Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

Nature

Volumn 442, Issue 7105, 2006, Pages 920-924

  Cruts, Marc ^a,b,c   Gijselinck, Ilse ^a,b,c   Van Der Zee, Julie ^a,b,c   Engelborghs, Sebastiaan ^b,c,d   Wils, Hans ^a,b,c   Pirici, Daniel ^a,b,c   Rademakers, Rosa ^a,b,c   Vandenberghe, Rik ^e   Dermaut, Bart ^f   Martin, Jean Jacques ^b,c   Van Duijn, Cornelia ^g   Peeters, Karin ^a,b,c   Sciot, Raf ^e   Santens, Patrick ^f   De Pooter, Tim ^a,b,c   Mattheijssens, Maria ^a,b,c   Van Den Broeck, Marleen ^a,b,c   Cuijt, Ivy ^a,b,c   Vennekens, Krist'l ^a,b,c   De Deyn, Peter P ^b,c,d   Kumar Singh, Samir ^a,b,c   Van Broeckhoven, Christine ^a,b,c   more..

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b UNIVERSITY OF ANTWERP   (Belgium)

^c UNIVERSITY OF ANTWERP   (Belgium)

^d MIDDELHEIM HOSPITAL   (Belgium)

^e UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^f GHENT UNIVERSITY HOSPITAL   (Belgium)

^g ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOMES; CYTOLOGY; IMMUNOLOGY; NEUROLOGY; PATHOLOGY; PATIENT TREATMENT; PROTEINS;

FRONTOTEMPORAL DEMENTIA (FTD); GENE CODING; NEURONAL INCLUSIONS (BOTH; NULL MUTATIONS;

GENETIC ENGINEERING;

GROWTH FACTOR; PROGRANULIN; UBIQUITIN;

CHROMOSOME; GENE; GENE EXPRESSION; GENOMICS; HYBRIDIZATION; MUTATION; NERVOUS SYSTEM DISORDER; PATHOLOGY; PROTEIN;

ADULT; AGED; ARTICLE; CELL SURVIVAL; CHROMOSOME 17Q; CODON; CONTROLLED STUDY; FEMALE; FRONTOTEMPORAL DEMENTIA; GENE MUTATION; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; NERVE DEGENERATION; NULL ALLELE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; STOP CODON; TRANSLATION INITIATION;

EID: 33746910649     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature05017     Document Type: Article

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