Monocarboxylate transporter 4 regulates maturation and trafficking of CD147 to the plasma membrane in the metastatic breast cancer cell line MDA-MB-231

Cancer Research

Volumn 67, Issue 9, 2007, Pages 4182-4189

  Gallagher, Shannon M ^a   Castorino, John J ^a   Wang, Dian ^a   Philp, Nancy J ^a,b  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD147 ANTIGEN; HYALURONIC ACID; MATRIX METALLOPROTEINASE; MESSENGER RNA; MONOCARBOXYLATE TRANSPORTER 4;

ANGIOGENESIS; ARTICLE; BREAST CANCER; BREAST METASTASIS; CANCER CELL; CELL MATURATION; CELL MEMBRANE; CELL MIGRATION; CELL SURFACE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LYSOSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ANTIGENS, CD147; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MEMBRANE; CELL MOVEMENT; GENE SILENCING; HL-60 CELLS; HUMANS; K562 CELLS; MONOCARBOXYLIC ACID TRANSPORTERS; MUSCLE PROTEINS; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 34249293335     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-3184     Document Type: Article

References (46)

1. Plas DR, Thompson CB. Akt-dependent transformation: there is more to growth than just surviving. Oncogene 2005;24:7435-42.
2. Semenza GL, Artemov D, Bedi A, et al. 'The metabolism of tumours': 70 years later. Novartis Found Symp 2001;240:251-60; discussion 260-4.
3. Warburg O. On respiratory impairment in cancer cells. Science 1956;124:269-70.
4. Czernin J, Phelps ME. Positron emission tomography scanning: current and future applications. Annu Rev Med 2002;53:89-112.
5. Halestrap AP, Meredith D. The SLC16 gene family - from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch 2004;447:619-28.
6. Enerson BE, Drewes LR. Molecular features, regulation, and function of monocarboxylate transporters: implications for drug delivery. J Pharm Sci 2003;92:1531-44.
7. +-linked monocarboxylate transporter (MCT1/SLC16A1): a potential therapeutic target for high-risk neuroblastoma. Mol Pharmacol 2006;70:2108-15.
8. Koukourakis MI, Giatromanolaki A, Harris AL, Sivridis E. Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma. Cancer Res 2006;66:632-7.
9. Philp NJ, Ochrietor JD, Rudoy C, Muramatsu T, Linser PJ. Loss of MCT1, MCT3, and MCT4 expression in the retinal pigment epithelium and neural retina of the 5A11/basigin-null mouse. Invest Ophthalmol Vis Sci 2003;44:1305-11.
10. Dimmer KS, Friedrich B, Lang F, Deitmer JW, Broer S. The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells. Biochem J 2000;350 Pt 1:219-27.
11. Kirk P, Wilson MC, Heddle C, Brown MH, Barclay AN, Halestrap AP. CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression. EMBO J 2000;19:3896-904.
12. Halestrap AP, Price NT. The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem J 1999;343 Pt 2:281-99.
13. Kim JW, Dang CV. Multifaceted roles of glycolytic enzymes. Trends Biochem Sci 2005;30:142-50.
14. Biswas C, Zhang Y, DeCastro R, et al. The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily. Cancer Res 1995;55:434-9.
15. Yan L, Zucker S, Toole BP. Roles of the multifunctional glycoprotein, emmprin (basigin; CD147), in tumour progression. Thromb Haemost 2005;93:199-204.
16. Tang Y, Kesavan P, Nakada MT, Yan L. Tumor-stroma interaction: positive feedback regulation of extracellular matrix metalloproteinase inducer (EMMPRIN) expression and matrix metalloproteinase-dependent generation of soluble EMMPRIN. Mol Cancer Res 2004;2:73-80.
17. Deora AA, Philp N, Hu J, Bok D, Rodriguez-Boulan E. Mechanisms regulating tissue-specific polarity of monocarboxylate transporters and their chaperonc CD147 in kidney and retinal epithelia. Proc Natl Acad Sci U S A 2005;102:16245-50.
18. Wilson MC, Meredith D, Fox JE, Manoharan C, Davies AJ, Halestrap AP. Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70). J Biol Chem 2005;280:27213-21.
19. Wilson MC, Meredith D, Halestrap AP. Fluorescence resonance energy transfer studies on the interaction between the lactate transporter MCT1 and CD147 provide information on the topology and stoichiometry of the complex in situ. J Biol Chem 2002;277:3666-72.
20. Philp NJ, Wang D, Yoon H, Hjelmeland LM. Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells. Invest Ophthalmol Vis Sci 2003;44:1716-21.
21. Sidhu SS, Mengistab AT, Tauscher AN, LaVail J, Basbaum C. The microvesicle as a vehicle for EMMPRIN in tumor-stromal interactions. Oncogene 2004;23:956-63.
22. Dolo V, Ginestra A, Ghersi G, Nagase H, Vittorelli MI. Human breast carcinoma cells cultured in the presence of serum shed membrane vesicles rich in gelatinolytic activities. J Submicrosc Cytol Pathol 1994;26:173-80.
23. Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis? Nat Rev Cancer 2004;4:891-9.
24. Dolo V, DAscenzo S, Violini S, et al. Matrix-degrading proteinases are shed in membrane vesicles by ovarian cancer cells in vivo and in vitro. Clin Exp Metastasis 1999;17:131-40.
25. Ginestra A, La Placa MD, Saladino F, Cassara D, Nagase H, Vittorelli ML. The amount and proteolytic content of vesicles shed by human cancer cell lines correlates with their in vitro invasiveness. Anticancer Res 1998;18:3433-7.
26. Xu D, Hemler ME. Metabolic activation-related CD147-CD98 complex. Mol Cell Proteomics 2005;4:1061-71.
27. 1-integrins, and CD147 in the induction of U937 homotypic aggregation. Blood 2001;98:374-82.
28. Riethdorf S, Reimers N, Assmann V, et al. High incidence of EMMPRIN expression in human tumors. Int J Cancer 2006;119:1800-10.
29. Nabeshima K, Iwasaki H, Koga K, Hojo H, Suzumiya J, Kikuchi M. Emmprin (basigin/CD147): matrix metalloproteinase modulator and multifunctional cell recognition molecule that plays a critical role in cancer progression. Pathol Int 2006;56:359-67.
30. Zucker S, Hymowitz M, Rollo EE, et al. Tumorigenic potential of extracellular matrix metalloproteinase inducer. Am J Pathol 2001;158:1921-8.
31. Pushkarsky T, Yurchenko V, Vanpouille C, et al. Cell surface expression of CD147/EMMPRIN is regulated by cyclophilin 60. J Biol Chem 2005;280:27866-71.
32. Tang W, Chang SB, Hemler ME. Links between CD147 function, glycosylation, and caveolin-1. Mol Biol Cell 2004;15:4043-50.
33. Fanelli A, Grollman EF, Wang D, Philp NJ. MCT1 and its accessory protein CD147 are differentially regulated by TSH in rat thyroid cells. Am J Physiol Endocrinol Metab 2003;285:E1223-9.
34. Padbury JF, Diah SK, McGonnigal B, et al. Transcriptional regulation of the LAT-1/CD98 light chain. Biochem Biophys Res Commun 2004;318:529-34.
35. Beckner ME, Stracke ML, Liotta LA, Schiffmann E. Glycolysis as primary energy source in tumor cell chemotaxis. J Natl Cancer Inst 1990;82:1836-40.
36. Nguyen TN, Wang HJ, Zalzal S, Nanci A, Nabi IR. Purification and characterization of β-actin-rich tumor cell pseudopodia: role of glycolysis. Exp Cell Res 2000;258:171-83.
37. Betapudi V, Licate LS, Egelhoff TT. Distinct roles of nonmuscle myosin II isoforms in the regulation of MDA-MB-231 breast cancer cell spreading and migration. Cancer Res 2006;66:4725-33.
38. Stock C, Gassner B, Hauck CR, et al. Migration of human melanoma cells depends on extracellular pH and Na+/H+ exchange. J Physiol 2005;567:225-38.
39. Fantin VR, St-Pierre J, Leder P. Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell 2006;9:425-34.
40. Udabage L, Brownlee GR, Waltham M, et al. Antisense-mediated suppression of hyaluronan synthase 2 inhibits the tumorigenesis and progression of breast cancer. Cancer Res 2005;65:6139-50.
41. Hochachka PW, Rupert JL, Goldenberg L, Gleave M, Kozlowski P. Going malignant: the hypoxia-cancer connection in the prostate. Bioessays 2002;24:749-57.
42. Ullah MS, Davies AJ, Halestrap AP. The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1α-dependent mechanism. J Biol Chem 2006;281:9030-7.
43. Jamerson MH, Johnson MD, Dickson RB. Of mice and myc: c-Myc and mammary tumorigenesis. J Mammary Gland Biol Neoplasia 2004;9:27-37.
44. Liao DJ, Dickson RB. c-myc in breast cancer. Endocr Relat Cancer 2000;7:143-64.
45. Moeller LC, Dumitrescu AM, Refetoff S. Cytosolic action of thyroid hormone leads to induction of hypoxia-inducible factor-1α and glycolytic genes. Mol Endocrinol 2005;19:2955-63.
46. Hausmann S, Claus R, Walzel H. Short-term culture of surface-biotinylated cells: application in non-radioactive analysis of surface protein shedding. Immunol Lett 1995;48:175-80.