Nuclear factor Nrf2 and antioxidant response element regulate NRH:quinone oxidoreductase 2 (NQO2) gene expression and antioxidant induction

Free Radical Biology and Medicine

Volumn 40, Issue 7, 2006, Pages 1119-1130

  Wang, Wei ^a   Jaiswal, Anil K ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Antioxidant response element; Free radical; NAD(P)H:quinone oxidoreductase 1; Nrf2, NF E2 related factor 2; NRH:quinone oxidoreductase 2; Polycyclic aromatic hydrocarbon; tert Butylhydroquinone

Indexed keywords

ANTIOXIDANT; LUCIFERASE; NUCLEAR FACTOR; OLIGONUCLEOTIDE; OXIDOREDUCTASE; QUINONE OXIDOREDUCTASE 2; TERT BUTYLHYDROQUINONE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIOXIDANT ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CELL STRAIN HEPG2; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GENE CONTROL; GENE DELETION; GENE EXPRESSION; GENE INDUCTION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

ANTIOXIDANTS; BLOTTING, NORTHERN; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; DOWN-REGULATION; GENE DELETION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; HYDROQUINONES; MUTAGENESIS; NF-E2-RELATED FACTOR 2; PROMOTER REGIONS (GENETICS); QUINONE REDUCTASES; REPRESSOR PROTEINS; TRANSFECTION; UP-REGULATION;

EID: 33644911742     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2005.10.063     Document Type: Article

References (30)

1. 2 gene locus on chromosome 6 Biochemistry 29 1990 1899 1906
2. A.K. Jaiswal Human NAD(P)H:quinone oxidoreductase2: gene structure and tissue specific expression J. Biol. Chem. 269 1994 14502 14508
3. K. Wu, R. Knox, X.Z. Sun, P. Joseph, A.K. Jaiswal, D. Zhang, P.S.K. Deng, and S. Chen Catalytic properties of NAD(P)H:quinone oxidoreductase2 (NQO2), a dihydronicotinamide riboside dependent oxidoreductase Arch. Biochem. Biophys. 345 1997 221 228
4. Q. Zhao, X.L. Yang, W.D. Holtzclaw, and P. Talalay Unexpected genetic and structural relationships of a long-forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase) Proc. Natl. Acad. Sci. USA 94 1997 1669 1674
5. R.J. Knox, T.C. Jenkins, S.M. Hobbs, S. Chen, R.G. Melton, and P.J. Burke Bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by human NAD(P)H: quinone oxidoreductase 2: a novel co-substrate-mediated antitumor prodrug therapy Cancer Res. 60 2000 4179 4186
6. C.E. Foster, M.A. Bianchet, P. Talalay, Q. Zhao, and L.M. Amzel Crystal structure of human quinone reductase type 2, a metalloflavoprotein Biochemistry 38 1999 9881 9886
7. 2) leads to myeloid hyperplasia of bone marrow and decreased sensitivity to menadione toxicity J. Biol. Chem. 277 2002 46131 46139
8. K. Iskander, M. Paquet, C. Brayton, and A.K. Jaiswal Deficiency of NRH:quinone oxidoreductase 2 increases susceptibility to 7,12-dimethybenz(a) anthracene and benzo(a)pyrene-induced skin carcinogenesis Cancer Res. 64 2004 5925 5928
9. O. Nosjean, J. Nicolas, F. Klupsch, P. Delagrange, E. Canet, and J.A. Boutin Comparative pharmacological studies of melatonin receptors: MT1, MT2 and MT3/QR2. Tisssue distribution of MT3/QR2 Biochem. Pharmacol. 61 2001 1369 1379
10. O. Nosjean, M. Ferro, F. Coge, P. Beauverger, J. Henlin, F. Lefoulon, J. Fauchere, P. Delagrange, E. Canet, and J.A. Boutin Identification of the melatonin-binding site MT3 as the quinone reductase 2 J. Biol. Chem. 275 2000 31311 31317
11. O. Ostrousky, S. Meged, R. Loewenthal, A. Valevski, A. Weizman, H. Carp, and E. Gazit NQO2 gene is associated with clozapine-induced agranulocytosis Tissue Antigens 62 2003 483 491
12. S. Harada, C. Fujii, A. Hayashi, and N. Okhoshi An association between idiopathic Parkinson's disease and polymorphisms of phase II detoxification enzymes: glutathione S-transferase M1 and quinone oxidoreductase1 and 2 Biochem. Biophys. Res. Commun. 288 2001 14502 14508
13. W. Wang, and A.K. Jaiswal Sp3 repression of polymorphic human NRH:quinone oxidoreductase 2 gene promoter Free Radic. Biol. Med. 37 2004 1231 1243
14. A.K. Jaiswal Human NAD(P)H:quinone oxidoreductase2: gene structure, activity, and tissue-specific expression J. Biol. Chem. 269 1994 14502 14508
15. D.J. Long II, and A.K. Jaiswal Mouse NRH:quinone oxidoreductase (NQO2): cloning of cDNA and gene- and tissue-specific expression Gene 252 2000 107 117
16. P.J. Joseph, D.J. Long II, A.J.P. Klein-Szanto, and A.K. Jaiswal Role of NAD(P)H:quinone oxidoreductase1 (DT diaphorase) in protection against quinone toxicity Biochem. Pharmacol. 60 2000 207 214
17. A.K. Jaiswal Nrf2 signaling in coordinated activation of antioxidant gene expression Free Radic. Biol. Med. 15 2004 1199 1207
18. S. Dhakshinamoorthy, and A.K. Jaiswal Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene Oncogene 20 2001 3906 3917
19. K. Itoh, N. Wakabayashi, Y. Katoh, T. Ishii, K. Igarashi, J.D. Engel, and M. Yamamoto Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain Genes Dev. 13 1999 76 86
20. R. Venugopal, and A.K. Jaiswal Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes Oncogene 17 1998 3145 3156
21. M.G. Marini, K. Chan, L. Casula, Y.W. Kan, A. Cao, and P. Moi hMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2 J. Biol. Chem. 272 1997 16490 16497
22. D. Bloom, S. Dhakshinamoorthy, and A.K. Jaiswal Site-directed mutagenesis of cysteine to serine in the DNA-binding region of Nrf2 decreases its capacity to upregulate antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene Oncogene 21 2002 2191 2200
23. M.K. Francis, D.G. Phinney, and K. Ryder Analysis of the hormone-dependent regulation of a JunD-estrogen receptor chimera J. Biol. Chem. 270 1995 11502 11513
24. J. Sambrook, E.F. Fritsch, and T. Maniatis Molecular cloning: a laboratory manual second ed. 1989 Cold Spring Harbor Laboratory Press New York
25. A.K. Jaiswal Regulation of antioxidant response element-dependent induction of detoxifying enzyme synthesis Methods in Enzymol. 378 2004 221 238
26. A. Okuda, M. Imagawa, M. Sakai, and M. Muramatsu Functional cooperativity between two TPA responsive elements in undifferentiated F9 emryonic stem cells EMBO J. 9 1990 1131 1135
27. K. Sankaranarayanan, and A.K. Jaiswal Nrf3 negatively regulates antioxidant-response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene J. Biol. Chem. 279 2004 50810 50817
28. G.N. Wogan, S.S. Hecht, J.S. Felton, A.H. Conney, and L.A. Loeb Environmental and chemical carcinogenesis Semin. Cancer Biol. 14 2004 473 486
29. S.A. Sheweita, and A.K. Tilmisany Cancer and phase II drug-metabolizing enzymes Curr. Drug Metab. 4 2003 45 58
30. T. Xie, M. Belinsky, and A.K. Jaiswal ARE- and TRE-mediated regulation of gene expression. Response to xenobiotics and antioxidants J. Biol. Chem. 270 1995 6894 6900