Regulation of autophagy through multiple independent hypoxic signaling pathways

Current Molecular Medicine

Volumn 9, Issue 4, 2009, Pages 417-424

  Rouschop, Kasper M A ^a   Wouters, Bradly G ^a,b,c,d  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b UNIVERSITY OF TORONTO   (Canada)

^c PRINCESS MARGARET HOSPITAL   (Canada)

^d ONTARIO INSTITUTE FOR CANCER RESEARCH   (Canada)

Author keywords

ATG; Autophagy; HIF; Hypoxia; mTOR; UPR

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; MEMBRANE PROTEIN; PROTEIN BNIP3; PROTEIN IRE1; PROTEIN PERK; TUBERIN; UNCLASSIFIED DRUG;

AUTOPHAGY; CELL SURVIVAL; CELLULAR STRESS RESPONSE; DRUG TARGETING; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; HUMAN; HYPOXIA; NONHUMAN; PROTEIN SYNTHESIS; REVIEW; SIGNAL TRANSDUCTION; TUMOR CELL; UNFOLDED PROTEIN RESPONSE;

ANIMALS; AUTOPHAGY; CELL HYPOXIA; CELL SURVIVAL; HUMANS; MODELS, BIOLOGICAL; NEOPLASMS; PROTEIN KINASES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

MAMMALIA;

EID: 68349135032     PISSN: 15665240     EISSN: None     Source Type: Journal    
DOI: 10.2174/156652409788167131     Document Type: Review

References (86)

1. Nordsmark, M. (1996) Strahlenther. Onkol., 2, 8-9.
2. Olive, P.L., Banath, J.P. and Durand, R.E. (2002) Radiat. Res., 158, 159-166.
3. Vaupel, P., Schlenger, K., Knoop, C. and Hockel, M. (1991) Cancer Res., 51, 3316-3322.
4. Brown, J.M. and Wilson, W.R. (2004) Nat. Rev. Cancer, 4, 437-447.
5. Tatum, J.L., Kelloff, G.J., Gillies, R.J., Arbeit, J.M., Brown, J.M., Chao, K.S., Chapman, J.D., Eckelman, W.C., Fyles, A.W., Giaccia, A.J., Hill, R.P., Koch, C.J., Krishna, M.C., Krohn, K.A., Lewis, J.S., Mason, R.P., Melillo, G., Padhani, A.R., Powis, G., Rajendran, J.G., Reba, R., Robinson, S.P., Semenza, G.L., Swartz, H.M., Vaupel, P., Yang, D., Croft, B., Hoffman, J., Liu, G., Stone, H. and Sullivan, D. (2006) Int. J. Radiat. Biol., 82, 699-757.
6. Brizel, D.M., Sibley, G.S., Prosnitz, L.R., Scher, R.L. and Dewhirst, M.W. (1997) Int. J. Radiat. Oncol. Biol. Phys., 38, 285-289.
7. Hockel, M., Schlenger, K., Aral, B., Mitze, M., Schaffer, U. and Vaupel, P. (1996) Cancer Res., 56, 4509-4515.
8. Young, S.D., Marshall, R.S. and Hill, R.P. (1988) Proc. Natl. Acad. Sci. USA, 85, 9533-9537.
9. Bristow, R.G. and Hill, R.P. (2008) Nat. Rev. Cancer, 8, 180-192.
10. Gillies, R.J., Robey, I. and Gatenby, R.A. (2008) J. Nucl. Med., 49, 24S-42S.
11. Pugh, C.W. and Ratcliffe, P.J. (2003) Nat. Med., 9, 677-684.
12. Bacon, A.L. and Harris, A.L. (2004) Ann. Med., 36, 530-539.
13. Graeber, T.G., Osmanian, C., Jacks, T., Housman, D.E., Koch, C.J., Lowe, S.W. and Giaccia, A.J. (1996) Nature, 379, 88-91.
14. Shen, Y. and White, E. (2001) Adv. Cancer Res., 82, 55-84.
15. Xie, Z. and Klionsky, D.J. (2007) Nat. Cell Biol., 9, 1102-1109.
16. Tanida, I., Ueno, T. and Kominami, E. (2004) Int. J. Biochem. Cell Biol., 36, 2503-2518.
17. Kuma, A., Hatano, M., Matsui, M., Yamamoto, A., Nakaya, H., Yoshimori, T., Ohsumi, Y., Tokuhisa, T. and Mizushima, N. (2004) Nature, 432, 1032-1036.
18. Mizushima, N., Ohsumi, Y. and Yoshimori, T. (2002) Cell Struct. Funct., 27, 421-429.
19. Ding, W.X., Ni, H.M., Gao, W., Yoshimori, T., Stolz, D.B., Ron, D. and Yin, X.M. (2007) Am. J. Pathol., 171, 513-524.
20. Iwata, A., Christianson, J.C., Bucci, M., Ellerby, L.M., Nukina, N., Forno, L.S. and Kopito, R.R. (2005) Proc. Natl. Acad. Sci. USA, 102, 13135-13140.
21. Zhang, H., Bosch-Marce, M., Shimoda, L.A., Tan, Y.S., Baek, J.H., Wesley, J.B., Gonzalez, F.J. and Semenza, G.L. (2008) J. Biol. Chem., 283, 10892-10903.
22. Semenza, G.L. (2008) Autophagy, 4, 534-536.
23. Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J., Tanida, I., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E. and Tanaka, K. (2006) Nature, 441, 880-884.
24. Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R., Yokoyama, M., Mishima, K., Saito, I., Okano, H. and Mizushima, N. (2006) Nature, 441, 885-889.
25. Clarke, P.G. (1990) Anat. Embryol. (Berl)., 181, 195-213.
26. Tracy, K., Dibling, B.C., Spike, B.T., Knabb, J.R., Schumacker, P. and Macleod, K.F. (2007) Mol. Cell Biol., 27, 6229-6242.
27. Decker, R.S. and Wildenthal, K. (1980) Am. J. Pathol., 98, 425-444.
28. Papandreou, I., Lim, A.L., Laderoute, K. and Denko, N.C. (2008) Cell Death Differ., 15, 1572-81.
29. Azad, M.B., Chen, Y., Henson, E.S., Cizeau, J., McMillan-Ward, E., Israels, S.J. and Gibson, S.B. (2008) Autophagy, 4, 195-204.
30. Degenhardt, K., Mathew, R., Beaudoin, B., Bray, K., Anderson, D., Chen, G., Mukherjee, C., Shi, Y., Gelinas, C., Fan, Y., Nelson, D.A., Jin, S. and White, E. (2006) Cancer Cell, 10, 51-64.
31. Lum, J.J., DeBerardinis, R.J. and Thompson, C.B. (2005) Nat. Rev. Mol. Cell Biol., 6, 439-448.
32. Mizushima, N. (2005) Cell Death Differ., 12(Suppl 2), 1535-1541.
33. Huang, L.E., Gu, J., Schau, M. and Bunn, H.F. (1998) Proc. Natl. Acad. Sci. USA, 95, 7987-7992.
34. Jaakkola, P., Mole, D.R., Tian, Y.M., Wilson, M.I., Gielbert, J., Gaskell, S.J., Kriegsheim, A., Hebestreit, H.F., Mukherji, M., Schofield, C.J., Maxwell, P.H., Pugh, C.W. and Ratcliffe, P.J. (2001) Science, 292, 468-472.
35. Greijer, A.E., van der Groep, P., Kemming, D., Shvarts, A., Semenza, G.L., Meijer, G.A., van de Wiel, M.A., Belien, J.A., van Diest, P.J. and van der Wall, E. (2005) J. Pathol., 206, 291-304.
36. Harris, A.L. (2002) Nat. Rev. Cancer, 2, 38-47.
37. Semenza, G.L. (2003) Nat. Rev. Cancer, 3, 721-732.
38. Bos, R., Zhong, H., Hanrahan, C.F., Mommers, E.C., Semenza, G.L., Pinedo, H.M., Abeloff, M.D., Simons, J.W., van Diest, P.J. and van der Wall, E. (2001) J. Natl. Cancer Inst., 93, 309-314.
39. Zhong, H., Agani, F., Baccala, A.A., Laughner, E., Rioseco-Camacho, N., Isaacs, W.B., Simons, J.W. and Semenza, G.L. (1998) Cancer Res., 58, 5280-5284.
40. Zhong, H., De Marzo, A.M., Laughner, E., Lim, M., Hilton, D.A., Zagzag, D., Buechler, P., Isaacs, W.B., Semenza, G.L. and Simons, J.W. (1999) Cancer Res., 59, 5830-5835.
41. Seagroves, T.N., Ryan, H.E., Lu, H., Wouters, B.G., Knapp, M., Thibault, P., Laderoute, K. and Johnson, R.S. (2001) Mol. Cell Biol., 21, 3436-3444.
42. Moeller, B.J., Dreher, M.R., Rabbani, Z.N., Schroeder, T., Cao, Y., Li, C.Y. and Dewhirst, M.W. (2005) Cancer Cell, 8, 99-110.
43. Bruick, R.K. (2000) Proc. Natl. Acad. Sci. USA, 97, 9082-9087.
44. Guo, K., Searfoss, G., Krolikowski, D., Pagnoni, M., Franks, C., Clark, K., Yu, K.T., Jaye, M. and Ivashchenko, Y. (2001) Cell Death Differ., 8, 367-376.
45. Sowter, H.M., Ratcliffe, P.J., Watson, P., Greenberg, A.H. and Harris, A.L. (2001) Cancer Res., 61, 6669-6673.
46. Vande Velde, C., Cizeau, J., Dubik, D., Alimonti, J., Brown, T., Israels, S., Hakem, R. and Greenberg, A.H. (2000) Mol. Cell Biol., 20, 5454-5468.
47. Yu, L., Alva, A., Su, H., Dutt, P., Freundt, E., Welsh, S., Baehrecke, E.H. and Lenardo, M.J. (2004) Science, 304, 1500-1502.
48. Pattingre, S. and Levine, B. (2006) Cancer Res., 66, 2885-2888.
49. Pattingre, S., Tassa, A., Qu, X., Garuti, R., Liang, X.H., Mizushima, N., Packer, M., Schneider, M.D. and Levine, B. (2005) Cell, 122, 927-939.
50. Hamacher-Brady, A., Brady, N.R., Logue, S.E., Sayen, M.R., Jinno, M., Kirshenbaum, L.A., Gottlieb, R.A. and Gustafsson, A.B. (2007) Cell Death Differ., 14, 146-157.
51. Koritzinsky, M., Magagnin, M.G., van den Beucken, T., Seigneuric, R., Savelkouls, K., Dostie, J., Pyronnet, S., Kaufman, R.J., Weppler, S.A., Voncken, J.W., Lambin, P., Koumenis, C., Sonenberg, N. and Wouters, B.G. (2006) EMBO J., 25, 1114-1125.
52. Koumenis, C., Naczki, C., Koritzinsky, M., Rastani, S., Diehl, A., Sonenberg, N., Koromilas, A. and Wouters, B.G. (2002) Mol. Cell Biol., 22, 7405-7416.
53. Wouters, B.G., van den Beucken, T., Magagnin, M.G., Koritzinsky, M., Fels, D. and Koumenis, C. (2005) Semin. Cell Dev. Biol., 16, 487-501.
54. Koritzinsky, M., Seigneuric, R., Magagnin, M.G., van den Beucken, T., Lambin, P. and Wouters, B.G. (2005) Radiother. Oncol., 76, 177-186.
55. Bi, M., Naczki, C., Koritzinsky, M., Fels, D., Blais, J., Hu, N., Harding, H., Novoa, I., Varia, M., Raleigh, J., Scheuner, D., Kaufman, R.J., Bell, J., Ron, D., Wouters, B.G. and Koumenis, C. (2005) EMBO J., 24, 3470-3481.
56. Koritzinsky, M., Rouschop, K.M., van den Beucken, T., Magagnin, M.G., Savelkouls, K., Lambin, P. and Wouters, B.G. (2007) Radiother. Oncol., 83, 353-361.
57. Bertolotti, A., Zhang, Y., Hendershot, L.M., Harding, H.P. and Ron, D. (2000) Nat. Cell Biol., 2, 326-332.
58. Liu, C.Y. and Kaufman, R.J. (2003) J. Cell Sci., 116, 1861-1862.
59. Drogat, B., Auguste, P., Nguyen, D.T., Bouchecareilh, M., Pineau, R., Nalbantoglu, J., Kaufman, R.J., Chevet, E., Bikfalvi, A. and Moenner, M. (2007) Cancer Res., 67, 6700-6707.
60. Romero-Ramirez, L., Cao, H., Nelson, D., Hammond, E., Lee, A.H., Yoshida, H., Mori, K., Glimcher, L.H., Denko, N.C., Giaccia, A.J., Le, Q.T. and Koong, A.C. (2004) Cancer Res., 64, 5943-5947.
61. Bernales, S., McDonald, K.L. and Walter, P. (2006) PLoS Biol., 4, e423.
62. Yorimitsu, T., Nair, U., Yang, Z. and Klionsky, D.J. (2006) J. Biol. Chem., 281, 30299-30304.
63. Ding, W.X., NI, H.M., Gao, W., Hou, Y.F., Melan, M.A., Chen, X., Stolz, D.B., Shao, Z.M. and Yin, X.M. (2007) J. Biol. Chem., 282, 4702-4710.
64. Ding, W.X. and Yin, X.M. (2008) Autophagy, 4, 141-50.
65. Kouroku, Y., Fujita, E., Tanida, I., Ueno, T., Isoai, A., Kumagai, H., Ogawa, S., Kaufman, R.J., Kominami, E. and Momoi, T. (2007) Cell Death Differ., 14, 230-239.
66. Ogata, M., Hino, S., Saito, A., Morikawa, K., Kondo, S., Kanemoto, S., Murakami, T., Taniguchi, M., Tanii, I., Yoshinaga, K., Shiosaka, S., Hammarback, J.A., Urano, F. and Imaizumi, K. (2006) Mol. Cell Biol., 26, 9220-9231.
67. Kegel, K.B., Kim, M., Sapp, E., McIntyre, C., Castano, J.G., Aronin, N. and DiFiglia, M. (2000) J. Neurosci., 20, 7268-7278.
68. Park, M.A., Yacoub, A., Sarkar, D., Emdad, L., Rahmani, M., Spiegel, S., Koumenis, C., Graf, M., Curiel, D.T., Grant, S., Fisher, P.B. and Dent, P. (2008) Autophagy, 4, 513-515.
69. Talloczy, Z., Jiang, W., Virgin, H.W.t., Leib, D.A., Scheuner, D., Kaufman, R.J., Eskelinen, E.L. and Levine, B. (2002) Proc. Natl. Acad. Sci. USA, 99, 190-195.
70. Sir, D., Chen, W.L., Choi, J., Wakita, T., Yen, T.S. and Ou, J.H. (2008) Hepatology, 48, 1054-1061.
71. Gingras, A.C., Raught, B. and Sonenberg, N. (1999) Annu. Rev. Biochem., 68, 913-963.
72. Hay, N. and Sonenberg, N. (2004) Genes Dev., 18, 1926-1945.
73. Koumenis, C. and Wouters, B.G. (2006) Mol. Cancer Res., 4, 423-436.
74. Arsham, A.M., Howell, J.J. and Simon, M.C. (2003) J. Biol. Chem., 278, 29655-29660.
75. Brugarolas, J., Lei, K., Hurley, R.L., Manning, B.D., Reiling, J.H., Hafen, E., Witters, L.A., Ellisen, L.W. and Kaelin, W.G., Jr. (2004) Genes Dev., 18, 2893-2904.
76. Tee, A.R., Manning, B.D., Roux, P.P., Cantley, L.C. and Blenis, J. (2003) Curr. Biol., 13, 1259-1268.
77. Garami, A., Zwartkruis, F.J., Nobukuni, T., Joaquin, M., Roccio, M., Stocker, H., Kozma, S.C., Hafen, E., Bos, J.L. and Thomas, G. (2003) Mol. Cell, 11, 1457-1466.
78. Sofer, A., Lei, K., Johannessen, C.M. and Ellisen, L.W. (2005) Mol. Cell Biol., 25, 5834-5845.
79. Budanov, A.V., Shoshani, T., Faerman, A., Zelin, E., Kamer, I., Kalinski, H., Gorodin, S., Fishman, A., Chajut, A., Einat, P., Skaliter, R., Gudkov, A.V., Chumakov, P.M. and Feinstein, E. (2002) Oncogene, 21, 6017-6031.
80. DeYoung, M.P., Horak, P., Sofer, A., Sgroi, D. and Ellisen, L.W. (2008) Genes Dev., 22, 239-251.
81. Hardie, D.G. and Carling, D. (1997) Eur. J. Biochem., 246, 259-273.
82. Kemp, B.E., Mitchelhill, K.I., Stapleton, D., Michell, B.J., Chen, Z.P. and Witters, L.A. (1999) Trends Biochem. Sci., 24, 22-25.
83. Hardie, D.G. (2004) J. Cell Sci., 117, 5479-5487.
84. Liu, L., Cash, T.P., Jones, R.G., Keith, B., Thompson, C.B. and Simon, M.C. (2006) Mol. Cell, 21, 521-531.
85. Liang, J., Shao, S.H., Xu, Z.X., Hennessy, B., Ding, Z., Larrea, M., Kondo, S., Dumont, D.J., Gutterman, J.U., Walker, C.L., Slingerland, J.M. and Mills, G.B. (2007) Nat. Cell Biol., 9, 218-224.
86. Li, Y., Wang, Y., Kim, E., Beemiller, P., Wang, C.Y., Swanson, J., You, M. and Guan, K.L. (2007) J. Biol. Chem., 282, 35803-13.