-
1
-
-
34548036227
-
Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
-
Ballatore, C., Lee, V. M. & Trojanowski, J. Q. Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nature Rev. Neurosci. 8, 663-672 (2007).
-
(2007)
Nature Rev. Neurosci
, vol.8
, pp. 663-672
-
-
Ballatore, C.1
Lee, V.M.2
Trojanowski, J.Q.3
-
2
-
-
0034051319
-
S. Evidence for psychotropic effects of acetylcholinesterase inhibitors
-
Cummings, J. L. & Askin-Edgar, S. Evidence for psychotropic effects of acetylcholinesterase inhibitors. CNS Drugs 13, 385-395 (2000).
-
(2000)
CNS Drugs
, vol.13
, pp. 385-395
-
-
Cummings, J.L.1
Edgar, A.2
-
3
-
-
0025717816
-
The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease
-
Arnold, S. E., Hyman, B. T., Flory, J., Damasio, A. R. & Van Hoesen, G. W. The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease. Cereb. Cortex 1, 103-116 (1991).
-
(1991)
Cereb. Cortex
, vol.1
, pp. 103-116
-
-
Arnold, S.E.1
Hyman, B.T.2
Flory, J.3
Damasio, A.R.4
Van Hoesen, G.W.5
-
4
-
-
0031672540
-
Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria [see comments]
-
Neary, D. et al. Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria [see comments]. Neurology 51, 1546-1554 (1998).
-
(1998)
Neurology
, vol.51
, pp. 1546-1554
-
-
Neary, D.1
-
5
-
-
0035086145
-
Distinct behavioural profiles in frontotemporal dementia and semantic dementia
-
Snowden, J. S. et al. Distinct behavioural profiles in frontotemporal dementia and semantic dementia. J. Neurol. Neurosurg. Psychiatry 70, 323-332 (2001).
-
(2001)
J. Neurol. Neurosurg. Psychiatry
, vol.70
, pp. 323-332
-
-
Snowden, J.S.1
-
6
-
-
34447338567
-
Frontotemporal dementias: A review
-
Weder, N. D., Aziz, R., Wilkins, K. & Tampi, R. R. Frontotemporal dementias: a review. Ann. Gen. Psychiatry 6, 15 (2007).
-
(2007)
Ann. Gen. Psychiatry
, vol.6
, pp. 15
-
-
Weder, N.D.1
Aziz, R.2
Wilkins, K.3
Tampi, R.R.4
-
7
-
-
0037174618
-
Alzheimer's disease is a synaptic failure
-
Selkoe, D. J. Alzheimer's disease is a synaptic failure. Science 298, 789-791 (2002).
-
(2002)
Science
, vol.298
, pp. 789-791
-
-
Selkoe, D.J.1
-
8
-
-
0034940160
-
Neurodegenerative tauopathies
-
Lee, V. M., Goedert, M. & Trojanowski, J. Q. Neurodegenerative tauopathies. Annu. Rev. Neurosci. 24, 1121-1159 (2001).
-
(2001)
Annu. Rev. Neurosci
, vol.24
, pp. 1121-1159
-
-
Lee, V.M.1
Goedert, M.2
Trojanowski, J.Q.3
-
9
-
-
0026088977
-
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
-
Goate, A. et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349, 704-706 (1991).
-
(1991)
Nature
, vol.349
, pp. 704-706
-
-
Goate, A.1
-
10
-
-
0025950987
-
A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease
-
Murrell, J., Farlow, M., Ghetti, B. & Benson, M. D. A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease. Science 254, 97-99 (1991).
-
(1991)
Science
, vol.254
, pp. 97-99
-
-
Murrell, J.1
Farlow, M.2
Ghetti, B.3
Benson, M.D.4
-
11
-
-
0026907151
-
A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of β-amyloid
-
Mullan, M. et al. A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of β-amyloid. Nature Genet. 1, 345-347 (1992).
-
(1992)
Nature Genet
, vol.1
, pp. 345-347
-
-
Mullan, M.1
-
12
-
-
17944368176
-
The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation
-
Nilsberth, C. et al. The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation. Nature Neurosci. 4, 887-893 (2001).
-
(2001)
Nature Neurosci
, vol.4
, pp. 887-893
-
-
Nilsberth, C.1
-
13
-
-
20444504698
-
The genetic epidemiology of neurodegenerative disease
-
Bertram, L. & Tanzi, R. E. The genetic epidemiology of neurodegenerative disease. J. Clin. Invest. 115, 1449-1457 (2005).
-
(2005)
J. Clin. Invest
, vol.115
, pp. 1449-1457
-
-
Bertram, L.1
Tanzi, R.E.2
-
14
-
-
0032543684
-
Association of missense and 5β-splice-site mutations in tau with the inherited dementia FTDP-17
-
Hutton, M. et al. Association of missense and 5β-splice-site mutations in tau with the inherited dementia FTDP-17. Nature 393, 702-705 (1998).
-
(1998)
Nature
, vol.393
, pp. 702-705
-
-
Hutton, M.1
-
15
-
-
14444284106
-
Tau is a candidate gene for chromosome 17 frontotemporal dementia
-
Poorkaj, P. et al. Tau is a candidate gene for chromosome 17 frontotemporal dementia. Ann. Neurol. 43, 815-825 (1998).
-
(1998)
Ann. Neurol
, vol.43
, pp. 815-825
-
-
Poorkaj, P.1
-
16
-
-
0032560487
-
Mutation in the tau gene in familial multiple system tauopathy with presenile dementia
-
Spillantini, M. G. et al. Mutation in the tau gene in familial multiple system tauopathy with presenile dementia. Proc. Natl Acad. Sci. USA 95, 7737-7741 (1998).
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 7737-7741
-
-
Spillantini, M.G.1
-
17
-
-
41249089087
-
Loss of progranulin function in frontotemporal lobar degeneration
-
Cruts, M. & Van Broeckhoven, C. Loss of progranulin function in frontotemporal lobar degeneration. Trends Genet. (2008).
-
(2008)
Trends Genet
-
-
Cruts, M.1
Van Broeckhoven, C.2
-
18
-
-
33746919083
-
Mutations in progranulin cause taunegative frontotemporal dementia linked to chromosome 17
-
Baker, M. et al. Mutations in progranulin cause taunegative frontotemporal dementia linked to chromosome 17. Nature 442, 916-919 (2006).
-
(2006)
Nature
, vol.442
, pp. 916-919
-
-
Baker, M.1
-
19
-
-
33746910649
-
-
Cruts, M. et al. Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21. Nature 442, 920-924 (2006). This study, together with reference 18, identifies null mutations in progranulin as a cause of taunegative frontotemporal dementia.
-
Cruts, M. et al. Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21. Nature 442, 920-924 (2006). This study, together with reference 18, identifies null mutations in progranulin as a cause of taunegative frontotemporal dementia.
-
-
-
-
20
-
-
33749632259
-
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
-
This study shows that the tau-negative, ubiquitinpositive lesions in some forms of frontotemporal dementia and amyotrophic lateral sclerosis contain the protein TDP-43
-
Neumann, M. et al. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 314, 130-133 (2006). This study shows that the tau-negative, ubiquitinpositive lesions in some forms of frontotemporal dementia and amyotrophic lateral sclerosis contain the protein TDP-43.
-
(2006)
Science
, vol.314
, pp. 130-133
-
-
Neumann, M.1
-
21
-
-
41949119043
-
TDP-43 A315T mutation in familial motor neuron disease
-
Gitcho, M. A. et al. TDP-43 A315T mutation in familial motor neuron disease. Ann. Neurol. 63, 535-538 (2008).
-
(2008)
Ann. Neurol
, vol.63
, pp. 535-538
-
-
Gitcho, M.A.1
-
22
-
-
42649120983
-
TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
-
Kabashi, E. et al. TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis. Nature Genet. 40, 572-574 (2008).
-
(2008)
Nature Genet
, vol.40
, pp. 572-574
-
-
Kabashi, E.1
-
23
-
-
42949094584
-
TDP-43 mutation in familial amyotrophic lateral sclerosis
-
Yokoseki, A. et al. TDP-43 mutation in familial amyotrophic lateral sclerosis. Ann. Neurol. 63, 538-542 (2008).
-
(2008)
Ann. Neurol
, vol.63
, pp. 538-542
-
-
Yokoseki, A.1
-
24
-
-
26444621357
-
Inaugural Article: Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane
-
Ye, Y. et al. Inaugural Article: Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane. Proc. Natl Acad. Sci. USA 102, 14132-14138 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 14132-14138
-
-
Ye, Y.1
-
25
-
-
33846815066
-
TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations
-
Neumann, M. et al. TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations. J. Neuropathol. Exp. Neurol. 66, 152-157 (2007).
-
(2007)
J. Neuropathol. Exp. Neurol
, vol.66
, pp. 152-157
-
-
Neumann, M.1
-
26
-
-
35448929818
-
Alteration of behavioural phenotype in mice by targeted disruption of the progranulin gene
-
Kayasuga, Y. et al. Alteration of behavioural phenotype in mice by targeted disruption of the progranulin gene. Behav. Brain Res. 185, 110-118 (2007).
-
(2007)
Behav. Brain Res
, vol.185
, pp. 110-118
-
-
Kayasuga, Y.1
-
27
-
-
33847199377
-
A decade of tau transgenic animal models and beyond
-
Götz, J. et al. A decade of tau transgenic animal models and beyond Brain Pathol. 17, 91-103 (2007).
-
(2007)
Brain Pathol
, vol.17
, pp. 91-103
-
-
Götz, J.1
-
28
-
-
0028965635
-
Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform
-
Götz, J. et al. Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform. Embo J. 14, 1304-1313 (1995).
-
(1995)
Embo J
, vol.14
, pp. 1304-1313
-
-
Götz, J.1
-
29
-
-
0034426011
-
-
Lewis, J. et al. Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nature Genet. 25, 402-405 (2000). This study presented the first mouse model with NFT formation by expression of FTDP-17 (P301L) mutant tau.
-
Lewis, J. et al. Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nature Genet. 25, 402-405 (2000). This study presented the first mouse model with NFT formation by expression of FTDP-17 (P301L) mutant tau.
-
-
-
-
30
-
-
0035943436
-
Formation of neurofibrillary tangles in P301L tau transgenic mice induced by Aβ 42 fibrils
-
Götz, J., Chen, F., van Dorpe, J. & Nitsch, R. M. Formation of neurofibrillary tangles in P301L tau transgenic mice induced by Aβ 42 fibrils. Science 293, 1491-1495 (2001).
-
(2001)
Science
, vol.293
, pp. 1491-1495
-
-
Götz, J.1
Chen, F.2
van Dorpe, J.3
Nitsch, R.M.4
-
31
-
-
3142655729
-
Transgenic animal models of Alzheimer's disease and related disorders: Histopathology, behavior and therapy
-
Götz, J. et al. Transgenic animal models of Alzheimer's disease and related disorders: Histopathology, behavior and therapy. Mol. Psychiatry 9, 664-683 (2004).
-
(2004)
Mol. Psychiatry
, vol.9
, pp. 664-683
-
-
Götz, J.1
-
32
-
-
22344438508
-
Tau suppression in a neurodegenerative mouse model improves memory function
-
This study shows that NFT formation is not related to functional impairment in mice
-
Santacruz, K. et al. Tau suppression in a neurodegenerative mouse model improves memory function. Science 309, 476-481 (2005). This study shows that NFT formation is not related to functional impairment in mice.
-
(2005)
Science
, vol.309
, pp. 476-481
-
-
Santacruz, K.1
-
33
-
-
26844433190
-
Axonal degeneration induced by targeted expression of mutant human tau in oligodendrocytes of transgenic mice that model glial tauopathies
-
Higuchi, M. et al. Axonal degeneration induced by targeted expression of mutant human tau in oligodendrocytes of transgenic mice that model glial tauopathies. J. Neurosci. 25, 9434-9443 (2005).
-
(2005)
J. Neurosci
, vol.25
, pp. 9434-9443
-
-
Higuchi, M.1
-
34
-
-
17044411592
-
Transgenic mouse model of tau pathology in astrocytes leading to nervous system degeneration
-
Forman, M. S. et al. Transgenic mouse model of tau pathology in astrocytes leading to nervous system degeneration. J. Neurosci. 25, 3539-3550 (2005).
-
(2005)
J. Neurosci
, vol.25
, pp. 3539-3550
-
-
Forman, M.S.1
-
35
-
-
0036850725
-
Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein
-
Allen, B. et al. Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein. J. Neurosci. 22, 9340-9351 (2002).
-
(2002)
J. Neurosci
, vol.22
, pp. 9340-9351
-
-
Allen, B.1
-
36
-
-
33846538660
-
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model
-
Yoshiyama, Y. et al. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron 53, 337-351 (2007).
-
(2007)
Neuron
, vol.53
, pp. 337-351
-
-
Yoshiyama, Y.1
-
37
-
-
7244242262
-
Induction of inflammatory mediators and microglial activation in mice transgenic for mutant human P301S tau protein
-
Bellucci, A. et al. Induction of inflammatory mediators and microglial activation in mice transgenic for mutant human P301S tau protein. Am. J. Pathol. 165, 1643-1652 (2004).
-
(2004)
Am. J. Pathol
, vol.165
, pp. 1643-1652
-
-
Bellucci, A.1
-
38
-
-
33748471099
-
Inflammation in Alzheimer disease: Driving force, bystander or beneficial response?
-
Wyss-Coray, T. Inflammation in Alzheimer disease: driving force, bystander or beneficial response? Nature Med. 12, 1005-1015 (2006).
-
(2006)
Nature Med
, vol.12
, pp. 1005-1015
-
-
Wyss-Coray, T.1
-
39
-
-
0034992339
-
Tau and transgenic animal models
-
Götz, J. Tau and transgenic animal models. Brain Res. Brain Res. Rev. 35, 266-286 (2001).
-
(2001)
Brain Res. Brain Res. Rev
, vol.35
, pp. 266-286
-
-
Götz, J.1
-
40
-
-
34248181511
-
Reducing endogenous tau ameliorates amyloid β-induced deficits in an Alzheimer's disease mouse model
-
This study shows that tau reduction protects from Aβ-mediated toxicity and excitotoxicity
-
Roberson, E. D. et al. Reducing endogenous tau ameliorates amyloid β-induced deficits in an Alzheimer's disease mouse model. Science 316, 750-754 (2007). This study shows that tau reduction protects from Aβ-mediated toxicity and excitotoxicity.
-
(2007)
Science
, vol.316
, pp. 750-754
-
-
Roberson, E.D.1
-
41
-
-
17944382037
-
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant Tau and APP
-
Lewis, J. et al. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant Tau and APP. Science 293, 1487-1491 (2001).
-
(2001)
Science
, vol.293
, pp. 1487-1491
-
-
Lewis, J.1
-
42
-
-
38349013141
-
Induction of tau pathology by intracerebral infusion of amyloid-β-containing brain extract and by amyloid-β deposition in APP x Tau transgenic mice
-
Bolmont, T. et al. Induction of tau pathology by intracerebral infusion of amyloid-β-containing brain extract and by amyloid-β deposition in APP x Tau transgenic mice. Am. J. Pathol. 171, 2012-2020 (2007).
-
(2007)
Am. J. Pathol
, vol.171
, pp. 2012-2020
-
-
Bolmont, T.1
-
43
-
-
40449098952
-
Amyloid activates GSK-3β to aggravate neuronal tauopathy in bigenic mice
-
Terwel, D. et al. Amyloid activates GSK-3β to aggravate neuronal tauopathy in bigenic mice. Am. J. Pathol. 172, 786-798 (2008).
-
(2008)
Am. J. Pathol
, vol.172
, pp. 786-798
-
-
Terwel, D.1
-
44
-
-
0038187674
-
GSK-3α regulates production of Alzheimer's disease amyloid-β peptides
-
Phiel, C. J., Wilson, C. A., Lee, V. M. & Klein, P. S. GSK-3α regulates production of Alzheimer's disease amyloid-β peptides. Nature 423, 435-439 (2003).
-
(2003)
Nature
, vol.423
, pp. 435-439
-
-
Phiel, C.J.1
Wilson, C.A.2
Lee, V.M.3
Klein, P.S.4
-
45
-
-
0043069764
-
Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration
-
Liou, Y. C. et al. Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. Nature 424, 556-561 (2003).
-
(2003)
Nature
, vol.424
, pp. 556-561
-
-
Liou, Y.C.1
-
46
-
-
33645300736
-
The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production
-
Pastorino, L. et al. The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production. Nature 440, 528-534 (2006).
-
(2006)
Nature
, vol.440
, pp. 528-534
-
-
Pastorino, L.1
-
47
-
-
0042697305
-
-
Oddo, S. et al. Triple-transgenic model of Alzheimer's disease with plaques and tangles. Intracellular aβ and synaptic dysfunction. Neuron 39, 409-421 (2003). This study combines transgenic expression of mutant APP, PSEN1 and tau, achieving both Aβ plaque and NFT formation.
-
Oddo, S. et al. Triple-transgenic model of Alzheimer's disease with plaques and tangles. Intracellular aβ and synaptic dysfunction. Neuron 39, 409-421 (2003). This study combines transgenic expression of mutant APP, PSEN1 and tau, achieving both Aβ plaque and NFT formation.
-
-
-
-
48
-
-
4644276796
-
Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Aβ42 accumulation in a novel Alzheimer transgenic model
-
Casas, C. et al. Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Aβ42 accumulation in a novel Alzheimer transgenic model. Am. J. Pathol. 165, 1289-1300 (2004).
-
(2004)
Am. J. Pathol
, vol.165
, pp. 1289-1300
-
-
Casas, C.1
-
49
-
-
0031914718
-
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
-
Holcomb, L. et al. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nature Med. 4, 97-100 (1998).
-
(1998)
Nature Med
, vol.4
, pp. 97-100
-
-
Holcomb, L.1
-
50
-
-
12144288683
-
Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease
-
Schmitz, C. et al. Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease. Am. J. Pathol. 164, 1495-1502 (2004).
-
(2004)
Am. J. Pathol
, vol.164
, pp. 1495-1502
-
-
Schmitz, C.1
-
51
-
-
33744952846
-
Wild-type presenilin 1 protects against Alzheimer disease mutation-induced amyloid pathology
-
Wang, R., Wang, B., He, W. & Zheng, H. Wild-type presenilin 1 protects against Alzheimer disease mutation-induced amyloid pathology. J. Biol. Chem. 281, 15330-15336 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 15330-15336
-
-
Wang, R.1
Wang, B.2
He, W.3
Zheng, H.4
-
52
-
-
0346055155
-
BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease
-
Ohno, M. et al. BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease. Neuron 41, 27-33 (2004).
-
(2004)
Neuron
, vol.41
, pp. 27-33
-
-
Ohno, M.1
-
53
-
-
34548847452
-
Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP transgenic mice
-
McConlogue, L. et al. Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP transgenic mice. J. Biol. Chem. 282, 26326-26334 (2007).
-
(2007)
J. Biol. Chem
, vol.282
, pp. 26326-26334
-
-
McConlogue, L.1
-
54
-
-
7244234177
-
β-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic mice
-
Willem, M. et al. β-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic mice. Am. J. Pathol. 165, 1621-1631 (2004).
-
(2004)
Am. J. Pathol
, vol.165
, pp. 1621-1631
-
-
Willem, M.1
-
55
-
-
34249951869
-
Involvement of β-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activitydependent synaptic plasticity
-
Ma, H. et al. Involvement of β-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activitydependent synaptic plasticity. Proc. Natl Acad. Sci. USA 104, 8167-8172 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 8167-8172
-
-
Ma, H.1
-
56
-
-
85047690140
-
A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model
-
Postina, R. et al. A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model. J. Clin. Invest. 113, 1456-1464 (2004).
-
(2004)
J. Clin. Invest
, vol.113
, pp. 1456-1464
-
-
Postina, R.1
-
57
-
-
0031278270
-
Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition
-
Bales, K. R. et al. Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition. Nature Genet. 17, 263-264 (1997).
-
(1997)
Nature Genet
, vol.17
, pp. 263-264
-
-
Bales, K.R.1
-
58
-
-
12844273475
-
Gene delivery of human apolipoprotein E alters brain Aβ burden in a mouse model of Alzheimer's disease
-
Dodart, J. C. et al. Gene delivery of human apolipoprotein E alters brain Aβ burden in a mouse model of Alzheimer's disease. Proc. Natl Acad. Sci. USA 102, 1211-1216 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 1211-1216
-
-
Dodart, J.C.1
-
59
-
-
30044442937
-
Deletion of Abca1 increases Aβ deposition in the PDAPP transgenic mouse model of Alzheimer disease
-
Wahrle, S. E. et al. Deletion of Abca1 increases Aβ deposition in the PDAPP transgenic mouse model of Alzheimer disease. J. Biol. Chem. 280, 43236-43242 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 43236-43242
-
-
Wahrle, S.E.1
-
60
-
-
30044438463
-
Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice
-
Koldamova, R., Staufenbiel, M. & Lefterov, I. Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice. J. Biol. Chem. 280, 43224-43235 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 43224-43235
-
-
Koldamova, R.1
Staufenbiel, M.2
Lefterov, I.3
-
61
-
-
30044441879
-
The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease
-
Hirsch-Reinshagen, V. et al. The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease. J. Biol. Chem. 280, 43243-43256 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 43243-43256
-
-
Hirsch-Reinshagen, V.1
-
62
-
-
38849086036
-
Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease
-
Wahrle, S. E. et al. Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease. J. Clin. Invest. 118, 671-682 (2008).
-
(2008)
J. Clin. Invest
, vol.118
, pp. 671-682
-
-
Wahrle, S.E.1
-
63
-
-
14844331501
-
Molecular motors and mechanisms of directional transport in neurons
-
Hirokawa, N. & Takemura, R. Molecular motors and mechanisms of directional transport in neurons. Nature Rev. Neurosci. 6, 201-214 (2005).
-
(2005)
Nature Rev. Neurosci
, vol.6
, pp. 201-214
-
-
Hirokawa, N.1
Takemura, R.2
-
64
-
-
0033230886
-
Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform
-
Ishihara, T. et al. Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform. Neuron 24, 751-762 (1999).
-
(1999)
Neuron
, vol.24
, pp. 751-762
-
-
Ishihara, T.1
-
65
-
-
20044385920
-
-
Stokin, G. B. et al. Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science 307, 1282-1288 (2005). This study identifies correlates of impaired axonal transport in APP transgenic mice and AD brains. Formation of spheroids increases with reduced kinesin function.
-
Stokin, G. B. et al. Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science 307, 1282-1288 (2005). This study identifies correlates of impaired axonal transport in APP transgenic mice and AD brains. Formation of spheroids increases with reduced kinesin function.
-
-
-
-
66
-
-
39749165656
-
Differential regulation of dynein and kinesin motor proteins by tau
-
Dixit, R., Ross, J. L., Goldman, Y. E. & Holzbaur, E. L. Differential regulation of dynein and kinesin motor proteins by tau. Science 319, 1086-1089 (2008).
-
(2008)
Science
, vol.319
, pp. 1086-1089
-
-
Dixit, R.1
Ross, J.L.2
Goldman, Y.E.3
Holzbaur, E.L.4
-
67
-
-
0033636136
-
Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I
-
Kamal, A., Stokin, G. B., Yang, Z., Xia, C. H. & Goldstein, L. S. Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I. Neuron 28, 449-459 (2000).
-
(2000)
Neuron
, vol.28
, pp. 449-459
-
-
Kamal, A.1
Stokin, G.B.2
Yang, Z.3
Xia, C.H.4
Goldstein, L.S.5
-
68
-
-
0035818998
-
Kinesin-mediated axonal transport of a membrane compartment containing β-secretase and presenilin-1 requires APP
-
Kamal, A., Almenar-Queralt, A., LeBlanc, J. F., Roberts, E. A. & Goldstein, L. S. Kinesin-mediated axonal transport of a membrane compartment containing β-secretase and presenilin-1 requires APP. Nature 414, 643-648 (2001).
-
(2001)
Nature
, vol.414
, pp. 643-648
-
-
Kamal, A.1
Almenar-Queralt, A.2
LeBlanc, J.F.3
Roberts, E.A.4
Goldstein, L.S.5
-
69
-
-
33750705653
-
A century of Alzheimer's disease
-
Goedert, M. & Spillantini, M. G. A century of Alzheimer's disease. Science 314, 777-781 (2006).
-
(2006)
Science
, vol.314
, pp. 777-781
-
-
Goedert, M.1
Spillantini, M.G.2
-
70
-
-
35649028013
-
Interaction of tau protein with the dynactin complex
-
Magnani, E. et al. Interaction of tau protein with the dynactin complex. Embo J. 26, 4546-4554 (2007).
-
(2007)
Embo J
, vol.26
, pp. 4546-4554
-
-
Magnani, E.1
-
71
-
-
0037373633
-
Dying for a cause: Invertebrate genetics takes on human neurodegeneration
-
Driscoll, M. & Gerstbrein, B. Dying for a cause: invertebrate genetics takes on human neurodegeneration. Nature Rev. Genet. 4, 181-194 (2003).
-
(2003)
Nature Rev. Genet
, vol.4
, pp. 181-194
-
-
Driscoll, M.1
Gerstbrein, B.2
-
72
-
-
0035958642
-
-
Wittmann, C. W. et al. Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles. Science 293, 711-714 (2001). This study shows in D. melanogaster that tau-mediated neurodegeneration can occur in the absence of NFT formation.
-
Wittmann, C. W. et al. Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles. Science 293, 711-714 (2001). This study shows in D. melanogaster that tau-mediated neurodegeneration can occur in the absence of NFT formation.
-
-
-
-
73
-
-
0037118247
-
Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila
-
Jackson, G. R. et al. Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila. Neuron 34, 509-519 (2002).
-
(2002)
Neuron
, vol.34
, pp. 509-519
-
-
Jackson, G.R.1
-
74
-
-
33846080531
-
Oxidative stress mediates tau-induced neurodegeneration in Drosophila
-
Dias-Santagata, D., Fulga, T. A., Duttaroy, A. & Feany, M. B. Oxidative stress mediates tau-induced neurodegeneration in Drosophila. J. Clin. Invest. 117, 236-245 (2007).
-
(2007)
J. Clin. Invest
, vol.117
, pp. 236-245
-
-
Dias-Santagata, D.1
Fulga, T.A.2
Duttaroy, A.3
Feany, M.B.4
-
75
-
-
0348108123
-
Synaptic plasticity and cell cycle activation in neurons are alternative effector pathways: The 'Dr. Jekyll and Mr. Hyde concept' of Alzheimer's disease or the yin and yang of neuroplasticity
-
Arendt, T. Synaptic plasticity and cell cycle activation in neurons are alternative effector pathways: the 'Dr. Jekyll and Mr. Hyde concept' of Alzheimer's disease or the yin and yang of neuroplasticity. Prog. Neurobiol. 71, 83-248 (2003).
-
(2003)
Prog. Neurobiol
, vol.71
, pp. 83-248
-
-
Arendt, T.1
-
76
-
-
31944434543
-
TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model
-
Khurana, V. et al. TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model. Curr. Biol. 16, 230-241 (2006).
-
(2006)
Curr. Biol
, vol.16
, pp. 230-241
-
-
Khurana, V.1
-
77
-
-
0141960033
-
β-amyloid induces PHF-like tau filaments in tissue culture
-
Ferrari, A., Hoerndli, F., Baechi, T., Nitsch, R. M. & Götz, J. β-amyloid induces PHF-like tau filaments in tissue culture. J. Biol. Chem. 278, 40162-40168 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 40162-40168
-
-
Ferrari, A.1
Hoerndli, F.2
Baechi, T.3
Nitsch, R.M.4
Götz, J.5
-
78
-
-
37049027122
-
Tau phosphorylation sites work in concert to promote neurotoxicity in vivo
-
Steinhilb, M. L., Dias-Santagata, D., Fulga, T. A., Felch, D. L. & Feany, M. B. Tau phosphorylation sites work in concert to promote neurotoxicity in vivo. Mol. Biol. Cell 18, 5060-5068 (2007).
-
(2007)
Mol. Biol. Cell
, vol.18
, pp. 5060-5068
-
-
Steinhilb, M.L.1
Dias-Santagata, D.2
Fulga, T.A.3
Felch, D.L.4
Feany, M.B.5
-
79
-
-
33947286683
-
Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo
-
This study links tau pathology to the formation of actin-containing rods
-
Fulga, T. A. et al. Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo. Nature Cell Biol. 9, 139-148 (2007). This study links tau pathology to the formation of actin-containing rods.
-
(2007)
Nature Cell Biol
, vol.9
, pp. 139-148
-
-
Fulga, T.A.1
-
80
-
-
0037468759
-
The role of presenilin cofactors in the γ-secretase complex
-
Takasugi, N. et al. The role of presenilin cofactors in the γ-secretase complex. Nature 422, 438-441 (2003).
-
(2003)
Nature
, vol.422
, pp. 438-441
-
-
Takasugi, N.1
-
81
-
-
0032506013
-
Transgenic Drosophila expressing human amyloid precursor protein show γ-secretase activity and a blistered-wing phenotype
-
Fossgreen, A. et al. Transgenic Drosophila expressing human amyloid precursor protein show γ-secretase activity and a blistered-wing phenotype. Proc. Natl Acad. Sci. USA 95, 13703-13708 (1998).
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 13703-13708
-
-
Fossgreen, A.1
-
82
-
-
0242668337
-
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
-
Kayed, R. et al. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 300, 486-489 (2003).
-
(2003)
Science
, vol.300
, pp. 486-489
-
-
Kayed, R.1
-
83
-
-
0037022297
-
Conformational Abs recognizing a generic amyloid fibril epitope
-
O'Nuallain, B. & Wetzel, R. Conformational Abs recognizing a generic amyloid fibril epitope. Proc. Natl Acad. Sci. USA 99, 1485-1490 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 1485-1490
-
-
O'Nuallain, B.1
Wetzel, R.2
-
84
-
-
37649019187
-
Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Aβ protofibrils
-
Habicht, G. et al. Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Aβ protofibrils. Proc. Natl Acad. Sci. USA 104, 19232-19237 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 19232-19237
-
-
Habicht, G.1
-
85
-
-
20044362721
-
Family-based association between Alzheimer's disease and variants in UBQLN1
-
Bertram, L. et al. Family-based association between Alzheimer's disease and variants in UBQLN1. N. Engl. J. Med. 352, 884-894 (2005).
-
(2005)
N. Engl. J. Med
, vol.352
, pp. 884-894
-
-
Bertram, L.1
-
86
-
-
35448970692
-
-
Li, A. et al. Isolation and characterization of the Drosophila ubiquilin ortholog dUbqln: in vivo interaction with early-onset Alzheimer disease genes. Hum. Mol. Genet. 16, 2626-2639 (2007).
-
Li, A. et al. Isolation and characterization of the Drosophila ubiquilin ortholog dUbqln: in vivo interaction with early-onset Alzheimer disease genes. Hum. Mol. Genet. 16, 2626-2639 (2007).
-
-
-
-
87
-
-
2342473791
-
Dissecting the pathological effects of human Aβ40 and Aβ42 in Drosophila: A potential model for Alzheimer's disease
-
Iijima, K. et al. Dissecting the pathological effects of human Aβ40 and Aβ42 in Drosophila: a potential model for Alzheimer's disease. Proc. Natl Acad. Sci. USA 101, 6623-6628 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 6623-6628
-
-
Iijima, K.1
-
88
-
-
37249017468
-
Systematic in vivo analysis of the intrinsic determinants of amyloid β pathogenicity
-
Luheshi, L. M. et al. Systematic in vivo analysis of the intrinsic determinants of amyloid β pathogenicity. PLoS Biol. 5, e290 (2007).
-
(2007)
PLoS Biol
, vol.5
-
-
Luheshi, L.M.1
-
89
-
-
33646715856
-
Modeling clinically heterogeneous presenilin mutations with transgenic Drosophila
-
Seidner, G. A., Ye, Y., Faraday, M. M., Alvord, W. G. & Fortini, M. E. Modeling clinically heterogeneous presenilin mutations with transgenic Drosophila. Curr. Biol. 16, 1026-1033 (2006).
-
(2006)
Curr. Biol
, vol.16
, pp. 1026-1033
-
-
Seidner, G.A.1
Ye, Y.2
Faraday, M.M.3
Alvord, W.G.4
Fortini, M.E.5
-
90
-
-
0036514504
-
Modelling neurodegenerative diseases in Drosophila: A fruitful approach?
-
Muqit, M. M. & Feany, M. B. Modelling neurodegenerative diseases in Drosophila: a fruitful approach? Nature Rev. Neurosci. 3, 237-243 (2002).
-
(2002)
Nature Rev. Neurosci
, vol.3
, pp. 237-243
-
-
Muqit, M.M.1
Feany, M.B.2
-
91
-
-
0037271081
-
γ-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila
-
Micchelli, C. A. et al. γ-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila. Faseb J. 17, 79-81 (2003).
-
(2003)
Faseb J
, vol.17
, pp. 79-81
-
-
Micchelli, C.A.1
-
92
-
-
0042889049
-
From the Cover: Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy
-
Kraemer, B. C. et al. From the Cover: Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy. Proc. Natl Acad. Sci. USA 100, 9980-9985 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 9980-9985
-
-
Kraemer, B.C.1
-
93
-
-
26944463072
-
Progressive neurodegeneration in C. elegans model of tauopathy
-
Miyasaka, T. et al. Progressive neurodegeneration in C. elegans model of tauopathy. Neurobiol. Dis. 20, 372-383 (2005).
-
(2005)
Neurobiol. Dis
, vol.20
, pp. 372-383
-
-
Miyasaka, T.1
-
94
-
-
33745959291
-
Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species
-
Dickey, C. A. et al. Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species. J. Neurosci. 26, 6985-6996 (2006).
-
(2006)
J. Neurosci
, vol.26
, pp. 6985-6996
-
-
Dickey, C.A.1
-
95
-
-
34548389257
-
SUT-1 enables tau-induced neurotoxicity in C. elegans
-
Kraemer, B. C. & Schellenberg, G. D. SUT-1 enables tau-induced neurotoxicity in C. elegans. Hum. Mol. Genet. 16, 1959-1971 (2007).
-
(2007)
Hum. Mol. Genet
, vol.16
, pp. 1959-1971
-
-
Kraemer, B.C.1
Schellenberg, G.D.2
-
96
-
-
18444417998
-
aph-1 and pen-2 are required for Notch pathway signaling, γ-secretase cleavage of βAPP, and presenilin protein accumulation
-
Francis, R. et al. aph-1 and pen-2 are required for Notch pathway signaling, γ-secretase cleavage of βAPP, and presenilin protein accumulation. Dev. Cell 3, 85-97 (2002).
-
(2002)
Dev. Cell
, vol.3
, pp. 85-97
-
-
Francis, R.1
-
97
-
-
33845636602
-
Genetics of egg-laying in worms
-
Schafer, W. F. Genetics of egg-laying in worms. Annu. Rev. Genet. 40, 487-509 (2006).
-
(2006)
Annu. Rev. Genet
, vol.40
, pp. 487-509
-
-
Schafer, W.F.1
-
98
-
-
33750181976
-
Presenilin function in Caenorhabditis elegans
-
Smialowska, A. & Baumeister, R. Presenilin function in Caenorhabditis elegans. Neurodegener. Dis. 3, 227-232 (2006).
-
(2006)
Neurodegener. Dis
, vol.3
, pp. 227-232
-
-
Smialowska, A.1
Baumeister, R.2
-
99
-
-
16544386054
-
Screening for presenilin inhibitors using the free-living nematode, Caenorhabditis elegans
-
Ellerbrock, B. R., Coscarelli, E. M., Gurney, M. E. & Geary, T. G. Screening for presenilin inhibitors using the free-living nematode, Caenorhabditis elegans. J. Biomol. Screen 9, 147-152 (2004).
-
(2004)
J. Biomol. Screen
, vol.9
, pp. 147-152
-
-
Ellerbrock, B.R.1
Coscarelli, E.M.2
Gurney, M.E.3
Geary, T.G.4
-
100
-
-
25444464112
-
Functional Genomics meets neurodegenerative disorders Part I: Transcriptomic and proteomic technology
-
David, D., Hoerndli, F. & Götz, J. Functional Genomics meets neurodegenerative disorders Part I: Transcriptomic and proteomic technology. Prog. Neurobiol. 76, 153-168 (2005).
-
(2005)
Prog. Neurobiol
, vol.76
, pp. 153-168
-
-
David, D.1
Hoerndli, F.2
Götz, J.3
-
101
-
-
25444467721
-
Functional genomics meets neurodegenerative disorders. Part II: Application and data integration
-
Hoerndli, F., David, D. & Götz, J. Functional genomics meets neurodegenerative disorders. Part II: Application and data integration. Prog. Neurobiol. 76, 169-188 (2005).
-
(2005)
Prog. Neurobiol
, vol.76
, pp. 169-188
-
-
Hoerndli, F.1
David, D.2
Götz, J.3
-
102
-
-
35948933394
-
Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins
-
Ray, S. et al. Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins. Nature Med. 13, 1359-1362 (2007).
-
(2007)
Nature Med
, vol.13
, pp. 1359-1362
-
-
Ray, S.1
-
103
-
-
0035905027
-
Transcriptional profiling reveals strict boundaries between hippocampal subregions
-
Zhao, X. et al. Transcriptional profiling reveals strict boundaries between hippocampal subregions. J. Comp. Neurol. 441, 187-196 (2001).
-
(2001)
J. Comp. Neurol
, vol.441
, pp. 187-196
-
-
Zhao, X.1
-
104
-
-
0034718595
-
Regional and strain-specific gene expression mapping in the adult mouse brain
-
This study shows differentially regulated genes in subregions of the hippocampus
-
Sandberg, R. et al. Regional and strain-specific gene expression mapping in the adult mouse brain. Proc. Natl Acad. Sci. USA 97, 11038-11043 (2000). This study shows differentially regulated genes in subregions of the hippocampus.
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 11038-11043
-
-
Sandberg, R.1
-
105
-
-
0035942240
-
Amygdala-enriched genes identified by microarray technology are restricted to specific amygdaloid subnuclei
-
Zirlinger, M., Kreiman, G. & Anderson, D. J. Amygdala-enriched genes identified by microarray technology are restricted to specific amygdaloid subnuclei. Proc. Natl Acad. Sci. USA 98, 5270-5275 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 5270-5275
-
-
Zirlinger, M.1
Kreiman, G.2
Anderson, D.J.3
-
106
-
-
33847662852
-
Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer's amyloid β-peptide
-
Haass, C. & Selkoe, D. J. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide. Nature Rev. Mol. Cell Biol. 8, 101-112 (2007).
-
(2007)
Nature Rev. Mol. Cell Biol
, vol.8
, pp. 101-112
-
-
Haass, C.1
Selkoe, D.J.2
-
107
-
-
0032476645
-
Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: Implications for Alzheimer's disease
-
Ebneth, A. et al. Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease. J. Cell Biol. 143, 777-794 (1998).
-
(1998)
J. Cell Biol
, vol.143
, pp. 777-794
-
-
Ebneth, A.1
-
108
-
-
21244486781
-
Proteomic and functional analysis reveal a mitochondrial dysfunction in P301L tau transgenic mice
-
David, D. C. et al. Proteomic and functional analysis reveal a mitochondrial dysfunction in P301L tau transgenic mice. J. Biol. Chem. 280, 23802-23814 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 23802-23814
-
-
David, D.C.1
-
109
-
-
38849150935
-
-
Melov, S. et al. Mitochondrial oxidative stress causes hyperphosphorylation of tau. PLoS ONE 2, e536 (2007).
-
Melov, S. et al. Mitochondrial oxidative stress causes hyperphosphorylation of tau. PLoS ONE 2, e536 (2007).
-
-
-
-
110
-
-
11144353586
-
ABAD directly links Aβ to mitochondrial toxicity in Alzheimer's disease
-
Lustbader, J. W. et al. ABAD directly links Aβ to mitochondrial toxicity in Alzheimer's disease. Science 304, 448-452 (2004).
-
(2004)
Science
, vol.304
, pp. 448-452
-
-
Lustbader, J.W.1
-
111
-
-
33847686377
-
Proteomic and functional alterations in brain mitochondria from Tg2576 mice occur before amyloid plaque deposition
-
Gillardon, F. et al. Proteomic and functional alterations in brain mitochondria from Tg2576 mice occur before amyloid plaque deposition. Proteomics 7, 605-616 (2007).
-
(2007)
Proteomics
, vol.7
, pp. 605-616
-
-
Gillardon, F.1
-
112
-
-
0037010289
-
Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: Transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling
-
Colangelo, V. et al. Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling. J. Neurosci. Res. 70, 462-473 (2002).
-
(2002)
J. Neurosci. Res
, vol.70
, pp. 462-473
-
-
Colangelo, V.1
-
113
-
-
0035823418
-
Gene expression profiling of the tau mutant (P301L) transgenic mouse brain
-
Ho, L. et al. Gene expression profiling of the tau mutant (P301L) transgenic mouse brain. Neurosci. Lett. 310, 1-4 (2001).
-
(2001)
Neurosci. Lett
, vol.310
, pp. 1-4
-
-
Ho, L.1
-
114
-
-
0035808361
-
Tau filament formation in transgenic mice expressing P301L tau
-
Götz, J., Chen, F., Barmettler, R. & Nitsch, R. M. Tau filament formation in transgenic mice expressing P301L tau. J. Biol. Chem. 276, 529-534 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, pp. 529-534
-
-
Götz, J.1
Chen, F.2
Barmettler, R.3
Nitsch, R.M.4
-
115
-
-
2442652837
-
Role for glyoxalase I in Alzheimer's disease
-
Chen, F. et al. Role for glyoxalase I in Alzheimer's disease. Proc. Natl Acad. Sci. USA 101, 7687-7692 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 7687-7692
-
-
Chen, F.1
-
116
-
-
33846019607
-
β-Amyloid treatment of two complementary P301L tau-expressing Alzheimer's disease models reveals similar deregulated cellular processes
-
David, D. C. et al. β-Amyloid treatment of two complementary P301L tau-expressing Alzheimer's disease models reveals similar deregulated cellular processes. Proteomics 6, 6566-6577 (2006).
-
(2006)
Proteomics
, vol.6
, pp. 6566-6577
-
-
David, D.C.1
-
117
-
-
33748174617
-
A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration
-
Karsten, S. L. et al. A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration. Neuron 51, 549-560 (2006).
-
(2006)
Neuron
, vol.51
, pp. 549-560
-
-
Karsten, S.L.1
-
118
-
-
0037775776
-
Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein + presenilin-1 transgenic mice
-
Dickey, C. A. et al. Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein + presenilin-1 transgenic mice. J. Neurosci. 23, 5219-5226 (2003).
-
(2003)
J. Neurosci
, vol.23
, pp. 5219-5226
-
-
Dickey, C.A.1
-
119
-
-
20044377403
-
Environmental enrichment reduces Aβ levels and amyloid deposition in transgenic mice
-
This study shows how environmental enrichment can reduce Aβ levels and improve memory deficits
-
Lazarov, O. et al. Environmental enrichment reduces Aβ levels and amyloid deposition in transgenic mice. Cell 120, 701-713 (2005). This study shows how environmental enrichment can reduce Aβ levels and improve memory deficits.
-
(2005)
Cell
, vol.120
, pp. 701-713
-
-
Lazarov, O.1
-
120
-
-
61649107693
-
Gene expression profile of the PDAPP mouse model for Alzheimer's disease with and without Apolipoprotein E
-
Sep 29, doi:10.1016/j.neurobiolaging.2007.08.006
-
Selwood, S. P. et al. Gene expression profile of the PDAPP mouse model for Alzheimer's disease with and without Apolipoprotein E. Neurobiol. Aging Sep 29 2007 (doi:10.1016/j.neurobiolaging.2007.08.006).
-
(2007)
Neurobiol. Aging
-
-
Selwood, S.P.1
-
121
-
-
0034691124
-
In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease
-
Skovronsky, D. M. et al. In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease. Proc. Natl Acad. Sci. USA 97, 7609-7614 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 7609-7614
-
-
Skovronsky, D.M.1
-
122
-
-
10744232413
-
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B
-
This study shows that the Pittsburgh Compound-B (PIB) is a suitable PET tracer in vivo
-
Klunk, W. E. et al. Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann. Neurol. 55, 306-319 (2004). This study shows that the Pittsburgh Compound-B (PIB) is a suitable PET tracer in vivo.
-
(2004)
Ann. Neurol
, vol.55
, pp. 306-319
-
-
Klunk, W.E.1
-
123
-
-
0142123057
-
Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-β ligand in transgenic mice
-
This study introduces the Pittsburgh Compound-B (PIB) that binds to Aβ plaques in vivo
-
Bacskai, B. J. et al. Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-β ligand in transgenic mice. Proc. Natl Acad. Sci. USA 100, 12462-12467 (2003). This study introduces the Pittsburgh Compound-B (PIB) that binds to Aβ plaques in vivo.
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 12462-12467
-
-
Bacskai, B.J.1
-
124
-
-
27944471285
-
Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-β in Alzheimer's disease brain but not in transgenic mouse brain
-
Klunk, W. E. et al. Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-β in Alzheimer's disease brain but not in transgenic mouse brain. J. Neurosci. 25, 10598-10606 (2005).
-
(2005)
J. Neurosci
, vol.25
, pp. 10598-10606
-
-
Klunk, W.E.1
-
125
-
-
35348821915
-
Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography
-
Maeda, J. et al. Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography. J. Neurosci. 27, 10957-10968 (2007).
-
(2007)
J. Neurosci
, vol.27
, pp. 10957-10968
-
-
Maeda, J.1
-
126
-
-
20044392910
-
19F and 1H MRI detection of amyloid β plaques in vivo
-
Higuchi, M. et al. 19F and 1H MRI detection of amyloid β plaques in vivo. Nature Neurosci. 8, 527-533 (2005).
-
(2005)
Nature Neurosci
, vol.8
, pp. 527-533
-
-
Higuchi, M.1
-
127
-
-
23844505632
-
Monitoring disease progression in transgenic mouse models of Alzheimer's disease with proton magnetic resonance spectroscopy
-
Marjanska, M. et al. Monitoring disease progression in transgenic mouse models of Alzheimer's disease with proton magnetic resonance spectroscopy. Proc. Natl Acad. Sci. USA 102, 11906-11910 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 11906-11910
-
-
Marjanska, M.1
-
128
-
-
33750503415
-
Drug discovery in dementia: The role of rodent models
-
Van Dam, D. & De Deyn, P. P. Drug discovery in dementia: the role of rodent models. Nature Rev. Drug Discov. 5, 956-970 (2006).
-
(2006)
Nature Rev. Drug Discov
, vol.5
, pp. 956-970
-
-
Van Dam, D.1
De Deyn, P.P.2
-
129
-
-
38449088277
-
Antibody-based approaches in Alzheimer's research: Safety, pharmacokinetics, metabolism, and analytical tools
-
Lichtlen, P. & Mohajeri, M. H. Antibody-based approaches in Alzheimer's research: safety, pharmacokinetics, metabolism, and analytical tools. J. Neurochem. 104, 859-874 (2008).
-
(2008)
J. Neurochem
, vol.104
, pp. 859-874
-
-
Lichtlen, P.1
Mohajeri, M.H.2
-
130
-
-
0033536163
-
Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
-
Schenk, D. et al. Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400, 173-177 (1999).
-
(1999)
Nature
, vol.400
, pp. 173-177
-
-
Schenk, D.1
-
131
-
-
0033835996
-
Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
-
Bard, F. et al. Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nature Med. 6, 916-919 (2000).
-
(2000)
Nature Med
, vol.6
, pp. 916-919
-
-
Bard, F.1
-
132
-
-
33846015514
-
Reduction of soluble Aβ and tau, but not soluble Aβ alone, ameliorates cognitive decline in transgenic mice with plaques and tangles
-
Oddo, S. et al. Reduction of soluble Aβ and tau, but not soluble Aβ alone, ameliorates cognitive decline in transgenic mice with plaques and tangles. J. Biol. Chem. 281, 39413-39423 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 39413-39423
-
-
Oddo, S.1
-
133
-
-
10744230547
-
Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization
-
Orgogozo, J. M. et al. Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization. Neurology 61, 46-54 (2003).
-
(2003)
Neurology
, vol.61
, pp. 46-54
-
-
Orgogozo, J.M.1
-
134
-
-
0038100154
-
Antibodies against β-amyloid slow cognitive decline in Alzheimer's disease
-
Hock, C. et al. Antibodies against β-amyloid slow cognitive decline in Alzheimer's disease. Neuron 38, 547-554 (2003).
-
(2003)
Neuron
, vol.38
, pp. 547-554
-
-
Hock, C.1
-
135
-
-
34548146119
-
Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements
-
Asuni, A. A., Boutajangout, A., Quartermain, D. & Sigurdsson, E. M. Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements. J. Neurosci. 27, 9115-9129 (2007).
-
(2007)
J. Neurosci
, vol.27
, pp. 9115-9129
-
-
Asuni, A.A.1
Boutajangout, A.2
Quartermain, D.3
Sigurdsson, E.M.4
-
136
-
-
33645049049
-
Active immunization trial in Aβ(42)-injected P301L tau transgenic mice
-
Kulic, L. et al. Active immunization trial in Aβ(42)-injected P301L tau transgenic mice. Neurobiol. Dis. 22, 50-56 (2005).
-
(2005)
Neurobiol. Dis
, vol.22
, pp. 50-56
-
-
Kulic, L.1
-
137
-
-
19944429064
-
Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model
-
Zhang, B. et al. Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model. Proc. Natl Acad. Sci. USA 102, 227-231 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 227-231
-
-
Zhang, B.1
-
138
-
-
34547653708
-
Acute inhibition of calcineurin restores associative learning and memory in Tg2576 APP transgenic mice
-
Dineley, K. T., Hogan, D., Zhang, W. R. & Taglialatela, G. Acute inhibition of calcineurin restores associative learning and memory in Tg2576 APP transgenic mice. Neurobiol. Learn. Mem. 88, 217-224 (2007).
-
(2007)
Neurobiol. Learn. Mem
, vol.88
, pp. 217-224
-
-
Dineley, K.T.1
Hogan, D.2
Zhang, W.R.3
Taglialatela, G.4
-
139
-
-
0037197836
-
-
-/- mice that tau is needed for Aβ-mediated toxicity.
-
-/- mice that tau is needed for Aβ-mediated toxicity.
-
-
-
-
140
-
-
14644421534
-
Caloric restriction attenuates Aβ-deposition in Alzheimer transgenic models
-
Patel, N. V. et al. Caloric restriction attenuates Aβ-deposition in Alzheimer transgenic models. Neurobiol. Aging 26, 995-1000 (2005).
-
(2005)
Neurobiol. Aging
, vol.26
, pp. 995-1000
-
-
Patel, N.V.1
-
141
-
-
33947264635
-
Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease
-
Halagappa, V. K. et al. Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease. Neurobiol. Dis. 26, 212-220 (2007).
-
(2007)
Neurobiol. Dis
, vol.26
, pp. 212-220
-
-
Halagappa, V.K.1
-
142
-
-
34447308268
-
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis
-
Kim, D. et al. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. Embo J. 26, 3169-3179 (2007).
-
(2007)
Embo J
, vol.26
, pp. 3169-3179
-
-
Kim, D.1
-
143
-
-
25444500410
-
Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice
-
Rezai-Zadeh, K. et al. Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice. J. Neurosci. 25, 8807-8814 (2005).
-
(2005)
J. Neurosci
, vol.25
, pp. 8807-8814
-
-
Rezai-Zadeh, K.1
-
144
-
-
16244416174
-
A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model
-
Lim, G. P. et al. A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. J. Neurosci. 25, 3032-3040 (2005).
-
(2005)
J. Neurosci
, vol.25
, pp. 3032-3040
-
-
Lim, G.P.1
-
145
-
-
18844447457
-
Perinatal omega-3 polyunsaturated fatty acid supply modifies brain zinc homeostasis during adulthood
-
Jayasooriya, A. P. et al. Perinatal omega-3 polyunsaturated fatty acid supply modifies brain zinc homeostasis during adulthood. Proc. Natl Acad. Sci. USA 102, 7133-7138 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 7133-7138
-
-
Jayasooriya, A.P.1
-
146
-
-
33845620279
-
Moderate consumption of Cabernet Sauvignon attenuates Aβ neuropathology in a mouse model of Alzheimer's disease
-
Wang, J. et al. Moderate consumption of Cabernet Sauvignon attenuates Aβ neuropathology in a mouse model of Alzheimer's disease. Faseb J. 20, 2313-2320 (2006).
-
(2006)
Faseb J
, vol.20
, pp. 2313-2320
-
-
Wang, J.1
-
147
-
-
28844441954
-
Transgenic potato expressing Aβ reduce Aβ burden in Alzheimer's disease mouse model
-
Youm, J. W. et al. Transgenic potato expressing Aβ reduce Aβ burden in Alzheimer's disease mouse model. FEBS Lett. 579, 6737-6744 (2005).
-
(2005)
FEBS Lett
, vol.579
, pp. 6737-6744
-
-
Youm, J.W.1
-
148
-
-
34447273123
-
-
Cheng, H. et al. Mechanisms of disease: new therapeutic strategies for Alzheimer's disease - targeting APP processing in lipid rafts. Nature Clin. Pract Neurol. 3, 374-382 (2007).
-
Cheng, H. et al. Mechanisms of disease: new therapeutic strategies for Alzheimer's disease - targeting APP processing in lipid rafts. Nature Clin. Pract Neurol. 3, 374-382 (2007).
-
-
-
-
149
-
-
1642308134
-
Neurodegenerative diseases and oxidative stress
-
Barnham, K. J., Masters, C. L. & Bush, A. I. Neurodegenerative diseases and oxidative stress. Nature Rev. Drug Discov. 3, 205-214 (2004).
-
(2004)
Nature Rev. Drug Discov
, vol.3
, pp. 205-214
-
-
Barnham, K.J.1
Masters, C.L.2
Bush, A.I.3
-
150
-
-
33344458827
-
M1 receptors play a central role in modulating AD-like pathology in transgenic mice
-
Caccamo, A. et al. M1 receptors play a central role in modulating AD-like pathology in transgenic mice. Neuron 49, 671-682 (2006).
-
(2006)
Neuron
, vol.49
, pp. 671-682
-
-
Caccamo, A.1
-
151
-
-
0036672695
-
Calpain inhibitors: A treatment for Alzheimer's disease
-
Di Rosa, G., Odrijin, T., Nixon, R. A. & Arancio, O. Calpain inhibitors: a treatment for Alzheimer's disease. J. Mol. Neurosci. 19, 135-141 (2002).
-
(2002)
J. Mol. Neurosci
, vol.19
, pp. 135-141
-
-
Di Rosa, G.1
Odrijin, T.2
Nixon, R.A.3
Arancio, O.4
-
152
-
-
21044458540
-
Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Aβ42 production
-
Kukar, T. et al. Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Aβ42 production. Nature Med. 11, 545-550 (2005).
-
(2005)
Nature Med
, vol.11
, pp. 545-550
-
-
Kukar, T.1
-
153
-
-
34250818767
-
Lithium reduces tau phosphorylation but not Aβ or working memory deficits in a transgenic model with both plaques and tangles
-
Caccamo, A., Oddo, S., Tran, L. X. & LaFerla, F. M. Lithium reduces tau phosphorylation but not Aβ or working memory deficits in a transgenic model with both plaques and tangles. Am. J. Pathol. 170, 1669-1675 (2007).
-
(2007)
Am. J. Pathol
, vol.170
, pp. 1669-1675
-
-
Caccamo, A.1
Oddo, S.2
Tran, L.X.3
LaFerla, F.M.4
-
154
-
-
33847214486
-
Neuroprotective effects of regulators of the glycogen synthase kinase-3β signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation
-
Rockenstein, E. et al. Neuroprotective effects of regulators of the glycogen synthase kinase-3β signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation. J. Neurosci. 27, 1981-1991 (2007).
-
(2007)
J. Neurosci
, vol.27
, pp. 1981-1991
-
-
Rockenstein, E.1
-
155
-
-
0021256895
-
Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
-
Glenner, G. G. & Wong, C. W. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem. Biophys. Res. Commun. 120, 885-890 (1984).
-
(1984)
Biochem. Biophys. Res. Commun
, vol.120
, pp. 885-890
-
-
Glenner, G.G.1
Wong, C.W.2
-
156
-
-
0012510759
-
Amyloid plaque core protein in Alzheimer disease and Down syndrome
-
Masters, C. L. et al. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc. Natl Acad. Sci. USA 82, 4245-4249 (1985).
-
(1985)
Proc. Natl Acad. Sci. USA
, vol.82
, pp. 4245-4249
-
-
Masters, C.L.1
-
157
-
-
22544482926
-
Aβ42 is essential for parenchymal and vascular amyloid deposition in mice
-
McGowan, E. et al. Aβ42 is essential for parenchymal and vascular amyloid deposition in mice. Neuron 47, 191-199 (2005).
-
(2005)
Neuron
, vol.47
, pp. 191-199
-
-
McGowan, E.1
-
158
-
-
34248586543
-
Aβ40 protects non-toxic Aβ42 monomer from aggregation
-
Yan, Y. & Wang, C. Aβ40 protects non-toxic Aβ42 monomer from aggregation. J. Mol. Biol. 369, 909-916 (2007).
-
(2007)
J. Mol. Biol
, vol.369
, pp. 909-916
-
-
Yan, Y.1
Wang, C.2
-
159
-
-
0033595706
-
β-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar, R. et al. β-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286, 735-741 (1999).
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
-
160
-
-
0038664363
-
Reconstitution of γ-secretase activity
-
Edbauer, D. et al. Reconstitution of γ-secretase activity. Nature Cell Biol. 5, 486-488 (2003).
-
(2003)
Nature Cell Biol
, vol.5
, pp. 486-488
-
-
Edbauer, D.1
-
161
-
-
0002792366
-
Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: Identification as the microtubule-associated protein tau
-
Goedert, M., Wischik, C. M., Crowther, R. A., Walker, J. E. & Klug, A. Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau. Proc. Natl Acad. Sci. USA 85, 4051-4055 (1988).
-
(1988)
Proc. Natl Acad. Sci. USA
, vol.85
, pp. 4051-4055
-
-
Goedert, M.1
Wischik, C.M.2
Crowther, R.A.3
Walker, J.E.4
Klug, A.5
-
162
-
-
26444463460
-
The H1c haplotype at the MAPT locus is associated with Alzheimer's disease
-
Myers, A. J. et al. The H1c haplotype at the MAPT locus is associated with Alzheimer's disease. Hum. Mol. Genet. 14, 2399-2404 (2005).
-
(2005)
Hum. Mol. Genet
, vol.14
, pp. 2399-2404
-
-
Myers, A.J.1
-
163
-
-
33749020837
-
Exogenous induction of cerebral β-amyloidogenesis is governed by agent and host
-
This study shows shared properties between prions and Aβ with regards to host and agent dictating pathology
-
Meyer-Luehmann, M. et al. Exogenous induction of cerebral β-amyloidogenesis is governed by agent and host. Science 313, 1781-1784 (2006). This study shows shared properties between prions and Aβ with regards to host and agent dictating pathology.
-
(2006)
Science
, vol.313
, pp. 1781-1784
-
-
Meyer-Luehmann, M.1
-
164
-
-
33645038471
-
A specific amyloid-β protein assembly in the brain impairs memory
-
Lesne, S. et al. A specific amyloid-β protein assembly in the brain impairs memory. Nature 440, 352-357 (2006).
-
(2006)
Nature
, vol.440
, pp. 352-357
-
-
Lesne, S.1
-
165
-
-
16644379264
-
Natural oligomers of the amyloid-β protein specifically disrupt cognitive function
-
Cleary, J. P. et al. Natural oligomers of the amyloid-β protein specifically disrupt cognitive function. Nature Neurosci. 8, 79-84 (2005).
-
(2005)
Nature Neurosci
, vol.8
, pp. 79-84
-
-
Cleary, J.P.1
-
166
-
-
34548258322
-
Accelerating amyloid-β fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models
-
Cheng, I. H. et al. Accelerating amyloid-β fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models. J. Biol. Chem. 282, 23818-23828 (2007).
-
(2007)
J. Biol. Chem
, vol.282
, pp. 23818-23828
-
-
Cheng, I.H.1
-
167
-
-
33750455150
-
Control of peripheral nerve myelination by the β-secretase BACE1
-
This study identifies a role for the β-secretase BACE in processing neuregulin
-
Willem, M. et al. Control of peripheral nerve myelination by the β-secretase BACE1. Science 314, 664-666 (2006). This study identifies a role for the β-secretase BACE in processing neuregulin.
-
(2006)
Science
, vol.314
, pp. 664-666
-
-
Willem, M.1
-
168
-
-
54249083070
-
The effects of a neuregulin 1 variant on white matter density and integrity
-
9 Oct, doi: 10.1038/sj.mp.4002103
-
McIntosh, A. M. et al. The effects of a neuregulin 1 variant on white matter density and integrity. Mol. Psychiatry 9 Oct 2007 (doi: 10.1038/sj.mp.4002103).
-
(2007)
Mol. Psychiatry
-
-
McIntosh, A.M.1
-
169
-
-
33749519841
-
Alzheimer disease: BACE1 branches out
-
Schubert, C. Alzheimer disease: BACE1 branches out. Nature Med. 12, 1123 (2006).
-
(2006)
Nature Med
, vol.12
, pp. 1123
-
-
Schubert, C.1
|