neurosci 8: 79-84.
23. Cohen E, Bieschke J, Perciavalle RM, Kelly JW, Dillin A (2006) Opposing activities protect against age-onset proteotoxicity. Science 313: 1604-1610.
24. Townsend M, Shankar GM, Mehta T, Walsh DM, Selkoe DJ (2006) Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers. J Physiol 572: 477-492.
25. DuBay KF, Pawar AP, Chiti F, Zurdo J, Dobson CM, et al. (2004) Prediction of the absolute aggregation rates of amyloidogenic polypeptide chains. J Mol Biol 341: 1317-1326.
26. Tartaglia GG, Pechmann S, Dobson CM, Vendruscolo M (2007) Life on the edge: a link between gene expression levels and aggregation rates of human proteins. Trends Biochem Sci 32: 204-206.
27. Rovelet-Lecrux A, Hannequin D, Raux G, Le Meur N, Laquerriere A, et al. (2006) APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy. Nat Genet 38: 24-26.
28. Dobson CM (2006) An accidental breach of a protein's natural defenses. Nat Struct Mol Biol 13: 295-297.
29. Tsubuki S, Takaki Y, Saido TC (2003) Dutch, Flemish, Italian, and Arctic mutations of APP and resistance of Abeta to physiologically relevant proteolytic degradation. Lancet 361: 1957-1958.
30. Chiti F, Taddei N, Baroni F, Capanni C, Stefani M, et al. (2002) Kinetic partitioning of protein folding and aggregation. Nat Struct Biol 9: 137-143.