-
1
-
-
0027328452
-
The experimental development of bioreductive drugs and their role in cancer therapy
-
Workman P, Stratford IJ: The experimental development of bioreductive drugs and their role in cancer therapy. Cancer Met Rev 12:73-82, 1993
-
(1993)
Cancer Met Rev
, vol.12
, pp. 73-82
-
-
Workman, P.1
Stratford, I.J.2
-
2
-
-
0030028884
-
Hypoxia-specific cytotoxins in cancer therapy
-
Brown MJ, Siim BG: Hypoxia-specific cytotoxins in cancer therapy. Semin Radiat Oncol 6:22-36, 1996
-
(1996)
Semin Radiat Oncol
, vol.6
, pp. 22-36
-
-
Brown, M.J.1
Siim, B.G.2
-
3
-
-
0029884764
-
Recent developments in the design of bioreductive drugs
-
Denny WA, Wilson WR, Hay MP: Recent developments in the design of bioreductive drugs. Br J Cancer 74, S32-S38, 1996
-
(1996)
Br J Cancer
, vol.74
-
-
Denny, W.A.1
Wilson, W.R.2
Hay, M.P.3
-
5
-
-
0031742631
-
Bioreductive therapies: An overview of drugs and their mechanisms of action
-
Rauth AM, Melo T, Misra V: Bioreductive therapies: An overview of drugs and their mechanisms of action. Int J Radiat Oncol Biol Phys 42:755-762, 1998
-
(1998)
Int J Radiat Oncol Biol Phys
, vol.42
, pp. 755-762
-
-
Rauth, A.M.1
Melo, T.2
Misra, V.3
-
6
-
-
0035010504
-
Electron transfer and oxidative stress as key factors in the design of drugs selectively active in hypoxia
-
Wardman P: Electron transfer and oxidative stress as key factors in the design of drugs selectively active in hypoxia. Curr Med Chem 8:739-761, 2001
-
(2001)
Curr Med Chem
, vol.8
, pp. 739-761
-
-
Wardman, P.1
-
7
-
-
0036173591
-
Hypoxia as a target for combined modality treatments
-
Wouters BG, Weppler SA, Koritzinsky M, et al: Hypoxia as a target for combined modality treatments. Eur J Cancer 38:240-257, 2002
-
(2002)
Eur J Cancer
, vol.38
, pp. 240-257
-
-
Wouters, B.G.1
Weppler, S.A.2
Koritzinsky, M.3
-
8
-
-
0016275208
-
Selective chemotherapy of non-cycling cells in an in vitro tumour model
-
Sutherland RM: Selective chemotherapy of non-cycling cells in an in vitro tumour model. Cancer Res 34:3501-3503, 1974
-
(1974)
Cancer Res
, vol.34
, pp. 3501-3503
-
-
Sutherland, R.M.1
-
9
-
-
0018914018
-
The hypoxic tumor cell: A target for selective cancer chemotherapy
-
Kennedy KA, Teicher BA, Rockwell S, et al: The hypoxic tumor cell: A target for selective cancer chemotherapy. Biochem Pharmacol 29:1-8, 1980.
-
(1980)
Biochem Pharmacol
, vol.29
, pp. 1-8
-
-
Kennedy, K.A.1
Teicher, B.A.2
Rockwell, S.3
-
10
-
-
0023902264
-
Therapeutic attack of hypoxic cells of solid tumours: Presidential address
-
Sartorelli AC: Therapeutic attack of hypoxic cells of solid tumours: presidential address. Cancer Res.48:775-778, 1988
-
(1988)
Cancer Res.
, vol.48
, pp. 775-778
-
-
Sartorelli, A.C.1
-
11
-
-
0017256549
-
Increased cell killing by metronidazole and nitrofurazone of hypoxic compared to aerobic mammalian cells
-
Mohindra JK, Rauth AM: Increased cell killing by metronidazole and nitrofurazone of hypoxic compared to aerobic mammalian cells. Cancer Res 36:930-936, 1976
-
(1976)
Cancer Res
, vol.36
, pp. 930-936
-
-
Mohindra, J.K.1
Rauth, A.M.2
-
12
-
-
0001611802
-
The chemistry of nitroarene and aromatic N-oxide radicals
-
Alfassi ZB (ed): New York, John Wiley
-
Wardman P: The chemistry of nitroarene and aromatic N-oxide radicals, in Alfassi ZB (ed): The chemistry of N-centred radicals. New York, John Wiley, 1998, pp 98-126
-
(1998)
The Chemistry of N-centred Radicals
, pp. 98-126
-
-
Wardman, P.1
-
13
-
-
0018100758
-
Split dose cytotoxic experiments with misonidazole
-
Stratford IJ: Split dose cytotoxic experiments with misonidazole. Br J Cancer 38:130-136, 1978
-
(1978)
Br J Cancer
, vol.38
, pp. 130-136
-
-
Stratford, I.J.1
-
14
-
-
0018965511
-
Sulphydryls, ascorbate and oxygen as modifiers of the toxicity and metabolism of misonidazole in vitro
-
Taylor YC, Rauth AM: Sulphydryls, ascorbate and oxygen as modifiers of the toxicity and metabolism of misonidazole in vitro. Br J Cancer 41:892-900, 1980
-
(1980)
Br J Cancer
, vol.41
, pp. 892-900
-
-
Taylor, Y.C.1
Rauth, A.M.2
-
15
-
-
0027227590
-
Unusual oxygen concentration dependence of toxicity of SR-4233, a hypoxic cell toxin
-
Koch CJ: Unusual oxygen concentration dependence of toxicity of SR-4233, a hypoxic cell toxin. Cancer Res 53:3992-3997, 1993
-
(1993)
Cancer Res
, vol.53
, pp. 3992-3997
-
-
Koch, C.J.1
-
16
-
-
0034104328
-
Tirapazamine plus cisplatin versus cisplatin in advanced non-small-cell lung cancer: A report of the international CATAPULT I study group. Cisplatin and tirapazamine in subjects with advanced previously untreated non-small-cell lung tumors
-
von Pawel J, von Roemeling R, Gatzemeier U, et al: Tirapazamine plus cisplatin versus cisplatin in advanced non-small-cell lung cancer: A report of the international CATAPULT I study group. Cisplatin and Tirapazamine in Subjects with Advanced Previously Untreated Non-Small-Cell Lung Tumors. J Clin Oncol 18:1351-1359, 2000
-
(2000)
J Clin Oncol
, vol.18
, pp. 1351-1359
-
-
Von Pawel, J.1
Von Roemeling, R.2
Gatzemeier, U.3
-
17
-
-
0023153554
-
Nitroimidazole bioreductive metabolism: Quantitation and characterisation of mouse tissue benzonidazole nitroreductases in vivo and in vitro
-
Walton MI, Workman P: Nitroimidazole bioreductive metabolism: Quantitation and characterisation of mouse tissue benzonidazole nitroreductases in vivo and in vitro. Biochem Pharmacol 36:887-896, 1987
-
(1987)
Biochem Pharmacol
, vol.36
, pp. 887-896
-
-
Walton, M.I.1
Workman, P.2
-
18
-
-
0030692717
-
Overexpression of human NADPH: Cytochrome c (P450) reductase confers enhanced sensitivity to both tirapazamine (SR 4233) and RSU 1069
-
Patterson AV, Saunders MP, Chinje EC, et al: Overexpression of human NADPH: Cytochrome c (P450) reductase confers enhanced sensitivity to both tirapazamine (SR 4233) and RSU 1069. Br J Cancer 76:1338-1347, 1997
-
(1997)
Br J Cancer
, vol.76
, pp. 1338-1347
-
-
Patterson, A.V.1
Saunders, M.P.2
Chinje, E.C.3
-
19
-
-
0025284525
-
Enzymology of the reductive bioactivation of SR 4233: A novel benzotriazine di-N-oxide hypoxic cell cytotoxin
-
Walton MI, Workman P: Enzymology of the reductive bioactivation of SR 4233: A novel benzotriazine di-N-oxide hypoxic cell cytotoxin. Biochem Pharmacol 39:17351742, 1990
-
(1990)
Biochem Pharmacol
, vol.39
, pp. 17351742
-
-
Walton, M.I.1
Workman, P.2
-
20
-
-
0028867912
-
Importance of P450 reductase activity in determining sensitivity of breast tumour cells to the bioreductive drug, tirapazamine (SR 4233)
-
Patterson AV, Barham HM, Chinje EC, et al: Importance of P450 reductase activity in determining sensitivity of breast tumour cells to the bioreductive drug, tirapazamine (SR 4233). Br J Cancer 72:1144-1150, 1995
-
(1995)
Br J Cancer
, vol.72
, pp. 1144-1150
-
-
Patterson, A.V.1
Barham, H.M.2
Chinje, E.C.3
-
21
-
-
0033961216
-
The importance of P450 reductase for determining the sensitivity of human tumour cells to the indolequinone E09 and related analogues lacking functionality in the C-2 and C-3 positions
-
Saunders MP, Jaffar M, Patterson AV, et al: The importance of P450 reductase for determining the sensitivity of human tumour cells to the indolequinone E09 and related analogues lacking functionality in the C-2 and C-3 positions. Biochem Pharmacol 59:993-996, 2000
-
(2000)
Biochem Pharmacol
, vol.59
, pp. 993-996
-
-
Saunders, M.P.1
Jaffar, M.2
Patterson, A.V.3
-
22
-
-
0029609610
-
Expression of the bacterial nitroreductases enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954
-
Bridgewater JA, Springer CJ, Knox RJ, et al: Expression of the bacterial nitroreductases enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954. Eur J Cancer 31:2362-2370, 1995
-
(1995)
Eur J Cancer
, vol.31
, pp. 2362-2370
-
-
Bridgewater, J.A.1
Springer, C.J.2
Knox, R.J.3
-
23
-
-
0034900493
-
Glucose transporter Glut-1 expression correlates with tumour hypoxia and predicts metastasis free survival in advanced carcinoma of the cervix
-
Airley R, Loncaster J, Davidson S, et al: Glucose transporter Glut-1 expression correlates with tumour hypoxia and predicts metastasis free survival in advanced carcinoma of the cervix. Clin Cancer Res 7:928-934, 2001
-
(2001)
Clin Cancer Res
, vol.7
, pp. 928-934
-
-
Airley, R.1
Loncaster, J.2
Davidson, S.3
-
24
-
-
0035418586
-
CA IX expression, a potential new intrinisic marker of hypoxia: Correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix
-
Loncaster JA, Harris AL, Davison SE, et al: CA IX expression, a potential new intrinisic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res 61:6394-6399, 2001
-
(2001)
Cancer Res
, vol.61
, pp. 6394-6399
-
-
Loncaster, J.A.1
Harris, A.L.2
Davison, S.E.3
-
25
-
-
0017810592
-
In vivo evaluation of the radio-sensitizing and cytotoxic properties of newly synthesized electron-affinic drugs
-
Brown JM, Yu NY, Cory MJ, et al: In vivo evaluation of the radio-sensitizing and cytotoxic properties of newly synthesized electron-affinic drugs. Br J Cancer 37:206-211, 1978 (suppl)
-
(1978)
Br J Cancer
, vol.37
, Issue.SUPPL.
, pp. 206-211
-
-
Brown, J.M.1
Yu, N.Y.2
Cory, M.J.3
-
27
-
-
0018116095
-
Differences in the toxicity and metabolism of the 2-nitroimidazole misonidazole (Ro-07-0582) in HeLa and CHO cells
-
Taylor YC, Rauth AM: Differences in the toxicity and metabolism of the 2-nitroimidazole misonidazole (Ro-07-0582) in HeLa and CHO cells. Cancer Res 38:2745-2752, 1978
-
(1978)
Cancer Res
, vol.38
, pp. 2745-2752
-
-
Taylor, Y.C.1
Rauth, A.M.2
-
28
-
-
0022474587
-
Effects of some proliferative and environmental factors on the toxicity of mitomycin C to tumor cells in vitro
-
Rockwell S: Effects of some proliferative and environmental factors on the toxicity of mitomycin C to tumor cells in vitro. Int J Cancer 38:229-235, 1986
-
(1986)
Int J Cancer
, vol.38
, pp. 229-235
-
-
Rockwell, S.1
-
29
-
-
0022608804
-
RSU 1069, a nitroimidazole containing an aziridine group: Bioreduction greatly increases cytotoxicity under hypoxic conditions
-
Stratford IJ, O'Neill P, Sheldon PW, et al: RSU 1069, a nitroimidazole containing an aziridine group: Bioreduction greatly increases cytotoxicity under hypoxic conditions. Biochem Pharmacol 35:105-110, 1986
-
(1986)
Biochem Pharmacol
, vol.35
, pp. 105-110
-
-
Stratford, I.J.1
O'Neill, P.2
Sheldon, P.W.3
-
30
-
-
0023228137
-
Induction of DNA crosslinks in vitro upon reduction of the nitroimidazoleaziridines RSU-1069 and RSU-1131
-
O'Neill P, McNeil SS, Jenkins TC: Induction of DNA crosslinks in vitro upon reduction of the nitroimidazoleaziridines RSU-1069 and RSU-1131 Biochem Pharmacol 36:1787-1792, 1987
-
(1987)
Biochem Pharmacol
, vol.36
, pp. 1787-1792
-
-
O'Neill, P.1
McNeil, S.S.2
Jenkins, T.C.3
-
31
-
-
0024593747
-
Induction of tumour hypoxia post-irradiation: A method for increasing the sensitizing efficiency of misonidazole and RSU 1069 in vivo
-
Stratford IJ, Adams GE, Godden J, et al: Induction of tumour hypoxia post-irradiation: A method for increasing the sensitizing efficiency of misonidazole and RSU 1069 in vivo. Int J Radiat Biol 55:411-422, 1989
-
(1989)
Int J Radiat Biol
, vol.55
, pp. 411-422
-
-
Stratford, I.J.1
Adams, G.E.2
Godden, J.3
-
32
-
-
0027031154
-
Bioreductive drugs in cancer therapy
-
Stratford J: Bioreductive drugs in cancer therapy. Br J Radiol 24:128-136, 1992 (suppl)
-
Br J Radiol
, vol.24
, Issue.SUPPL.
, pp. 128-136
-
-
Stratford, J.1
-
33
-
-
0022879286
-
A toxicity and pharmacokinetics study in man of the hypoxic radiosensitizer RSU-1069
-
Horwich A, Holliday SB, Deacon JM, et al: A toxicity and pharmacokinetics study in man of the hypoxic radiosensitizer RSU-1069. Br J Radiol 59:1238-1240, 1986
-
(1986)
Br J Radiol
, vol.59
, pp. 1238-1240
-
-
Horwich, A.1
Holliday, S.B.2
Deacon, J.M.3
-
34
-
-
0027290844
-
Assessing the bioreductive effectiveness of the nitroimidazole RSU1069 and its prodrug RB6145: With particular reference to in vivo methods of evaluation
-
Bremner JC: Assessing the bioreductive effectiveness of the nitroimidazole RSU1069 and its prodrug RB6145: With particular reference to in vivo methods of evaluation. Cancer Met Rev 12:177-193, 1993
-
(1993)
Cancer Met Rev
, vol.12
, pp. 177-193
-
-
Bremner, J.C.1
-
35
-
-
0025023154
-
Synthesis and evaluation of alpha-[)2-haloethyl)amino]methyl]-2-nitro-1H-imidazole-1-ethanols as prodrugs of alpha-[(1-aziridinyl)methyl-2-nitro-1H-imidazole-1-ethanol (RSU-1069) and its analogues which are radiosensitizers and bioreductively activated cytotoxins
-
Jenkins T, Naylor MA, O'Neill P, et al: Synthesis and evaluation of alpha-[)2-haloethyl)amino]methyl]-2-nitro-1H-imidazole-1-ethanols as prodrugs of alpha-[(1-aziridinyl)methyl-2-nitro-1H-imidazole-1-ethanol (RSU-1069) and its analogues which are radiosensitizers and bioreductively activated cytotoxins. J Med Chem 33:2603-2610, 1990
-
(1990)
J Med Chem
, vol.33
, pp. 2603-2610
-
-
Jenkins, T.1
Naylor, M.A.2
O'Neill, P.3
-
36
-
-
0026072447
-
Pharmacokinetic contribution to the improved therapeutic selectivity of a novel bromoethylamino prodrug (RB 6145) of the mixed-function hypoxic cell sensitizer/cytotoxin alpha-(1-aziridinomethyl)-2-ni-tro-1H-imidazole-1-ethanol (RSU 1069)
-
Binger M, Workman P: Pharmacokinetic contribution to the improved therapeutic selectivity of a novel bromoethylamino prodrug (RB 6145) of the mixed-function hypoxic cell sensitizer/cytotoxin alpha-(1-aziridinomethyl)-2-ni-tro-1H-imidazole-1-ethanol (RSU 1069). Cancer Chem Pharmacol 29:37-47, 1991
-
(1991)
Cancer Chem Pharmacol
, vol.29
, pp. 37-47
-
-
Binger, M.1
Workman, P.2
-
37
-
-
0034652379
-
Hypoxia-dependent retinal toxicity of bioreductive anticancer prodrugs in mice
-
Lee AE, Wilson WR: Hypoxia-dependent retinal toxicity of bioreductive anticancer prodrugs in mice. Toxicol Appl Pharmacol 163:50-59, 2000
-
(2000)
Toxicol Appl Pharmacol
, vol.163
, pp. 50-59
-
-
Lee, A.E.1
Wilson, W.R.2
-
38
-
-
0022493495
-
SR-4233: A new bioreactive agent with high selective toxicity for hypoxic mammalian cells
-
Zeman EM, Brown JM, Lemmon MJ, et al: SR-4233: A new bioreactive agent with high selective toxicity for hypoxic mammalian cells. Int J Radiat Oncol Biol Phys 12:1239-1242, 1968
-
(1968)
Int J Radiat Oncol Biol Phys
, vol.12
, pp. 1239-1242
-
-
Zeman, E.M.1
Brown, J.M.2
Lemmon, M.J.3
-
39
-
-
0023750547
-
Enhancement of radiation-induced tumor cell killing by the hypoxic cell toxin SR4233
-
Zeman EM, Hirst VK, Lemmon MJ, et al: Enhancement of radiation-induced tumor cell killing by the hypoxic cell toxin SR 4233. Radiother Oncol 12:209-218, 1988
-
(1988)
Radiother Oncol
, vol.12
, pp. 209-218
-
-
Zeman, E.M.1
Hirst, V.K.2
Lemmon, M.J.3
-
40
-
-
0024363523
-
Pre-and post-irradiation radiosensitization by SR 4233
-
Zeman EM, Brown JM: Pre-and post-irradiation radiosensitization by SR 4233. Int J Rad Oncol Biol Phys 16:967-971, 1989
-
(1989)
Int J Rad Oncol Biol Phys
, vol.16
, pp. 967-971
-
-
Zeman, E.M.1
Brown, J.M.2
-
41
-
-
0026073332
-
SR4233 cytotoxicity and metabolism in DNA repair-competent and repair-deficient cell cultures
-
Biedermann KA, Wang J, Graham RP, et al: SR4233 cytotoxicity and metabolism in DNA repair-competent and repair-deficient cell cultures. Br J Cancer 63:358-362, 1991
-
(1991)
Br J Cancer
, vol.63
, pp. 358-362
-
-
Biedermann, K.A.1
Wang, J.2
Graham, R.P.3
-
42
-
-
0026802366
-
Repair of DNA and chromosome breaks in cells exposed to SR4233 under hypoxia and to ionising radiation
-
Wang J, Biedermann KA, Brown JM: Repair of DNA and chromosome breaks in cells exposed to SR4233 under hypoxia and to ionising radiation. Cancer Res 52:4473-4477, 1992
-
(1992)
Cancer Res
, vol.52
, pp. 4473-4477
-
-
Wang, J.1
Biedermann, K.A.2
Brown, J.M.3
-
43
-
-
0024414046
-
The differential hypoxic cytotoxicity of bioreductive agents determined in vitro by the MTT assay
-
Stratford IJ, Stephens MA: The differential hypoxic cytotoxicity of bioreductive agents determined in vitro by the MTT assay. Int J Radiat Oncol Biol Phys 16:973-976, 1989
-
(1989)
Int J Radiat Oncol Biol Phys
, vol.16
, pp. 973-976
-
-
Stratford, I.J.1
Stephens, M.A.2
-
44
-
-
0025646401
-
Potentiation by the hypoxic cytotoxin SR 4233 of cell killing produced by fractionated irradiation of mouse tumours
-
Brown JM, Lemmon MJ: Potentiation by the hypoxic cytotoxin SR4233 of cell killing produced by fractionated irradiation of mouse tumours. Cancer Res 50:7745-7749, 1990
-
(1990)
Cancer Res
, vol.50
, pp. 7745-7749
-
-
Brown, J.M.1
Lemmon, M.J.2
-
45
-
-
0028079669
-
Comparison of the enhancement of tumor responses to fractionated irradiation by SR4233 (tirapazamine) and by nicotinamide with carbogen
-
Dorie MJ, Menke D, Brown JM: Comparison of the enhancement of tumor responses to fractionated irradiation by SR 4233 (tirapazamine) and by nicotinamide with carbogen. Int J Radiat Oncol Biol Phys 28:145-150, 1994
-
(1994)
Int J Radiat Oncol Biol Phys
, vol.28
, pp. 145-150
-
-
Dorie, M.J.1
Menke, D.2
Brown, J.M.3
-
46
-
-
0028084787
-
Tumour hypoxia: The picture has changed in the 1990s
-
Brown JM, Giaccia AJ: Tumour hypoxia: The picture has changed in the 1990s. Int J Radiat Biol 65:95-102, 1994
-
(1994)
Int J Radiat Biol
, vol.65
, pp. 95-102
-
-
Brown, J.M.1
Giaccia, A.J.2
-
47
-
-
0022471797
-
Sensitizers and radiation close fractionation: Results and interpretations
-
Hill RP: Sensitizers and radiation close fractionation: Results and interpretations. Int J Radiat Oncol Biol Phys 12:1049-1054, 1986
-
(1986)
Int J Radiat Oncol Biol Phys
, vol.12
, pp. 1049-1054
-
-
Hill, R.P.1
-
48
-
-
0011276770
-
Fractionation increases the antitumour effect of adding a hypoxic cytotoxin to irradiation
-
Dewey WC (ed): San Diego, CA, Academic
-
Brown JM, Lemmon MJ: Fractionation increases the antitumour effect of adding a hypoxic cytotoxin to irradiation, in Dewey WC (ed): Radiation research a twentieth century perspective. San Diego, CA, Academic, 1992, pp 807-812
-
(1992)
Radiation Research a Twentieth Century Perspective
, pp. 807-812
-
-
Brown, J.M.1
Lemmon, M.J.2
-
49
-
-
0008401242
-
Mitomycin C and radiation
-
Hill BT (ed): Boca Raton, FL, CRC Press, Inc
-
Rockwell S, Sartorelli AC: Mitomycin C and radiation, in Hill BT (ed): Antitumor drug-radiation interactions. Boca Raton, FL, CRC Press, Inc, 1990, pp 126-139
-
(1990)
Antitumor Drug-radiation Interactions
, pp. 126-139
-
-
Rockwell, S.1
Sartorelli, A.C.2
-
50
-
-
0024322497
-
Randomized clinical trial of mitomycin C as an adjunct to radiotherapy in head and neck cancer
-
Weissberg JB, Papac RJ, Son YH, et al: Randomized clinical trial of mitomycin C as an adjunct to radiotherapy in head and neck cancer. Int J Radiat Oncol Biol Phys 17:3-9, 1989
-
(1989)
Int J Radiat Oncol Biol Phys
, vol.17
, pp. 3-9
-
-
Weissberg, J.B.1
Papac, R.J.2
Son, Y.H.3
-
51
-
-
0027358606
-
Mitomycin C as an adjunct to postoperative radiation therapy in squamous cell carcinoma of the head and neck: Results from two randomized clinical trials
-
Haffty BG, Son YH, Sasaki CT, et al: Mitomycin C as an adjunct to postoperative radiation therapy in squamous cell carcinoma of the head and neck: results from two randomized clinical trials. Int J Radiat Oncol Biol Phys 27:241-250, 1994
-
(1994)
Int J Radiat Oncol Biol Phys
, vol.27
, pp. 241-250
-
-
Haffty, B.G.1
Son, Y.H.2
Sasaki, C.T.3
-
52
-
-
0023798415
-
Preclinical studies of porfiromycin as an adjunct to radiotherapy
-
Rockwell S, Keyes SR, Sartorelli AC: Preclinical studies of porfiromycin as an adjunct to radiotherapy. Radiat Res 116:100-113, 1988
-
(1988)
Radiat Res
, vol.116
, pp. 100-113
-
-
Rockwell, S.1
Keyes, S.R.2
Sartorelli, A.C.3
-
53
-
-
0031875844
-
Exploring the mechanistic aspects of mitomycing antibiotic bioactivation in Chinese hamster ovary cells overexpressing NADPH: Cytochrome C (P450) reductase and DT-diaphorase
-
Belcourt MF, Hodnick WF, Rockwell S, et al: Exploring the mechanistic aspects of mitomycing antibiotic bioactivation in Chinese hamster ovary cells overexpressing NADPH: Cytochrome C (P450) reductase and DT-diaphorase. Adv Enzyme Regul 38:111-133, 1998
-
(1998)
Adv Enzyme Regul
, vol.38
, pp. 111-133
-
-
Belcourt, M.F.1
Hodnick, W.F.2
Rockwell, S.3
-
54
-
-
0023547926
-
Metabolism and reactions of quinoid anticancer agents
-
Powis G: Metabolism and reactions of quinoid anticancer agents. Pharmacol Ther 35:57-162, 1987
-
(1987)
Pharmacol Ther
, vol.35
, pp. 57-162
-
-
Powis, G.1
-
55
-
-
0021687360
-
Role of NADPH: Cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C
-
Keyes SR, Fracasso PM, Heimbrook DC, et al: Role of NADPH: Cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C. Cancer Research 44:5638-5643, 1984
-
(1984)
Cancer Research
, vol.44
, pp. 5638-5643
-
-
Keyes, S.R.1
Fracasso, P.M.2
Heimbrook, D.C.3
-
56
-
-
12644264303
-
Bioreductive alkylating agent porfiromycin in combination with radiation therapy for the management of squamous cell carcinoma of the head and neck
-
Haffty BG, Son YH, Wilson LD, et al: Bioreductive alkylating agent porfiromycin in combination with radiation therapy for the management of squamous cell carcinoma of the head and neck. Radiat Oncol Investig 5:235-245, 1997
-
(1997)
Radiat Oncol Investig
, vol.5
, pp. 235-245
-
-
Haffty, B.G.1
Son, Y.H.2
Wilson, L.D.3
-
57
-
-
0028101349
-
Factors affecting sensitivity to EO9 in rodent and human tumour cells in vitro: DT-diaphorase activity and hypoxia
-
Robertson N, Haigh A, Adams GE, et al: Factors affecting sensitivity to EO9 in rodent and human tumour cells in vitro: DT-diaphorase activity and hypoxia. Eur J Cancer 30A:1013-1019, 1994
-
(1994)
Eur J Cancer
, vol.30 A
, pp. 1013-1019
-
-
Robertson, N.1
Haigh, A.2
Adams, G.E.3
-
58
-
-
0028097816
-
Unusually marked hypoxic sensitisation to indoloquinone EO9 and mitomycin C in a human colon-tumour cell line that lacks DT-diaphorase activity
-
Plumb JA, Workman P: Unusually marked hypoxic sensitisation to indoloquinone EO9 and mitomycin C in a human colon-tumour cell line that lacks DT-diaphorase activity. Int J Cancer 56:134-139, 1994
-
(1994)
Int J Cancer
, vol.56
, pp. 134-139
-
-
Plumb, J.A.1
Workman, P.2
-
59
-
-
0028339820
-
Bioreductive drugs for cancer therapy: The search for tumor specificity
-
Adams GE, Stratford IJ: Bioreductive drugs for cancer therapy: The search for tumor specificity. Int J Radiat Oncol Biol Phys 29:231-238, 1994
-
(1994)
Int J Radiat Oncol Biol Phys
, vol.29
, pp. 231-238
-
-
Adams, G.E.1
Stratford, I.J.2
-
60
-
-
0031930369
-
5-Substituted analogues of 3-hydroxymethyl-1-5-arziridinyl-1-methyl-2-[1H-indole-4, 7-dione]prop-2-en-ol (E09, NSC 382459) and their regiosomers as hypoxia-selective agents: Structure-cytotoxicity in vitro
-
Jaffar M, Naylor MA, Robertson N, et al: 5-Substituted analogues of 3-hydroxymethyl-1-5-arziridinyl-1-methyl-2-[1H-indole-4, 7-dione]prop-2-en-ol (E09, NSC 382459) and their regiosomers as hypoxia-selective agents: Structure-cytotoxicity in vitro. Anticancer Drug Des 13:105-123, 1998
-
(1998)
Anticancer Drug Des
, vol.13
, pp. 105-123
-
-
Jaffar, M.1
Naylor, M.A.2
Robertson, N.3
-
61
-
-
0029943044
-
Development, pharmacology, role of DT-diaphorase and prospects of the indolequinone EO9
-
Smitskamp-Wilms E, Hendriks HR, Peters GJ: Development, pharmacology, role of DT-diaphorase and prospects of the indolequinone EO9. Gene Pharmacol 27:421-429, 1996
-
(1996)
Gene Pharmacol
, vol.27
, pp. 421-429
-
-
Smitskamp-Wilms, E.1
Hendriks, H.R.2
Peters, G.J.3
-
62
-
-
0028338822
-
Phase I and pharmacologic study of the novel indoloquinone bioreductive alkylating cytotoxic drug EO9
-
Schellens JH, Planting AS, van Acker BA, et al: Phase I and pharmacologic study of the novel indoloquinone bioreductive alkylating cytotoxic drug EO9. J Nat Cancer Inst 86:906-912, 1994
-
(1994)
J Nat Cancer Inst
, vol.86
, pp. 906-912
-
-
Schellens, J.H.1
Planting, A.S.2
Van Acker, B.A.3
-
63
-
-
0030016605
-
A randomized phase II study with two schedules of the novel indoloquinone EO9 in non-small-cell lung cancer: A study of the EORTC early clinical studies group (ECSG)
-
Pavlidis N, Hanauske AR, Gamucci T, et al: A randomized phase II study with two schedules of the novel indoloquinone EO9 in non-small-cell lung cancer: A study of the EORTC early clinical studies group (ECSG). Ann Oncol 7:529-531, 1996
-
(1996)
Ann Oncol
, vol.7
, pp. 529-531
-
-
Pavlidis, N.1
Hanauske, A.R.2
Gamucci, T.3
-
64
-
-
0027220811
-
Rationale for the use of aliphatic N-oxides of cytotoxic anthraquinones as prodrug DNA binding: A new class of bioreductive agent
-
Patterson LH: Rationale for the use of aliphatic N-oxides of cytotoxic anthraquinones as prodrug DNA binding: A new class of bioreductive agent. Cancer Met Rev 12:119-134, 1993
-
(1993)
Cancer Met Rev
, vol.12
, pp. 119-134
-
-
Patterson, L.H.1
-
65
-
-
0029054994
-
AQ4N: An alkylaminoanthraquinone N-oxide showing bioreductive potential and positive interaction with radiation in vivo
-
McKeown SR, Hejmadi MV, McIntyre IA, et al: AQ4N: An alkylaminoanthraquinone N-oxide showing bioreductive potential and positive interaction with radiation in vivo. Br J Cancer 72:76-81, 1995
-
(1995)
Br J Cancer
, vol.72
, pp. 76-81
-
-
McKeown, S.R.1
Hejmadi, M.V.2
McIntyre, I.A.3
-
66
-
-
0029885455
-
Evidence for a therapeutic gain when AQ4N or tirapazamine is combined with radiation
-
McKeown SR, Friery OP, McIntyre IA, et al: Evidence for a therapeutic gain when AQ4N or tirapazamine is combined with radiation. Br J Cancer 27:S39-42, 1996 (suppl)
-
(1996)
Br J Cancer
, vol.27
, Issue.SUPPL.
-
-
McKeown, S.R.1
Friery, O.P.2
McIntyre, I.A.3
-
67
-
-
0033495991
-
Antitumour prodrug development using cytochrome P450 (CYP) mediated activation
-
Patterson LH, McKeown SR, Robson T, et al: Antitumour prodrug development using cytochrome P450 (CYP) mediated activation. Anticancer Drug Des Dec 14:473-486, 1999
-
(1999)
Anticancer Drug Des Dec
, vol.14
, pp. 473-486
-
-
Patterson, L.H.1
McKeown, S.R.2
Robson, T.3
-
68
-
-
0033519175
-
Bioreductivelyactivated prodrugs for targeting hypoxic tissues: Elimination of Aspirin from 2-nitroimidazole derivatives
-
Everett SA, Naylor MA, Patel KB, et al: Bioreductivelyactivated prodrugs for targeting hypoxic tissues: Elimination of Aspirin from 2-nitroimidazole derivatives. Bio Med Chem Lett 9:1267-1272, 1999
-
(1999)
Bio Med Chem Lett
, vol.9
, pp. 1267-1272
-
-
Everett, S.A.1
Naylor, M.A.2
Patel, K.B.3
-
69
-
-
0036015560
-
Antiangiogenic, bioreductive and gene therapy approaches to the treatment of hypoxic tumours
-
McNally VA, Patterson AV, Williams KJ, et al: Antiangiogenic, bioreductive and gene therapy approaches to the treatment of hypoxic tumours. Curr Pharm Des 1319-1333, 2002
-
(2002)
Curr Pharm Des
, pp. 1319-1333
-
-
McNally, V.A.1
Patterson, A.V.2
Williams, K.J.3
-
70
-
-
0029439313
-
Radicals from oneelectron reduction of nitro compounds, aromatic-N-oxides and quinones: The kinetic basis for hypoxia-selective bioreductive drugs
-
Wardman P, Derris MF, Everett SA: Radicals from oneelectron reduction of nitro compounds, aromatic-N-oxides and quinones: The kinetic basis for hypoxia-selective bioreductive drugs. Biochem Soc Symp 61:171-178, 1995
-
(1995)
Biochem Soc Symp
, vol.61
, pp. 171-178
-
-
Wardman, P.1
Derris, M.F.2
Everett, S.A.3
-
71
-
-
0022532889
-
Modification of the cytotoxic activity of mitomycin C by oxygen and ascorbic acid in chinese hamster ovary cells and in a repair deficient mutant
-
Marshall RS, Rauth AM: Modification of the cytotoxic activity of mitomycin C by oxygen and ascorbic acid in chinese hamster ovary cells and in a repair deficient mutant. Cancer Res 46:2709-2713, 1986
-
(1986)
Cancer Res
, vol.46
, pp. 2709-2713
-
-
Marshall, R.S.1
Rauth, A.M.2
-
72
-
-
0021180633
-
Effect of oxygen on misonidazole chemosensitization and cytotoxicity in vitro
-
Mulcahy RT: Effect of oxygen on misonidazole chemosensitization and cytotoxicity in vitro. Cancer Res 44:4409-4413, 1984
-
(1984)
Cancer Res
, vol.44
, pp. 4409-4413
-
-
Mulcahy, R.T.1
-
74
-
-
0027288316
-
SR 4233 (Tirapazamine): A new anticancer drug exploiting hypoxia in solid tumours
-
Brown JM: SR 4233 (Tirapazamine): A new anticancer drug exploiting hypoxia in solid tumours. Br J Cancer 67:1163-1170, 1993
-
(1993)
Br J Cancer
, vol.67
, pp. 1163-1170
-
-
Brown, J.M.1
-
76
-
-
0036145795
-
Hypoxia-inducible regulation of a prodrug-activating enzyme for tumor-specific gene therapy
-
Shibata T, Giaccia AJ, Brown JM: Hypoxia-inducible regulation of a prodrug-activating enzyme for tumor-specific gene therapy. Neoplasia 4:40-48, 2002
-
(2002)
Neoplasia
, vol.4
, pp. 40-48
-
-
Shibata, T.1
Giaccia, A.J.2
Brown, J.M.3
-
77
-
-
0036328116
-
Oxygensensitive gene-directed enzyme-prodrug therapy (02-GDEPT) for solid tumours: Potentially curative when combined with x-rays
-
Patterson AV, Williams KJ, Cowen RL, et al: Oxygensensitive gene-directed enzyme-prodrug therapy (02-GDEPT) for solid tumours: Potentially curative when combined with x-rays. Gene Ther 9:946-954, 2002
-
(2002)
Gene Ther
, vol.9
, pp. 946-954
-
-
Patterson, A.V.1
Williams, K.J.2
Cowen, R.L.3
-
78
-
-
0031909654
-
A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85
-
Overgaard J, Hansen HS, Overgaard M, et al: A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85. Radiother Oncol 46:135-146, 1998
-
(1998)
Radiother Oncol
, vol.46
, pp. 135-146
-
-
Overgaard, J.1
Hansen, H.S.2
Overgaard, M.3
-
79
-
-
0036131908
-
Synthesis of novel paclitaxel prodrugs designed for bioreductive activation in hypoxic tumour tissue
-
Damen EW, Nevalainen TJ, van den Bergh TJ, et al: Synthesis of novel paclitaxel prodrugs designed for bioreductive activation in hypoxic tumour tissue. Bioorg Med Chem. 10(1):71-77, 2002
-
(2002)
Bioorg Med Chem
, vol.10
, Issue.1
, pp. 71-77
-
-
Damen, E.W.1
Nevalainen, T.J.2
Van den Bergh, T.J.3
-
80
-
-
0034571055
-
4-[3-(2-Nitro-1imidazolyl)propylamino]-7-chloroquinoline hydrochloride (NLCQ-1), a novel bioreductive agent as radiosensitizer in vitro and in vivo: Comparison with tirapazamine
-
Papadopoulou MV, Ji M, Rao MK, et al: 4-[3-(2-Nitro-1imidazolyl)propylamino]-7-chloroquinoline hydrochloride (NLCQ-1), a novel bioreductive agent as radiosensitizer in vitro and in vivo: Comparison with tirapazamine. Oncol Res 12:323-333, 2000
-
(2000)
Oncol Res
, vol.12
, pp. 323-333
-
-
Papadopoulou, M.V.1
Ji, M.2
Rao, M.K.3
-
81
-
-
0035846072
-
Hypoxia-selective anti-tumor agents. 16. Nitroarylmethyl quaternary salts as bioreductive prodrugs of the alkylating agent mechlorethamine
-
Tercel M, Lee AE, Hogg A, et al: Hypoxia-selective anti-tumor agents. 16. Nitroarylmethyl quaternary salts as bioreductive prodrugs of the alkylating agent mechlorethamine. J Med Chem 11:3511-3522, 2001
-
(2001)
J Med Chem
, vol.11
, pp. 3511-3522
-
-
Tercel, M.1
Lee, A.E.2
Hogg, A.3
-
82
-
-
0035346937
-
Quinoxaline 1,4-dioxides as anticancer and hypoxia-selective drugs
-
Gali-Muhtasib HU, Haddadin MJ, Rahhal DN, et al: Quinoxaline 1,4-dioxides as anticancer and hypoxia-selective drugs. Oncol Rep 8:679-684, 2001
-
(2001)
Oncol Rep
, vol.8
, pp. 679-684
-
-
Gali-Muhtasib, H.U.1
Haddadin, M.J.2
Rahhal, D.N.3
-
83
-
-
0034597583
-
Sulfoxide-containing aromatic nitrogen mustards as hypoxia-directed bioreductive cytotoxins
-
Sun ZY, Botros E, Su AD, et al: Sulfoxide-containing aromatic nitrogen mustards as hypoxia-directed bioreductive cytotoxins. J Med Chem 43:4160-4168, 2000
-
(2000)
J Med Chem
, vol.43
, pp. 4160-4168
-
-
Sun, Z.Y.1
Botros, E.2
Su, A.D.3
|