Hypoxia-induced genetic instability - A calculated mechanism underlying tumor progression

Journal of Molecular Medicine

Volumn 85, Issue 2, 2007, Pages 139-148

  Huang, L Eric ^a   Bindra, Ranjit S ^b   Glazer, Peter M ^b   Harris, Adrian L ^c  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

DNA repair; Genetic instability; HIF; Hypoxia; Tumor microenvironment; Tumor progression

Indexed keywords

CARBOPLATIN; CISPLATIN; DOXORUBICIN; EPIRUBICIN; ETOPOSIDE;

CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CARCINOGENESIS; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; EXCISION REPAIR; GENE AMPLIFICATION; GENE MUTATION; GENETIC STABILITY; GENETIC TRANSCRIPTION; HOMOLOGOUS RECOMBINATION; HUMAN; HYPOXIA; MICROENVIRONMENT; MISMATCH REPAIR; MOLECULAR MECHANICS; NONHUMAN; OXIDATIVE STRESS; REOXYGENATION; REVIEW; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR VASCULARIZATION;

ANOXIA; DISEASE PROGRESSION; DNA REPAIR; GENOMIC INSTABILITY; HUMANS; NEOPLASMS;

EID: 33846697957     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-006-0133-6     Document Type: Review

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