Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance

Cancer Research

Volumn 68, Issue 2, 2008, Pages 605-614

  Chan, Norman ^a,b   Koritzinsky, Marianne ^c   Zhao, Helen ^a,b   Bindra, Ranjit ^d   Glazer, Peter M ^d   Powell, Simon ^e   Belmaaza, Abdellah ^f   Wouters, Brad ^c   Bristow, Robert G ^a,b,g  

^a Princess Margaret Hospital (University Health Network)   (Netherlands)

^b UNIVERSITY OF TORONTO   (Canada)

^c MAASTRICHT UNIVERSITY   (Netherlands)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e WASHINGTON UNIVERSITY   (United States)

^f CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^g PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA2 PROTEIN; CISPLATIN; DNA; GREEN FLUORESCENT PROTEIN; MESSENGER RNA; MITOMYCIN C; PACLITAXEL; RAD51 PROTEIN; SMALL INTERFERING RNA; VASCULOTROPIN; OXYGEN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; RAD51 PROTEIN, HUMAN; UNCLASSIFIED DRUG;

ACUTE DISEASE; ANOXIA; ARTICLE; CELL ACTIVATION; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; CHRONIC DISEASE; CONTROLLED STUDY; CYTOTOXICITY; DISEASE SEVERITY; DNA CROSS LINKING; DNA REPAIR; DOWN REGULATION; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; HYPOXIA; LUNG CARCINOMA; OXYGEN ENHANCEMENT RATIO; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN SYNTHESIS; RADIOSENSITIVITY; REPORTER GENE; BIOSYNTHESIS; CELL CULTURE; CELL HYPOXIA; DRUG EFFECT; DRUG RESISTANCE; GENETIC RECOMBINATION; GENETICS; METABOLISM; PHYSIOLOGY; RADIATION DOSE; TIME;

CELL HYPOXIA; CELL PROLIFERATION; CELL SURVIVAL; DNA REPAIR ENZYMES; DRUG RESISTANCE, NEOPLASM; HUMANS; OXYGEN; RAD51 RECOMBINASE; RADIATION TOLERANCE; RECOMBINATION, GENETIC; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 39049163047     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-5472     Document Type: Article

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