Enzyme-directed bioreductive drug development revisited: a commentary on recent progress and future prospects with emphasis on quinone anticancer agents and quinone metabolizing enzymes, particularly DT-diaphorase
Workman P. Enzyme-directed bioreductive drug development revisited: a commentary on recent progress and future prospects with emphasis on quinone anticancer agents and quinone metabolizing enzymes, particularly DT-diaphorase. Oncol Res 6 (1994) 461-475
EO9: a novel bioreductive alkylating indoloquinone with preferential solid tumour activity and lack of bone marrow toxicity in preclinical models
Hendriks H.R., Pizao P.E., Berger D.P., et al. EO9: a novel bioreductive alkylating indoloquinone with preferential solid tumour activity and lack of bone marrow toxicity in preclinical models. Eur J Cancer 29A (1993) 897-906
EO9 phase II study in advanced breast, gastric, pancreatic and colorectal carcinoma by the EORTC Early Clinical Studies Group
Dirix L.Y., Tonnesen F., Cassidy J., et al. EO9 phase II study in advanced breast, gastric, pancreatic and colorectal carcinoma by the EORTC Early Clinical Studies Group. Eur J Cancer 32A (1996) 2019-2022
A randomized phase II study with two schedules of the novel indoloquinone EO9 in non-small-cell lung cancer: a study of the EORTC Early Clinical Studies Group (ECSG)
Pavlidis N., Hanauske A.R., Gamucci T., et al. A randomized phase II study with two schedules of the novel indoloquinone EO9 in non-small-cell lung cancer: a study of the EORTC Early Clinical Studies Group (ECSG). Ann Oncol 7 (1996) 529-531
Evaluation of a novel in vitro assay for assessing drug penetration into avascular regions of tumours
Phillips R.M., Loadman P.M., and Cronin B.P. Evaluation of a novel in vitro assay for assessing drug penetration into avascular regions of tumours. Br J Cancer 77 (1998) 2112-2119
A novel strategy for NQO1 (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) mediated therapy of bladder cancer based on the pharmacological properties of EO9
Choudry G.A., Stewart P.A., Double J.A., et al. A novel strategy for NQO1 (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) mediated therapy of bladder cancer based on the pharmacological properties of EO9. Br J Cancer 85 (2001) 1137-1146
Phase I/II pilot study of intravesical apaziquone (EO9) for superficial bladder cancer
Puri R., Palit V., Loadman P.M., et al. Phase I/II pilot study of intravesical apaziquone (EO9) for superficial bladder cancer. J Urol 176 (2006) 1344-1348
Phase II marker lesion study with intravesical instillation of apaziquone for superficial bladder cancer: toxicity and marker response
van der Heijden A.G., Moonen P.M., Cornel E.B., et al. Phase II marker lesion study with intravesical instillation of apaziquone for superficial bladder cancer: toxicity and marker response. J Urol 176 (2006) 1349-1353
Can intravesical bacillus Calmette-Guérin reduce recurrence in patients with superficial bladder cancer?. A meta-analysis of randomized trials
Han R.F., and Pan J.G. Can intravesical bacillus Calmette-Guérin reduce recurrence in patients with superficial bladder cancer?. A meta-analysis of randomized trials. Urology 67 (2006) 1216-1223
A single immediate postoperative instillation of chemotherapy decreases the risk of recurrence in patients with stage Ta T1 bladder cancer: a meta-analysis of published results of randomized clinical trials
quiz 2435
Sylvester R.J., Oosterlinck W., and van der Meijden A.P. A single immediate postoperative instillation of chemotherapy decreases the risk of recurrence in patients with stage Ta T1 bladder cancer: a meta-analysis of published results of randomized clinical trials. J Urol 171 (2004) 2186-2190 quiz 2435
Intravesical gemcitabine in superficial bladder cancer: a phase II safety, efficacy and pharmacokinetic study
Mattioli F., Curotto A., Manfredi V., et al. Intravesical gemcitabine in superficial bladder cancer: a phase II safety, efficacy and pharmacokinetic study. Anticancer Res 25 (2005) 2493-2496
Effect of intravesical mitomycin C on recurrence of newly diagnosed superficial bladder cancer: interim report from the Medical Research Council Subgroup on Superficial Bladder Cancer (Urological Cancer Working Party)
Tolley D.A., Hargreave T.B., Smith P.H., et al. Effect of intravesical mitomycin C on recurrence of newly diagnosed superficial bladder cancer: interim report from the Medical Research Council Subgroup on Superficial Bladder Cancer (Urological Cancer Working Party). Br Med J (Clin Res Ed) 296 (1988) 1759-1761
A prospective European Organization for Research and Treatment of Cancer Genitourinary Group randomized trial comparing transurethral resection followed by a single intravesical instillation of epirubicin or water in single stage Ta, T1 papillary carcinoma of the bladder
Oosterlinck W., Kurth K.H., Schroder F., et al. A prospective European Organization for Research and Treatment of Cancer Genitourinary Group randomized trial comparing transurethral resection followed by a single intravesical instillation of epirubicin or water in single stage Ta, T1 papillary carcinoma of the bladder. J Urol 149 (1993) 749-752