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Volumn 1, Issue 7, 2005, Pages 371-376

Monocarboxylate Transporter Mctl is a Target for Immunosuppression

(27)  Murray, Clare M a   Hutchinson, Raymond a   Bantick, John R a   Belfield, Graham P a   Benjamin, Amanda D a   Brazma, Diana a,b   Bundick, Robert V a   Cook, I David a   Craggs, Robert I a   Edwards, Susan a   Evans, Leslie R a,c   Harrison, Richard a   Holness, Elain a   Jackson, Andrew P a   Jackson, Clive G a   Kingston, Lee P a   Perry, Matthew W D a   Ross, Andrew R J a   Rugman, Paul A a   Sidhu, Sasvinder S a   more..


Author keywords

[No Author keywords available]

Indexed keywords

COTRANSPORTER; IMMUNOSUPPRESSIVE AGENT; LACTIC ACID DERIVATIVE; MONOCARBOXYLATE TRANSPORT PROTEIN 1; MONOCARBOXYLATE TRANSPORTER; RECOMBINANT PROTEIN;

EID: 33644790739     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio744     Document Type: Article
Times cited : (218)

References (29)
  • 1
    • 1242340302 scopus 로고    scopus 로고
    • The SLC16 gene family - from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond
    • Halestrap, A.P. & Meredith, D. The SLC16 gene family - from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch. 447, 619-628 (2004).
    • (2004) Pflugers Arch , vol.447 , pp. 619-628
    • Halestrap, A.P.1    Meredith, D.2
  • 2
    • 0029050389 scopus 로고
    • Novel inhibitors of the nuclear factor of activated T cells (NFAT)-mediated transcription of p-galactosidase: Potential immunosuppressive and anti-inflammatory agents
    • Michne, W.F. et al. Novel inhibitors of the nuclear factor of activated T cells (NFAT)-mediated transcription of p-galactosidase: potential immunosuppressive and anti-inflammatory agents. J. Med. Chem. 38, 2557-2569 (1995).
    • (1995) J. Med. Chem. , vol.38 , pp. 2557-2569
    • Michne, W.F.1
  • 5
    • 0014848718 scopus 로고
    • A lymph node weight assay for the graft-versus-host activity of rat lymphoid cells
    • Ford, W.L., Burr, W. & Simonsen, M. A lymph node weight assay for the graft-versus-host activity of rat lymphoid cells. Transplantation 10, 258-266 (1970).
    • (1970) Transplantation , vol.10 , pp. 258-266
    • Ford, W.L.1    Burr, W.2    Simonsen, M.3
  • 7
    • 0028940113 scopus 로고
    • Functional characterization of novel IL-2 transcriptional inhibitors
    • Baine, Y. et al. Functional characterization of novel IL-2 transcriptional inhibitors. J. Immunol. 154, 3667-3677 (1995).
    • (1995) J. Immunol. , vol.154 , pp. 3667-3677
    • Baine, Y.1
  • 8
    • 0347717903 scopus 로고    scopus 로고
    • T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
    • Mempel, T.R., Henrickson, S.E. & von Andrian, U.H. T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 427, 154-159 (2004).
    • (2004) Nature , vol.427 , pp. 154-159
    • Mempel, T.R.1    Henrickson, S.E.2    Von Andrian, U.H.3
  • 10
    • 0033431775 scopus 로고    scopus 로고
    • Overexpression of monocarbox-ylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in β cells
    • Ishihara, H., Wang, H., Drewes, L.R. & Wollheim, C.B. Overexpression of monocarbox-ylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in β cells. J. Clin. Invest. 104, 1621-1629 (1999).
    • (1999) J. Clin. Invest. , vol.104 , pp. 1621-1629
    • Ishihara, H.1    Wang, H.2    Drewes, L.R.3    Wollheim, C.B.4
  • 12
    • 0033569442 scopus 로고    scopus 로고
    • The proton-linked monocarboxylate transporter (MCT) family: Structure, function and regulation
    • Halestrap, A.P. & Price, N.T. The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem. J. 343, 281-299 (1999).
    • (1999) Biochem. J. , vol.343 , pp. 281-299
    • Halestrap, A.P.1    Price, N.T.2
  • 13
    • 0027511220 scopus 로고
    • The role of the Crabtree effect and an endogenous fuel inthe energymetabolism of resting and proliferating thymocytes
    • Guppy, M., Greiner, E. & Brand, K. The role of the Crabtree effect and an endogenous fuel in the energymetabolism of resting and proliferating thymocytes. Eur. J. Biochem. 212, 95-99 (1993).
    • (1993) Eur. J. Biochem. , vol.212 , pp. 95-99
    • Guppy, M.1    Greiner, E.2    Brand, K.3
  • 14
    • 0027474296 scopus 로고
    • Metabolic changes in activated T cells: An NMR study of human peripheral blood lymphocytes
    • Bental, M. & Deutsch, C. Metabolic changes in activated T cells: an NMR study of human peripheral blood lymphocytes. Magn. Reson. Med. 29, 317-326 (1993).
    • (1993) Magn. Reson. Med. , vol.29 , pp. 317-326
    • Bental, M.1    Deutsch, C.2
  • 15
    • 0036069699 scopus 로고    scopus 로고
    • The CD28 signaling pathway regulates glucose metabolism
    • Frauwirth, K.A. et al. The CD28 signaling pathway regulates glucose metabolism. Immunity16, 769-777 (2002).
    • (2002) Immunity16 , pp. 769-777
    • Frauwirth, K.A.1
  • 16
    • 7144253117 scopus 로고    scopus 로고
    • Lactic acid efflux from white skeletal muscle is catalyzed by themonocarboxylate transporter isoform MCT3
    • Wilson, M.C. et al. Lactic acid efflux from white skeletal muscle is catalyzed by the monocarboxylate transporter isoform MCT3. J. Biol. Chem. 273, 15920-15926 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 15920-15926
    • Wilson, M.C.1
  • 17
    • 0034663601 scopus 로고    scopus 로고
    • The low-affinitymonocarboxylate transporter MCT4 is adapted to the export of lactate in highlyglycolytic cells
    • Dimmer, K-S., Friedrich, B., Lang, F., Deitmer, J.W. & Broer, S. The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells. Biochem. J. 350, 219-227 (2000).
    • (2000) Biochem. J. , vol.350 , pp. 219-227
    • Dimmer, K.-S.1    Friedrich, B.2    Lang, F.3    Deitmer, J.W.4    Broer, S.5
  • 18
    • 0034525940 scopus 로고    scopus 로고
    • Characterisation of human mono-carboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle
    • Manning Fox, J.E., Meredith, D. & Halestrap, A.P. Characterisation of human mono-carboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle. J. Physiol. (Lond.) 529, 285-293 (2000).
    • (2000) J. Physiol. (Lond.) , vol.529 , pp. 285-293
    • Manning Fox, J.E.1    Meredith, D.2    Halestrap, A.P.3
  • 20
    • 0028802746 scopus 로고
    • A hierarchy of ATP-consuming processes in mammalian cells
    • Buttgereit, F. & Brand, M.D. A hierarchy of ATP-consuming processes in mammalian cells. Biochem. J. 312, 163-167 (1995).
    • (1995) Biochem. J. , vol.312 , pp. 163-167
    • Buttgereit, F.1    Brand, M.D.2
  • 21
    • 0029585361 scopus 로고
    • Importance of ribonu-cleotide availability to proliferating T-lymphocytes from healthy humans. Dispropor-tionate expansion of pyrimidine pools and contrasting effects of de novo synthesisinhibitors
    • Fairbanks, L.D., Bofill, M., Ruckemann, K. & Simmonds, H.A. Importance of ribonu-cleotide availability to proliferating T-lymphocytes from healthy humans. Dispropor-tionate expansion of pyrimidine pools and contrasting effects of de novo synthesis inhibitors. J. Biol. Chem. 270, 29682-29689 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 29682-29689
    • Fairbanks, L.D.1    Bofill, M.2    Ruckemann, K.3    Simmonds, H.A.4
  • 22
    • 1842581892 scopus 로고    scopus 로고
    • Regulation of T-lymphocyte metabolism
    • Frauwirth, K.A. & Thompson, C.B. Regulation of T-lymphocyte metabolism. J. Immunol. 172, 4661-4665 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 4661-4665
    • Frauwirth, K.A.1    Thompson, C.B.2
  • 23
    • 0028348441 scopus 로고
    • F-NMR study of primary human T lymphocyte activation: Effects of mitogen on intracellular pH
    • 19F-NMR study of primary human T lymphocyte activation: effects of mitogen on intracellular pH. Am. J. Physiol. 266, C541-C551 (1994).
    • (1994) Am. J. Physiol. , vol.266 , pp. C541-C551
    • Bental, M.1    Deutsch, C.2
  • 24
    • 0041417655 scopus 로고    scopus 로고
    • Monocar-boxylatetransporter 1 mediates biotin uptake in human peripheral blood mononuclear cells
    • Daberkow, R.L., White, B.R., Cederberg, R.A., Griffin, J.B. & Zempleni, J. Monocar-boxylatetransporter 1 mediates biotin uptake in human peripheral blood mononuclear cells. J. Nutr. 133, 2703-2706 (2003).
    • (2003) J. Nutr. , vol.133 , pp. 2703-2706
    • Daberkow, R.L.1    White, B.R.2    Cederberg, R.A.3    Griffin, J.B.4    Zempleni, J.5
  • 25
    • 0023245199 scopus 로고
    • Regulation of T-cell functions by L-lactate
    • Droge, W., Roth, S., Altmann, A. & Mihm, S. Regulation of T-cell functions by L-lactate. Cell. Immunol. 108, 405-416 (1987).
    • (1987) Cell. Immunol. , vol.108 , pp. 405-416
    • Droge, W.1    Roth, S.2    Altmann, A.3    Mihm, S.4
  • 26
    • 0025826956 scopus 로고
    • Regulation of interleukin 2 production, interleukin 2 mRNA expression and intracellular glutathione levels in ex vivo derived T lymphocytes by lactate
    • Roth, S. & Droge, W. Regulation of interleukin 2 production, interleukin 2 mRNA expression and intracellular glutathione levels in ex vivo derived T lymphocytes by lactate. Eur. J. Immunol. 21, 1933-1937 (1991).
    • (1991) Eur. J. Immunol. , vol.21 , pp. 1933-1937
    • Roth, S.1    Droge, W.2
  • 27
    • 0034254638 scopus 로고    scopus 로고
    • CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression
    • Kirk, P. et al. CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression. EMBO J. 19, 3896-3904 (2000).
    • (2000) EMBO J , vol.19 , pp. 3896-3904
    • Kirk, P.1
  • 28
    • 0037094140 scopus 로고    scopus 로고
    • A role for CD147 in thymic development
    • Renno, T. et al. A role for CD147 in thymic development. J. Immunol. 168, 4946-4950 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 4946-4950
    • Renno, T.1
  • 29
    • 0041589484 scopus 로고    scopus 로고
    • Selective inhibition of T cell activation via CD147 through novel modulation of lipid rafts
    • Staffler, G. et al. Selective inhibition of T cell activation via CD147 through novel modulation of lipid rafts. J. Immunol. 171, 1707-1714 (2003).
    • (2003) J. Immunol. , vol.171 , pp. 1707-1714
    • Staffler, G.1


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