AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10

Biochemical Journal

Volumn 425, Issue 3, 2010, Pages 523-530

  Ovens, Matthew J ^a   Davies, Andrew J ^a   Wilson, Marieangela C ^a   Murray, Clare M ^b   Halestrap, Andrew P ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Chimaeric transporter; Erythrocyte; Lactate transport; Monocarboxylate transporter (MCT); Xenopus oocytes

Indexed keywords

DIFFERENT DOMAINS; L-LACTATE; MOLECULAR MODELS; N-TERMINALS; POTENT INHIBITOR; PYRUVATES; SUBSTRATE BINDING; TIME-DEPENDENT; TRANSMEMBRANE HELICES; TRANSMEMBRANES; TRANSPORT KINETIC; TURNOVER NUMBER; XENOPUS LAEVIS OOCYTES; XENOPUS OOCYTE;

ARGON; BINDING ENERGY; BIOCHEMISTRY; ENZYME ACTIVITY;

BINDING SITES;

AR C 155858; ARGININE; ASPARTIC ACID; IMMUNOSUPPRESSIVE AGENT; LACTIC ACID; MONOCARBOXYLATE TRANSPORTER 1; MONOCARBOXYLATE TRANSPORTER 2; MONOCARBOXYLATE TRANSPORTER 4; PHENYLALANINE; PYRUVIC ACID; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SENSITIVITY; ERYTHROCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEIN TRANSPORT; RAT; XENOPUS LAEVIS;

ANIMALS; BINDING SITES; CATALYTIC DOMAIN; CHICKENS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ERYTHROCYTES; MONOCARBOXYLIC ACID TRANSPORTERS; PHENYLALANINE; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RATS; SYMPORTERS; THIOPHENES; URACIL; XENOPUS LAEVIS;

CHIMAERIFORMES; RATTUS; XENOPUS LAEVIS;

EID: 74349094033     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20091515     Document Type: Article

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