Spin trapping of radicals other than the •OH radical upon reduction of the anticancer agent tirapazamine by cytochrome P450 reductase

Journal of the American Chemical Society

Volumn 131, Issue 40, 2009, Pages 14220-14221

  Shinde, Sujata S ^a,b   Hay, Michael P ^b   Patterson, Adam V ^b   Denny, William A ^b   Anderson, Robert F ^a,b  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

A-CARBON; ANTI-CANCER AGENTS; BENZOTRIAZINYL RADICAL; BIOREDUCTIVE DRUGS; CHEMICAL EQUATIONS; COMPOSITE SPECTRA; CYTOCHROME P450; ELECTRON PARAMAGNETIC RESONANCE SPECTROSCOPY; EPR SPECTRA; OH RADICAL; ONE-ELECTRON REDUCTIONS; RADICAL SPECIES; REDOX EQUILIBRIUM; SPIN TRAP; SPIN TRAPPING; TIRAPAZAMINE;

AMINES; CHEMICAL REACTIONS; ELECTRON RESONANCE; ELECTRONS; FREE RADICALS; PARAMAGNETIC RESONANCE; PARAMAGNETISM; QUANTUM THEORY; SPIN DYNAMICS;

ELECTRON SPIN RESONANCE SPECTROSCOPY;

1,2,4 BENZOTRIAZINE 1,4 DIOXIDE; 5 DIETHOXYPHOSPHORYL 5 METHYL 1 PYRROLINE 1 OXIDE; 5,5 DIMETHYL 1 PYRROLINE 1 OXIDE; CYTOCHROME P450 REDUCTASE; ISOTOPE; NITROGEN; OXYGEN; RADICAL; SKATOLE; TIRAPAZAMINE;

ARTICLE; ELECTRON SPIN RESONANCE; HYPOXIA; MICROSOME; OXIDATION REDUCTION POTENTIAL; PROTEIN PHOSPHORYLATION; PROTON TRANSPORT; SPIN TRAPPING; TEMPERATURE SENSITIVITY;

ANTINEOPLASTIC AGENTS; CYCLIC N-OXIDES; ELECTRON SPIN RESONANCE SPECTROSCOPY; HYDROXYL RADICAL; NADPH-FERRIHEMOPROTEIN REDUCTASE; OXIDATION-REDUCTION; PYRROLES; SPIN LABELS; SPIN TRAPPING; TRIAZINES;

EID: 70349921764     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja906860a     Document Type: Article

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