-
2
-
-
0034102337
-
ATR disruption leads to chromosomal fragmentation and early embryonic lethality
-
Brown E.J., Baltimore D. ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev. 14:2000;397-402.
-
(2000)
Genes Dev.
, vol.14
, pp. 397-402
-
-
Brown, E.J.1
Baltimore, D.2
-
3
-
-
0345073699
-
A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome
-
O'Driscoll M., Ruiz-Perez V.L., Woods C.G., Jeggo P.A., Goodship J.A. A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. Nat. Genet. 33:2003;497-501.
-
(2003)
Nat. Genet.
, vol.33
, pp. 497-501
-
-
O'Driscoll, M.1
Ruiz-Perez, V.L.2
Woods, C.G.3
Jeggo, P.A.4
Goodship, J.A.5
-
4
-
-
0034707047
-
The DNA damage response: Putting checkpoints in perspective
-
Zhou B.B., Elledge S.J. The DNA damage response: putting checkpoints in perspective. Nature. 408:2000;433-439.
-
(2000)
Nature
, vol.408
, pp. 433-439
-
-
Zhou, B.B.1
Elledge, S.J.2
-
5
-
-
0032472330
-
Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints
-
Cliby W.A., Roberts C.J., Cimprich K.A., Stringer C.M., Lamb J.R., Schreiber S.L., Friend S.H. Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. EMBO J. 17:1998;159-169.
-
(1998)
EMBO J.
, vol.17
, pp. 159-169
-
-
Cliby, W.A.1
Roberts, C.J.2
Cimprich, K.A.3
Stringer, C.M.4
Lamb, J.R.5
Schreiber, S.L.6
Friend, S.H.7
-
6
-
-
0036179376
-
Hypoxia links ATR and p53 through replication arrest
-
Hammond E.M., Denko N.C., Dorie M.J., Abraham R.T., Giaccia A.J. Hypoxia links ATR and p53 through replication arrest. Mol. Cell. Biol. 22:2002;1834-1843.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 1834-1843
-
-
Hammond, E.M.1
Denko, N.C.2
Dorie, M.J.3
Abraham, R.T.4
Giaccia, A.J.5
-
7
-
-
0037080675
-
Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin
-
Zou L., Cortez D., Elledge S.J. Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes Dev. 16:2002;198-208.
-
(2002)
Genes Dev.
, vol.16
, pp. 198-208
-
-
Zou, L.1
Cortez, D.2
Elledge, S.J.3
-
8
-
-
0035797383
-
The DNA replication checkpoint response stabilizes stalled replication forks
-
Lopes M., Cotta-Ramusino C., Pellicioli A., Liberi G., Plevani P., Muzi-Falconi M., Newlon C.S., Foiani M. The DNA replication checkpoint response stabilizes stalled replication forks. Nature. 412:2001;557-561.
-
(2001)
Nature
, vol.412
, pp. 557-561
-
-
Lopes, M.1
Cotta-Ramusino, C.2
Pellicioli, A.3
Liberi, G.4
Plevani, P.5
Muzi-Falconi, M.6
Newlon, C.S.7
Foiani, M.8
-
9
-
-
0035797444
-
Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint
-
Tercero J.A., Diffley J.F. Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint. Nature. 412:2001;553-557.
-
(2001)
Nature
, vol.412
, pp. 553-557
-
-
Tercero, J.A.1
Diffley, J.F.2
-
10
-
-
0038730929
-
A central role for DNA replication forks in checkpoint activation and response
-
Tercero J.A., Longhese M.P., Diffley J.F. A central role for DNA replication forks in checkpoint activation and response. Mol. Cell. 11:2003;1323-1336.
-
(2003)
Mol. Cell.
, vol.11
, pp. 1323-1336
-
-
Tercero, J.A.1
Longhese, M.P.2
Diffley, J.F.3
-
12
-
-
0038013782
-
Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation
-
Gatei M., Sloper K., Sorensen C., Syljuasen R., Falck J., Hobson K., Savage K., Lukas J., Zhou B.B., Bartek J., Khanna K.K. Ataxia-telangiectasia- mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation. J. Biol. Chem. 278:2003;14806-14811.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 14806-14811
-
-
Gatei, M.1
Sloper, K.2
Sorensen, C.3
Syljuasen, R.4
Falck, J.5
Hobson, K.6
Savage, K.7
Lukas, J.8
Zhou, B.B.9
Bartek, J.10
Khanna, K.K.11
-
13
-
-
0037335861
-
Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance
-
Brown E.J., Baltimore D. Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev. 17:2003;615-628.
-
(2003)
Genes Dev.
, vol.17
, pp. 615-628
-
-
Brown, E.J.1
Baltimore, D.2
-
14
-
-
0037567268
-
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
-
Zou L., Elledge S.J. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science. 300:2003;1542-1548.
-
(2003)
Science
, vol.300
, pp. 1542-1548
-
-
Zou, L.1
Elledge, S.J.2
-
15
-
-
0035206628
-
Hydroxyurea induces site-specific DNA damage via formation of hydrogen peroxide and nitric oxide
-
Sakano K., Oikawa S., Hasegawa K., Kawanishi S. Hydroxyurea induces site-specific DNA damage via formation of hydrogen peroxide and nitric oxide. Jpn. J. Cancer Res. 92:2001;1166-1174.
-
(2001)
Jpn. J. Cancer Res.
, vol.92
, pp. 1166-1174
-
-
Sakano, K.1
Oikawa, S.2
Hasegawa, K.3
Kawanishi, S.4
-
16
-
-
0037138483
-
Aphidicolin induces 6-thioguanine resistant mutants in human diploid fibroblasts
-
Kolman A., Kotova N., Grawe J. Aphidicolin induces 6-thioguanine resistant mutants in human diploid fibroblasts. Mutat. Res. 499:2002;227-233.
-
(2002)
Mutat. Res.
, vol.499
, pp. 227-233
-
-
Kolman, A.1
Kotova, N.2
Grawe, J.3
-
17
-
-
0035145591
-
P21(Cip1) and p27(Kip1) regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest
-
Green S.L., Freiberg R.A., Giaccia A.J. p21(Cip1) and p27(Kip1) regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest. Mol. Cell. Biol. 21:2001;1196-1206.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 1196-1206
-
-
Green, S.L.1
Freiberg, R.A.2
Giaccia, A.J.3
-
18
-
-
0037214282
-
Hypoxia-inducible factor 1α is essential for cell cycle arrest during hypoxia
-
Goda N., Ryan H.E., Khadivi B., McNulty W., Rickert R.C., Johnson R.S. Hypoxia-inducible factor 1α is essential for cell cycle arrest during hypoxia. Mol. Cell. Biol. 23:2003;359-369.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 359-369
-
-
Goda, N.1
Ryan, H.E.2
Khadivi, B.3
McNulty, W.4
Rickert, R.C.5
Johnson, R.S.6
-
19
-
-
0032882169
-
Hypoxic microenvironment within an embryo induces apoptosis and is essential for proper morphological development
-
Chen E.Y., Fujinaga M., Giaccia A.J. Hypoxic microenvironment within an embryo induces apoptosis and is essential for proper morphological development. Teratology. 60:1999;215-225.
-
(1999)
Teratology
, vol.60
, pp. 215-225
-
-
Chen, E.Y.1
Fujinaga, M.2
Giaccia, A.J.3
-
20
-
-
0029775242
-
Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
-
Hockel M., Schlenger K., Aral B., Mitze M., Schaffer U., Vaupel P. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res. 56:1996;4509-4515.
-
(1996)
Cancer Res.
, vol.56
, pp. 4509-4515
-
-
Hockel, M.1
Schlenger, K.2
Aral, B.3
Mitze, M.4
Schaffer, U.5
Vaupel, P.6
-
21
-
-
0030797708
-
Recombinant ATM protein complements the cellular A-T phenotype
-
Ziv Y., Bar-Shira A., Pecker I., Russell P., Jorgensen T.J., Tsarfati I., Shiloh Y. Recombinant ATM protein complements the cellular A-T phenotype. Oncogene. 15:1997;159-167.
-
(1997)
Oncogene
, vol.15
, pp. 159-167
-
-
Ziv, Y.1
Bar-Shira, A.2
Pecker, I.3
Russell, P.4
Jorgensen, T.J.5
Tsarfati, I.6
Shiloh, Y.7
-
22
-
-
0033870727
-
Hypoxia-inducible factor-1α is a positive factor in solid tumor growth
-
Ryan H.E., Poloni M., McNulty W., Elson D., Gassmann M., Arbeit J.M., Johnson R.S. Hypoxia-inducible factor-1α is a positive factor in solid tumor growth. Cancer Res. 60:2000;4010-4015.
-
(2000)
Cancer Res.
, vol.60
, pp. 4010-4015
-
-
Ryan, H.E.1
Poloni, M.2
McNulty, W.3
Elson, D.4
Gassmann, M.5
Arbeit, J.M.6
Johnson, R.S.7
-
23
-
-
0033222410
-
DNA damage measured by the comet assay in head and neck cancer patients treated with tirapazamine
-
Dorie M.J., Kovacs M.S., Gabalski E.C., Adam M., Le Q.T., Bloch D.A., Pinto H.A., Terris D.J., Brown J.M. DNA damage measured by the comet assay in head and neck cancer patients treated with tirapazamine. Neoplasia. 1:1999;461-467.
-
(1999)
Neoplasia
, vol.1
, pp. 461-467
-
-
Dorie, M.J.1
Kovacs, M.S.2
Gabalski, E.C.3
Adam, M.4
Le Q., T.5
Bloch, D.A.6
Pinto, H.A.7
Terris, D.J.8
Brown, J.M.9
-
24
-
-
0030761388
-
Dihydroorotat-ubiquinone oxidoreductase links mitochondria in the biosynthesis of pyrimidine nucleotides
-
Loffler M., Jockel J., Schuster G., Becker C. Dihydroorotat-ubiquinone oxidoreductase links mitochondria in the biosynthesis of pyrimidine nucleotides. Mol. Cell. Biochem. 174:1997;125-129.
-
(1997)
Mol. Cell. Biochem.
, vol.174
, pp. 125-129
-
-
Loffler, M.1
Jockel, J.2
Schuster, G.3
Becker, C.4
-
25
-
-
0038146962
-
ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation
-
Hammond E.M., Dorie M.J., Giaccia A.J. ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. J. Biol. Chem. 278:2003;12207-12213.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 12207-12213
-
-
Hammond, E.M.1
Dorie, M.J.2
Giaccia, A.J.3
-
26
-
-
0035979213
-
ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation
-
Nghiem P., Park P.K., Kim Y., Vaziri C., Schreiber S.L. ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation. Proc. Natl. Acad. Sci. U.S.A. 98:2001;9092-9097.
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 9092-9097
-
-
Nghiem, P.1
Park, P.K.2
Kim, Y.3
Vaziri, C.4
Schreiber, S.L.5
-
27
-
-
0034629072
-
DNA damage-induced activation of p53 by the checkpoint kinase Chk2
-
Hirao A., Kong Y.Y., Matsuoka S., Wakeham A., Ruland J., Yoshida H., Liu D., Elledge S.J., Mak T.W. DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science. 287:2000;1824-1827.
-
(2000)
Science
, vol.287
, pp. 1824-1827
-
-
Hirao, A.1
Kong, Y.Y.2
Matsuoka, S.3
Wakeham, A.4
Ruland, J.5
Yoshida, H.6
Liu, D.7
Elledge, S.J.8
Mak, T.W.9
-
28
-
-
0037108873
-
UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1
-
Yu Q., La Rose J., Zhang H., Takemura H., Kohn K.W., Pommier Y. UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1. Cancer Res. 62:2002;5743-5748.
-
(2002)
Cancer Res.
, vol.62
, pp. 5743-5748
-
-
Yu, Q.1
La Rose, J.2
Zhang, H.3
Takemura, H.4
Kohn, K.W.5
Pommier, Y.6
-
29
-
-
0038054343
-
The Chk2 tumor suppressor is not required for p53 responses in human cancer cells
-
Jallepalli P.V., Lengauer C., Vogelstein B., Bunz F. The Chk2 tumor suppressor is not required for p53 responses in human cancer cells. J. Biol. Chem. 278:2003;20475-20479.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 20475-20479
-
-
Jallepalli, P.V.1
Lengauer, C.2
Vogelstein, B.3
Bunz, F.4
-
30
-
-
0034003005
-
Stress signals utilize multiple pathways to stabilize p53
-
Ashcroft M., Taya Y., Vousden K.H. Stress signals utilize multiple pathways to stabilize p53. Mol. Cell. Biol. 20:2000;3224-3233.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 3224-3233
-
-
Ashcroft, M.1
Taya, Y.2
Vousden, K.H.3
-
31
-
-
0036205321
-
Mutation of mouse p53 Ser23 and the response to DNA damage
-
Wu Z., Earle J., Saito S., Anderson C.W., Appella E., Xu Y. Mutation of mouse p53 Ser23 and the response to DNA damage. Mol. Cell. Biol. 22:2002;2441-2449.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 2441-2449
-
-
Wu, Z.1
Earle, J.2
Saito, S.3
Anderson, C.W.4
Appella, E.5
Xu, Y.6
-
32
-
-
0037452605
-
Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro
-
Bermudez V.P., Lindsey-Boltz L.A., Cesare A.J., Maniwa Y., Griffith J.D., Hurwitz J., Sancar A. Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro. Proc. Natl. Acad. Sci. U.S.A. 100:2003;1633-1638.
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 1633-1638
-
-
Bermudez, V.P.1
Lindsey-Boltz, L.A.2
Cesare, A.J.3
Maniwa, Y.4
Griffith, J.D.5
Hurwitz, J.6
Sancar, A.7
-
33
-
-
0035936554
-
Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice
-
Zhu J., Petersen S., Tessarollo L., Nussenzweig A. Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice. Curr. Biol. 11:2001;105-109.
-
(2001)
Curr. Biol.
, vol.11
, pp. 105-109
-
-
Zhu, J.1
Petersen, S.2
Tessarollo, L.3
Nussenzweig, A.4
-
34
-
-
0037711771
-
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks
-
A. Celeste, O. Fernandez-Capetillo, M.J. Kruhlak, D.R. Pilch, D.W. Staudt, A. Lee, R.F. Bonner, W.M. Bonner, A. Nussenzweig, Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks, Nat. Cell. Biol. (2003).
-
(2003)
Nat. Cell. Biol.
-
-
Celeste, A.1
Fernandez-Capetillo, O.2
Kruhlak, M.J.3
Pilch, D.R.4
Staudt, D.W.5
Lee, A.6
Bonner, R.F.7
Bonner, W.M.8
Nussenzweig, A.9
-
35
-
-
0037038362
-
Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells
-
Tauchi H., Kobayashi J., Morishima K., van Gent D.C., Shiraishi T., Verkaik N.S., vanHeems D., Ito E., Nakamura A., Sonoda E., Takata M., Takeda S., Matsuura S., Komatsu K. Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells. Nature. 420:2002;93-98.
-
(2002)
Nature
, vol.420
, pp. 93-98
-
-
Tauchi, H.1
Kobayashi, J.2
Morishima, K.3
Van Gent, D.C.4
Shiraishi, T.5
Verkaik, N.S.6
Vanheems, D.7
Ito, E.8
Nakamura, A.9
Sonoda, E.10
Takata, M.11
Takeda, S.12
Matsuura, S.13
Komatsu, K.14
|