Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: Demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds

Carcinogenesis

Volumn 30, Issue 9, 2009, Pages 1571-1580

  Macleod, A Kenneth ^a   Mcmahon, Michael ^a   Plummer, Simon M ^b   Higgins, Larry G ^a   Penning, Trevor M ^c   Igarashi, Kazuhiko ^d   Hayes, John D ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b CXR Biosciences Ltd   (United Kingdom)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACROLEIN; ALDEHYDE KETONE REDUCTASE; BRIC A BRAC AND CAP' N' COLLAR HOMOLOGY 1; CHLORAMBUCIL; CUMENE HYDROPEROXIDE; ELECTROPHILE; GENE PRODUCT; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; HEME OXYGENASE 1; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MENADIONE; MESSENGER RNA; OXIDOREDUCTASE; PROTEIN AKR1B10; PROTEIN AKR1C1; PROTEIN AKR1C2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; 3 ALPHA BETA, 20 BETA HYDROXYSTEROID DEHYDROGENASE; 3 ALPHA-BETA, 20 BETA-HYDROXYSTEROID DEHYDROGENASE; 3ALPHA(OR 20BETA) HYDROXYSTEROID DEHYDROGENASE; AKR1C2 PROTEIN, HUMAN; BACH1 PROTEIN, HUMAN; BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; FANCONI ANEMIA PROTEIN; HMOX1 PROTEIN, HUMAN; HYDROXYSTEROID DEHYDROGENASE; KEAP1 PROTEIN, HUMAN; KERATIN; NFE2L2 PROTEIN, HUMAN; SIGNAL PEPTIDE;

ARTICLE; CATALYSIS; CELL PROTECTION; CONTROLLED STUDY; GENE IDENTIFICATION; GLUTATHIONE METABOLISM; HOMEOSTASIS; HUMAN; HUMAN CELL; KERATINOCYTE; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; TRANSCRIPTION INITIATION; UPREGULATION; CELL CULTURE; DNA RESPONSIVE ELEMENT; GENE EXPRESSION PROFILING; GENETICS; METABOLISM; NEOPLASM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

20-HYDROXYSTEROID DEHYDROGENASES; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELLS, CULTURED; CYTOPROTECTION; FANCONI ANEMIA COMPLEMENTATION GROUP PROTEINS; GENE EXPRESSION PROFILING; GLUTATHIONE; HEME OXYGENASE-1; HUMANS; HYDROXYSTEROID DEHYDROGENASES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KERATINOCYTES; KERATINS; NEOPLASMS; NF-E2-RELATED FACTOR 2; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION;

EID: 70249138697     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgp176     Document Type: Article

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