Fresh and globular amyloid β protein (1-42) induces rapid cellular degeneration: Evidence for AβP channel-mediated cellular toxicity

FASEB Journal

Volumn 14, Issue 9, 2000, Pages 1233-1243

  Bhatia, Rajinder ^a   Lin, Hai ^a   Lal, Ratneshwar ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

AFM; Alzheimer's disease; Amyloid protein; Calcium imaging; Cytoskeletal reorganization; Endothelial cells; Neurotoxicity; Real time cellular imaging; Scanning probe microscopy

Indexed keywords

AMYLOID BETA PROTEIN; CALCIUM;

ALZHEIMER DISEASE; ARTICLE; ATOMIC FORCE MICROSCOPY; CALCIUM CELL LEVEL; CELL DEGENERATION; CONFOCAL LASER MICROSCOPY; CYTOTOXICITY; DOWN SYNDROME; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

EID: 0034087948     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.14.9.1233     Document Type: Article

References (56)

1. Mattson, M. P. (1997) Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives. Physiol. Rev. 77, 1081-1132
2. Haass, C., Schlossmacher, M. G., Hung, A. Y., Vigo-Pelfrey, C., Mellon, A., Ostaszewski, B. L., Lieberburg, I., Koo, E. H., Schenk, D., Teplow, D. B., and Selkoe, D. J. (1992) Amyloid β-peptide is produced by cultured cells during normal metabolism. Nature (London) 359, 322-325
3. Nashlund, J., Thyberg, J., Tjernberg, L. O., Wernstedt, C., Karlstrom, A. R., Bogdanovic, N., Gandy, S. E., Lannfelt, L., Terenius, L., and Nordstedt, C. (1995) Characterization of stable complexes involving apolipoprotein E and the amyloid beta peptide in Alzheimer's disease brain. Neuron 15, 219-222
4. Antonsson, B., Conti, F., Ciavatta, A., Montessuit, S., Lewis, S., Martinou, I., Bernasconi, L., Benard, A., Mermod, J.-J., Mazzei, G., Maundrell, K., Gambale, F., Sadoul, R., and Martinou, J.-C. (1997) Inhibition of Bax channel-forming activity by Bcl-2. Science 277, 370-372
5. Duff, K., Eckman, C., Zher, C., Yu, X., Prada, C. M., Perez-Tur, J., Hutton, M., Buee, L., Harigaya., Y., Yager, D., Morgan, D., Gordon, M. N., Holcomb, L., Refolo, L., Zenk, B., Hardy, J., and Younkin, S. (1996) Increased amyloid β42(43) in brains of mice expressing mutant presenilin 1. Nature (London) 383, 710-713
6. Schendel, A. L., Xie, Z., Montal, M. O., Matsuyama, S., Montal, M., and Reed, J. C. (1997) Channel formation by antiapoptotic protein Bcl-2 Proc. Natl. Acad. Sci. USA 94, 5113-5118
7. Scheuner, D., Eckman, C., Jenson, M., Song, X., Citron, M., Suzuki, N., Bird, T. D., Hardy, J., Hutton, M., Kukull, W., Larson, E., Levy-Lahard, E., Vitanen, M., Peskind, E., Poorkar, P., Schellenberg, G., Tanzi, R., Wasco, W., Lanfelt, L., Selkoe, D., and Younkin. S. (1996) Secreted amyloid-β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med. 2, 864-870
8. Buee, L., Hof, P. R., Bouras, C., Delacourte, A., Perl, D. P., Morrison, J. H., and Fillit, H. M. (1994) Pathological alterations of the cerebral microvasculature in Alzheimer's disease and related dementing disorders. Acta Neuropath. 87, 469-480
9. Busciglio, J., Gabuzda, D. H., Matsu, P., and Yankner, B. A. (1993) Generation of beta-amyloid in the secretory pathway in neuronal and non-neuronal cells. Proc. Natl. Acad. Sci. USA 90, 2092-2096
10. Perry, G., Smith, M. A., McCann, C. E., Siedlak, S. L., Jones, P. K., and Friedland, R. P. (1998) Cerebrovascular muscle atrophy is a feature of Alzheimer's Disease. Brain Res. 791, 63-66
11. Grammas, P., Botchlet, T., Fugate, R., Ball, M. J., and Roher, A. E. (1995) Alzheimer disease amyloid proteins inhibit brain endothelial cell proliferation in vitro. Dementia 6, 120-130
12. Crawford, F., Suo, Z., Fang, C., and Mullan, M. (1998) Characteristics of the in vitro vasoactivity of β-amyloid peptides. Exp. Neurol. 150, 159-168
13. Thomas, T., Thomas, G., McLendon, C., Sutton, T., and Mullan, M. (1996) β-Amyloid-mediatcd vasoactivity and vascular endothelial damage. Nature (London) 380, 168-171
14. Mattila, K. M., Pirttila, T., Blennow, K., Wallin, A., Viitanen, M., and Frey, H. (1994) Altered blood-brain-barrier function in Alzheimer's disease? Acta Neurol. Scand. 89, 192-198
15. Mecocci, P., Parnetti, L., Romano, G., Scarelli, A., Chionne, F., Cecchetti, R., Polidori, M. C., Palumbo, B., Cherubini, A., and Senin, U. (1995) Serum anti-GFAP and anti-S100 autoantibodies in brain aging. Alzheimer's disease and vascular dementia. J. Neuroimmunol. 57, 165-170
16. Perlmutter, L. S. (1994) Microvascular pathology and vascular basement membrane components in Alzheimer's disease. Mol. Neurobiol. 9, 33-40
17. Blanc, E. M., Toborek, M., Mark, R. J., Henning, B., and Mattson, M. P. (1997) Amyloid β-peptide induces cell monolayer albumin permeability, impairs glucose transport, and induces apoptosis in vascular endothelial cells. J. Neurochem. 68, 1870-1881
18. 1-12 induced endothelial toxicity. Brian Res. 762, 144-152
19. Seilheimer, B., Bohrmann, B., Bondolfi, L., Muller, F., Stuber, D., and Dobeli, H. (1997) The toxicity of the Alzheimer's β-amyloid peptide correlates with a distinct fiber morphology. J. Struct. Biol. 119, 59-71
20. Geula, C., Wu, C. K., Saroff, D., Lorenzo, A., Yuan, M., and Yankner, B. A. (1998) Aging renders the brain vulnerable to amyloid β-protein neurotoxicity. Nat. Med. 4, 827-883
21. Pallitto, M. M., Ghanta, J., Heinzelam, P., Kiessling, L. L., and Murphy, R. M. (1999) Recognition sequence design for peptidyl modulators of amyloid aggregation and toxicity. Biochemistry 38, 3570-3578
22. 2+ interaction with Alzheimer amyloid β protein calcium channels. Proc. Natl. Acad. Sci. USA 83, 1710-1715
23. 2+-sensitive, cation-selective channels across excised membrane patches from hypothalamic neurons. Biophys. J. 73, 67-75
24. 2+-sensitive channel. J. Biol. Chem. 273, 13379-13382
25. 2+-sensitive channel in reconstituted lipid vesicles. Biochemistry 38, 11189-11196
26. Hirakura, Y., Lin, M. C., and Kagan, B. L. (1999) Alzheimer amyloid A beta 1-42 channels: effect of solvent, pH, and Congo red. J. Neurosci. Res. 57, 458-456.
27. Arispe, N., Pollard, H. B., Rojas, E. (1993) Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes. Proc. Natl. Acad. Sci. USA 90, 10573-10577
28. Lal, R., and John, S. A. (1994) Biological application of atomic force microscopy. Am. J. Physiol. 266, C1-C21
29. Barbee, K. A.. Mundel, T., Lal. R., and Davies, P. F. (1995) Subcellular distribution of shear stress at the surface of flow-aligned and nonaligned endothelial monolayers. Am. J. Physiol. 268, H1765-H1772
30. Lal, R., Drake, B., Blumberg, D., Saner, D. R., Hansma, P. K., and Feinstein, S. C. (1995) Imaging real-neurite outgrowth and cytoskeletal reorganisation with an atomic force microscope. Am. J. Physiol. 269, C275-C285
31. Ivins, K. J., Ivins, J. K., Sharp, J. P., and Cotman, C. W. (1999) Multiple pathways of apoptosis in PC12 cells J. Biol. Chem. 274, 2107-2112
32. 25-35 peptide-mediated neurotoxicity in rat hippocampal cultures J. Neurosci. Res. 39, 494-550
33. Lane, N. J., Balbo, A., Fukuma, R., Rapoport, S. I., and Galdzicki, Z. (1998) The ultra-structural effects of β-amyloid peptide on cultured PC12 cells: changes in cytoplasmic and intramembranous features. J. Neurocytol. 27, 707-718
34. Shearman, M. S., Ragan, C. I., and Iversen, L. L. (1994) Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of beta-amyloid-mediated cell death. Proc. Natl. Acad. Sci. USA 91, 1470-1474
35. Liu, Y., and Schubert, D. (1998) Steroid hormones block amyloid libril-induced 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) formazan exocytosis: relationship to neurotoxicity. J. Neurochem. 71, 2322-2329
36. Zhu, Y. J., Lin, H., and Lal, R. (2000) Fresh and non-fibrillar Amyloid β Protein (1-40) induces rapid cellular degeneration in aged human fibroblasts: Evidence for AβP-channel mediated cellular toxicity. FASEB J. 14, 1244-1254
37. Maestre, G. E., Tate, B. E., Mojacha, R. E., and Marotta, C. A. (1993) Membrane surface ruffling in cells that overexpress Alzheimer amyloid β/A4 C-terminal peptide. Brain Res. 621, 145-149
38. Yankner, B. A., Duffy, L. K., and Kirschner, D. A. (1990) Neurotrophic and neurotoxic effects of amyloid β protein: reversal by tachykinin neuropeptides. Science 250, 279-282
39. Kosik, K. S., and Coleman, P. (1992) Is β-amyloid neurotoxic? Neurobiol. Aging 13, 535-630
40. + channels. Science 264, 276-279
41. 2+ mobilization is altered in fibroblasts from patients with Alzheimer disease. Proc. Natl. Acad. Sci. USA 91, 534-538
42. Dikalov, S. I., Vitec, M. P., Maples, K. R., and Mason, R. P. (1999) Amyloid beta peptides do not form peptide derived free radicals spontaneously. J. Biol. Chem. 274, 9392-9399
43. Benzi, G., and Moretti, A. (1995) Are reactive oxygen species involved in Alzheimer's disease? Neurobiol. Aging 16, 661-674
44. Kim, T. W., Pettingell, W. H., Jung, Y. K., Kovacs, D. M., and Tanzi, R. E. (1997) Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Science 277, 373-376
45. Koh, J.-V., Yang, L. L., and Cotman, C. W. (1990) β-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage. Brain Res. 533, 315-320
46. Li, J., Xu, M., Zhou, H., Ma, H., and Potter, H. (1997) Alzheimer's presenilins in the nuclear membrane, interphase kenetochores, and centrosomes suggest a role in chromosome segregation. Cell 90, 917-927
47. White, A. R., Zheng, H., Galatis, D., Maher, F., Hesse, L., Multhaup, G., Beyreuther, K. Masters, C. L., and Cappai, R. (1998) Survival of cultured neurons from amyloid precursor protein knock-out mice against Alzheimer's amyloid-beta toxicity and oxidative stress. J. Neurosci. 18, 6207-6217
48. Mattson, M. P., Cheng, B., Davis, B., Bryant, K., Lieberburg, I., and Rydel, R. E. (1992) β-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J. Neurosci. 12, 376-389
49. + current in rat hippocampal neurons. Biophys. J. 70, 296-304
50. Sanderson, K. L., Butler, L., and Ingram, V. M. (1997) Aggregates of a beta-amyloid peptide are required to induce calcium currents in neuron-like human teratocarcinoma cells: relation to Alzheimer's disease. Brain Res. 744, 7-14
51. Whitson, J. S., and Appel, S. H. (1995) Neurotoxicity of amyloid beta protein is not altered by calcium channel blockade. Neurobiol. Aging 16, 5-10
52. Jansen, J., Ashley, R. H., Harrison, D., McIntyre, S., and Butler, P. C. (1999) The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles. Diabetes 48, 491-498
53. Hirakura, Y., and Kagan, B. L. (1999) Channel formation by serum amyloid A: a mechanism for amyloid pathogenesis and host defence. Biophys. J. 76, A443 (abstr.)
54. Lin, M., Mirzabekov, T., and Kagan, B. L. (1997) Channel formation by a neurotoxic fragment of the prion protein J. Biol. Chem. 272, 44-47
55. Mirzabekov, T., Lin, M., and Kagan, B. L. (1996) Pore formation by the cytotoxic islet amyloid peptide amylin. J. Biol. Chem. 271, 1988-1992
56. Berridge, M. J. (1997) Elementary and global aspects of calcium signalling. J. Physiol. 499, 291-306