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Volumn 12, Issue 9, 2007, Pages 3483-3501

Targeting tumors with hypoxia-activated cytotoxins

Author keywords

Bioreductive prodrug; Hypoxia; Radiation activated prodrug; Radiosensitizer; Review; Tumor

Indexed keywords

BACTERIA (MICROORGANISMS); CLOSTRIDIA;

EID: 34347212864     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/2329     Document Type: Review
Times cited : (47)

References (225)
  • 1
    • 84966192535 scopus 로고
    • The histological structure of some human lung cancers and the possible implications for radiotherapy
    • Thomlinson, R. H., and L. H. Gray: The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer 9, 539-549 (1955)
    • (1955) Br J Cancer , vol.9 , pp. 539-549
    • Thomlinson, R.H.1    Gray, L.H.2
  • 2
    • 0018760476 scopus 로고
    • Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation
    • Brown, J. M.: Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation. Br J Radiol 52, 650-656 (1979) (Pubitemid 9239867)
    • (1979) British Journal of Radiology , vol.52 , Issue.620 , pp. 650-656
    • Brown, J.M.1
  • 3
    • 0032053823 scopus 로고    scopus 로고
    • The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy
    • Brown, J. M., and A. J. Giaccia: The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy. Cancer Res 58, 1408-1416 (1998) (Pubitemid 28193601)
    • (1998) Cancer Research , vol.58 , Issue.7 , pp. 1408-1416
    • Brown, J.M.1    Giaccia, A.J.2
  • 5
    • 0024312188 scopus 로고
    • Use of a carbocyanine dye as a marker of functional vasculature in murine tumours
    • Trotter, M. J., D. J. Chaplin, and P. L. Olive: Use of a carbocyanine dye as a marker of functional vasculature in murine tumours. Br J Cancer 59, 706-709 (1989) (Pubitemid 19148529)
    • (1989) British Journal of Cancer , vol.59 , Issue.5 , pp. 706-709
    • Trotter, M.J.1    Chaplin, D.J.2    Olive, P.L.3
  • 6
    • 0030476061 scopus 로고    scopus 로고
    • Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma
    • Kimura, H., R. D. Braun, E. T. Ong, R. Hsu, T. W. Secomb, D. Papahadjopoulos, K. Hong, and M. W. Dewhirst: Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma. Cancer Res 56, 5522-5528 (1996) (Pubitemid 27011389)
    • (1996) Cancer Research , vol.56 , Issue.23 , pp. 5522-5528
    • Kimura, H.1    Braun, R.D.2    Ong, E.T.3    Hsu, R.4    Secomb, T.W.5    Papahadjopoulos, D.6    Hong, K.7    Dewhirst, M.W.8
  • 8
    • 2942590732 scopus 로고    scopus 로고
    • Exploiting tumour hypoxia in cancer treatment
    • Brown, J. M., and W. R. Wilson: Exploiting tumour hypoxia in cancer treatment. Nat Rev Cancer 4, 437-447 (2004) (Pubitemid 38745529)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.6 , pp. 437-447
    • Brown, J.M.1    Wilson, W.R.2
  • 9
    • 0029955072 scopus 로고    scopus 로고
    • Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck
    • DOI 10.1016/S0167-8140(96)91811-3, PII S0167814096018117
    • Nordsmark, M., M. Overgaard, and J. Overgaard: Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother Oncol 41, 31-39 (1996) (Pubitemid 26396294)
    • (1996) Radiotherapy and Oncology , vol.41 , Issue.1 , pp. 31-39
    • Nordsmark, M.1    Overgaard, M.2    Overgaard, J.3
  • 13
    • 0028603270 scopus 로고
    • The influence of microenvironmental factors during cancer therapy
    • Durand, R. E.: The influence of microenvironmental factors during cancer therapy. In vivo 8, 691-702 (1994)
    • (1994) In Vivo , vol.8 , pp. 691-702
    • Durand, R.E.1
  • 15
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza, G. L.: Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3, 721-732 (2003) (Pubitemid 37328811)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.10 , pp. 721-732
    • Semenza, G.L.1
  • 19
    • 27944473690 scopus 로고    scopus 로고
    • VEGF as a key mediator of angiogenesis in cancer
    • DOI 10.1159/000088478
    • Carmeliet, P.: VEGF as a key mediator of angiogenesis in cancer. Oncology 69, 4-10 (2005) (Pubitemid 41680947)
    • (2005) Oncology , vol.69 , Issue.SUPPL. 3 , pp. 4-10
    • Carmeliet, P.1
  • 21
    • 0029775242 scopus 로고    scopus 로고
    • Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
    • Hockel, M., K. Schlenger, B. Aral, M. Mitze, U. Schaffer, and P. Vaupel: Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 56, 4509-4515 (1996) (Pubitemid 26330463)
    • (1996) Cancer Research , vol.56 , Issue.19 , pp. 4509-4515
    • Hockel, M.1    Schlenger, K.2    Aral, B.3    Mitze, M.4    Schaffer, U.5    Vaupel, P.6
  • 22
    • 0018123111 scopus 로고
    • Hyperbaric oxygen and radiotherapy: A Medical Research Council trial in carcinoma of the cervix
    • Watson, E. R., K. E. Halnan, S. Dische, M. I. Saunders, I. S. Cade, J. B. McEwen, G. Wiernik, D. J. D. Perrins, and I. Sutherland: Hyperbaric oxygen and radiotherapy: a Medical Research Council trial in carcinoma of the cervix. Br J Radiol 51, 879-887 (1978) (Pubitemid 9033490)
    • (1978) British Journal of Radiology , vol.51 , Issue.611 , pp. 879-887
    • Watson, E.R.1    Halnan, K.E.2    Dische, S.3
  • 23
    • 0020608102 scopus 로고
    • Carcinoma of the cervix - anaemia, radiotherapy and hyperbaric oxygen
    • Dische, S., P. J. Anderson, R. Sealy, and E. R. Watson: Carcinoma of the cervix: anaemia, radiotherapy and hyperbaric oxygen. Br J Radiol 56, 251-255 (1983) (Pubitemid 13119078)
    • (1983) British Journal of Radiology , vol.56 , Issue.664 , pp. 251-255
    • Dische, S.1    Anderson, P.J.2    Sealy, R.3    Watson, E.R.4
  • 24
    • 0022453572 scopus 로고
    • Late results of a trial of hyperbaric oxygen and radiotherapy in head and neck cancer: A rationale for hypoxic cell sensitizers?
    • Henk, J. M.: Late results of a trial of hyperbaric oxygen and radiotherapy in head and neck cancer: a rationale for hypoxic cell radiosensitizers. Int J Radiat Oncol Biol Phys 12, 1339-1341 (1986) (Pubitemid 16030612)
    • (1986) International Journal of Radiation Oncology Biology Physics , vol.12 , Issue.8 , pp. 1339-1341
    • Henk, J.M.1
  • 25
    • 0031307796 scopus 로고    scopus 로고
    • Oxygen delivery: Implications for the biology and therapy of solid tumors
    • Rockwell, S.: Oxygen delivery: implications for the biology and therapy of solid tumors. Oncol Res 9, 383-390 (1997) (Pubitemid 127825992)
    • (1997) Oncology Research , vol.9 , Issue.6-7 , pp. 383-390
    • Rockwell, S.1
  • 26
    • 0023222372 scopus 로고
    • Radiosensitization by nicotinamide in vivo: A greater enhancement of tumor damage compared to that of normal tissues
    • DOI 10.2307/3577048
    • Horsman, M. R., D. J. Chaplin, and J. M. Brown: Radiosensitization by nicotinamide in vivo: a greater enhancement of tumor damage compared to that of normal tissues. Radiat Res 109, 479-489 (1987) (Pubitemid 17059700)
    • (1987) Radiation Research , vol.109 , Issue.3 , pp. 479-489
    • Horsman, M.R.1    Chaplin, D.J.2    Brown, J.M.3
  • 27
    • 0026098826 scopus 로고
    • Nicotinamide, Fluosol DA and carbogen: A strategy to oxygenate acutely and chronically hypoxic cells in vivo
    • Chaplin, D. J., M. R. Horsman, and D. S. Aoki: Nicotinamide, Fluosol DA and carbogen: a strategy to oxygenate acutely and chronically hypoxic cells in vivo. Br J Cancer 63, 109-113 (1991)
    • (1991) Br J Cancer , vol.63 , pp. 109-113
    • Chaplin, D.J.1    Horsman, M.R.2    Aoki, D.S.3
  • 28
    • 0025939872 scopus 로고
    • A therapeutic benefit from combining normobaric carbogen or oxygen with nicotinamide in fractionated X-ray treatments
    • Kjellen, E., M. C. Joiner, J. M. Collier, J. Johns, and A. Rojas: A therapeutic benefit from combining normobaric carbogen or oxygen with nicotinamide in fractionated X-ray treatments. Radiother Oncol 22, 81-91 (1991)
    • (1991) Radiother Oncol , vol.22 , pp. 81-91
    • Kjellen, E.1    Joiner, M.C.2    Collier, J.M.3    Johns, J.4    Rojas, A.5
  • 29
    • 10044237958 scopus 로고    scopus 로고
    • Strategies to overcome accelerated repopulation and hypoxia - What have we learned from clinical trials?
    • DOI 10.1053/j.seminoncol.2004.09.005, PII S0093775404004026, Head and Neck Cancer
    • Corry, J., and D. Rischin: Strategies to overcome accelerated repopulation and hypoxia-what have we learned from clinical trials? Semin Oncol 31, 802-808 (2004) (Pubitemid 39602686)
    • (2004) Seminars in Oncology , vol.31 , Issue.6 , pp. 802-808
    • Corry, J.1    Rischin, D.2
  • 30
    • 0023895209 scopus 로고
    • Chemical modification of tumour blood flow
    • Jirtle, R.: Chemical modification of tumour blood flow. Int J Hyperthermia 4, 355-371 (1988)
    • (1988) Int J Hyperthermia , vol.4 , pp. 355-371
    • Jirtle, R.1
  • 31
    • 0021192849 scopus 로고
    • Oxygen-carrying perfluorochemical emulsion as an adjuvant to radiation therapy in mice
    • Teicher, B. A., and C. M. Rose: Oxygen-carrying perfluorochemical emulsion as an adjuvant to radiation therapy in mice. Cancer Res 44, 4285-4288 (1984) (Pubitemid 14008736)
    • (1984) Cancer Research , vol.44 , Issue.10 , pp. 4285-4288
    • Teicher, B.A.1    Rose, C.M.2
  • 32
    • 0022457633 scopus 로고
    • Reactions of tumors and normal tissues in mice to irradiation in the presence and absence of a perfluorochemical emulsion
    • Rockwell, S., T. P. Mate, C. G. Irvin, and M. Nierenburg: Reactions of tumors and normal tissues in mice to irradiation in the presence and absence of a perfluorochemical emulsion. Int J Radiat Oncol Biol Phys 12, 1315-1318 (1986) (Pubitemid 16030607)
    • (1986) International Journal of Radiation Oncology Biology Physics , vol.12 , Issue.8 , pp. 1315-1318
    • Rockwell, S.1    Mate, T.P.2    Irvin, C.G.3    Nierenburg, M.4
  • 33
    • 0024319894 scopus 로고
    • Altered radiosensitivity in a mouse carcinoma after administration of clofibrate and bezafibrate
    • DOI 10.1016/0167-8140(89)90118-7
    • Hirst, D. G., and P. J. Wood: Altered radiosensitivity in a mouse carcinoma after administration of clofibrate and benzafibrate. Radiother Oncol 15, 55-61 (1989) (Pubitemid 19147620)
    • (1989) Radiotherapy and Oncology , vol.15 , Issue.1 , pp. 55-61
    • Hirst, D.G.1    Wood, P.J.2
  • 35
    • 0035089032 scopus 로고    scopus 로고
    • Improvement of tumor oxygenation by mild hyperthermia
    • Song, C. W., H. Park, and R. Griffin: Improvement of tumor oxygenation by mild hyperthermia. Radiat Res 155, 515-528 (2001) (Pubitemid 32260249)
    • (2001) Radiation Research , vol.155 , Issue.4 , pp. 515-528
    • Song, C.W.1    Park, H.2    Griffin, R.J.3
  • 36
    • 0014541115 scopus 로고
    • Electron-affinic sensitization. I. A structural basis for chemical radiosensitizers in bacteria
    • Adams, G. E., and M. S. Cooke: Electron-affinic sensitization. I. A structural basis for chemical radiosensitizers in bacteria. Int J Radiat Biol Relat Stud Phys Chem Med 15, 457-471 (1969)
    • (1969) Int J Radiat Biol Relat Stud Phys Chem Med , vol.15 , pp. 457-471
    • Adams, G.E.1    Cooke, M.S.2
  • 38
    • 0017388874 scopus 로고
    • Clinical testing of the radiosensitizer Ro 07-0582: experience with multiple doses
    • Dische, S., M. I. Saunders, M. E. Lee, G. E. Adams, and I. R. Flockhart: Clinical testing of the radiosensitizer Ro 07-0582: Experience with multiple doses. Br J Cancer 35, 567-579 (1977) (Pubitemid 8107820)
    • (1977) British Journal of Cancer , vol.35 , Issue.5 , pp. 567-579
    • Dische, S.1    Saunders, M.I.2    Lee, M.E.3
  • 39
    • 0021972468 scopus 로고
    • Chemical sensitizers for hypoxic cells: A decade of experience in clinical radiotherapy
    • Dische, S.: Chemical sensitisers for hypoxic cells: A decade of experience in clinical radiotherapy. Radiother Oncol 3, 97-115 (1985) (Pubitemid 15170205)
    • (1985) Radiotherapy and Oncology , vol.3 , Issue.2 , pp. 97-115
    • Dische, S.1
  • 40
    • 0028632781 scopus 로고
    • Clinical evaluation of nitroimidazoles as modifiers of hypoxia in solid tumors
    • Overgaard, J.: Clinical evaluation of nitroimidazoles as modifiers of hypoxia in solid tumors. Oncol Res 6, 509-518 (1994)
    • (1994) Oncol Res , vol.6 , pp. 509-518
    • Overgaard, J.1
  • 41
    • 0019413573 scopus 로고
    • SR-2508: A 2-nitroimidazole amide which should be superior to misonidazole as a radiosensitizer for clinical use
    • Brown, J. M., N. Y. Yu, D. M. Brown, and W. W. Lee: SR-2508: A 2-nitroimidazole amide which should be superior to misonidazole as a radiosensitizer for clinical use. Int J Radiat Oncol Biol Phys 7, 695-703 (1981) (Pubitemid 11060951)
    • (1981) International Journal of Radiation Oncology Biology Physics , vol.7 , Issue.6 , pp. 695-703
    • Brown, J.M.1    Yu, N.Y.2    Brown, D.M.3    Lee, W.W.4
  • 43
    • 0031909654 scopus 로고    scopus 로고
    • A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85
    • DOI 10.1016/S0167-8140(97)00220-X, PII S016781409700220X
    • Overgaard, J., H. S. Hansen, M. Overgaard, L. Bastholt, A. Berthelsen, L. Specht, B. Lindelov, and K. A. Jorgensen: A randomized double-blind phase III study of nimorazole as a hypoxic radionsensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85. Radiother Oncol 46, 135-146 (1998) (Pubitemid 28109172)
    • (1998) Radiotherapy and Oncology , vol.46 , Issue.2 , pp. 135-146
    • Overgaard, J.1    Hansen, H.S.2    Overgaard, M.3    Bastholt, L.4    Berthelsen, A.5    Specht, L.6    Lindelov, B.7    Jorgensen, K.8
  • 44
    • 26444467146 scopus 로고    scopus 로고
    • Plasma osteopontin, hypoxia, and response to the hypoxia sensitiser nimorazole in radiotherapy of head and neck cancer: Results from the DAHANCA 5 randomised double-blind placebo-controlled trial
    • DOI 10.1016/S1470-2045(05)70292-8, PII S1470204505702928
    • Overgaard, J., J. G. Eriksen, M. Nordsmark, J. Alsner, and M. R. Horsman: Plasma osteopontin, hypoxia, and response to the hypoxia sensitiser nimorazole in radiotherapy of head and neck cancer: results from the DAHANCA 5 randomised double-blind placebo-controlled trial. Lancet Oncol 6, 757-764 (2005) (Pubitemid 41430716)
    • (2005) Lancet Oncology , vol.6 , Issue.10 , pp. 757-764
    • Overgaard, J.1    Eriksen, J.G.2    Nordsmark, M.3    Alsner, J.4    Horsman, M.R.5
  • 47
    • 0019967261 scopus 로고
    • Mechanisms of hypoxic cell radiosensitization and the development of new sensitizers
    • Stratford, I. J.: Mechanisms of hypoxic cell radiosensitizers and the development of new sensitizers. Int J Radiat Oncol Biol Phys 8, 391-398 (1982) (Pubitemid 12090543)
    • (1982) International Journal of Radiation Oncology Biology Physics , vol.8 , Issue.3-4 , pp. 391-398
    • Stratford, I.J.1
  • 48
    • 0021260987 scopus 로고
    • Radiation sensitization and chemopotentiation: RSU 1069, a compound more efficient than misonidazole in vitro and in vivo
    • Adams, G. E., I. Ahmed, P. W. Sheldon, and I. J. Stratford: Radiation sensitization and chemopotentiation: RSU 1069, a compound more efficient than misonidazole in vitro and in vivo. Br J Cancer 49, 571-577 (1984) (Pubitemid 14101679)
    • (1984) British Journal of Cancer , vol.49 , Issue.5 , pp. 571-577
    • Adams, G.E.1    Ahmed, I.2    Sheldon, P.W.3    Stratford, I.J.4
  • 49
    • 0022486242 scopus 로고
    • Studies of the in vivo and in vitro cytotoxicity of the drug RSU-1069
    • Hill, R. P., S. Gulyas, and G. F. Whitmore: Studies of the in vivo and in vitro cytotoxicity of the drug RSU-1069. Br J Cancer 53, 743-751 (1986) (Pubitemid 16082030)
    • (1986) British Journal of Cancer , vol.53 , Issue.6 , pp. 743-751
    • Hill, R.P.1    Gulyas, S.2    Whitmore, G.F.3
  • 50
    • 0023216902 scopus 로고
    • Hypoxia-selective radiosensitization of mammalian cells by nitracrine, an electron-affinic DNA intercalator
    • Roberts, P. B., R. F. Anderson, and W. R. Wilson: Hypoxia-selective radiosensitization of mammalian cells by nitracrine, an electron-affinic DNA intercalator. Int J Radiat Biol Relat Stud Phys Chem Med 51, 641-654 (1987) (Pubitemid 17081459)
    • (1987) International Journal of Radiation Biology , vol.51 , Issue.4 , pp. 641-654
    • Roberts, P.B.1    Anderson, R.F.2    Wilson, W.R.3
  • 52
    • 0025776614 scopus 로고
    • Targeting radiosensitizers to DNA by attachment of an intercalating group: Nitroimidazole-linked phenanthridines
    • Cowan, D. S., R. Panicucci, R. A. McClelland, and A. M. Rauth: Targeting radiosensitizers to DNA by attachment of an intercalating group: nitroimidazole-linked phenanthridines. Radiat Res 127, 81-89 (1991)
    • (1991) Radiat Res , vol.127 , pp. 81-89
    • Cowan, D.S.1    Panicucci, R.2    McClelland, R.A.3    Rauth, A.M.4
  • 53
    • 0026594484 scopus 로고
    • Radiosensitization and hypoxic cell toxicity of NLA-1 and NLA-2, two bioreductive compounds
    • Papadopoulou, M. V., M. W. Epperly, D. S. Shields, and W. D. Bloomer: Radiosensitization and hypoxic cell toxicity of NLA-1 and NLA-2, two bioreductive compounds. Jpn J Cancer Res 83, 410-414 (1992)
    • (1992) Jpn J Cancer Res , vol.83 , pp. 410-414
    • Papadopoulou, M.V.1    Epperly, M.W.2    Shields, D.S.3    Bloomer, W.D.4
  • 55
    • 0017808576 scopus 로고
    • Sensitization of mouse tumours using fractionated X-irradiation
    • Denekamp, J., and F. A. Stewart: Sensitization of mouse tumours using fractionated X-irradiation. Br J Cancer 37, 259-263 (1978) (Pubitemid 8363760)
    • (1978) British Journal of Cancer , vol.37 , Issue.SUPPL.3 , pp. 259-263
    • Denekamp, J.1    Stewart, F.A.2
  • 56
    • 0017886093 scopus 로고
    • The effect of misonidazole in combination with radiation dose fractionation
    • Hill, R. P., and R. S. Bush: The effect of misonidazole in combination with radiation dose fractionation. Br J Cancer 37, 255-258 (1978) (Pubitemid 8363759)
    • (1978) British Journal of Cancer , vol.37 , Issue.SUPPL.3 , pp. 255-258
    • Hill, R.P.1    Bush, R.S.2
  • 57
    • 0017807635 scopus 로고
    • Radiosensitization by misonidazole (Ro-07-0582) of fractionated X-rays in murine tumour
    • Sheldon, P. W., and J. F. Fowler: Radiosensitization by misonidazole (Ro-07-0582) of fractionated X-rays in murine tumour. Br J Cancer 37, 243-245 (1978)
    • (1978) Br J Cancer , vol.37 , pp. 243-245
    • Sheldon, P.W.1    Fowler, J.F.2
  • 58
    • 0021184329 scopus 로고
    • Radiosensitization of hypoxic cells in vivo by SR 2508 at low radiation doses: A preliminary report
    • Brown, J. M., and N. Y. Yu: Radiosensitization of hypoxic cells in vivo by SR 2508 at low radiation doses: A preliminary report. Int J Radiat Oncol Biol Phys 10, 1207-1212 (1984) (Pubitemid 14029864)
    • (1984) International Journal of Radiation Oncology Biology Physics , vol.10 , Issue.8 , pp. 1207-1212
    • Brown, J.M.1    Yu, N.Y.2
  • 59
    • 0030926491 scopus 로고    scopus 로고
    • Cells at intermediate oxygen levels can be more important than the 'hypoxic fraction' in determining tumor response to fractionated radiotherapy
    • Wouters, B. G., and J. M. Brown: Cells at intermediate oxygen levels can be more important than the "hypoxic fraction" in determining tumor response to fractionated radiotherapy. Radiat Res 147, 541-550 (1997) (Pubitemid 27204090)
    • (1997) Radiation Research , vol.147 , Issue.5 , pp. 541-550
    • Wouters, B.G.1    Brown, J.M.2
  • 60
    • 0033405294 scopus 로고    scopus 로고
    • The hypoxic cell: A target for selective cancer therapy - Eighteenth Bruce F. Cain Memorial Award Lecture
    • Brown, J. M.: The hypoxic cell: a target for selective cancer therapy-eighteenth Bruce F. Cain Memorial Award lecture. Cancer Res 59, 5863-5870 (1999) (Pubitemid 30004940)
    • (1999) Cancer Research , vol.59 , Issue.23 , pp. 5863-5870
    • Brown, J.M.1
  • 61
    • 0016275208 scopus 로고
    • Selective chemotherapy of noncycling cells in an in vitro tumor model
    • Sutherland, R. M.: Selective chemotherapy of noncycling cells in an in vitro tumor model. Cancer Res 34, 3501-3503 (1974)
    • (1974) Cancer Res , vol.34 , pp. 3501-3503
    • Sutherland, R.M.1
  • 62
    • 0016817106 scopus 로고
    • Hypoxic radiosensitisers: Radiobiological studies at the cellular level
    • Hall, E. J., and L. Roizon-Towle: Hypoxic radiosensitisers: radiobiological studies at the cellular level. Radiology 117, 453-457 (1975)
    • (1975) Radiology , vol.117 , pp. 453-457
    • Hall, E.J.1    Roizon-Towle, L.2
  • 63
    • 0016722580 scopus 로고
    • The mechanism of microsomal and mitochondrial nitroreductase
    • Mason, R. P., and J. L. Holtzman: The mechanism of microsomal and mitochondrial nitroreductase. Biochemistry 14, 1626-1632 (1975)
    • (1975) Biochemistry , vol.14 , pp. 1626-1632
    • Mason, R.P.1    Holtzman, J.L.2
  • 64
    • 15844413214 scopus 로고
    • Metabolic activation of carcinogenic nitro-compounds to oxygen reactive intermediates
    • Eds: R. A. Floyd. Marcel Dekker, New York
    • Biaglow, J. E., M. E. Varnes, C. J. Koch, and R. Sridhar: Metabolic activation of carcinogenic nitro-compounds to oxygen reactive intermediates. In: Free radicals and Cancer, Eds: R. A. Floyd. Marcel Dekker, New York, (1982)
    • (1982) Free Radicals and Cancer
    • Biaglow, J.E.1    Varnes, M.E.2    Koch, C.J.3    Sridhar, R.4
  • 65
    • 0029439313 scopus 로고
    • Radicals from one-electron reduction of nitro compounds, aromatic N-oxides and quinones: The kinetic basis of hypoxia-selective, bioreductive drugs
    • Wardman, P., M. F. Dennis, S. A. Everett, K. B. Patel, M. R. Stratford, and M. Tracy: Radicals from one-electron reduction of nitro compounds, aromatic N-oxides and quinones: The kinetic basis of hypoxia-selective, bioreductive drugs. Biochem Soc Symp 61, 171-194 (1995)
    • (1995) Biochem Soc Symp , vol.61 , pp. 171-194
    • Wardman, P.1    Dennis, M.F.2    Everett, S.A.3    Patel, K.B.4    Stratford, M.R.5    Tracy, M.6
  • 66
    • 0035010504 scopus 로고    scopus 로고
    • Electron transfer and oxidative stress as key factors in the design of drugs selectively active in hypoxia
    • Wardman, P.: Electron transfer and oxidative stress as key factors in the design of drugs selectively active in hypoxia. Curr Med Chem 8, 739-761 (2001) (Pubitemid 32427904)
    • (2001) Current Medicinal Chemistry , vol.8 , Issue.7 , pp. 739-761
    • Wardman, P.1
  • 67
    • 0027219332 scopus 로고
    • Bioreducible mustards: A paradigm for hypoxia-selective prodrugs of diffusible cytotoxins (HPDCs)
    • Denny, W. A., and W. R. Wilson: Bioreducible mustards: a paradigm for hypoxia-selective prodrugs of diffusible cytotoxins (HPDCs). Cancer Met Rev 12, 135-151 (1993) (Pubitemid 23220677)
    • (1993) Cancer and Metastasis Reviews , vol.12 , Issue.2 , pp. 135-151
    • Denny, W.A.1    Wilson, W.R.2
  • 68
    • 0026417645 scopus 로고
    • Therapeutic advantage of hypoxic cells in tumors: A theoretical study
    • Brown, J. M., and A. Koong: Therapeutic advantage of hypoxic cells in tumors: a theoretical study. J Natl Cancer Inst 83, 178-185 (1991)
    • (1991) J Natl Cancer Inst , vol.83 , pp. 178-185
    • Brown, J.M.1    Koong, A.2
  • 70
    • 0028261377 scopus 로고
    • Hypoxia-selective antitumor agents. 8. Bis(nitroimidazolyl) alkanecarboxamides: A new class of hypoxia-selective cytotoxins and hypoxic cell radiosensitisers
    • Hay, M. P., W. R. Wilson, J. W. Moselen, B. D. Palmer, and W. A. Denny: Hypoxia-selective antitumor agents. 8. Bis (nitroimidazolyl) alkanecarboxamides: a new class of hypoxia-selective cytotoxins and hypoxic cell radiosensitisers. J Med Chem 37, 381-391 (1994) (Pubitemid 24079948)
    • (1994) Journal of Medicinal Chemistry , vol.37 , Issue.3 , pp. 381-391
    • Hay, M.P.1    Wilson, W.R.2    Moselen, J.W.3    Palmer, B.D.4    Denny, W.A.5
  • 71
    • 0028952450 scopus 로고
    • N-[2-(2-methyl-5-nitroimidazolyl) ethyl]-4-(2-nitroimidazolyl) butanamide (NSC 639862), a bisnitroimidazole with enhanced selectivity as a bioreductive drug
    • Moselen, J. W., M. P. Hay, W. A. Denny, and W. R. Wilson: N-[2-(2-methyl-5-nitroimidazolyl) ethyl]-4-(2-nitroimidazolyl) butanamide (NSC 639862), a bisnitroimidazole with enhanced selectivity as a bioreductive drug. Cancer Res 55, 574-580 (1995)
    • (1995) Cancer Res , vol.55 , pp. 574-580
    • Moselen, J.W.1    Hay, M.P.2    Denny, W.A.3    Wilson, W.R.4
  • 72
    • 0034571055 scopus 로고    scopus 로고
    • 4-[3-(2-nitro-1-imidazolyl) propylamino]-7-chloroquinoline hydrochloride (NLCQ-1), a novel bioreductive agent as radiosensitizer in vitro and in vivo: Comparison with tirapazamine
    • Papadopoulou, M. V., M. Ji, M. K. Rao, and W. D. Bloomer: 4-[3-(2-nitro-1-imidazolyl) propylamino]-7-chloroquinoline hydrochloride (NLCQ-1), a novel bioreductive agent as radiosensitizer in vitro and in vivo: comparison with tirapazamine. Oncol Res 12, 325-333 (2000)
    • (2000) Oncol Res , vol.12 , pp. 325-333
    • Papadopoulou, M.V.1    Ji, M.2    Rao, M.K.3    Bloomer, W.D.4
  • 73
    • 0028555808 scopus 로고
    • 9-[3-) 2-nitro-1-imidazolyl) propylamino]-1, 2, 3, 4-tetrahydroacridine hydrochloride. A novel DNA-affinic hypoxic cell cytotoxin and radiosensitizer. Comparison with NLA-1
    • Papadopoulou, M. V., H. S. Rosenzweig, M. Doddi, and W. D. Bloomer: 9-[3-) 2-nitro-1-imidazolyl) propylamino]-1, 2, 3, 4-tetrahydroacridine hydrochloride. A novel DNA-affinic hypoxic cell cytotoxin and radiosensitizer. Comparison with NLA-1. Oncol Res 6, 439-448 (1994)
    • (1994) Oncol Res , vol.6 , pp. 439-448
    • Papadopoulou, M.V.1    Rosenzweig, H.S.2    Doddi, M.3    Bloomer, W.D.4
  • 74
    • 0029993225 scopus 로고    scopus 로고
    • THNLA-1 as radio/chemosensitiser of EMT-6 tumours in mice
    • Papadopoulou, M. V., M. Ji, and W. D. Bloomer: THNLA-1 as radio/chemosensitiser of EMT-6 tumours in mice. Br J Cancer 74, S267-S270 (1996) (Pubitemid 26237976)
    • (1996) British Journal of Cancer , vol.74 , Issue.SUPPL. XXVII
    • Papadopoulou, M.V.1    Ji, M.2    Bloomer, W.D.3
  • 75
    • 0004427572 scopus 로고    scopus 로고
    • HPLC analysis and murine pharmacokinetics of the cytotoxic bioreductive agent NLCQ-1 (NSC 709257)
    • Squillace, D. P., S. L. Ruben, J. M. Reid, and M. M. Ames: HPLC analysis and murine pharmacokinetics of the cytotoxic bioreductive agent NLCQ-1 (NSC 709257). Proc Am Assoc Cancer Res 41, 706 (2000)
    • (2000) Proc Am Assoc Cancer Res , vol.41 , pp. 706
    • Squillace, D.P.1    Ruben, S.L.2    Reid, J.M.3    Ames, M.M.4
  • 76
    • 0022625557 scopus 로고
    • Biochemistry of misonidazole reduction by NADPH-cytochrome c (P-450) reductase
    • Heimbrook, D. C., and A. C. Sartorelli: Biochemistry of misonidazole by NADPH-cytochrome c (P-450) reductase. Mol Pharmacol 29, 168-172 (1986) (Pubitemid 16165851)
    • (1986) Molecular Pharmacology , vol.29 , Issue.2 , pp. 168-172
    • Heimbrook, D.C.1    Sartorelli, A.C.2
  • 77
    • 0023153554 scopus 로고
    • Nitroimidazole bioreductive metabolism. Quantitation and characterisation of mouse tissue benznidazole nitroreductases in vivo and in vitro
    • DOI 10.1016/0006-2952(87)90181-X
    • Walton, M. I., and P. Workman: Nitroimidazole bioreductive metabolism. Quantitation and characterisation of mouse tissue benznidazole nitroreductases in vivo and in vitro. Biochem Pharmacol 36, 887-896 (1987) (Pubitemid 17038036)
    • (1987) Biochemical Pharmacology , vol.36 , Issue.6 , pp. 887-896
    • Walton, M.I.1    Workman, P.2
  • 78
    • 0031656984 scopus 로고    scopus 로고
    • Use of 2-nitroimidazoles as bioreductive markers for tumour hypoxia
    • Hodgkiss, R. J.: Use of 2-nitroimidazoles as bioreductive markers for tumour hypoxia. Anticancer Drug Des 13, 687-702 (1998) (Pubitemid 28410155)
    • (1998) Anti-Cancer Drug Design , vol.13 , Issue.6 , pp. 687-702
    • Hodgkiss, R.J.1
  • 79
    • 0018826389 scopus 로고
    • The reductive metabolism of metronidazole and ronidazole by aerobic liver microsomes
    • Perez-Reyez, E., B. Kalyanaraman, and R. P. Mason: The reductive metabolism of metronidazole and ronidazole by aerobic liver microsomes. Mol Pharmacol 17, 239-244 (1980) (Pubitemid 10125311)
    • (1980) Molecular Pharmacology , vol.17 , Issue.2 , pp. 239-244
    • Perez-Reyes, E.1    Kalyanaraman, B.2    Mason, R.P.3
  • 80
    • 0017069834 scopus 로고
    • Oxygen inhibition of nitroreductase: Electron transfer from nitro radical-anions to oxygen
    • Wardman, P., and E. D. Clarke: Oxygen inhibition of nitroreductase: Electron transfer from nitro radical-anions to oxygen. Biochem Biophys Res Commun 69, 942-949 (1976)
    • (1976) Biochem Biophys Res Commun , vol.69 , pp. 942-949
    • Wardman, P.1    Clarke, E.D.2
  • 81
    • 0017089008 scopus 로고
    • Hypoxia-dependent reduction of 1-(2-nitro-1-imidazolyl) 3-methoxy-2-propanol by Chinese hamster ovary cells and KHT tumor cells in vitro and in vivo
    • Varghese, A. J., S. Gulyas, and J. K. Mohindra: Hypoxia-dependent reduction of 1-(2-nitro-1-imidazolyl) 3-methoxy-2-propanol by Chinese hamster ovary cells and KHT tumor cells in vitro and in vivo. Cancer Res 36, 3761-3765 (1976)
    • (1976) Cancer Res , vol.36 , pp. 3761-3765
    • Varghese, A.J.1    Gulyas, S.2    Mohindra, J.K.3
  • 82
    • 0017873260 scopus 로고
    • Pharmacokinetic and metabolic studies of the hypoxic cell radiosensitizer misonidazole
    • Flockhart, I. R., P. Large, D. Troup, S. H. Malcolm, and T. R. Marten: Pharmacokinetic and metabolic studies of the hypoxic cell radiosensitizer misonidazole. Xenobiotica 8 (1978)
    • (1978) Xenobiotica , vol.8
    • Flockhart, I.R.1    Large, P.2    Troup, D.3    Malcolm, S.H.4    Marten, T.R.5
  • 83
    • 0021325112 scopus 로고
    • 2-Hydroxylaminoimidazolesunstable intermediates in the reduction of 2-nitroimidazoles
    • McClelland, R. A., J. R. Fuller, N. E. Seaman, A. M. Rauth, and R. Battistella: 2-Hydroxylaminoimidazolesunstable intermediates in the reduction of 2-nitroimidazoles. Biochem Pharmacol 33, 303-309 (1984)
    • (1984) Biochem Pharmacol , vol.33 , pp. 303-309
    • McClelland, R.A.1    Fuller, J.R.2    Seaman, N.E.3    Rauth, A.M.4    Battistella, R.5
  • 84
    • 0024205344 scopus 로고
    • The nitroreductase enzyme in Walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-yl)-4- hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2)
    • DOI 10.1016/0006-2952(88)90336-X
    • Knox, R. J., M. P. Boland, F. Friedlos, B. Coles, C. Southan, and J. J. Roberts: The nitroreductase enzyme in Walker cells that activates 5-(aziridin-1-yl)-2, 4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-yl)-4- hydroxylamino-2-nitrobenzamide is a form of NAD (P) H dehydrogenase (quinone) (EC 1.6.99.2). Biochem Pharmacol 37, 4671-4677 (1988) (Pubitemid 19006306)
    • (1988) Biochemical Pharmacology , vol.37 , Issue.24 , pp. 4671-4677
    • Knox, R.J.1    Boland, M.P.2    Friedlos, F.3    Coles, B.4    Southan, C.5    Roberts, J.J.6
  • 85
    • 0024209370 scopus 로고
    • A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4- hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2, 4-dinitrobenzamide (CB 1954) by nitroreductase enzyme in Walker carcinoma cells
    • Knox, R. J., F. Friedlos, M. Jarman, and J. J. Roberts: A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2- nitrobenzamide, is formed from 5-(aziridin-1-yl)-2, 4-dinitrobenzamide (CB 1954) by nitroreductase enzyme in Walker carcinoma cells. Biochem Pharmacol 37, 4661 (1988)
    • (1988) Biochem Pharmacol , vol.37 , pp. 4661
    • Knox, R.J.1    Friedlos, F.2    Jarman, M.3    Roberts, J.J.4
  • 87
    • 0037399470 scopus 로고    scopus 로고
    • Effect of nitroreduction on the alkylating reactivity and cytotoxicity of the 2,4-dinitrobenzamide-5-aziridine CB 1954 and the corresponding nitrogen mustard SN 23862: Distinct mechanisms of bioreductive activation
    • DOI 10.1021/tx025662b
    • Helsby, N. A., S. J. Wheeler, F. B. Pruijn, B. D. Palmer, S. Yang, W. A. Denny, and W. R. Wilson: Effect of nitroreduction on the alkylating reactivity and cytotoxicity of the 2, 4-dinitrobenzamide-5-aziridine CB1954 and the corresponding nitrogen mustard SN 23862: Distinct mechanisms of bioreductive activation. Chem Res Toxicol 16, 469-478 (2003) (Pubitemid 36514504)
    • (2003) Chemical Research in Toxicology , vol.16 , Issue.4 , pp. 469-478
    • Helsby, N.A.1    Wheeler, S.J.2    Pruijn, F.B.3    Palmer, B.D.4    Yang, S.5    Denny, W.A.6    Wilson, W.R.7
  • 88
    • 0026075733 scopus 로고
    • Bioactivation of CB 1954: Reaction of the active 4-hydroxylamino derivative with thioesters to form the ultimate DNA-DNA interstrand crosslinking species
    • Knox, R. J., F. Friedlos, T. Marchbank, and J. J. Roberts: Bioactivation of CB 1954: reaction of the active 4-hydroxylamino derivative with thioesters to form the ultimate DNA-DNA interstrand crosslinking species. Biochem Pharmacol 42, 1691-1697 (1991)
    • (1991) Biochem Pharmacol , vol.42 , pp. 1691-1697
    • Knox, R.J.1    Friedlos, F.2    Marchbank, T.3    Roberts, J.J.4
  • 89
    • 0029609610 scopus 로고
    • Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954
    • DOI 10.1016/0959-8049(95)00436-X
    • Bridgewater, J. A., C. J. Springer, R. J. Knox, N. P. Minton, N. P. Michael, and M. K. Collins: Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954. Eur J Cancer 31A, 2362-2370 (1995) (Pubitemid 26053242)
    • (1995) European Journal of Cancer Part A: General Topics , vol.31 , Issue.13-14 , pp. 2362-2370
    • Bridgewater, J.A.1    Springer, C.J.2    Knox, R.J.3    Minton, N.P.4    Michael, N.P.5    Collins, M.K.6
  • 92
    • 15944399454 scopus 로고    scopus 로고
    • From bench to bedside for gene-directed enzyme prodrug therapy of cancer
    • DOI 10.1097/00001813-200504000-00001
    • Dachs, G. U., J. Tupper, and G. M. Tozer: From bench to bedside for gene-directed enzyme prodrug therapy of cancer. Anti-Cancer Drugs 16, 349-359 (2005) (Pubitemid 40434601)
    • (2005) Anti-Cancer Drugs , vol.16 , Issue.4 , pp. 349-359
    • Dachs, G.U.1    Tupper, J.2    Tozer, G.M.3
  • 93
    • 0031306972 scopus 로고    scopus 로고
    • Nitro reduction as an electronic switch for bioreductive drug activation
    • Siim, B. G., W. A. Denny, and W. R. Wilson: Nitro reduction as an electronic switch for bioreductive drug activation. Oncol Res 9, 357-369 (1997) (Pubitemid 127825990)
    • (1997) Oncology Research , vol.9 , Issue.6-7 , pp. 357-369
    • Sum, B.G.1    Denny, W.A.2    Wilson, W.R.3
  • 94
    • 0028916689 scopus 로고
    • Reductive chemistry of the novel hypoxia-selective cytotoxin 5-[N, N-bis (2-chloroethyl) amino]-2, 4-dinitrobenzamide
    • Palmer, B. D., P. van Zijl, W. A. Denny, and W. R. Wilson: Reductive chemistry of the novel hypoxia-selective cytotoxin 5-[N, N-bis (2-chloroethyl) amino]-2, 4-dinitrobenzamide. J Med Chem 38, 1229-1241 (1995)
    • (1995) J Med Chem , vol.38 , pp. 1229-1241
    • Palmer, B.D.1    Van Zijl, P.2    Denny, W.A.3    Wilson, W.R.4
  • 96
    • 0036494169 scopus 로고    scopus 로고
    • Quantitation of bystander effects in nitroreductase suicide gene therapy using three-dimensional cell cultures
    • Wilson, W. R., S. M. Pullen, A. Hogg, N. A. Helsby, K. O. Hicks, and W. A. Denny: Quantitation of bystander effects in nitroreductase suicide gene therapy using threedimensional cell cultures. Cancer Res 62, 1425-1432 (2002) (Pubitemid 34407802)
    • (2002) Cancer Research , vol.62 , Issue.5 , pp. 1425-1432
    • Wilson, W.R.1    Pullen, S.M.2    Hogg, A.3    Helsby, N.A.4    Hicks, K.O.5    Denny, W.A.6
  • 97
    • 1942424798 scopus 로고    scopus 로고
    • 2-Amino metabolites are key mediators of CB 1954 and SN 23862 bystander effects in nitroreductase GDEPT
    • DOI 10.1038/sj.bjc.6601612
    • Helsby, N. A., D. M. Ferry, A. V. Patterson, S. M. Pullen, and W. R. Wilson: 2-Amino metabolites are key mediators of CB 1954 and SN 23862 bystander effects in nitroreductase GDEPT. Br J Cancer 90, 1084-1092 (2004) (Pubitemid 38495832)
    • (2004) British Journal of Cancer , vol.90 , Issue.5 , pp. 1084-1092
    • Helsby, N.A.1    Ferry, D.M.2    Patterson, A.V.3    Pullen, S.M.4    Wilson, W.R.5
  • 101
    • 0022613468 scopus 로고
    • The differential cytotoxicity of RSU 1069: Cell survival studies indicating interaction with DNA as a possible mode of action
    • Stratford, I. J., J. M. Walling, and A. R. J. Silver: The differential toxicity of RSU 1069: Cell survival studies indicating interaction with DNA as possible mode of action. Br J Cancer 53, 339-344 (1986) (Pubitemid 16133103)
    • (1986) British Journal of Cancer , vol.53 , Issue.3 , pp. 339-344
    • Stratford, I.J.1    Walling, J.M.2    Silver, A.R.J.3
  • 103
    • 0022879286 scopus 로고
    • A toxicity and pharmacokinetic study in man of the hypoxic-cell radiosensitiser RSU-1069
    • Horwich, A., S. B. Holliday, J. M. Deacon, and M. J. Peckham: A toxicity and pharmacokinetic study in man of the hypoxic-cell radiosensitizer RSU-1069. Br J Radiol 59, 1238-1240 (1986) (Pubitemid 17223261)
    • (1986) British Journal of Radiology , vol.59 , Issue.708 , pp. 1238-1240
    • Horwich, A.1    Holliday, S.B.2    Deacon, J.M.3
  • 104
    • 0025023154 scopus 로고
    • Synthesis and evaluation of α-[[(2-haloethyl)amino]methyl]-2-nitro- 1H-imidazole-1-ethanols as prodrugs of α-[(1-aziridinyl)methyl]-2-nitro- 1H-imidazole-1-ethanol (RSU-1069) and its analogues which are radiosensitizers and bioreductively activated cytotoxins
    • DOI 10.1021/jm00171a040
    • Jenkins, T. C., M. A. Naylor, P. O'Neill, M. D. Threadgill, S. Cole, I. J. Stratford, G. E. Adams, E. M. Fielden, M. J. Suto, and M. A. Stier: Synthesis and evaluation of alpha-[[(2-haloethyl) amino]methyl]-2-nitro-1H-imidazole-1- ethanols as prodrugs of alpha-[[(2-aziridinyl) methyl]2-nitro-1H-imidazole-1- ethanol (RSU-1069) and its analogues which are radiosensitizers and bioreductively activated cytotoxins. J Med Chem 33, 2603-2610 (1990) (Pubitemid 20274220)
    • (1990) Journal of Medicinal Chemistry , vol.33 , Issue.9 , pp. 2603-2610
    • Jenkins, T.C.1    Naylor, M.A.2    O'Neill, P.3    Threadgill, M.D.4    Cole, S.5    Stratford, I.J.6    Adams, G.E.7    Fielden, E.M.8    Suto, M.J.9    Stier, M.A.10
  • 105
    • 0025204646 scopus 로고
    • Dual-function 2-nitroimidazoles as hypoxic cell radiosensitizers and bioreductive cytotoxins: In vivo evaluation in KHT murine sarcomas
    • Cole, S., I. J. Stratford, G. E. Adams, E. M. Fielden, and T. C. Jenkins: Dual-function 2-nitroimidazoles as hypoxic cell radiosensitizers and bioreductive cytotoxins: in vivo evaluation in KHT murine sarcomas. Radiat Res 124, S38-S43 (1990)
    • (1990) Radiat Res , vol.124
    • Cole, S.1    Stratford, I.J.2    Adams, G.E.3    Fielden, E.M.4    Jenkins, T.C.5
  • 106
    • 0031969730 scopus 로고    scopus 로고
    • Retinal degeneration in rats induced by CI-1010, a 2-nitroimidazole radiosensitizer
    • Breider, M. A., G. D. Pilcher, M. J. Graziano, and A. W. Gough: Retinal degeneration in rats induced by CI-1010, a 2-nitroimidazole radiosensitizer. Toxicol Pathol 26, 234-239 (1998) (Pubitemid 28155329)
    • (1998) Toxicologic Pathology , vol.26 , Issue.2 , pp. 234-239
    • Breider, M.A.1    Pilcher, G.D.2    Graziano, M.J.3    Gough, A.W.4
  • 107
    • 0012761037 scopus 로고    scopus 로고
    • Alkylating property of nitro-imidazole radiosensitizers is required for induction of murine retinal degeneration
    • Parker, R. F., P. W. Vincent, and W. L. Elliot: Alkylating property of nitro-imidazole radiosensitizers is required for induction of murine retinal degeneration. Vet Pathol 33, 625 (1996)
    • (1996) Vet Pathol , vol.33 , pp. 625
    • Parker, R.F.1    Vincent, P.W.2    Elliot, W.L.3
  • 109
    • 0022492516 scopus 로고
    • Cytotoxicity and DNA lesions produced by mitomycin C and porfiromycin in hypoxic and aerobic EMT6 and Chinese hamster ovary cells
    • Fracasso, P. M., and A. C. Sartorelli: Cytotoxicity and DNA lesions produced by mitomycin C and porfiromycin in hypoxic and aerobic EMT6 and Chinese hamster ovary cells. Cancer Res 46, 3939-3944 (1986) (Pubitemid 16075888)
    • (1986) Cancer Research , vol.46 , Issue.8 , pp. 3939-3944
    • Fracasso, P.M.1    Sartorelli, A.C.2
  • 110
    • 78651117965 scopus 로고
    • Mitomycins and porfiromycin: Chemical mechanisms of activation and cross-linking of DNA
    • Iyer, N. V., and W. Szybalski: Mitomycins and porfiromycin: Chemical mechanisms of activation and cross-linking of DNA. Microbiology 50, 355-362 (1963)
    • (1963) Microbiology , vol.50 , pp. 355-362
    • Iyer, N.V.1    Szybalski, W.2
  • 111
    • 0023123806 scopus 로고
    • Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA
    • Tomasz, M., R. Lipman, D. Chowdary, J. Pawlak, G. L. Verdine, and K. Nakanishi: Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA. Science 235, 1204-1208 (1987) (Pubitemid 17034007)
    • (1987) Science , vol.235 , Issue.4793 , pp. 1204-1208
    • Tomasz, M.1    Lipman, R.2    Chowdary, D.3
  • 112
    • 20444459895 scopus 로고    scopus 로고
    • Formation of DNA interstrand cross-links as a marker of Mitomycin C bioreductive activation and chemosensitivity
    • DOI 10.1016/j.ejca.2005.03.014, PII S0959804905002418
    • Volpato, M., J. Seargent, P. M. Loadman, and R. M. Phillips: Formation of DNA interstrand cross-links as a marker of Mitomycin C bioreductive activation and chemosensitivity. Eur J Cancer 41, 1331-1338 (2005) (Pubitemid 40813011)
    • (2005) European Journal of Cancer , vol.41 , Issue.9 , pp. 1331-1338
    • Volpato, M.1    Seargent, J.2    Loadman, P.M.3    Phillips, R.M.4
  • 113
    • 0021345793 scopus 로고
    • Reductive activation of mitomycin C and mitomycin C metabolites catalyzed by NADPH-cytochrome P-450 reductase and xanthine oxidase
    • Pan, S. S., P. A. Andrews, C. J. Glover, and N. R. Bachur: Reductive activation of mitomycin C and mitomycin C metabolites catalysed by NADPH-cytochrome P-450 reductase and xanthine oxidase. J Biol Chem 259, 959-966 (1984) (Pubitemid 14192450)
    • (1984) Journal of Biological Chemistry , vol.259 , Issue.2 , pp. 959-966
    • Pan, S.S.1    Andrews, P.A.2    Glover, C.J.3    Bachur, N.R.4
  • 114
    • 0021687360 scopus 로고
    • Role of NADPH:cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C
    • Keyes, S. R., P. M. Fracasso, D. C. Heimbrook, S. Rockwell, S. G. Sligar, and A. C. Sartorelli: Role of NADPH:cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C. Cancer Res 44, 5638-5643 (1984) (Pubitemid 15183570)
    • (1984) Cancer Research , vol.44 , Issue.12 , pp. 5638-5643
    • Keyes, S.R.1    Fracesso, P.M.2    Heimbrook, D.C.3
  • 115
    • 0018194637 scopus 로고
    • A general mechanism for microsomal activation of quinone anticancer agents to free radicals
    • Bachur, N. R., S. L. Gordon, and M. V. Gee: A general mechanism for microsomal activation of quinone anticancer agents to free radicals. Cancer Res 38, 1745-1750 (1978) (Pubitemid 8349723)
    • (1978) Cancer Research , vol.38 , Issue.6 , pp. 1745-1750
    • Bachur, N.R.1    Gordon, S.L.2    Gee, M.V.3
  • 117
    • 0022622807 scopus 로고
    • Generation of reactive oxygen radicals through bioactivation of mitomycin antibiotics
    • Pritsos, C. A., and A. C. Sartorelli: Generation of reactive oxygen radicals through bioactivation of mitomycin antibiotics. Cancer Res 46, 3528-3532 (1986) (Pubitemid 16096902)
    • (1986) Cancer Research , vol.46 , Issue.7 , pp. 3528-3532
    • Pritsos, C.A.1    Sartorelli, A.C.2
  • 118
    • 0014842505 scopus 로고
    • One-electron reactions in biochemical systems. V. Differences in the mechanism of quinone reduction by the NADP dehydrogenase and the HAD (P) H dehydrogenase (DT-diaphorase)
    • Iyanagi, T., and I. Yamazaki: One-electron reactions in biochemical systems. V. Differences in the mechanism of quinone reduction by the NADP dehydrogenase and the HAD (P) H dehydrogenase (DT-diaphorase). Biochim Biophys Acta 216, 282-294 (1970)
    • (1970) Biochim Biophys Acta , vol.216 , pp. 282-294
    • Iyanagi, T.1    Yamazaki, I.2
  • 119
    • 0018642880 scopus 로고
    • Combination therapy with radiation and mitomycin C: Preliminary results with EMT6 tumor cells in vitro and in vivo
    • Rockwell, S., and K. A. Kennedy: Combination therapy with radiation and mitomycin C: Preliminary results with EMT6 tumor cells in vitro and in vivo. Int J Radiat Oncol Biol Phys 5, 1673-1676 (1979) (Pubitemid 10130815)
    • (1979) International Journal of Radiation Oncology Biology Physics , vol.5 , Issue.9 , pp. 1673-1676
    • Rockwell, S.1    Kennedy, K.A.2
  • 122
    • 0031032568 scopus 로고    scopus 로고
    • Chemotherapy as an adjunct to radiation in the treatment of squamous cell carcinoma of the head and neck: Results of the Yale mitomycin randomized trials
    • Haffty, B. G., Y. H. Son, R. Papac, C. T. Sasaki, J. B. Weissberg, D. Fischer, S. Rockwell, A. C. Sartorelli, and J. J. Fischer: Chemotherapy as an adjunct to radiation in the treatment of squamous cell carcinoma of the head and neck: Results of the Yale Mitomycin Randomized Trials. J Clin Oncol 15, 268-276 (1997) (Pubitemid 27020583)
    • (1997) Journal of Clinical Oncology , vol.15 , Issue.1 , pp. 268-276
    • Haffty, B.G.1    Son, Y.H.2    Papac, R.3    Sasaki, C.T.4    Weissberg, J.B.5    Fischer, D.6    Rockwell, S.7    Sartorelli, A.C.8    Fischer, J.J.9
  • 124
    • 10044265307 scopus 로고    scopus 로고
    • Biweekly escalated, accelerated hyperfractionated radiotherapy with concomitant single-dose mitomycin C results in a high rate of local control in advanced laryngeal and hypopharyngeal cancer
    • DOI 10.1097/01.coc.0000135737.78861.2d
    • Saarilahti, K., M. Kajanti, T. Atula, A. Makitie, L.-M. Aaltonen, M. Kouri, and M. Mantyla: Biweekly escalated, accelerated hyperfractionated radiotherapy with concomitant single-dose mitomycin C results in a high rate of local control in advanced laryngeal and hypopharyngeal cancer. Am J Clin Oncol 27, 589-594 (2004) (Pubitemid 39603274)
    • (2004) American Journal of Clinical Oncology: Cancer Clinical Trials , vol.27 , Issue.6 , pp. 589-594
    • Saarilahti, K.1    Kajanti, M.2    Atula, T.3    Makitie, A.4    Aaltonen, L.-M.5    Kouri, M.6    Mantyla, M.7
  • 125
    • 0023798415 scopus 로고
    • Preclinical studies of porfiromycin as adjunct to radiotherapy
    • Rockwell, S., S. R. Keyes, and A. C. Sartorelli: Preclinical studies of porfiromycin as adjunct to radiotherapy. Radiat Res 116, 100-113 (1988)
    • (1988) Radiat Res , vol.116 , pp. 100-113
    • Rockwell, S.1    Keyes, S.R.2    Sartorelli, A.C.3
  • 126
    • 0021971997 scopus 로고
    • Porfiromycin as a bioreductive alkylating agent with selective toxicity to hypoxic EMT6 tumor cells in vivo and in vitro
    • Keyes, S. R., S. Rockwell, and A. C. Sartorelli: Porfiromycin as a bioreductive alkylating agent with selective toxicity to hypoxic EMT6 tumor cells in vivo and in vitro. Cancer Res 45, 3642-3645 (1985) (Pubitemid 15226438)
    • (1985) Cancer Research , vol.45 , Issue.8 , pp. 3642-3645
    • Keyes, S.R.1    Rockwell, S.2    Sartorelli, A.C.3
  • 128
    • 0023104247 scopus 로고
    • Mitomycin analogs. I. Indoloquinones as (potential) bisalkylating agents
    • DOI 10.1016/S0040-4020(01)89952-X
    • Oostveen, E. A., and W. N. Speckamp: Mitomycin analogs. I. Indoloquinones as (potential) bisalkylating agents. Tetrahedron 43, 255-262 (1987) (Pubitemid 17227832)
    • (1987) Tetrahedron , vol.43 , Issue.1 , pp. 255-262
    • Oostveen, E.A.1    Speckamp, W.N.2
  • 129
    • 0028987032 scopus 로고
    • Indoloquinone EO9: DNA interstrand cross-linking upon reduction by DT-diaphorase or xanthine oxidase
    • Maliepaard, M., A. Wolfs, S. E. Groot, N. J. de Mol, and L. H. M. Janssen: Indoloquinone EO9: DNA interstrand cross-linking upon reduction by DT-diaphorase or xanthine oxidase. Br J Cancer 71, 836-839 (1995)
    • (1995) Br J Cancer , vol.71 , pp. 836-839
    • Maliepaard, M.1    Wolfs, A.2    Groot, S.E.3    De Mol, N.J.4    Janssen, L.H.M.5
  • 130
    • 0028063368 scopus 로고
    • DT-diaphorase protects cells from the hypoxic cytotoxicity of indoloquinone EO9
    • Plumb, J. A., M. Gerritsen, and P. Workman: DT-diaphorase protects cells from the hypoxic cytotoxicity of indoloquinone EO9. Br J Cancer 70, 1136-1143 (1994) (Pubitemid 24358951)
    • (1994) British Journal of Cancer , vol.70 , Issue.6 , pp. 1136-1143
    • Plumb, J.A.1    Gerritsen, M.2    Workman, P.3
  • 131
    • 0010298103 scopus 로고
    • Free radical generation following reduction of EO9: Involvement in cytotoxicity
    • Bailey, S. M., A. D. Lewis, L. H. Patterson, G. R. Fischer, and P. Workman: Free radical generation following reduction of EO9: Involvement in cytotoxicity. Br J Cancer 67, 8 (1993)
    • (1993) Br J Cancer , vol.67 , pp. 8
    • Bailey, S.M.1    Lewis, A.D.2    Patterson, L.H.3    Fischer, G.R.4    Workman, P.5
  • 134
    • 0030582840 scopus 로고    scopus 로고
    • Bioreductive activation of a series of analogues of 5-aziridinyl-3- hydroxymethyl-1-methyl-2-[1H-indole-4,7-dione] prop-β-en-α-ol (EO9) by human DT-diaphorase
    • DOI 10.1016/S0006-2952(96)00521-7, PII S0006295296005217
    • Phillips, R. M.: Bioreductive activation of a series of analogues of 5-aziridinyl-3-hydroxymethyl-1-methyl-2-[1H-indole-4, 7-dione]prop-beta-en- alpha-ol (EO9) by human DT-diaphorase. Biochem Pharmacol 52, 1711-1718 (1996) (Pubitemid 26407986)
    • (1996) Biochemical Pharmacology , vol.52 , Issue.11 , pp. 1711-1718
    • Phillips, R.M.1
  • 135
    • 0027328452 scopus 로고
    • The experimental development of bioreductive drugs and their role in cancer therapy
    • Workman, P., and I. J. Stratford: The experimental development of bioreductive drugs and their role in cancer therapy. Cancer Met Rev 12, 73-82 (1993) (Pubitemid 23220673)
    • (1993) Cancer and Metastasis Reviews , vol.12 , Issue.2 , pp. 73-82
    • Workman, P.1    Stratford, I.J.2
  • 136
    • 0026767519 scopus 로고
    • Reductive metabolism of diaziquone (AZQ) in the S9 fraction of MCF-7 cells
    • Fisher, G. R., J. Donis, and P. L. Gutierrez: Reductive metabolism of diaziquone (AZQ) in the S9 fraction of MCF-7 cells. Biochem Pharmacol 44, 1625-1635 (1992)
    • (1992) Biochem Pharmacol , vol.44 , pp. 1625-1635
    • Fisher, G.R.1    Donis, J.2    Gutierrez, P.L.3
  • 137
    • 0037676119 scopus 로고    scopus 로고
    • Cytotoxicity of RH1 and related aziridinylbenzoquinones: Involvement of activation by NAD(P)H:quinone oxidoreductase (NQO1) and oxidative stress
    • DOI 10.1016/S0003-9861(03)00281-9
    • Nemeikaite-Ceniene, A., J. Sarlauskas, Z. Anusevicius, H. Nivinskas, and N. Cenas: Cytotoxicitiy of RH1 and related aziridinylbenzoquinones: involvement of activation by NAD (P) H:quinone oxidoreductase (NQO1) and oxidative stress. Arch Biochem Biophys 416, 110-118 (2003) (Pubitemid 36818854)
    • (2003) Archives of Biochemistry and Biophysics , vol.416 , Issue.1 , pp. 110-118
    • Nemeikaite-Ceniene, A.1    Sarlauskas, J.2    Anusevicius, Z.3    Nivinskas, H.4    Cenas, N.5
  • 138
    • 0032435478 scopus 로고    scopus 로고
    • A new screening system for NAD(P)H:quinone oxidoreductase (NQO1)- directed antitumor quinones: Identification of a new aziridinylbenzoquinone, RH1, as a NQO1-directed antitumor agent
    • Winski, S. L. R., R. H. J. Hargreaves, J. Butler, and D. Ross: New screening system for NAD (P) H:quinone oxidoreductase (NQO1)-directed antitumour quinones: The identification of a new aziridinylbenzoquinone, RH1, as a NQO1-directed antitumour agent. Clin Cancer Res 4, 3083-3088 (1998) (Pubitemid 29001485)
    • (1998) Clinical Cancer Research , vol.4 , Issue.12 , pp. 3083-3088
    • Winski, S.L.1    Hargreaves, R.H.J.2    Butler, J.3    Ross, D.4
  • 139
    • 0034321640 scopus 로고    scopus 로고
    • Mechanisms of action of quinone-containing alkylating agents: DNA alkylation by aziridinylquinones
    • Hargreaves, R. H. J., J. A. Hartley, and J. Butler: Mechanisms of action of quinone-containing alkylating agents: DNA alkylation by aziridinylquinones. Front Biosci 5, e172-180 (2000)
    • (2000) Front Biosci , vol.5
    • Hargreaves, R.H.J.1    Hartley, J.A.2    Butler, J.3
  • 140
    • 18044364834 scopus 로고    scopus 로고
    • RH1 induces cellular damage in an NAD(P)H:quinone oxidoreductase 1-dependent manner: Relationship between DNA cross-linking, cell cycle perturbations, and apoptosis
    • DOI 10.1124/jpet.104.081380
    • Dehn, D. L., S. H. Inayat-Hussain, and D. Ross: RH1 induces cellular damage in an NAD (P) H:quinone oxidoreductase 1-dependent manner: Relationship between DNA cross-linking, cell cycle perturbations, and apoptosis. J Pharmacol Exp Ther 313, 771-779 (2005) (Pubitemid 40604178)
    • (2005) Journal of Pharmacology and Experimental Therapeutics , vol.313 , Issue.2 , pp. 771-779
    • Dehn, D.L.1    Inayat-Hussain, S.H.2    Ross, D.3
  • 141
    • 3242742185 scopus 로고    scopus 로고
    • DT-diaphorase: A target for new anticancer drugs
    • DOI 10.1016/j.ctrv.2004.01.002, PII S030573720400026X
    • Danson, S., T. H. Ward, J. Butler, and M. Ranson: DT-diaphorase: a target for new anticancer drugs. Cancer Treat Rev 30, 437-449 (2004) (Pubitemid 38968124)
    • (2004) Cancer Treatment Reviews , vol.30 , Issue.5 , pp. 437-449
    • Danson, S.1    Ward, T.H.2    Butler, J.3    Ranson, M.4
  • 142
    • 0026047102 scopus 로고
    • Microsomal reduction of 3-amino-1, 2, 4-benzotriazine-1, 4-dioxide to a free radical
    • Lloyd, R. V., D. R. Duling, G. V. Rumyantseva, R. P. Mason, and P. K. Bridson: Microsomal reduction of 3-amino-1, 2, 4-benzotriazine-1, 4-dioxide to a free radical. Mol Pharmacol 40, 440-445 (1991)
    • (1991) Mol Pharmacol , vol.40 , pp. 440-445
    • Lloyd, R.V.1    Duling, D.R.2    Rumyantseva, G.V.3    Mason, R.P.4    Bridson, P.K.5
  • 143
    • 0037460188 scopus 로고    scopus 로고
    • Activation of 3-amino-1,2,4-benzotriazine 1,4-dioxide antitumor agents to oxidizing species following their one-electron reduction
    • DOI 10.1021/ja0209363
    • Anderson, R. F., S. S. Shinde, M. P. Hay, S. A. Gamage, and W. A. Denny: Activation of 3-amino-1, 2, 4-benzotriazine 1, 4-dioxide antitumor agents to oxidizing species following their one-electron reduction. J Am Chem Soc 125, 748-756 (2003) (Pubitemid 36109936)
    • (2003) Journal of the American Chemical Society , vol.125 , Issue.3 , pp. 748-756
    • Anderson, R.F.1    Shinde, S.S.2    Hay, M.P.3    Gamage, S.A.4    Denny, W.A.5
  • 144
    • 0023689603 scopus 로고
    • Metabolism of SR 4233 by Chinese hamster ovary cells: Basis of selective hypoxic cytotoxicity
    • Baker, M. A., E. M. Zeman, V. K. Hirst, and J. M. Brown: Metabolism of SR 4233 by Chinese hamster ovary cells: basis of selective hypoxic cytotoxicity. Cancer Res 48, 5947-5952 (1988) (Pubitemid 18266781)
    • (1988) Cancer Research , vol.48 , Issue.21 , pp. 5947-5952
    • Baker, M.A.1    Zeman, E.M.2    Hirst, V.K.3    Brown, J.M.4
  • 145
    • 0141507967 scopus 로고    scopus 로고
    • Multicellular resistance to tirapazamine is due to restricted extravascular transport: A pharmacokinetic/pharmacodynamic study in HT29
    • Hicks, K. O., F. B. Pruijn, J. R. Sturman, W. A. Denny, and W. R. Wilson: Multicellular resistance to tirapazamine is due to restricted extravascular transport: A pharmacokinetic/pharmacodynamic study in HT29 multicellualr layer cultures. Cancer Res 63, 5970-5977 (2003) (Pubitemid 37187499)
    • (2003) Cancer Research , vol.63 , Issue.18 , pp. 5970-5977
    • Hicks, K.O.1    Pruijn, F.B.2    Sturman, J.R.3    Denny, W.A.4    Wilson, W.R.5
  • 146
    • 0027524919 scopus 로고
    • Pharmacokinetics and bioreductive metabolism of the novel benzotriazine di-N-oxide hypoxic cell cytotoxin tirapazamine (WIN 59075; SR 4233; NSC 130181) in mice
    • Walton, M. I., and P. Workman: Pharmacokinetics and bioreductive metabolism of the novel benzotriazine di-N-oxide hypoxic cell cytotoxin tirapazamine (WIN 59075; SR 4233; NSC 130181) in mice. J Pharmacol Exp Ther 265, 938-947 (1993) (Pubitemid 23315608)
    • (1993) Journal of Pharmacology and Experimental Therapeutics , vol.265 , Issue.2 , pp. 938-947
    • Walton, M.I.1    Workman, P.2
  • 147
    • 8244234465 scopus 로고    scopus 로고
    • Pharmacokinetics of the hypoxic cell cytotoxic agent tirapazamine and its major bioreductive metabolites in mice and humans: Retrospective analysis of a pharmacokinetically guided dose-escalation strategy in a a phase I trial
    • DOI 10.1007/s002800050617
    • Grahams, M. A., S. Senan, H. J. Robin, N. Eckhardt, D. Lendrem, J. Hinks, D. Greenslade, R. Rampling, S. B. Kaye, R. von Roemeling, and P. Workman: Pharmacokinetics of the hypoxic cell cytotoxic agent tirapazamine and its major bioreductive metabolites in mice and humans: retrospective analysis of a pharmacokinetically guided dose-escalation strategy in a phase I trial. Cancer Chemother Pharmacol 40, 1-10 (1997) (Pubitemid 27160953)
    • (1997) Cancer Chemotherapy and Pharmacology , vol.40 , Issue.1 , pp. 1-10
    • Graham, M.A.1    Senan, S.2    Robin Jr., H.3    Eckhardt, N.4    Lendrem, D.5    Hincks, J.6    Greenslade, D.7    Rampling, R.8    Kaye, S.B.9    Von Roemeling, R.10    Workman, P.11
  • 148
    • 0026502752 scopus 로고
    • Enzymology of the reduction of the potent benzotriazine-di-N-oxide hypoxic cell cytotoxin SR 4233 (WIN 59075) by NAD (P) H: (quinone acceptor) oxidoreductase (EC 1.6.99.2) purified from Walker 256 rat tumour cells
    • Riley, R. J., and P. Workman: Enzymology of the reduction of the potent benzotriazine-di-N-oxide hypoxic cell cytotoxin SR 4233 (WIN 59075) by NAD (P) H: (quinone acceptor) oxidoreductase (EC 1.6.99.2) purified from Walker 256 rat tumour cells. Biochem Pharmacol 43, 167-174 (1992)
    • (1992) Biochem Pharmacol , vol.43 , pp. 167-174
    • Riley, R.J.1    Workman, P.2
  • 149
    • 0031704448 scopus 로고    scopus 로고
    • Tirapazamine: Laboratory data relevant to clinical activity
    • Brown, J. M., and L. H. Wang: Tirapazamine: laboratory data relevant to clinical activity. Anticancer Drug Des 13, 529-539 (1998) (Pubitemid 28410147)
    • (1998) Anti-Cancer Drug Design , vol.13 , Issue.6 , pp. 529-539
    • Brown, J.M.1    Wang, L.-H.2
  • 150
    • 0027227590 scopus 로고
    • Unusual oxygen concentration dependence of toxicity of SR-4233, a hypoxic cell toxin
    • Koch, C. J.: Unusual oxygen concentration dependence of toxicity of SR-4233, a hypoxic cell toxin. Cancer Res 53, 3992-3997 (1993) (Pubitemid 23267700)
    • (1993) Cancer Research , vol.53 , Issue.17 , pp. 3992-3997
    • Koch, C.J.1
  • 151
    • 3042537843 scopus 로고    scopus 로고
    • Oxygen dependence of the metabolic activation and cytotoxicity of tirapazamine: Implications for extravascular transport and activity in tumors
    • DOI 10.1667/RR3178
    • Hicks, K. O., B. G. Siim, F. B. Pruijn, and W. R. Wilson: Oxygen dependence of the metabolic activation and cytotoxicity of tirapazamine: Implications for extravascular transport and activity in tumors. Radiat Res 161, 656-666 (2004) (Pubitemid 39149574)
    • (2004) Radiation Research , vol.161 , Issue.6 , pp. 656-666
    • Hicks, K.O.1    Siim, B.G.2    Pruijn, F.B.3    Wilson, W.R.4
  • 152
    • 0022493495 scopus 로고
    • SR-4233: A new bioreductive agent with high selective toxicity for hypoxic mammalian cells
    • Zeman, E. M., J. M. Brown, M. J. Lemmon, V. K. Hirst, and W. W. Lee: SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells. Int J Radiat Oncol Biol Phys 12, 1239-1242 (1986) (Pubitemid 16055893)
    • (1986) International Journal of Radiation Oncology Biology Physics , vol.12 , Issue.7 , pp. 1239-1242
    • Zeman, E.M.1    Brown, J.M.2    Lemmon, M.J.3
  • 153
    • 0026073332 scopus 로고
    • SR 4233 cytotoxicity and metabolism in DNA repair-competent and repair-deficient cell cultures
    • Beidermann, K. A., J. Wang, R. P. Graham, and J. M. Brown: SR 4233 cytotoxicity and metabolism in DNA repair-competent and repair-deficient cell cultures. Br J Cancer 63, 358-362 (1991)
    • (1991) Br J Cancer , vol.63 , pp. 358-362
    • Beidermann, K.A.1    Wang, J.2    Graham, R.P.3    Brown, J.M.4
  • 154
    • 0026802366 scopus 로고
    • Repair of DNA and chromosome breaks in cells exposed to SR 4233 under hypoxia or to ionizing radiation
    • Wang, J., K. A. Biedermann, and J. M. Brown: Repair of DNA and chromosome breaks in cells exposed to SR 4233 under hypoxia or to ionizing radiation. Cancer Res 52, 4473-4477 (1992)
    • (1992) Cancer Res , vol.52 , pp. 4473-4477
    • Wang, J.1    Biedermann, K.A.2    Brown, J.M.3
  • 155
    • 0030009223 scopus 로고    scopus 로고
    • Tirapazamine-induced DNA damage measured using the comet assay correlates with cytotoxicity towards hypoxic tumour cells in vitro
    • Siim, B. G., P. Van Zijl, and J. M. Brown: Tirapazamine-induced DNA damage measured using the comet assay correlates with cytotoxicity towards hypoxic tumour cells in vitro. Br J Cancer 73, 952-960 (1996) (Pubitemid 26116748)
    • (1996) British Journal of Cancer , vol.73 , Issue.8 , pp. 952-960
    • Siim, B.G.1    Van Zijl, P.L.2    Brown, J.M.3
  • 156
    • 0026642263 scopus 로고
    • The role of cytochrome P450 and cytochrome P450 reductase in the reductive bioactivation of the novel benzotriazine di-N-oxide hypoxic cytotoxin 3-amino-1, 2, 4-benzotriazine-1, 4-dioxide (SR 4233, WIN 59075) by mouse liver
    • Walton, M. I., C. R. Wolf, and P. Workman: The role of cytochrome P450 and cytochrome P450 reductase in the reductive bioactivation of the novel benzotriazine di-N-oxide hypoxic cytotoxin 3-amino-1, 2, 4-benzotriazine-1, 4-dioxide (SR 4233, WIN 59075) by mouse liver. Biochem Pharmacol 44, 251-259 (1992)
    • (1992) Biochem Pharmacol , vol.44 , pp. 251-259
    • Walton, M.I.1    Wolf, C.R.2    Workman, P.3
  • 157
    • 0027418726 scopus 로고
    • Metabolism of the bioreductive cytotoxin SR 4233 by tumour cells: Enzymatic studies
    • Wang, J., K. A. Biedermann, C. R. Wolf, and J. M. Brown: Metabolism of the bioreductive cytotoxin SR 4233 by tumour cells: enzymatic studies. Br J Cancer 67, 321-325 (1993) (Pubitemid 23049556)
    • (1993) British Journal of Cancer , vol.67 , Issue.2 , pp. 321-325
    • Wang, J.1    Biedermann, K.A.2    Wolf, C.R.3    Brown, J.M.4
  • 158
    • 0027407629 scopus 로고
    • Initial characterization of the major mouse cytochrome P450 enzymes involved in the reductive metabolism of the hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (tirapazamine, SR 4233, WIN 59075)
    • DOI 10.1016/0006-2952(93)90251-Q
    • Riley, R. J., S. A. Hemingway, M. A. Graham, and P. Workman: Initial characterization of the major mouse cytochrome P450 enzymes involved in the reductive metabolism of the hypoxic cytotoxin 3-amino-1, 2, 4-benzotriazine-1, 4-di-N-oxide (tirapazamine, SR 4233, WIN 59075). Biochem Pharmacol 45, 1065-1077 (1993) (Pubitemid 23079984)
    • (1993) Biochemical Pharmacology , vol.45 , Issue.5 , pp. 1065-1077
    • Riley, R.J.1    Hemingway, S.A.2    Graham, M.A.3    Workman, P.4
  • 159
    • 0025073825 scopus 로고
    • Reductive metabolism of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) and the induction of unscheduled DNA synthesis in rat and human derived cell lines
    • Cahill, A., and I. N. White: Reductive metabolism of 3-amino-1, 2, 4-benzotriazine-1, 4-dioxide (SR 4233) and the induction of unschedules DNA synthesis in rat and human derived cell lines. Carcinogenesis 11, 1407-1411 (1990) (Pubitemid 20245718)
    • (1990) Carcinogenesis , vol.11 , Issue.8 , pp. 1407-1411
    • Cahill, A.1    White, I.N.H.2
  • 160
    • 0028867912 scopus 로고
    • Importance of P450 reductase activity in determining sensitivity of breast tumour cells to the bioreductive drug, tirapazamine (SR 4233)
    • Patterson, A. V., H. M. Barham, E. C. Chinje, G. E. Adams, A. L. Harris, and I. J. Stratford: Importance of P450 reductase activity in determining sensitivity of breast tumour cells to the bioreductive drug, tirapazamine (SR 4233). Br J Cancer 72, 1144-1150 (1995)
    • (1995) Br J Cancer , vol.72 , pp. 1144-1150
    • Patterson, A.V.1    Barham, H.M.2    Chinje, E.C.3    Adams, G.E.4    Harris, A.L.5    Stratford, I.J.6
  • 161
    • 0030692717 scopus 로고    scopus 로고
    • Overexpression of human NADPH:cytochrome c (P450) reductase confers enhanced sensitivity to both tirapazamine (SR 4233) and RSU 1069
    • Patterson, A. V., M. P. Saunders, E. C. Chinje, D. A. Talbot, A. L. Harris, and I. J. Stratford: Overexpression of human NADPH:cytochrome c (P450) reductase confers enhanced sensitivity to both tirapazamine (SR 4233) and RSU 1069. Br J Cancer 76, 1338-1347 (1997) (Pubitemid 27474977)
    • (1997) British Journal of Cancer , vol.76 , Issue.10 , pp. 1338-1347
    • Patterson, A.V.1    Saunders, M.P.2    Chinje, E.C.3    Talbot, D.C.4    Harris, A.L.5    Stratford, I.J.6
  • 162
    • 0023929181 scopus 로고
    • Molecular mechanisms for the hypoxia-dependent activation of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233)
    • DOI 10.1016/0006-2952(88)90010-X
    • Laderoute, K., P. Wardman, and A. M. Rauth: Molecular mechanisms for the hypoxia-dependent activation of 3-amino-1, 2, 4-benzotriazine-1, 4-dioxide (SR 4233). Biochem Pharmacol 37, 1487-1495 (1988) (Pubitemid 18093342)
    • (1988) Biochemical Pharmacology , vol.37 , Issue.8 , pp. 1487-1495
    • Laderoute, K.1    Wardman, P.2    Rauth, M.3
  • 163
    • 0032523899 scopus 로고    scopus 로고
    • Tirapazamine is metabolized to its DNA-damaging radical by intranuclear enzymes
    • Evans, J. W., K. Yudoh, Y. M. Delahoussaye, and J. M. Brown: Tirapazamine is metabolized to its DNA-damaging radical by intranuclear enzymes. Cancer Res 58, 2098-2101 (1998) (Pubitemid 28232893)
    • (1998) Cancer Research , vol.58 , Issue.10 , pp. 2098-2101
    • Evans, J.W.1    Yudoh, K.2    Delahoussaye, Y.M.3    Brown, J.M.4
  • 164
    • 0035504709 scopus 로고    scopus 로고
    • Metabolism of tirapazamine by multiple reductases in the nucleus
    • DOI 10.1016/S0006-2952(01)00784-5, PII S0006295201007845
    • Delahoussaye, Y. M., J. W. Evans, and J. M. Brown: Metabolism of tirapazamine by multiple reductases in the nucleus. Biochem Pharmacol 62, 1201-1209 (2001) (Pubitemid 33055624)
    • (2001) Biochemical Pharmacology , vol.62 , Issue.9 , pp. 1201-1209
    • Delahoussaye, Y.M.1    Evans, J.W.2    Brown J.Martin3
  • 165
    • 0035878747 scopus 로고    scopus 로고
    • Inhibition of DNA replication by tirapazamine
    • Peters, K. B., H. Wang, J. M. Brown, and G. Iliakis: Inhibition of DNA replication by tirapazamine. Cancer Res 61, 5425-5431 (2001) (Pubitemid 32694922)
    • (2001) Cancer Research , vol.61 , Issue.14 , pp. 5425-5431
    • Peters, K.B.1    Wang, H.2    Brown, J.M.3    Iliakis, G.4
  • 166
    • 0037105653 scopus 로고    scopus 로고
    • Tirapazamine: A hypoxia-activated topoisomerase II poison
    • Peters, K. B., and J. M. Brown: Tirapazamine: a hypoxia-activated topoisomerase II poison. Cancer Res 62, 5248-5253 (2002) (Pubitemid 35024598)
    • (2002) Cancer Research , vol.62 , Issue.18 , pp. 5248-5253
    • Peters, K.B.1    Brown, J.M.2
  • 167
    • 0025646401 scopus 로고
    • Potentiation by the hypoxic cytotoxin SR 4233 of cell killing produced by fractionated irradiation of mouse tumors
    • Brown, J. M., and M. J. Lemmon: Potentiation by the hypoxic cytotoxin SR 4233 of cell killing produced by fractionated irradiation of mouse tumors. Cancer Res 50, 7745-7749 (1990)
    • (1990) Cancer Res , vol.50 , pp. 7745-7749
    • Brown, J.M.1    Lemmon, M.J.2
  • 168
    • 84965808588 scopus 로고
    • Tumor-specific, schedule-dependent interaction between tirapazamine (SR 4233) and cisplatin
    • Dorie, M. J., and J. M. Brown: Tumor-specific, schedule-dependent interaction between tirapazamine (SR 4233) and cisplatin. Cancer Res 53, 4633-4636 (1993) (Pubitemid 23304391)
    • (1993) Cancer Research , vol.53 , Issue.18 , pp. 4633-4636
    • Dorie, M.J.1    Brown, J.M.2
  • 170
    • 0031462199 scopus 로고    scopus 로고
    • Phase II study of the combination of the novel bioreductive agent, tirapazamine, with cisplatin in patients with advanced non-small-cell lung cancer
    • DOI 10.1023/A:1008219125746
    • Miller, V. A., Ng, K. K., Grant, S. C., Kindler, H., Pizzo, B., Heelan, R. T., von Roemeling, R., Kris, M. G.: Phase II study of the combination of the novel bioreductive agent, tirapazamine, with cisplatin in patients with advanced non-small-cell lung cancer. Ann Oncol 8, 1269-1271 (1997) (Pubitemid 28164084)
    • (1997) Annals of Oncology , vol.8 , Issue.12 , pp. 1269-1271
    • Miller, V.A.1    Ng, K.R.2    Grant, S.C.3    Kindler, H.4    Pizzo, B.5    Heelan, R.T.6    Von Roemeling, R.7    Kris, M.G.8
  • 174
    • 16644377045 scopus 로고    scopus 로고
    • Tirapazamine, cisplatin, and radiation versus fluorouracil, cisplatin, and radiation in patients with locally advanced head and neck cancer: A randomized phase II trial of the Trans-Tasman Radiation Oncology Group (TROG 98.02)
    • DOI 10.1200/JCO.2005.01.072
    • Rischin, D., Peters, L., Fisher, R., Macann, A., Danham, J., Poulsen, M., Jackson, M., Kenny, L., Penniment, M., Corry, J., Lamb, D., McClure, B.: Tirapazamine, cisplatin, and radiation versus fluorouracil, cisplatin, and radiation in patients with locally advanced head and neck cancer: A randomized phase II trial of the trans-Tasman radiation oncology group (TROG 98.02). J Clin Oncol 23, 79-87 (2005) (Pubitemid 41702625)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.1 , pp. 79-87
    • Rischin, D.1    Peters, L.2    Fisher, R.3    Macann, A.4    Denham, J.5    Poulsen, M.6    Jackson, M.7    Kenny, L.8    Penniment, M.9    Carry, J.10    Lamb, D.11    McClure, B.12
  • 175
    • 0026520313 scopus 로고
    • Bisbioreductive agents as hypoxia-selective cytotoxins: Nitracrine N-oxide
    • Wilson, W. R., P. Van Zijl, and W. A. Denny: Bisbioreductive agents as hypoxia-selective cytotoxins: nitracrine N-oxide. Int J Radiat Oncol Biol Phys 22, 693-696 (1992)
    • (1992) Int J Radiat Oncol Biol Phys , vol.22 , pp. 693-696
    • Wilson, W.R.1    Van Zijl, P.2    Denny, W.A.3
  • 176
    • 0029952167 scopus 로고    scopus 로고
    • Hypoxia-selective antitumour agents. 13. Effects of acridine substitution on the hypoxia-selective cytotoxicity and metabolic reduction of the bis-bioreductive agent nitracrine N-oxide
    • Lee, H. H., W. R. Wilson, D. M. Ferry, P. Van Zijl, S. M. Pullen, and W. A. Denny: Hypoxia-selective antitumour agents. 13. Effects of acridine substitution on the hypoxia-selective cytotoxicity and metabolic reduction of the bis-bioreductive agent nitracrine N-oxide. J Med Chem 39, 2508-2517 (1996)
    • (1996) J Med Chem , vol.39 , pp. 2508-2517
    • Lee, H.H.1    Wilson, W.R.2    Ferry, D.M.3    Van Zijl, P.4    Pullen, S.M.5    Denny, W.A.6
  • 177
    • 0027220811 scopus 로고
    • Rationale for the use of aliphatic N-oxides of cytotoxic anthraquinones as prodrug DNA binding agents: A new class of bioreductive agent
    • Patterson, L. H.: Rationale for the use of aliphatic N-oxides of cytotoxic anthraquinones as prodrug DNA binding agents: a new class of bioreductive agent. Cancer Met Rev 12, 119-134 (1993) (Pubitemid 23220676)
    • (1993) Cancer and Metastasis Reviews , vol.12 , Issue.2 , pp. 119-134
    • Patterson, L.H.1
  • 178
    • 0031019255 scopus 로고    scopus 로고
    • Flow cytometric analysis and confocal imaging of anticancer alkylaminoanthraquinones and their N-oxides in intact human cells using 647-nm krypton laser excitation
    • DOI 10.1002/(SICI)1097-0320(19970101)27:1<43::AID-CYTO6>3.0.CO;2-M
    • Smith, P. J., R. Desnoyers, N. Blunt, Y. Giles, L. H. Patterson, and J. V. Watson: Flow cytometric analysis and confocal imaging of the anticancer alkylaminoanthraquinones and their N-oxides in intact human cells using 647-nm krypton laser excitation. Cytometry 27, 43-53 (1997) (Pubitemid 27059781)
    • (1997) Cytometry , vol.27 , Issue.1 , pp. 43-53
    • Smith, P.J.1    Desnoyers, R.2    Blunt, N.3    Giles, Y.4    Patterson, L.H.5    Watson, J.V.6
  • 179
    • 0031040944 scopus 로고    scopus 로고
    • DNA topoisomerase II-dependent cytotoxicity of alkylaminoanthraquinones and their N-oxides
    • DOI 10.1007/s002800050598
    • Smith, P. J., N. J. Blunt, R. Desnoyers, Y. Giles, and L. H. Patterson: DNA topoisomerase II-dependent cytotoxicity of alkyklaminoanthraquinones and their N-oxides. Cancer Chemother Pharmacol 39, 455-461 (1997) (Pubitemid 27078132)
    • (1997) Cancer Chemotherapy and Pharmacology , vol.39 , Issue.5 , pp. 455-461
    • Smith, P.J.1    Blunt, N.J.2    Desnoyers, R.3    Giles, Y.4    Patterson, L.H.5
  • 180
    • 0028650760 scopus 로고
    • Aliphatic amine N-oxides of DNA binding agents as bioreductive drugs
    • Patterson, L. H., M. R. Craven, G. R. Fisher, and P. Teesdale-Spittle: Aliphatic amine N-oxides of DNA binding agents as bioreductive drugs. Oncol Res 6, 533-538 (1994)
    • (1994) Oncol Res , vol.6 , pp. 533-538
    • Patterson, L.H.1    Craven, M.R.2    Fisher, G.R.3    Teesdale-Spittle, P.4
  • 182
    • 0034543132 scopus 로고    scopus 로고
    • AQ4N: A new approach to hypoxia-activated cancer chemotherapy
    • DOI 10.1054/bjoc.2000.1564
    • Patterson, L. H., and S. R. McKeown: AQ4N: a new approach to hypoxia-activated cancer chemotherapy. Br J Cancer 83, 1589-1593 (2000) (Pubitemid 32001698)
    • (2000) British Journal of Cancer , vol.83 , Issue.12 , pp. 1589-1593
    • Patterson, L.H.1    McKeown, S.R.2
  • 183
    • 0034029002 scopus 로고    scopus 로고
    • Enhancement of chemotherapy and radiotherapy of murine tumours by AQ4N, a bioreductively activated anti-tumour agent
    • Patterson, L. H., S. R. McKeown, K. Ruparelia, J. A. Double, M. C. Bibby, S. Cole, and I. J. Stratford: Enhancement of chemotherapy and radiotherapy of murine tumours by AQ4N, a bioreductively activated anti-tumour agent. Br J Cancer 82, 1984-1990 (2000) (Pubitemid 30326460)
    • (2000) British Journal of Cancer , vol.82 , Issue.12 , pp. 1984-1990
    • Patterson, L.H.1    McKeown, S.R.2    Ruparelia, K.3    Double, J.A.4    Bibby, M.C.5    Cole, S.6    Stratford, I.J.7
  • 184
    • 0032717495 scopus 로고    scopus 로고
    • Rat cytochromes P450 (CYP) specifically contribute to the reductive bioactivation of AQ4N, an alkylaminoanthraquinone-di-N-oxide anticancer drug
    • Raleigh, S. M., E. Wanogho, M. D. Burke, and L. H. Patterson: Rat cytochromes P450 (CYP) specifically contribute to the reductive bioactivation of AQ4N, an alkylaminoanthraquinone-di-N-oxide anticancer drug. Xenobiotica 29, 1115-1122 (1999)
    • (1999) Xenobiotica , vol.29 , pp. 1115-1122
    • Raleigh, S.M.1    Wanogho, E.2    Burke, M.D.3    Patterson, L.H.4
  • 185
    • 0031742538 scopus 로고    scopus 로고
    • Involvement of human cytochromes P450 (CYP) in the reductive metabolism of AQ4N, a hypoxia activated anthraquinone di-N-oxide prodrug
    • DOI 10.1016/S0360-3016(98)00308-3, PII S0360301698003083
    • Raleigh, S. M., E. Wanogho, M. D. Burke, S. R. McKeown, and L. H. Patterson: Involvement of human cytochromes P450 (CYP) in the reductive metabolism of AQ4N, a hypoxia activated anthraquinone di-N-oxide prodrug. Int J Radiat Oncol Biol Phys 42, 763-767 (1998) (Pubitemid 28559413)
    • (1998) International Journal of Radiation Oncology Biology Physics , vol.42 , Issue.4 , pp. 763-767
    • Raleigh, S.M.1    Wanogho, E.2    Burke, M.D.3    McKeown, S.R.4    Patterson, L.H.5
  • 186
    • 0029054994 scopus 로고
    • AQ4N: An alkylaminoanthraquinone N-oxide showing bioreductive potential and positive interaction with radiation in vivo
    • McKeown, S. R., M. V. Hejmadi, I. A. McIntyre, J. J. McAleer, and L. H. Patterson: AQ4N: an alkylaminoanthraquinone N-oxide showing bioreductive potential and positive interaction with radiation in vivo. Br J Cancer 72, 76-81 (1995)
    • (1995) Br J Cancer , vol.72 , pp. 76-81
    • McKeown, S.R.1    Hejmadi, M.V.2    McIntyre, I.A.3    McAleer, J.J.4    Patterson, L.H.5
  • 191
    • 0027160629 scopus 로고
    • Hypoxia-selective antitumor agents. 7. Metal complexes of aliphatic mustards as a new class of hypoxia-selective cytotoxins. Synthesis and evaluation of cobalt(III) complexes of bidentate mustards
    • Ware, D. C., B. D. Palmer, W. R. Wilson, and W. A. Denny: Hypoxia-selective antitumor agents. 7. Metal complexes of aliphatic mustards as a new class of hypoxiaselective cytotoxins. Synthesis and evaluation of cobalt (III) complexes of bidentate mustards. J Med Chem 36, 1839-1846 (1993) (Pubitemid 23203741)
    • (1993) Journal of Medicinal Chemistry , vol.36 , Issue.13 , pp. 1839-1846
    • Ware, D.C.1    Palmer, B.D.2    Wilson, W.R.3    Denny, W.A.4
  • 192
    • 0029931345 scopus 로고    scopus 로고
    • Pulse radiolysis studies on the hypoxia-selective toxicity of a colbalt - mustard complex
    • Anderson, R. F., W. A. Denny, D. C. Ware, and W. R. Wilson: Pulse radiolysis studies on the hypoxia-selective toxicity of a cobalt-mustard complex. Br J Cancer Suppl. 27, S48-S51 (1996) (Pubitemid 26237926)
    • (1996) British Journal of Cancer , vol.74 , Issue.SUPPL. XXVII
    • Anderson, R.F.1    Denny, W.A.2    Ware, D.C.3    Wilson, W.R.4
  • 194
    • 0025248106 scopus 로고
    • Cytosolic NAD(P)H:(quinone-acceptor)Oxidoreductase in human normal and tumor tissue: Effects of cigarette smoking and alcohol
    • Schlager, J. J., and G. Powis: Cytosolic NAD (P) H: (quinone-acceptor) oxidoreductase in human normal and tumour tissue: effects of cigarette smoking and alcohol. Int J Cancer 45, 403-409 (1990) (Pubitemid 20087182)
    • (1990) International Journal of Cancer , vol.45 , Issue.3 , pp. 403-409
    • Schlager, J.J.1    Powis, G.2
  • 195
    • 0034652379 scopus 로고    scopus 로고
    • Hypoxia-dependent retinal toxicity of bioreductive anticancer prodrugs in mice
    • DOI 10.1006/taap.1999.8834
    • Lee, A. E., and W. R. Wilson: Hypoxia-dependent retinal toxicity of bioreductive anticancer prodrugs in mice. Toxicol Appl Pharmacol 163, 50-59 (2000) (Pubitemid 30111976)
    • (2000) Toxicology and Applied Pharmacology , vol.163 , Issue.1 , pp. 50-59
    • Lee, A.E.1    Wilson, W.R.2
  • 196
    • 0027981814 scopus 로고
    • Oxygen dependence of the cytotoxicity and metabolic activation of 4-alkylamino-5-nitroquinoline bioreductive drugs
    • Siim, B. G., G. J. Atwell, and W. R. Wilson: Oxygen dependence of the cytotoxicity and metabolic activation of 4-alkylamino-5-nitroquinoline bioreductive drugs. Br J Cancer 70, 596-603 (1994) (Pubitemid 24305583)
    • (1994) British Journal of Cancer , vol.70 , Issue.4 , pp. 596-603
    • Siim, B.G.1    Atwell, G.J.2    Wilson, W.R.3
  • 197
    • 0023741181 scopus 로고
    • Oxygen and exposure kinetics as factors influencing the cytotoxicity of porfiromycin, a mitomycin C analogue, in Chinese hamster ovary cells
    • Marshall, R. S., and A. M. Rauth: Oxygen and exposure kinetics as factors influencing the cytotoxicity of porfiromycin, a mitomycin C analogue, in Chinese hamster ovary cells. Cancer Res 48, 5655-5659 (1988)
    • (1988) Cancer Res , vol.48 , pp. 5655-5659
    • Marshall, R.S.1    Rauth, A.M.2
  • 198
    • 0021180633 scopus 로고
    • Effect of oxygen on misonidazole chemosensitization and cytotoxicity in vitro
    • Mulcahy, R. T.: Effect of oxygen on misonidazole chemosensitization and cytotoxicity in vitro. Cancer Res 44, 4409-4413 (1984) (Pubitemid 14008757)
    • (1984) Cancer Research , vol.44 , Issue.10 , pp. 4409-4413
    • Mulcahy, R.T.1
  • 199
    • 0019978257 scopus 로고
    • Oxygen tension, cellular respiration, and redox state as variables influencing the cytotoxicity of the radiosensitizer misonidazole
    • DOI 10.2307/3575819
    • Taylor, Y. C., and A. M. Rauth: Oxygen tension, cellular respiration, and redox state as variables influencing the cytotoxicity of the radiosensitizer misonidazole. Radiat Res 91, 104-123 (1982) (Pubitemid 12092075)
    • (1982) Radiation Research , vol.91 , Issue.1 , pp. 104-123
    • Taylor, Y.C.1    Rauth, A.M.2
  • 200
    • 0031706557 scopus 로고    scopus 로고
    • Radiation-activated prodrugs as hypoxia-selective cytotoxins: Model studies with nitroarylmethyl quaternary salts
    • Wilson, W. R., M. Tercel, R. F. Anderson, and W. A. Denny: Radiation-activated prodrugs as hypoxia-selective cytotoxins: model studies with nitroarylmetyl quaternary salts. Anticancer Drug Des 13, 663-685 (1998) (Pubitemid 28410154)
    • (1998) Anti-Cancer Drug Design , vol.13 , Issue.6 , pp. 663-685
    • Wilson, W.R.1    Tercel, M.2    Anderson, R.F.3    Denny, W.A.4
  • 201
    • 0029884764 scopus 로고    scopus 로고
    • Recent developments in the design of bioreductive drugs
    • Denny, W. A., W. R. Wilson, and M. P. Hay: Recent developments in the design of bioreductive drugs. Br J Cancer Suppl 27, S32-S38 (1996) (Pubitemid 26237923)
    • (1996) British Journal of Cancer , vol.74 , Issue.SUPPL. XXVII
    • Denny, W.A.1    Wilson, W.R.2    Hay, M.P.3
  • 202
    • 0035846072 scopus 로고    scopus 로고
    • Hypoxia-selective antitumor agents. 16. Nitroarylmethyl quaternary salts as bioreductive prodrugs of the alkylating agent mechlorethamine
    • DOI 10.1021/jm010202l
    • Tercel, M., A. E. Lee, A. Hogg, R. F. Anderson, H. H. Lee, B. G. Siim, W. A. Denny, and W. R. Wilson: Hypoxiaselective antitumor agents. 16. Nitroarylmethyl quaternary salts as bioreductive prodrugs of the alkylating agent mechlorethamine. J Med Chem 44, 3511-3522 (2001) (Pubitemid 32947916)
    • (2001) Journal of Medicinal Chemistry , vol.44 , Issue.21 , pp. 3511-3522
    • Tercel, M.1    Lee, A.E.2    Hogg, A.3    Anderson, R.F.4    Lee, H.H.5    Siim, B.G.6    Denny, W.A.7    Wilson, W.R.8
  • 203
    • 0031342637 scopus 로고    scopus 로고
    • Pulse radiolysis studies on the fragmentation of arylmethyl quaternary nitrogen mustards by one-electron reduction in aqueous solution
    • Anderson, R. F., W. A. Denny, W. Li, J. E. Packer, M. Tercel, and W. R. Wilson: Pulse radiolysis studies on the fragmentation of arylmethyl quaternary nitrogen mustards by one-electron reduction in aqueous solution. J Phys Chem 101, 9704-9709 (1997) (Pubitemid 127617212)
    • (1997) Journal of Physical Chemistry A , vol.101 , Issue.50 , pp. 9704-9709
    • Anderson, R.F.1    Denny, W.A.2    Li, W.3    Packer, J.E.4    Tercel, M.5    Wilson, W.R.6
  • 204
    • 0022540198 scopus 로고
    • Potential antitumor agents. 46. Structure-activity relationships for acridine monosubstituted derivatives of the antitumor agent N-[2-(dimethylamino) ethyl]-9-aminoacridine-4-carboxamide
    • Rewcastle, G. W., G. J. Atwell, D. Chambers, B. C. Baguley, and W. A. Denny: Potential antitumor agents. 46. Structure-activity relationships for acridine monosubstituted derivatives of the antitumor agent N-[2-(dimethylamino) ethyl]-9-aminoacridine-4-carboxamide. J Med Chem 29, 472-477 (1986) (Pubitemid 16034763)
    • (1986) Journal of Medicinal Chemistry , vol.29 , Issue.4 , pp. 472-477
    • Rewcastle, G.W.1    Atwell, G.J.2    Chambers, D.3
  • 205
    • 0026718848 scopus 로고
    • 1-(5'-fluoro-6'-hydroxy-5', 6'-dihydrouracil-5'-yl) - 5-fluorouracil, a novel N (1)-C (5)-linked dimer that releases 5-fluorouracil by radiation activation under hypoxic conditions
    • Nishimoto, S. I., H. Hatta, H. Ureshima, and T. Kagiya: 1-(5'-fluoro-6'-hydroxy-5', 6'-dihydrouracil-5'-yl) - 5-fluorouracil, a novel N (1)-C (5)-linked dimer that releases 5-fluorouracil by radiation activation under hypoxic conditions. J Med Chem 35, 2711-2712 (1992)
    • (1992) J Med Chem , vol.35 , pp. 2711-2712
    • Nishimoto, S.I.1    Hatta, H.2    Ureshima, H.3    Kagiya, T.4
  • 206
    • 0034024791 scopus 로고    scopus 로고
    • A novel class of antitumor prodrug, 1-(2'-oxopropyl)-5-fluorouracil (OFU001), that releases 5-fluorouracil upon hypoxic irradiation
    • Shibamoto, Y., L. Zhou, H. Hatta, M. Mayuko, and S. Nishimoto: A novel class of antitumor prodrug, 1-(2'-oxopropyl)-5-fluorouracil (OFU001), that releases 5-fluorouracil upon hypoxic irradiation. Jpn J Cancer Res 91, 433-438 (2000) (Pubitemid 30312696)
    • (2000) Japanese Journal of Cancer Research , vol.91 , Issue.4 , pp. 433-438
    • Shibamoto, Y.1    Zhou, L.2    Hatta, H.3    Mori, M.4    Nishimoto, S.5
  • 208
    • 0035254229 scopus 로고    scopus 로고
    • In vivo evaluation of a novel antitumor prodrug, 1-(2'-oxopropyl)-5- fluorouracil (OFU001), which releases 5-fluorouracil upon hypoxic irradiation
    • DOI 10.1016/S0360-3016(00)01490-5, PII S0360301600014905
    • Shibamoto, Y., L. Zhou, H. Hatta, M. Mori, and S. Nishimoto: In vivo evaluation of a novel antitumor prodrug, 1-(2'-oxopropyl)-5-fluorouracil (OFU001), which releases 5-fluorouracil upon hypoxic irradiation. Int J Radiat Biol Phys 49, 407-413 (2001) (Pubitemid 32120237)
    • (2001) International Journal of Radiation Oncology Biology Physics , vol.49 , Issue.2 , pp. 407-413
    • Shibamoto, Y.1    Zhou, L.2    Hatta, H.3    Mori, M.4    Nishimoto, S.-I.5
  • 209
    • 33646497001 scopus 로고    scopus 로고
    • Radiolytic and cellular reduction of a novel hypoxia-activated cobalt (III) prodrug of a chloromethylbenzindoline DNA minor groove alkylator
    • Ahn, G. O., K. J. Botting, A. V. Patterson, D. C. Ware, M. Tercel, and W. R. Wilson: Radiolytic and cellular reduction of a novel hypoxia-activated cobalt (III) prodrug of a chloromethylbenzindoline DNA minor groove alkylator. Biochem Pharmacol 71, 1683-1694 (2006)
    • (2006) Biochem Pharmacol , vol.71 , pp. 1683-1694
    • Ahn, G.O.1    Botting, K.J.2    Patterson, A.V.3    Ware, D.C.4    Tercel, M.5    Wilson, W.R.6
  • 210
    • 80051529236 scopus 로고    scopus 로고
    • Plasma pharmacokinetics, tissue disposition, and extracellular diffusion properties of the hypoxia-activated prodrug SN 27892, a cobalt (III) complex of a potent DNA minor groove alkylator
    • Ahn, G., D. C. Ware, K. J. Botting, S. M. Stribbling, K. O. Hicks, and W. R. Wilson: Plasma pharmacokinetics, tissue disposition, and extracellular diffusion properties of the hypoxia-activated prodrug SN 27892, a cobalt (III) complex of a potent DNA minor groove alkylator. Cancer Chemother Pharmacol In preparation (2006)
    • (2006) Cancer Chemother Pharmacol in Preparation
    • Ahn, G.1    Ware, D.C.2    Botting, K.J.3    Stribbling, S.M.4    Hicks, K.O.5    Wilson, W.R.6
  • 211
    • 0038685423 scopus 로고    scopus 로고
    • Prodrugs for gene-directed enzyme-prodrug therapy (suicide gene therapy)
    • DOI 10.1155/S1110724303209098, PII S1110724303209098
    • Denny, W. A.: Prodrugs for Gene-Directed Enzyme-Prodrug Therapy (Suicide Gene Therapy). J Biomed Biotechnol 2003, 48-70 (2003) (Pubitemid 36828274)
    • (2003) Journal of Biomedicine and Biotechnology , vol.2003 , Issue.1 , pp. 48-70
    • Denny, W.A.1
  • 212
    • 0345257217 scopus 로고    scopus 로고
    • How to Overcome (and Exploit) Tumor Hypoxia for Targeted Gene Therapy
    • DOI 10.1002/jcp.10374
    • Greco, O., B. Marples, M. C. Joiner, and S. D. Scott: How to overcome (and exploit) tumor hypoxia for targeted gene therapy. J Cell Physiol 197, 312-325 (2003) (Pubitemid 37487030)
    • (2003) Journal of Cellular Physiology , vol.197 , Issue.3 , pp. 312-325
    • Greco, O.1    Marples, B.2    Joiner, M.C.3    Scott, S.D.4
  • 214
    • 0026468180 scopus 로고
    • A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    • Semenza, G. L., and G. L. Wang: A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 12, 5447-5454 (1992)
    • (1992) Mol Cell Biol , vol.12 , pp. 5447-5454
    • Semenza, G.L.1    Wang, G.L.2
  • 216
    • 1242271216 scopus 로고    scopus 로고
    • Hypoxia Targeted Gene Therapy to Increase the Efficacy of Tirapazamine as an Adjuvant to Radiotherapy: Reversing Tumor Radioresistance and Effecting Cure
    • DOI 10.1158/0008-5472.CAN-03-2698
    • Cowen, R. L., K. J. Williams, E. C. Chinje, M. Jaffar, F. C. D. Sheppard, B. A. Telfer, N. S. Wind, and I. J. Stratford: Hypoxia targeted gene therapy to increase the efficacy of tirapazamine as an adjuvant to radiotherapy: Reversing tumor resistance and effecting cure. Cancer Res 64, 1396-1402 (2004) (Pubitemid 38235608)
    • (2004) Cancer Research , vol.64 , Issue.4 , pp. 1396-1402
    • Cowen, R.L.1    Williams, K.J.2    Chinje, E.C.3    Jaffar, M.4    Sheppard, F.C.D.5    Telfer, B.A.6    Wind, N.S.7    Stratford, I.J.8
  • 218
    • 0029932035 scopus 로고    scopus 로고
    • Anaerobic bacteria as a delivery system for cancer gene therapy: In vitro activation of 5-fluorocytosine by genetically engineered clostridia
    • Fox, M. E., M. J. Lemmon, M. L. Mauchline, T. O. Davis, A. J. Giaccia, N. P. Minton, and J. M. Brown: Anaerobic bacteria as a delivery system for cancer gene therapy: activation of 5-fluorocytosine by genetically engineered clostridia. Gene Therapy 3, 173-178 (1996) (Pubitemid 26117427)
    • (1996) Gene Therapy , vol.3 , Issue.2 , pp. 173-178
    • Fox, M.E.1    Lemmon, M.J.2    Mauchline, M.L.3    Davis, T.O.4    Giaccia, A.J.5    Minton, N.P.6    Brown, J.M.7
  • 220
    • 0018098489 scopus 로고
    • The liquefaction (oncolysis) of malignant gliomas by a non pathogenic Clostridium
    • Heppner, F., and J. R. Mose: The liquefaction (oncolysis) of malignant gliomas by a non pathogenic clostridium. Acta Neuro 12, 123-125 (1978) (Pubitemid 8377876)
    • (1978) Acta Neurochirurgica , vol.42 , Issue.1-2 , pp. 123-125
    • Heppner, F.1    Mose, J.R.2
  • 222
    • 0030865697 scopus 로고    scopus 로고
    • Anaerobic bacteria as a gene delivery system that is controlled by the tumor microenvironment
    • Lemmon, M. L., P. Van Zijl, M. E. Fox, M. L. Mauchline, A. J. Giaccia, N. P. Minton, and J. M. Brown: Anaerobic bacteria as a gene delivery system that is controlled by the tumor microenvironment. Gene Thrapy 4, 791-796 (1997) (Pubitemid 27380161)
    • (1997) Gene Therapy , vol.4 , Issue.8 , pp. 791-796
    • Lemmon, M.J.1    Van Zijl, P.2    Fox, M.E.3    Mauchline, M.L.4    Giaccia, A.J.5    Minton, N.P.6    Brown, J.M.7
  • 223
    • 85047697737 scopus 로고    scopus 로고
    • Anticancer efficacy of systemically delivered anaerobic bacteria as gene therapy vectors targeting tumor hypoxia/necrosis
    • DOI 10.1038/sj/gt/3301659
    • Liu, S. C., N. P. Minton, A. J. Giaccia, and J. M. Brown: Anticancer efficacy of systemically delivered anaerobic bacteria as gene therapy vectors targeting tumor hypoxia/necrosis. Gene Therapy 9, 291-296 (2002) (Pubitemid 34256904)
    • (2002) Gene Therapy , vol.9 , Issue.4 , pp. 291-296
    • Liu, S.-C.1    Minton, N.P.2    Giaccia, A.J.3    Brown, J.M.4
  • 224
    • 80051491614 scopus 로고    scopus 로고
    • Enhanced antitumor activity of 5-FC by genetically engineered anaerobic bacteria C. sporogenes expressing cytosine deaminase when combined with a vascular targeting agent, ZD6126 or DMXAA
    • Miami, FL
    • Ahn, G. O., S. C. Liu, D. Menke, M. J. Dorie, and J. M. Brown (2004). Enhanced antitumor activity of 5-FC by genetically engineered anaerobic bacteria C. sporogenes expressing cytosine deaminase when combined with a vascular targeting agent, ZD6126 or DMXAA. 2nd International Conference on Vascular Targeting: Miami, FL.
    • (2004) 2nd International Conference on Vascular Targeting
    • Ahn, G.O.1    Liu, S.C.2    Menke, D.3    Dorie, M.J.4    Brown, J.M.5
  • 225
    • 0035023209 scopus 로고    scopus 로고
    • Specific targeting of cytosine deaminase to solid tumors by engineered Clostridium acetobutylicum
    • DOI 10.1038/sj.cgt.7700303
    • Theys, J., W. Landuyt, S. Nuyts, L. Van Mellaert, A. van Oosterom, P. Lambin, and J. Anne: Specific targeting of cytosine deaminase to solid tumors by engineered Clostridium acetobutylicum. Cancer Gene Ther 8, 294-297 (2001) (Pubitemid 32480066)
    • (2001) Cancer Gene Therapy , vol.8 , Issue.4 , pp. 294-297
    • Theys, J.1    Landuyt, W.2    Nuyts, S.3    Van Mellaert, L.4    Van Oosterom, A.5    Lambin, P.6    Anne, J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.