Hypoxia-selective antitumor agents. 12. Nitrobenzyl quaternary salts as bioreductive prodrugs of the alkylating agent mechlorethamine

Journal of Medicinal Chemistry

Volumn 39, Issue 5, 1996, Pages 1084-1094

  Tercel, Moana ^a   Wilson, William R ^a   Anderson, Robert F ^b   Denny, William A ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CYTOTOXIN; N (2 CHLOROETHYL) N METHYL 6 NITRO 1,2,3,4 TETRAHYDROISOQUINOLINIUM CHLORIDE; N (2 CHLOROETHYL) N METHYL 7 NITRO 1,2,3,4 TETRAHYDROISOQUINOLINIUM CHLORIDE; N (2 CHLOROETHYL) N METHYL 8 NITRO 1,2,3,4 TETRAHYDROISOQUINOLINIUM CHLORIDE; N,N BIS(2 CHLOROETHYL) N METHYL N (2 NITROBENZYL)AMMONIUM CHLORIDE; NAPHTHALENE DERIVATIVE; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER; CYTOTOXICITY; DNA ALKYLATION; HUMAN; HUMAN CELL; HYPOXIA; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, ALKYLATING; CELL HYPOXIA; CELL SURVIVAL; CHEMISTRY, PHYSICAL; DNA REPAIR; HUMANS; MECHLORETHAMINE; MOLECULAR STRUCTURE; NITROGEN MUSTARD COMPOUNDS; OXYGEN; PRODRUGS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0030004578     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9507791     Document Type: Article

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