-
1
-
-
2942590732
-
Exploiting tumor hypoxia in cancer treatment
-
J. M. Brown and W. R. Wilson, Exploiting tumor hypoxia in cancer treatment. Nat. Rev. Cancer 4, 437-447 (2004).
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 437-447
-
-
Brown, J.M.1
Wilson, W.R.2
-
2
-
-
0027339592
-
2 predicts survival in advanced cancer of the uterine cervix
-
2 predicts survival in advanced cancer of the uterine cervix. Radiother. Oncol. 26, 45-50 (1993).
-
(1993)
Radiother. Oncol
, vol.26
, pp. 45-50
-
-
Hockel, M.1
Knoop, C.2
Schlenger, K.3
Vorndran, B.4
Baussmann, E.5
Mitze, M.6
Knapstein, P.G.7
Vaupel, P.8
-
3
-
-
0029955072
-
Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck
-
M. Nordsmark, M. Overgaard and J. Overgaard, Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother. Oncol. 41, 31-39 (1996).
-
(1996)
Radiother. Oncol
, vol.41
, pp. 31-39
-
-
Nordsmark, M.1
Overgaard, M.2
Overgaard, J.3
-
4
-
-
0031716020
-
Oxygenation predicts radiation response and survival in patients with cervix cancer
-
A. W. Fyles, M. Milosevic, R. Wong, M. C. Kavanagh, M. Pintilie, A. Sun, W. Chapman, W. Levin, L. Manchul and R. P. Hill, Oxygenation predicts radiation response and survival in patients with cervix cancer. Radiother. Oncol. 48, 149-156 (1998).
-
(1998)
Radiother. Oncol
, vol.48
, pp. 149-156
-
-
Fyles, A.W.1
Milosevic, M.2
Wong, R.3
Kavanagh, M.C.4
Pintilie, M.5
Sun, A.6
Chapman, W.7
Levin, W.8
Manchul, L.9
Hill, R.P.10
-
5
-
-
0033922706
-
Hypoxia-induced treatment failure in advanced squamous cell carcinoma of the uterine cervix is primarily due to hypoxia-induced radiation resistance rather than hypoxia-induced metastasis
-
E. K. Rofstad, K. Sundfor, H. Lyng and C. G. Trope, Hypoxia-induced treatment failure in advanced squamous cell carcinoma of the uterine cervix is primarily due to hypoxia-induced radiation resistance rather than hypoxia-induced metastasis. Br. J Cancer 83, 354-359 (2000).
-
(2000)
Br. J Cancer
, vol.83
, pp. 354-359
-
-
Rofstad, E.K.1
Sundfor, K.2
Lyng, H.3
Trope, C.G.4
-
6
-
-
0036359548
-
Hypoxia - a key regulatory factor in tumour growth
-
A. L. Harris, Hypoxia - a key regulatory factor in tumour growth. Nat. Rev. Cancer 2, 38-47 (2002).
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 38-47
-
-
Harris, A.L.1
-
7
-
-
0037279517
-
The hypoxic tumour microenvironment and metastatic progression
-
P. Subarsky and R. P. Hill, The hypoxic tumour microenvironment and metastatic progression. Clin. Exp. Metastasis 20, 237-250 (2003).
-
(2003)
Clin. Exp. Metastasis
, vol.20
, pp. 237-250
-
-
Subarsky, P.1
Hill, R.P.2
-
8
-
-
10444287596
-
Genetic instability and the tumor microenvironment: Towards the concept of microvenivronment-induced mutagenesis
-
R. S. Bindra and P. M. Glazer, Genetic instability and the tumor microenvironment: Towards the concept of microvenivronment-induced mutagenesis. Mutat. Res. 569, 75-85 (2005).
-
(2005)
Mutat. Res
, vol.569
, pp. 75-85
-
-
Bindra, R.S.1
Glazer, P.M.2
-
9
-
-
33745303045
-
Hypoxia signalling in cancer and approaches to enforce tumour regression
-
J. Pouyssegur, F. Dayan and N. M. Mazure, Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 441, 437-443 (2006).
-
(2006)
Nature
, vol.441
, pp. 437-443
-
-
Pouyssegur, J.1
Dayan, F.2
Mazure, N.M.3
-
10
-
-
16644377045
-
Tirapazamine, cisplatin, and radiation versus fluorouracil, cisplatin, and radiation in patients with locally advanced head and neck cancer: A randomized phase II trial of the Trans-Tasman Radiation Oncology Group (TROG 98.02)
-
D. Rischin, L. Peters, R. Fisher, A. Macann, J. Denham, M. Poulsen, M. Jackson, L. Kenny, M. Pennimen and B. McClure, Tirapazamine, cisplatin, and radiation versus fluorouracil, cisplatin, and radiation in patients with locally advanced head and neck cancer: A randomized phase II trial of the Trans-Tasman Radiation Oncology Group (TROG 98.02). J. Clin. Oncol. 23, 79-87 (2005).
-
(2005)
J. Clin. Oncol
, vol.23
, pp. 79-87
-
-
Rischin, D.1
Peters, L.2
Fisher, R.3
Macann, A.4
Denham, J.5
Poulsen, M.6
Jackson, M.7
Kenny, L.8
Pennimen, M.9
McClure, B.10
-
11
-
-
0036041236
-
Bioreductively activated antitumor N-oxides: The case of AQ4N, a unique approach to hypoxia-activated cancer chemotherapy
-
L. H. Patterson, Bioreductively activated antitumor N-oxides: The case of AQ4N, a unique approach to hypoxia-activated cancer chemotherapy. Drug Metab. Rev. 34, 581-592 (2002).
-
(2002)
Drug Metab. Rev
, vol.34
, pp. 581-592
-
-
Patterson, L.H.1
-
12
-
-
0344629821
-
NLCQ-1 (NSC 709257): Exploiting hypoxia with a weak DNA-intercalating bioreductive drug
-
M. V. Papadopoulou and W. D. Bloomer, NLCQ-1 (NSC 709257): Exploiting hypoxia with a weak DNA-intercalating bioreductive drug. Clin. Cancer Res. 9, 5714-5720 (2003).
-
(2003)
Clin. Cancer Res
, vol.9
, pp. 5714-5720
-
-
Papadopoulou, M.V.1
Bloomer, W.D.2
-
13
-
-
21544441743
-
1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]car bonyl]hydrazine: An anticancer agent targeting hypoxic cells
-
H. A. Seow, P. G. Penketh, K. Shyam, S. Rockwell and A. C. Sartorelli, 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]car bonyl]hydrazine: An anticancer agent targeting hypoxic cells. Proc. Natl. Acad. Sci. USA 102, 9282-9287 (2005).
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 9282-9287
-
-
Seow, H.A.1
Penketh, P.G.2
Shyam, K.3
Rockwell, S.4
Sartorelli, A.C.5
-
14
-
-
39749179432
-
Metabolism and pharmacokinetics of PR-104, a hypoxia-activated nitrogen mustard prodrug in phase I clinical trial
-
K. Patel, Y. Gu, K. O. Hicks, G. J. Atwell, W. A. Denny, M. B. Jameson, D. Rischin, M. D. Pegram, J. Gutheil and W. R. Wilson, Metabolism and pharmacokinetics of PR-104, a hypoxia-activated nitrogen mustard prodrug in phase I clinical trial. Eur. J. Cancer 4 (Suppl.), 84 (2006).
-
(2006)
Eur. J. Cancer
, vol.4
, Issue.SUPPL.
, pp. 84
-
-
Patel, K.1
Gu, Y.2
Hicks, K.O.3
Atwell, G.J.4
Denny, W.A.5
Jameson, M.B.6
Rischin, D.7
Pegram, M.D.8
Gutheil, J.9
Wilson, W.R.10
-
15
-
-
34447122556
-
Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated and crosslinking agent PR-104
-
in press
-
A. V. Patterson, D. M. Ferry, S. J. Edwards, R. S. Singleton, K. Patel, S. M. Pullen, S. P. Syddall, K. D. Hicks, G. J. Atwell and W. R. Wilson, Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated and crosslinking agent PR-104. Clin. Cancer Res., in press.
-
Clin. Cancer Res
-
-
Patterson, A.V.1
Ferry, D.M.2
Edwards, S.J.3
Singleton, R.S.4
Patel, K.5
Pullen, S.M.6
Syddall, S.P.7
Hicks, K.D.8
Atwell, G.J.9
Wilson, W.R.10
-
16
-
-
0034652379
-
Hypoxia-dependent retinal toxicity of bioreductive anticancer prodrugs in mice
-
A. E. Lee and W. R. Wilson, Hypoxia-dependent retinal toxicity of bioreductive anticancer prodrugs in mice. Toxicol. Appl. Pharmacol. 163, 50-59 (2000).
-
(2000)
Toxicol. Appl. Pharmacol
, vol.163
, pp. 50-59
-
-
Lee, A.E.1
Wilson, W.R.2
-
18
-
-
34447616779
-
Oxygen saturation in the bone marrow of healthy volunteers
-
J. S. Harrison, P. Rameshwar, V. Chang and P. Bandari, Oxygen saturation in the bone marrow of healthy volunteers. Blood 99, 394 (2002).
-
(2002)
Blood
, vol.99
, pp. 394
-
-
Harrison, J.S.1
Rameshwar, P.2
Chang, V.3
Bandari, P.4
-
19
-
-
4043184065
-
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
-
D. J. Ceradini, A. R. Kulkarni, M. J. Callaghan, O. M. Tepper, N. Bastidas, M. E. Kleinman, J. M. Capla, R. D. Galiano, J. P. Levine and G. C. Gurtner, Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat. Med. 10, 858-864 (2004).
-
(2004)
Nat. Med
, vol.10
, pp. 858-864
-
-
Ceradini, D.J.1
Kulkarni, A.R.2
Callaghan, M.J.3
Tepper, O.M.4
Bastidas, N.5
Kleinman, M.E.6
Capla, J.M.7
Galiano, R.D.8
Levine, J.P.9
Gurtner, G.C.10
-
20
-
-
0030926491
-
Cells at intermediate oxygen levels can be more important than the "hypoxic fraction" in determining tumor response to fractionated radiotherapy
-
B. G. Wouters and J. M. Brown, Cells at intermediate oxygen levels can be more important than the "hypoxic fraction" in determining tumor response to fractionated radiotherapy. Radiat. Res. 147, 541-550 (1997).
-
(1997)
Radiat. Res
, vol.147
, pp. 541-550
-
-
Wouters, B.G.1
Brown, J.M.2
-
21
-
-
0030866977
-
An experimental and mathematical model for the extravascular transport of a DNA intercalator in tumours
-
K. O. Hicks, S. J. Ohms, P. L. van Zijl, W. A. Denny, P. J. Hunter and W. R. Wilson, An experimental and mathematical model for the extravascular transport of a DNA intercalator in tumours. Br. J. Cancer 76, 894-903 (1997).
-
(1997)
Br. J. Cancer
, vol.76
, pp. 894-903
-
-
Hicks, K.O.1
Ohms, S.J.2
van Zijl, P.L.3
Denny, W.A.4
Hunter, P.J.5
Wilson, W.R.6
-
22
-
-
0036015560
-
Antiangiogenic, bioreductive and gene therapy approaches to the treatment of hypoxic tumours
-
V. A. McNally, A. V. Patterson, K. J. Williams, R. L. Cowen, I. J. Stratford and M. Jaffar, Antiangiogenic, bioreductive and gene therapy approaches to the treatment of hypoxic tumours. Curr. Pharm. Des. 8, 1319-1333 (2002).
-
(2002)
Curr. Pharm. Des
, vol.8
, pp. 1319-1333
-
-
McNally, V.A.1
Patterson, A.V.2
Williams, K.J.3
Cowen, R.L.4
Stratford, I.J.5
Jaffar, M.6
-
23
-
-
0030738399
-
Adaptation of human tumor cells to tirapazamine under aerobic conditions: Implications of increased antioxidant enzyme activity to mechanism of aerobic cytotoxicity
-
J. H. Elwell, B. G. Siim, J. W. Evans and J. M. Brown, Adaptation of human tumor cells to tirapazamine under aerobic conditions: Implications of increased antioxidant enzyme activity to mechanism of aerobic cytotoxicity. Biochem. Pharmacol. 54, 249-257 (1997).
-
(1997)
Biochem. Pharmacol
, vol.54
, pp. 249-257
-
-
Elwell, J.H.1
Siim, B.G.2
Evans, J.W.3
Brown, J.M.4
-
24
-
-
0036494169
-
Quantitation of bystander effects in nitroreductase suicide gene therapy using three-dimensional cell cultures
-
W. R. Wilson, S. M. Pullen, A. Hogg, N. A. Helsby, K. O. Hicks and W. A. Denny, Quantitation of bystander effects in nitroreductase suicide gene therapy using three-dimensional cell cultures. Cancer Res. 62, 1425-1432 (2002).
-
(2002)
Cancer Res
, vol.62
, pp. 1425-1432
-
-
Wilson, W.R.1
Pullen, S.M.2
Hogg, A.3
Helsby, N.A.4
Hicks, K.O.5
Denny, W.A.6
-
25
-
-
37049118615
-
-
J. C. Mason and G. Tennant, Heterocyclic N-oxides. Part VI. Synthesis and nuclear magnetic resonance spectra of 3-aminobenzo-1,2,4-triazines and their mono- and di-N-oxides. J. Chem. Soc. B 911-916 (1970).
-
J. C. Mason and G. Tennant, Heterocyclic N-oxides. Part VI. Synthesis and nuclear magnetic resonance spectra of 3-aminobenzo-1,2,4-triazines and their mono- and di-N-oxides. J. Chem. Soc. B 911-916 (1970).
-
-
-
-
26
-
-
0027160629
-
Hypoxia-selective antitumor agents. 7. Metal complexes of aliphatic mustards as a new class of hypoxia-selective cytotoxins. Synthesis and evaluation of cobalt(III) complexes of bidentate mustards
-
D. C. Ware, B. D. Palmer, W. R. Wilson and W. A. Denny, Hypoxia-selective antitumor agents. 7. Metal complexes of aliphatic mustards as a new class of hypoxia-selective cytotoxins. Synthesis and evaluation of cobalt(III) complexes of bidentate mustards. J. Med. Chem. 36, 1839-1846 (1993).
-
(1993)
J. Med. Chem
, vol.36
, pp. 1839-1846
-
-
Ware, D.C.1
Palmer, B.D.2
Wilson, W.R.3
Denny, W.A.4
-
27
-
-
33646497001
-
Radiolytic and cellular reduction of a novel hypoxia-activated cobalt(III) prodrug of a chloromethylbenzindoline DNA minor groove alkylator
-
G. O. Ahn, K. J. Botting, A. V. Patterson, D. C. Ware, M. Tercel and W. R. Wilson, Radiolytic and cellular reduction of a novel hypoxia-activated cobalt(III) prodrug of a chloromethylbenzindoline DNA minor groove alkylator. Biochem. Pharmacol. 71, 1683-1694 (2006).
-
(2006)
Biochem. Pharmacol
, vol.71
, pp. 1683-1694
-
-
Ahn, G.O.1
Botting, K.J.2
Patterson, A.V.3
Ware, D.C.4
Tercel, M.5
Wilson, W.R.6
-
28
-
-
0028246907
-
Hypoxia-selective antitumor agents. 9. Structure-activity relationships for hypoxia-selective cytotoxicity among analogues of 5-[N,N-bis(2-chloroethyl) amino]-2,4-dinitrobenzamide
-
B. D. Palmer, W. R. Wilson, G. J. Atwell, D. Schultz, X. Z. Xu and W. A. Denny, Hypoxia-selective antitumor agents. 9. Structure-activity relationships for hypoxia-selective cytotoxicity among analogues of 5-[N,N-bis(2-chloroethyl) amino]-2,4-dinitrobenzamide. J. Med. Chem. 37, 2175-2184 (1994).
-
(1994)
J. Med. Chem
, vol.37
, pp. 2175-2184
-
-
Palmer, B.D.1
Wilson, W.R.2
Atwell, G.J.3
Schultz, D.4
Xu, X.Z.5
Denny, W.A.6
-
29
-
-
0037399470
-
Effect of nitroreduction on the alkylating reactivity and cytotoxicity of the 2,4-dinitrobenzamide-5-aziridine CB 1954 and the corresponding nitrogen mustard SN 23862: Distinct mechanisms of bioreductive activation
-
N. A. Helsby, S. J. Wheeler, F. B. Pruijn, B. D. Palmer, S. Yang, W. A. Denny and W. R. Wilson, Effect of nitroreduction on the alkylating reactivity and cytotoxicity of the 2,4-dinitrobenzamide-5-aziridine CB 1954 and the corresponding nitrogen mustard SN 23862: Distinct mechanisms of bioreductive activation. Chem. Res. Toxicol. 16, 469-478 (2003).
-
(2003)
Chem. Res. Toxicol
, vol.16
, pp. 469-478
-
-
Helsby, N.A.1
Wheeler, S.J.2
Pruijn, F.B.3
Palmer, B.D.4
Yang, S.5
Denny, W.A.6
Wilson, W.R.7
-
30
-
-
0021207993
-
Rapid detection of DNA-damaging agents using repair-deficient CHO cells
-
C. A. Hoy, E. P. Salazar and L. H. Thompson, Rapid detection of DNA-damaging agents using repair-deficient CHO cells. Mutat. Res. 130, 321-332 (1984).
-
(1984)
Mutat. Res
, vol.130
, pp. 321-332
-
-
Hoy, C.A.1
Salazar, E.P.2
Thompson, L.H.3
-
31
-
-
0030692717
-
Cytochrome c (P450) reductase confers enhanced sensitivity to both tirapazamine (SR 4233) and RSU 1069
-
Overexpression of human NADPH
-
A. V. Patterson, M. P. Saunders, E. C. Chinje, D. C. Talbot, A. L. Harris and I. J. Stratford, Overexpression of human NADPH: Cytochrome c (P450) reductase confers enhanced sensitivity to both tirapazamine (SR 4233) and RSU 1069. Br. J. Cancer 76, 1338-1347 (1997).
-
(1997)
Br. J. Cancer
, vol.76
, pp. 1338-1347
-
-
Patterson, A.V.1
Saunders, M.P.2
Chinje, E.C.3
Talbot, D.C.4
Harris, A.L.5
Stratford, I.J.6
-
32
-
-
0025211779
-
Quantitation of protein
-
C. M. Stoscheck, Quantitation of protein. Methods Enzymol. 182, 50-68 (1990).
-
(1990)
Methods Enzymol
, vol.182
, pp. 50-68
-
-
Stoscheck, C.M.1
-
33
-
-
0025341331
-
New colorimetric cytotoxicity assay for anticancer-drug screening
-
P. Skehan, R. Storeng, D. Scudiero, A. Monks, J. McMahon, D. Vistica, J. T. Warren, H. Bokesch, S. Kenney and M. R. Boyd, New colorimetric cytotoxicity assay for anticancer-drug screening. J. Natl. Cancer Inst. 82, 1107-1112 (1990).
-
(1990)
J. Natl. Cancer Inst
, vol.82
, pp. 1107-1112
-
-
Skehan, P.1
Storeng, R.2
Scudiero, D.3
Monks, A.4
McMahon, J.5
Vistica, D.6
Warren, J.T.7
Bokesch, H.8
Kenney, S.9
Boyd, M.R.10
-
34
-
-
1542676977
-
In vitro and in vivo models for evaluation of GDEPT: Quantifying bystander killing in cell cultures and tumors
-
C. J. Springer, Ed, pp, Humana Press, Totowa, NJ
-
W. R. Wilson, S. M. Pullen, A. Hogg, S. M. Hobbs, F. B. Pruijn and K. O. Hicks, In vitro and in vivo models for evaluation of GDEPT: Quantifying bystander killing in cell cultures and tumors. In Suicide Gene Therapy: Methods and Reviews (C. J. Springer, Ed.), pp. 403-432. Humana Press, Totowa, NJ, 2003.
-
(2003)
Suicide Gene Therapy: Methods and Reviews
, pp. 403-432
-
-
Wilson, W.R.1
Pullen, S.M.2
Hogg, A.3
Hobbs, S.M.4
Pruijn, F.B.5
Hicks, K.O.6
-
35
-
-
0031785201
-
Extravascular diffusion of tirapazamine - effect of metabolic consumption assessed using the multicellular layer model
-
K. O. Hicks, Y. Fleming, B. G. Siim, C. J. Koch and W. R. Wilson, Extravascular diffusion of tirapazamine - effect of metabolic consumption assessed using the multicellular layer model. Int. J. Radiat. Oncol. Biol. Phys. 42, 641-649 (1998).
-
(1998)
Int. J. Radiat. Oncol. Biol. Phys
, vol.42
, pp. 641-649
-
-
Hicks, K.O.1
Fleming, Y.2
Siim, B.G.3
Koch, C.J.4
Wilson, W.R.5
-
36
-
-
0028916689
-
Reductive chemistry of the novel hypoxia-selective cytotoxin 5-[N,N-bis(2-chloroethyl) amino]-2,4-dinitrobenzamide
-
B. D. Palmer, P. van Zijl, W. A. Denny and W. R. Wilson, Reductive chemistry of the novel hypoxia-selective cytotoxin 5-[N,N-bis(2-chloroethyl) amino]-2,4-dinitrobenzamide. J. Med. Chem. 38, 1229-1241 (1995).
-
(1995)
J. Med. Chem
, vol.38
, pp. 1229-1241
-
-
Palmer, B.D.1
van Zijl, P.2
Denny, W.A.3
Wilson, W.R.4
-
37
-
-
1942424798
-
2-amino metabolites are key mediators of CB 1954 and SN 23862 bystander effects in nitroreductase GDEPT
-
N. A. Helsby, D. M. Ferry, A. V. Patterson, S. M. Pullen and W. R. Wilson, 2-amino metabolites are key mediators of CB 1954 and SN 23862 bystander effects in nitroreductase GDEPT. Br. J. Cancer 90, 1084-1093 (2004).
-
(2004)
Br. J. Cancer
, vol.90
, pp. 1084-1093
-
-
Helsby, N.A.1
Ferry, D.M.2
Patterson, A.V.3
Pullen, S.M.4
Wilson, W.R.5
-
38
-
-
3042537843
-
Oxygen dependence of the metabolic activation and cytotoxicity of tirapazamine: Implications for extravascular transport and activity in tumors
-
K. O. Hicks, B. G. Siim, F. B. Pruijn and W. R. Wilson, Oxygen dependence of the metabolic activation and cytotoxicity of tirapazamine: Implications for extravascular transport and activity in tumors. Radiat. Res. 161, 656-666 (2004).
-
(2004)
Radiat. Res
, vol.161
, pp. 656-666
-
-
Hicks, K.O.1
Siim, B.G.2
Pruijn, F.B.3
Wilson, W.R.4
-
39
-
-
0021824209
-
Defective DNA cross-link removal in Chinese hamster cell mutants hypersensitive to bifunctional alkylating agents
-
C. A. Hoy, L. H. Thompson, C. L. Mooney and E. P. Salazar, Defective DNA cross-link removal in Chinese hamster cell mutants hypersensitive to bifunctional alkylating agents. Cancer Res. 45, 1737-1743 (1985).
-
(1985)
Cancer Res
, vol.45
, pp. 1737-1743
-
-
Hoy, C.A.1
Thompson, L.H.2
Mooney, C.L.3
Salazar, E.P.4
-
40
-
-
0034980559
-
Radiation-induced bystander effects: Past history and future directions
-
C. Mothersill and C. Seymour, Radiation-induced bystander effects: Past history and future directions. Radiat. Res. 155, 759-767 (2001).
-
(2001)
Radiat. Res
, vol.155
, pp. 759-767
-
-
Mothersill, C.1
Seymour, C.2
-
41
-
-
0038275987
-
The bystander effect
-
E. J. Hall, The bystander effect. Health Phys. 85, 31-35 (2003).
-
(2003)
Health Phys
, vol.85
, pp. 31-35
-
-
Hall, E.J.1
-
42
-
-
0030898609
-
Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells
-
C. Mothersill and C. B. Seymour, Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells. Int. J. Radiat. Biol. 71, 421-427 (1997).
-
(1997)
Int. J. Radiat. Biol
, vol.71
, pp. 421-427
-
-
Mothersill, C.1
Seymour, C.B.2
-
43
-
-
0023929181
-
Molecular mechanisms for the hypoxia-dependent activation of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233)
-
K. Laderoute, P. Wardman and A. M. Rauth, Molecular mechanisms for the hypoxia-dependent activation of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233). Biochem. Pharmacol. 37, 1487-1495 (1988).
-
(1988)
Biochem. Pharmacol
, vol.37
, pp. 1487-1495
-
-
Laderoute, K.1
Wardman, P.2
Rauth, A.M.3
-
44
-
-
0026802366
-
Repair of DNA and chromosome breaks in cells exposed to SR 4233 under hypoxia or to ionizing radiation
-
J. Wang, K. A. Biedermann and J. M. Brown, Repair of DNA and chromosome breaks in cells exposed to SR 4233 under hypoxia or to ionizing radiation. Cancer Res. 52, 4473-4477 (1992).
-
(1992)
Cancer Res
, vol.52
, pp. 4473-4477
-
-
Wang, J.1
Biedermann, K.A.2
Brown, J.M.3
-
45
-
-
0035010504
-
Electron transfer and oxidative stress as key factors in the design of drugs selectively active in hypoxia
-
P. Wardman, Electron transfer and oxidative stress as key factors in the design of drugs selectively active in hypoxia. Curr. Med. Chem. 8, 739-761 (2001).
-
(2001)
Curr. Med. Chem
, vol.8
, pp. 739-761
-
-
Wardman, P.1
-
46
-
-
0029959898
-
DNA cleavage by the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (SR4233): Evidence for involvement of hydroxyl radical
-
J. S. Daniels and K. S. Gates, DNA cleavage by the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (SR4233): Evidence for involvement of hydroxyl radical. J. Am. Chem. Soc. 118, 3380-3385 (1996).
-
(1996)
J. Am. Chem. Soc
, vol.118
, pp. 3380-3385
-
-
Daniels, J.S.1
Gates, K.S.2
-
47
-
-
0037460188
-
Activation of 3-amino-1,2,4-benzotriazine 1,4-dioxide antitumor agents to oxidizing species following their one-electron reduction
-
R. F. Anderson, S. S. Shinde, M. P. Hay, S. A. Gamage and W. A. Denny, Activation of 3-amino-1,2,4-benzotriazine 1,4-dioxide antitumor agents to oxidizing species following their one-electron reduction. J. Am. Chem. Soc. 125, 748-756 (2003).
-
(2003)
J. Am. Chem. Soc
, vol.125
, pp. 748-756
-
-
Anderson, R.F.1
Shinde, S.S.2
Hay, M.P.3
Gamage, S.A.4
Denny, W.A.5
-
48
-
-
0034660849
-
Combination of the bioreductive drug tirapazamine with the chemotherapeutic prodrug cyclophosphamide for P450/P450-reductase-based cancer gene therapy
-
Y. Jounaidi and D. J. Waxman, Combination of the bioreductive drug tirapazamine with the chemotherapeutic prodrug cyclophosphamide for P450/P450-reductase-based cancer gene therapy. Cancer Res. 60, 3761-3769 (2000).
-
(2000)
Cancer Res
, vol.60
, pp. 3761-3769
-
-
Jounaidi, Y.1
Waxman, D.J.2
-
49
-
-
0024414051
-
Toxicity of RSU-1069 for KHT cells treated in vivo or in vitro: Evidence for a diffusible toxic product
-
R. P. Hill, S. Gulyas and G. F. Whitmore, Toxicity of RSU-1069 for KHT cells treated in vivo or in vitro: Evidence for a diffusible toxic product. Int. J. Radiat. Oncol. Biol. Phys. 16, 1111-1114 (1989).
-
(1989)
Int. J. Radiat. Oncol. Biol. Phys
, vol.16
, pp. 1111-1114
-
-
Hill, R.P.1
Gulyas, S.2
Whitmore, G.F.3
-
50
-
-
0000116995
-
Kinetics and mechanism of the decomposition in aqueous solutions of 2-(hydroxylamino)imidazoles
-
J. L. Bolton and R. A. McClelland, Kinetics and mechanism of the decomposition in aqueous solutions of 2-(hydroxylamino)imidazoles. J. Am. Chem. Soc. 111, 8172-8181 (1989).
-
(1989)
J. Am. Chem. Soc
, vol.111
, pp. 8172-8181
-
-
Bolton, J.L.1
McClelland, R.A.2
-
51
-
-
0026510960
-
Use of a high frequency ultrasound microscope to image the action of 2-nitroimidazoles in multicellular spheroids
-
L. R. Berube, K. Harasiewicz, F. S. Foster, E. Dobrowsky, M. D. Sherar and A. M. Rauth, Use of a high frequency ultrasound microscope to image the action of 2-nitroimidazoles in multicellular spheroids. Br. J. Cancer 65, 633-640 (1992).
-
(1992)
Br. J. Cancer
, vol.65
, pp. 633-640
-
-
Berube, L.R.1
Harasiewicz, K.2
Foster, F.S.3
Dobrowsky, E.4
Sherar, M.D.5
Rauth, A.M.6
-
52
-
-
0024209370
-
A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydrozylamino-2- nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by nitroreductase enzyme in Walker carcinoma cells
-
R. J. Knox, F. Friedlos, M. Jarman and J. J. Robert, A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydrozylamino-2- nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by nitroreductase enzyme in Walker carcinoma cells. Biochem. Pharmacol. 37, 4661-4669 (1988).
-
(1988)
Biochem. Pharmacol
, vol.37
, pp. 4661-4669
-
-
Knox, R.J.1
Friedlos, F.2
Jarman, M.3
Robert, J.J.4
-
53
-
-
0029147264
-
Bioactivation of dinitrobenzamide mustards by an E. coli B nitroreductase
-
G. M. Anlezark, R. G. Melton, R. F. Sherwood, W. R. Wilson, W. A. Denny, B. D. Palmer, R. J. Knox, F. Friedlos and A. Williams, Bioactivation of dinitrobenzamide mustards by an E. coli B nitroreductase. Biochem. Pharmacol. 50, 609-618 (1995).
-
(1995)
Biochem. Pharmacol
, vol.50
, pp. 609-618
-
-
Anlezark, G.M.1
Melton, R.G.2
Sherwood, R.F.3
Wilson, W.R.4
Denny, W.A.5
Palmer, B.D.6
Knox, R.J.7
Friedlos, F.8
Williams, A.9
-
54
-
-
0141790765
-
Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form
-
E. Johansson, G. Parkinson, W. A. Denny and S. Neidle, Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form. J. Med. Chem. 46, 4009-4020 (2003).
-
(2003)
J. Med. Chem
, vol.46
, pp. 4009-4020
-
-
Johansson, E.1
Parkinson, G.2
Denny, W.A.3
Neidle, S.4
|