메뉴 건너뛰기




Volumn 16, Issue 23, 2010, Pages 5624-5629

Targeting hypoxic cells through the DNA damage response

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; ATR PROTEIN; AZD 7762; CHECKPOINT KINASE 1; DNA; GEMCITABINE; HISTONE H2AX; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NUCLEOTIDE; PROTEIN INHIBITOR; PROTEIN P53; RADIOSENSITIZING AGENT; UNCLASSIFIED DRUG; VELIPARIB;

EID: 78650333871     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-10-0286     Document Type: Review
Times cited : (96)

References (60)
  • 2
    • 0032053823 scopus 로고    scopus 로고
    • The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy
    • Brown JM, Giaccia AJ. The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Cancer Res 1998;58:1408-16.
    • (1998) Cancer Res , vol.58 , pp. 1408-1416
    • Brown, J.M.1    Giaccia, A.J.2
  • 3
    • 0029775242 scopus 로고    scopus 로고
    • Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
    • Hockel M, Schlenger K, Aral B, Mitze M, Schaffer U, Vaupel P. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 1996;56:4509-15.
    • (1996) Cancer Res , vol.56 , pp. 4509-4515
    • Hockel, M.1    Schlenger, K.2    Aral, B.3    Mitze, M.4    Schaffer, U.5    Vaupel, P.6
  • 4
    • 0030022252 scopus 로고    scopus 로고
    • Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma
    • Brizel DM, Scully SP, Harrelson JM, et al. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res 1996;56:941-3.
    • (1996) Cancer Res , vol.56 , pp. 941-943
    • Brizel, D.M.1    Scully, S.P.2    Harrelson, J.M.3
  • 5
    • 33646365644 scopus 로고    scopus 로고
    • Lysyl oxidase is essential for hypoxia-induced metastasis
    • Erler JT, Bennewith KL, Nicolau M, et al. Lysyl oxidase is essential for hypoxia-induced metastasis. Nature 2006;440:1222-6.
    • (2006) Nature , vol.440 , pp. 1222-1226
    • Erler, J.T.1    Bennewith, K.L.2    Nicolau, M.3
  • 8
    • 0024408986 scopus 로고
    • Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
    • Vaupel P, Kallinowski F, Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 1989;49:6449-65.
    • (1989) Cancer Res , vol.49 , pp. 6449-6465
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 10
    • 24344488419 scopus 로고    scopus 로고
    • The HIF pathway in cancer
    • Maxwell PH. The HIF pathway in cancer. Semin Cell Dev Biol 2005;16:523-30.
    • (2005) Semin Cell Dev Biol , vol.16 , pp. 523-530
    • Maxwell, P.H.1
  • 11
    • 34047156190 scopus 로고    scopus 로고
    • HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity
    • Gordan JD, Bertout JA, Hu CJ, Diehl JA, Simon MC. HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell 2007;11:335-47.
    • (2007) Cancer Cell , vol.11 , pp. 335-347
    • Gordan, J.D.1    Bertout, J.A.2    Hu, C.J.3    Diehl, J.A.4    Simon, M.C.5
  • 12
    • 33746886623 scopus 로고    scopus 로고
    • "Translating" tumor hypoxia: Unfolded protein response (UPR)-dependent and UPR-independent pathways
    • Koumenis C, Wouters BG. "Translating" tumor hypoxia: unfolded protein response (UPR)-dependent and UPR-independent pathways. Mol Cancer Res 2006;4:423-36.
    • (2006) Mol Cancer Res , vol.4 , pp. 423-436
    • Koumenis, C.1    Wouters, B.G.2
  • 13
    • 17144416875 scopus 로고    scopus 로고
    • Anoxia is necessary for tumor cell toxicity caused by a low-oxygen environment
    • Papandreou I, Krishna C, Kaper F, Cai D, Giaccia AJ, Denko NC. Anoxia is necessary for tumor cell toxicity caused by a low-oxygen environment. Cancer Res 2005;65:3171-8. (Pubitemid 40524598)
    • (2005) Cancer Research , vol.65 , Issue.8 , pp. 3171-3178
    • Papandreou, I.1    Krishna, C.2    Kaper, F.3    Cai, D.4    Giaccia, A.J.5    Denko, N.C.6
  • 15
    • 34249098462 scopus 로고    scopus 로고
    • The unfolded protein response and integrated stress response to anoxia
    • Rzymski T, Harris AL. The unfolded protein response and integrated stress response to anoxia. Clin Cancer Res 2007;13:2537-40.
    • (2007) Clin Cancer Res , vol.13 , pp. 2537-2540
    • Rzymski, T.1    Harris, A.L.2
  • 16
    • 70350504453 scopus 로고    scopus 로고
    • The DNA-damage response in human biology and disease
    • Jackson SP, Bartek J. The DNA-damage response in human biology and disease. Nature 2009;461:1071-8.
    • (2009) Nature , vol.461 , pp. 1071-1078
    • Jackson, S.P.1    Bartek, J.2
  • 17
    • 0034707047 scopus 로고    scopus 로고
    • The DNA damage response: Putting checkpoints in perspective
    • Zhou BB, Elledge SJ. The DNA damage response: putting checkpoints in perspective. Nature 2000;408:433-9.
    • (2000) Nature , vol.408 , pp. 433-439
    • Zhou, B.B.1    Elledge, S.J.2
  • 19
    • 76249122584 scopus 로고    scopus 로고
    • Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability
    • Pires IM, Bencokova Z, Milani M, et al. Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability. Cancer Res 2010;70:925-35.
    • (2010) Cancer Res , vol.70 , pp. 925-935
    • Pires, I.M.1    Bencokova, Z.2    Milani, M.3
  • 20
    • 4644318239 scopus 로고    scopus 로고
    • Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation
    • Hammond EM, Dorie MJ, Giaccia AJ. Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation. Cancer Res 2004;64:6556-62.
    • (2004) Cancer Res , vol.64 , pp. 6556-6562
    • Hammond, E.M.1    Dorie, M.J.2    Giaccia, A.J.3
  • 21
    • 0037567268 scopus 로고    scopus 로고
    • Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
    • Zou L, Elledge SJ. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 2003;300:1542-8.
    • (2003) Science , vol.300 , pp. 1542-1548
    • Zou, L.1    Elledge, S.J.2
  • 25
    • 28244496609 scopus 로고    scopus 로고
    • Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner
    • Gibson SL, Bindra RS, Glazer PM. Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner. Cancer Res 2005;65:10734-41.
    • (2005) Cancer Res , vol.65 , pp. 10734-10741
    • Gibson, S.L.1    Bindra, R.S.2    Glazer, P.M.3
  • 26
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • Bakkenist CJ, Kastan MB. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 2003;421:499-506.
    • (2003) Nature , vol.421 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 27
    • 34248158282 scopus 로고    scopus 로고
    • Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status
    • Hunt CR, Pandita RK, Laszlo A, et al. Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status. Cancer Res 2007;67:3010-7.
    • (2007) Cancer Res , vol.67 , pp. 3010-3017
    • Hunt, C.R.1    Pandita, R.K.2    Laszlo, A.3
  • 28
    • 33749163797 scopus 로고    scopus 로고
    • CHK2-dependent phosphorylation of BRCA1 in hypoxia
    • Gibson SL, Bindra RS, Glazer PM. CHK2-dependent phosphorylation of BRCA1 in hypoxia. Radiat Res 2006;166:646-51.
    • (2006) Radiat Res , vol.166 , pp. 646-651
    • Gibson, S.L.1    Bindra, R.S.2    Glazer, P.M.3
  • 30
    • 0038146962 scopus 로고    scopus 로고
    • ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation
    • Hammond EM, Dorie MJ, Giaccia AJ. ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. J Biol Chem 2003;278:12207-13.
    • (2003) J Biol Chem , vol.278 , pp. 12207-12213
    • Hammond, E.M.1    Dorie, M.J.2    Giaccia, A.J.3
  • 32
    • 65649113763 scopus 로고    scopus 로고
    • Histone H2AX is integral to hypoxia-driven neovascularization
    • Economopoulou M, Langer HF, Celeste A, et al. Histone H2AX is integral to hypoxia-driven neovascularization. Nat Med 2009;15:553-8.
    • (2009) Nat Med , vol.15 , pp. 553-558
    • Economopoulou, M.1    Langer, H.F.2    Celeste, A.3
  • 33
    • 66749169995 scopus 로고    scopus 로고
    • Angiogenesis: Escape from hypoxia
    • Coleman ML, Ratcliffe PJ. Angiogenesis: escape from hypoxia. Nat Med 2009;15:491-3.
    • (2009) Nat Med , vol.15 , pp. 491-493
    • Coleman, M.L.1    Ratcliffe, P.J.2
  • 35
    • 39749114978 scopus 로고    scopus 로고
    • Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability
    • Bristow RG, Hill RP. Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability. Nat Rev Cancer 2008;8:180-92.
    • (2008) Nat Rev Cancer , vol.8 , pp. 180-192
    • Bristow, R.G.1    Hill, R.P.2
  • 36
    • 15244344206 scopus 로고    scopus 로고
    • HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression
    • Koshiji M, To KK, Hammer S, et al. HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression. Mol Cell 2005;17:793-803.
    • (2005) Mol Cell , vol.17 , pp. 793-803
    • Koshiji, M.1    To, K.K.2    Hammer, S.3
  • 37
    • 59149091637 scopus 로고    scopus 로고
    • MicroRNA regulation of DNA repair gene expression in hypoxic stress
    • Crosby ME, Kulshreshtha R, Ivan M, Glazer PM. MicroRNA regulation of DNA repair gene expression in hypoxic stress. Cancer Res 2009;69:1221-9.
    • (2009) Cancer Res , vol.69 , pp. 1221-1229
    • Crosby, M.E.1    Kulshreshtha, R.2    Ivan, M.3    Glazer, P.M.4
  • 38
    • 33749494456 scopus 로고    scopus 로고
    • Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells
    • Chen H, Yan Y, Davidson TL, Shinkai Y, Costa M. Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells. Cancer Res 2006;66:9009-16.
    • (2006) Cancer Res , vol.66 , pp. 9009-9016
    • Chen, H.1    Yan, Y.2    Davidson, T.L.3    Shinkai, Y.4    Costa, M.5
  • 39
    • 34047112221 scopus 로고    scopus 로고
    • Repression of RAD51 gene expression by E2F4/p130 complexes in hypoxia
    • Bindra RS, Glazer PM. Repression of RAD51 gene expression by E2F4/p130 complexes in hypoxia. Oncogene 2007;26:2048-57.
    • (2007) Oncogene , vol.26 , pp. 2048-2057
    • Bindra, R.S.1    Glazer, P.M.2
  • 41
    • 34247481285 scopus 로고    scopus 로고
    • Targeting checkpoint kinase 1 in cancer therapeutics
    • DOI 10.1158/1078-0432.CCR-06-2793
    • Tse AN, Carvajal R, Schwartz GK. Targeting checkpoint kinase 1 in cancer therapeutics. Clin Cancer Res 2007;13:1955-60. (Pubitemid 46649860)
    • (2007) Clinical Cancer Research , vol.13 , Issue.7 , pp. 1955-1960
    • Tse, A.N.1    Carvajal, R.2    Schwartz, G.K.3
  • 42
    • 74549189337 scopus 로고    scopus 로고
    • New insights into checkpoint kinase 1 in the DNA damage response signaling network
    • Dai Y, Grant S. New insights into checkpoint kinase 1 in the DNA damage response signaling network.Clin Cancer Res 2010;16:376-83.
    • (2010) Clin Cancer Res , vol.16 , pp. 376-383
    • Dai, Y.1    Grant, S.2
  • 43
    • 77950650401 scopus 로고    scopus 로고
    • In vitro and in vivo radiation sensitization of human tumor cells by a novel checkpoint kinase inhibitor, AZD7762
    • Mitchell JB, Choudhuri R, Fabre K, et al. In vitro and in vivo radiation sensitization of human tumor cells by a novel checkpoint kinase inhibitor, AZD7762. Clin Cancer Res 2010;16:2076-84.
    • (2010) Clin Cancer Res , vol.16 , pp. 2076-2084
    • Mitchell, J.B.1    Choudhuri, R.2    Fabre, K.3
  • 44
    • 77953506262 scopus 로고    scopus 로고
    • Chk1 inhibition after replicative stress activates a double strand break response mediated by ATM and DNA-dependent protein kinase
    • McNeely S, Conti C, Sheikh T, et al. Chk1 inhibition after replicative stress activates a double strand break response mediated by ATM and DNA-dependent protein kinase. Cell Cycle 2010;9:995-1004.
    • (2010) Cell Cycle , vol.9 , pp. 995-1004
    • McNeely, S.1    Conti, C.2    Sheikh, T.3
  • 45
    • 33744970043 scopus 로고    scopus 로고
    • The roles of Chk 1 and Chk2 in hypoxia and reoxygenation
    • Hammond EM, Freiberg RA, Giaccia AJ. The roles of Chk 1 and Chk2 in hypoxia and reoxygenation. Cancer Lett 2006; 238:161-7.
    • (2006) Cancer Lett , vol.238 , pp. 161-167
    • Hammond, E.M.1    Freiberg, R.A.2    Giaccia, A.J.3
  • 46
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005;307:58-62.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 47
    • 33645123894 scopus 로고    scopus 로고
    • Overcoming physiologic barriers to cancer treatment by molecularly targeting the tumor microenvironment
    • Cairns R, Papandreou I, Denko N. Overcoming physiologic barriers to cancer treatment by molecularly targeting the tumor microenvironment. Mol Cancer Res 2006;4:61-70.
    • (2006) Mol Cancer Res , vol.4 , pp. 61-70
    • Cairns, R.1    Papandreou, I.2    Denko, N.3
  • 48
    • 0034114513 scopus 로고    scopus 로고
    • Changes in blood perfusion and hypoxia after irradiation of a human squamous cell carcinoma xenograft tumor line
    • Bussink J, Kaanders JH, Rijken PF, Raleigh JA, Van Der Kogel AJ. Changes in blood perfusion and hypoxia after irradiation of a human squamous cell carcinoma xenograft tumor line. Radiat Res 2000;153:398-404.
    • (2000) Radiat Res , vol.153 , pp. 398-404
    • Bussink, J.1    Kaanders, J.H.2    Rijken, P.F.3    Raleigh, J.A.4    Van Der Kogel, A.J.5
  • 49
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. JClin Oncol 2005;23:1011-27.
    • (2005) JClin Oncol , vol.23 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 50
    • 74949105013 scopus 로고    scopus 로고
    • Biomarkers of antiangiogenic therapy: How do we move from candidate biomarkers to valid biomarkers?
    • Duda DG, Ancukiewicz M, Jain RK. Biomarkers of antiangiogenic therapy: how do we move from candidate biomarkers to valid biomarkers? J Clin Oncol 2010;28:183-5.
    • (2010) J Clin Oncol , vol.28 , pp. 183-185
    • Duda, D.G.1    Ancukiewicz, M.2    Jain, R.K.3
  • 51
    • 74949090109 scopus 로고    scopus 로고
    • Distinct patterns of cytokine and angiogenic factor modulation and markers of benefit for vandetanib and/or chemotherapy in patients with non-small-cell lung cancer
    • Hanrahan EO, Lin HY, Kim ES, et al. Distinct patterns of cytokine and angiogenic factor modulation and markers of benefit for vandetanib and/or chemotherapy in patients with non-small-cell lung cancer. J Clin Oncol 2010;28:193-201.
    • (2010) J Clin Oncol , vol.28 , pp. 193-201
    • Hanrahan, E.O.1    Lin, H.Y.2    Kim, E.S.3
  • 52
    • 33751543273 scopus 로고    scopus 로고
    • Hypoxia: Importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy
    • Tatum JL, Kelloff GJ, Gillies RJ, et al. Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy. Int J Radiat Biol 2006;82:699-757.
    • (2006) Int J Radiat Biol , vol.82 , pp. 699-757
    • Tatum, J.L.1    Kelloff, G.J.2    Gillies, R.J.3
  • 53
    • 49149087379 scopus 로고    scopus 로고
    • A novel poly(ADP-ribose) polymerase inhibitor, ABT-888, radiosensitizes malignant human cell lines under hypoxia
    • Liu SK, Coackley C, Krause M, Jalali F, Chan N, Bristow RG. A novel poly(ADP-ribose) polymerase inhibitor, ABT-888, radiosensitizes malignant human cell lines under hypoxia. Radiother Oncol 2008;88:258-68.
    • (2008) Radiother Oncol , vol.88 , pp. 258-268
    • Liu, S.K.1    Coackley, C.2    Krause, M.3    Jalali, F.4    Chan, N.5    Bristow, R.G.6
  • 54
    • 33748065304 scopus 로고    scopus 로고
    • Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly (ADP-ribose) polymerase inhibition
    • McCabe N, Turner NC, Lord CJ, et al. Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly (ADP-ribose) polymerase inhibition. Cancer Res 2006;66:8109-15.
    • (2006) Cancer Res , vol.66 , pp. 8109-8115
    • McCabe, N.1    Turner, N.C.2    Lord, C.J.3
  • 55
    • 77953770987 scopus 로고    scopus 로고
    • Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair
    • Morgan MA, Parsels LA, Zhao L, et al. Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair. Cancer Res 2010;70:4972-81.
    • (2010) Cancer Res , vol.70 , pp. 4972-4981
    • Morgan, M.A.1    Parsels, L.A.2    Zhao, L.3
  • 56
    • 0030025773 scopus 로고    scopus 로고
    • Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors
    • Graeber TG, Osmanian C, Jacks T, et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors. Nature 1996;379:88-91.
    • (1996) Nature , vol.379 , pp. 88-91
    • Graeber, T.G.1    Osmanian, C.2    Jacks, T.3
  • 57
    • 77649256273 scopus 로고    scopus 로고
    • Restoring p53 function in cancer: Novel therapeutic approaches for applying the brakes to tumorigenesis
    • Di Cintio A, Di Gennaro E, Budillon A. Restoring p53 function in cancer: novel therapeutic approaches for applying the brakes to tumorigenesis. Recent Pat Anticancer Drug Discov 2010;5:1-13.
    • (2010) Recent Pat Anticancer Drug Discov , vol.5 , pp. 1-13
    • Di Cintio, A.1    Di Gennaro, E.2    Budillon, A.3
  • 58
    • 64649086259 scopus 로고    scopus 로고
    • Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell apoptosis in normoxia and hypoxia
    • Yang J, Ahmed A, Poon E, et al. Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell apoptosis in normoxia and hypoxia. Mol Cell Biol 2009;29:2243-53.
    • (2009) Mol Cell Biol , vol.29 , pp. 2243-2253
    • Yang, J.1    Ahmed, A.2    Poon, E.3
  • 59
    • 0345256634 scopus 로고    scopus 로고
    • The role of p53 in chemosensitivity and radiosensitivity
    • El-Deiry WS. The role of p53 in chemosensitivity and radiosensitivity. Oncogene 2003;22:7486-95.
    • (2003) Oncogene , vol.22 , pp. 7486-7495
    • El-Deiry, W.S.1
  • 60
    • 70350225829 scopus 로고    scopus 로고
    • The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype
    • Heddleston JM, Li Z, McLendon RE, Hjelmeland AB, Rich JN. The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype. Cell Cycle 2009;8:3274-84.
    • (2009) Cell Cycle , vol.8 , pp. 3274-3284
    • Heddleston, J.M.1    Li, Z.2    McLendon, R.E.3    Hjelmeland, A.B.4    Rich, J.N.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.