ERK1/2 activation mediates Aβ oligomer-induced neurotoxicity via caspase-3 activation and Tau cleavage in rat organotypic hippocampal slice cultures

Journal of Biological Chemistry

Volumn 281, Issue 29, 2006, Pages 20315-20325

  Young, Hae Chong ^a   Yoo, Jeong Shin ^a   Eun, Ok Lee ^a   Kayed, Rakez ^b   Glabe, Charles G ^b   Tenner, Andrea J ^b  

^a Ewha Womans University School of Medicine   (South Korea)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; ANIMAL CELL CULTURE; BIOMARKERS; DISEASES; ENZYMES; NEUROLOGY; OLIGOMERS;

ALZHEIMER DISEASE (AD); NEUROTOXICITY; SIGNAL TRANSDUCTION; SIGNALING PATHWAY;

TOXICITY;

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; 2 MORPHOLINO 8 PHENYLCHROMONE; AMYLOID BETA PROTEIN; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BIOLOGICAL MARKER; CASPASE 3; CASPASE 3 INHIBITOR; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; OLIGOMER; PROPIDIUM IODIDE; SB 202580; SYNAPTOPHYSIN; TAU PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CELL DEATH; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG INHIBITION; ENZYME ACTIVATION; HIPPOCAMPUS; IMMUNOREACTIVITY; NEUROTOXICITY; NONHUMAN; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; SIGNAL TRANSDUCTION; STAINING; SYNAPSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; CASPASE 3; CASPASES; CELL DEATH; ENZYME ACTIVATION; HIPPOCAMPUS; HUMANS; L-LACTATE DEHYDROGENASE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEUROTOXINS; ORGAN CULTURE TECHNIQUES; PROTEIN KINASE INHIBITORS; RATS; TAU PROTEINS;

EID: 33745985711     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M601016200     Document Type: Article

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