Tumor hypoxia as a modifier of DNA strand break and cross-link repair

Current Molecular Medicine

Volumn 9, Issue 4, 2009, Pages 401-410

  Chan, Norman ^a   Koch, Cameron J ^b   Bristow, Robert G ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Bioreductive drugs; Chemosensitivity; DNA repair; Homologous recombination; Hypoxia; OER; PARP inhibitors; Radiosensitivity

Indexed keywords

1 FLUORO 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL F 18; 4 HYDROPEROXYIFOSFAMIDE; ANTINEOPLASTIC AGENT; BLEOMYCIN; CARBOPLATIN; CISPLATIN; DINITROBENZAMIDE MUSTARD; ETOPOSIDE; GEMCITABINE; IRINOTECAN; MITOMYCIN C; OXALIPLATIN; OXYGEN; PACLITAXEL; PORFIROMYCIN; PR 104; TIRAPAZAMINE; UNCLASSIFIED DRUG;

CANCER CHEMOTHERAPY; CLINICAL TRIAL; DNA CROSS LINKING; DNA REPAIR; DNA STRAND BREAKAGE; DRUG SENSITIVITY; GENETIC RECOMBINATION; HOMOLOGOUS RECOMBINATION; HUMAN; HYPOXIA; MALIGNANT NEOPLASTIC DISEASE; MICROENVIRONMENT; NONHOMOLOGOUS END JOINING PATHWAY; NONHUMAN; NUCLEIC ACID STRUCTURE, METABOLISM AND FUNCTION; OXYGEN ENHANCEMENT RATIO; RADIOSENSITIVITY; REVIEW; SOLID TUMOR; TUMOR CELL; TUMOR GROWTH; TUMOR RESISTANCE;

ANIMALS; CELL HYPOXIA; DNA BREAKS, DOUBLE-STRANDED; DNA BREAKS, SINGLE-STRANDED; DNA DAMAGE; DNA REPAIR; HUMANS; NEOPLASMS; RECOMBINATION, GENETIC;

EID: 68349157265     PISSN: 15665240     EISSN: None     Source Type: Journal    
DOI: 10.2174/156652409788167050     Document Type: Review

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