메뉴 건너뛰기




Volumn 24, Issue 19, 2004, Pages 8504-8518

Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MESSENGER RNA; RAD51 PROTEIN;

EID: 4544324453     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.24.19.8504-8518.2004     Document Type: Article
Times cited : (317)

References (50)
  • 1
    • 0345304254 scopus 로고    scopus 로고
    • Overexpression of mammalian Rad51 does not stimulate tumorigenesis while a dominant-negative Rad51 affects centrosome fragmentation, ploidy and stimulates tumorigenesis, in p53-defective CHO cells
    • Bertrand, P., S. Lambert, C. Joubert, and B. S. Lopez. 2003. Overexpression of mammalian Rad51 does not stimulate tumorigenesis while a dominant-negative Rad51 affects centrosome fragmentation, ploidy and stimulates tumorigenesis, in p53-defective CHO cells. Oncogene 22:7587-7592.
    • (2003) Oncogene , vol.22 , pp. 7587-7592
    • Bertrand, P.1    Lambert, S.2    Joubert, C.3    Lopez, B.S.4
  • 4
    • 0037248566 scopus 로고    scopus 로고
    • Cell death in irradiated prostate epithelial cells: Role of apoptotic and clonogenic cell kill
    • Bromfield, G. P., A. Meng, P. Warde, and R. G. Bristow. 2003. Cell death in irradiated prostate epithelial cells: role of apoptotic and clonogenic cell kill. Prostate Cancer Prostatic Dis. 6:73-85.
    • (2003) Prostate Cancer Prostatic Dis. , vol.6 , pp. 73-85
    • Bromfield, G.P.1    Meng, A.2    Warde, P.3    Bristow, R.G.4
  • 5
    • 0033597251 scopus 로고    scopus 로고
    • Targeted correction of an episomal gene in mammalian cells by a short DNA fragment tethered to a triplex-forming oligonucleotide
    • Chan, P. P., M. Lin, A. F. Faruqi, J. Powell, M. M. Seidman, and P. M. Glazer. 1999. Targeted correction of an episomal gene in mammalian cells by a short DNA fragment tethered to a triplex-forming oligonucleotide. J. Biol. Chem. 274:11541-11548.
    • (1999) J. Biol. Chem. , vol.274 , pp. 11541-11548
    • Chan, P.P.1    Lin, M.2    Faruqi, A.F.3    Powell, J.4    Seidman, M.M.5    Glazer, P.M.6
  • 6
    • 0033038190 scopus 로고    scopus 로고
    • A quantitative analysis of the reduction in oxygen levels required to induce up-regulation of vascular endothelial growth factor (VEGF) mRNA in cervical cancer cell lines
    • Chiarotto, J. A., and R. P. Hill. 1999. A quantitative analysis of the reduction in oxygen levels required to induce up-regulation of vascular endothelial growth factor (VEGF) mRNA in cervical cancer cell lines. Br. J. Cancer 80:1518-1524.
    • (1999) Br. J. Cancer. , vol.80 , pp. 1518-1524
    • Chiarotto, J.A.1    Hill, R.P.2
  • 7
    • 0032132806 scopus 로고    scopus 로고
    • A new role for hypoxia in tumor progression: Induction of fragile site triggering genomic rearrangements and formation of complex DMs and HSRs
    • Coquelle, A., F. Toledo, S. Stern, A. Bieth, and M. Debatisse. 1998. A new role for hypoxia in tumor progression: induction of fragile site triggering genomic rearrangements and formation of complex DMs and HSRs. Mol. Cell 2:259-265.
    • (1998) Mol. Cell , vol.2 , pp. 259-265
    • Coquelle, A.1    Toledo, F.2    Stern, S.3    Bieth, A.4    Debatisse, M.5
  • 8
    • 0035947657 scopus 로고    scopus 로고
    • Triplex-induced recombination in human cell-free extracts. Dependence on XPA and HsRad51
    • Datta, H. J., P. P. Chan, K. M. Vasquez, R. C. Gupta, and P. M. Glazer. 2001. Triplex-induced recombination in human cell-free extracts. Dependence on XPA and HsRad51. J. Biol. Chem. 276:18018-18023.
    • (2001) J. Biol. Chem. , vol.276 , pp. 18018-18023
    • Datta, H.J.1    Chan, P.P.2    Vasquez, K.M.3    Gupta, R.C.4    Glazer, P.M.5
  • 9
    • 0035805046 scopus 로고    scopus 로고
    • Relationship of hypoxia to metastatic ability in rodent tumours
    • De Jaeger, K., M. C. Kavanagh, and R. P. Hill. 2001. Relationship of hypoxia to metastatic ability in rodent tumours. Br. J. Cancer 84:1280-1285.
    • (2001) Br. J. Cancer , vol.84 , pp. 1280-1285
    • De Jaeger, K.1    Kavanagh, M.C.2    Hill, R.P.3
  • 10
    • 0028784382 scopus 로고
    • Identification of hypoxia in cells and tissues of epigastric 9L rat glioma using EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamidel
    • Evans, S. M., B. Joiner, W. T. Jenkins, K. M. Laughlin, E. M. Lord, and C. J. Koch. 1995. Identification of hypoxia in cells and tissues of epigastric 9L rat glioma using EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3- pentafluoropropyl) acetamidel. Br. J. Cancer 72:875-882.
    • (1995) Br. J. Cancer , vol.72 , pp. 875-882
    • Evans, S.M.1    Joiner, B.2    Jenkins, W.T.3    Laughlin, K.M.4    Lord, E.M.5    Koch, C.J.6
  • 11
    • 0001501341 scopus 로고    scopus 로고
    • Expression of the human RAD51 gene during the cell cycle in primary human peripheral blood lymphocytes
    • Flygare, J., F. Benson, and D. Hellgren. 1996. Expression of the human RAD51 gene during the cell cycle in primary human peripheral blood lymphocytes. Biochim. Biophys. Acta 1312:231-236.
    • (1996) Biochim. Biophys. Acta , vol.1312 , pp. 231-236
    • Flygare, J.1    Benson, F.2    Hellgren, D.3
  • 12
    • 0029761644 scopus 로고    scopus 로고
    • Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    • Forsythe, J. A., B. H. Jiang, N. V. Iyer, F. Agani, S. W. Leung, R. D. Koos, and G. L. Semenza. 1996. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell. Biol. 16:4604-4613.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4604-4613
    • Forsythe, J.A.1    Jiang, B.H.2    Iyer, N.V.3    Agani, F.4    Leung, S.W.5    Koos, R.D.6    Semenza, G.L.7
  • 13
    • 0346093892 scopus 로고    scopus 로고
    • Tumbling down a different pathway to genetic instability
    • Guo, H. H., and L. A. Loeb. 2003. Tumbling down a different pathway to genetic instability. J. Clin. Investig. 112:1793-1795.
    • (2003) J. Clin. Investig. , vol.112 , pp. 1793-1795
    • Guo, H.H.1    Loeb, L.A.2
  • 15
    • 0038146962 scopus 로고    scopus 로고
    • ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation
    • Hammond, E. M., M. J. Dorie, and A. J. Giaccia. 2003. ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. J. Biol. Chem. 278:12207-12213.
    • (2003) J. Biol. Chem. , vol.278 , pp. 12207-12213
    • Hammond, E.M.1    Dorie, M.J.2    Giaccia, A.J.3
  • 16
    • 0345708265 scopus 로고    scopus 로고
    • Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest
    • Hammond, E. M., S. L. Green, and A. J. Giaccia. 2003. Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest. Mutat. Res. 532:205-213.
    • (2003) Mutat. Res. , vol.532 , pp. 205-213
    • Hammond, E.M.1    Green, S.L.2    Giaccia, A.J.3
  • 17
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - A key regulatory factor in tumour growth
    • Harris, A. L. 2002. Hypoxia - a key regulatory factor in tumour growth. Nat. Rev. Cancer 2:38-47.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 18
    • 0242268056 scopus 로고    scopus 로고
    • Homologous recombination and cell cycle checkpoints: Rad51 in tumour progression and therapy resistance
    • Henning, W., and H. W. Sturzbecher. 2003. Homologous recombination and cell cycle checkpoints: Rad51 in tumour progression and therapy resistance. Toxicology 193:91-109.
    • (2003) Toxicology , vol.193 , pp. 91-109
    • Henning, W.1    Sturzbecher, H.W.2
  • 20
    • 0043239271 scopus 로고    scopus 로고
    • Separation of live cells in different phases of the cell cycle for gene expression analysis
    • Juan, G., E. Hernando, and C. Cordon-Cardo. 2002. Separation of live cells in different phases of the cell cycle for gene expression analysis. Cytometry 49:170-175.
    • (2002) Cytometry , vol.49 , pp. 170-175
    • Juan, G.1    Hernando, E.2    Cordon-Cardo, C.3
  • 22
    • 0035863398 scopus 로고    scopus 로고
    • Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures
    • Li, C. Y., J. B. Little, K. Hu, W. Zhang, L. Zhang, M. W. Dewhirst, and Q. Huang. 2001. Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures. Cancer Res. 61:428-432.
    • (2001) Cancer Res. , vol.61 , pp. 428-432
    • Li, C.Y.1    Little, J.B.2    Hu, K.3    Zhang, W.4    Zhang, L.5    Dewhirst, M.W.6    Huang, Q.7
  • 24
    • 0031907152 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2
    • Lonergan, K. M., O. Iliopoulos, M. Ohh, T. Kamura, R. C. Conaway, J. W. Conaway, and W. G. Kaelin, Jr. 1998. Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2. Mol. Cell. Biol. 18:732-741.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 732-741
    • Lonergan, K.M.1    Iliopoulos, O.2    Ohh, M.3    Kamura, T.4    Conaway, R.C.5    Conaway, J.W.6    Kaelin Jr., W.G.7
  • 26
    • 0029955072 scopus 로고    scopus 로고
    • Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck
    • Nordsmark, M., M. Overgaard, and J. Overgaard. 1996. Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother. Oncol. 41:31-39.
    • (1996) Radiother. Oncol. , vol.41 , pp. 31-39
    • Nordsmark, M.1    Overgaard, M.2    Overgaard, J.3
  • 27
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • Nowell, P. C. 1976. The clonal evolution of tumor cell populations. Science 194:23-28.
    • (1976) Science , vol.194 , pp. 23-28
    • Nowell, P.C.1
  • 28
    • 0032540152 scopus 로고    scopus 로고
    • In vitro and in vivo potentiation of radiosensitivity of malignant gliomas by antisense inhibition of the RAD51 gene
    • Ohnishi, T., T. Taki, S. Hiraga, N. Arita, and T. Morita. 1998. In vitro and in vivo potentiation of radiosensitivity of malignant gliomas by antisense inhibition of the RAD51 gene. Biochem. Biophys. Res. Commun. 245:319-324.
    • (1998) Biochem. Biophys. Res. Commun. , vol.245 , pp. 319-324
    • Ohnishi, T.1    Taki, T.2    Hiraga, S.3    Arita, N.4    Morita, T.5
  • 29
    • 0028179096 scopus 로고
    • In vivo enhancement of genomic instability in minisatellite sequences of mouse C3H/10T1/2 cells transformed in vitro by X-rays
    • Paquette, B., and J. B. Little. 1994. In vivo enhancement of genomic instability in minisatellite sequences of mouse C3H/10T1/2 cells transformed in vitro by X-rays. Cancer Res. 54:3173-3178.
    • (1994) Cancer Res. , vol.54 , pp. 3173-3178
    • Paquette, B.1    Little, J.B.2
  • 31
    • 0029753768 scopus 로고    scopus 로고
    • Genetic instability induced by the tumor microenvironment
    • Reynolds, T. Y., S. Rockwell, and P. M. Glazer. 1996. Genetic instability induced by the tumor microenvironment. Cancer Res. 56:5754-5757.
    • (1996) Cancer Res. , vol.56 , pp. 5754-5757
    • Reynolds, T.Y.1    Rockwell, S.2    Glazer, P.M.3
  • 32
    • 0031307796 scopus 로고    scopus 로고
    • Oxygen delivery: Implications for the biology and therapy of solid tumors
    • Rockwell, S. 1997. Oxygen delivery: implications for the biology and therapy of solid tumors. Oncol. Res. 9:383-390.
    • (1997) Oncol. Res. , vol.9 , pp. 383-390
    • Rockwell, S.1
  • 35
    • 0034017489 scopus 로고    scopus 로고
    • Development of a hypoxia-responsive vector for tumor-specific gene therapy
    • Shibata, T., A. J. Giaccia, and J. M. Brown. 2000. Development of a hypoxia-responsive vector for tumor-specific gene therapy. Gene Ther. 7:493-498.
    • (2000) Gene Ther. , vol.7 , pp. 493-498
    • Shibata, T.1    Giaccia, A.J.2    Brown, J.M.3
  • 37
    • 0037279517 scopus 로고    scopus 로고
    • The hypoxic tumour microenvironment and metastatic progression
    • Subarsky, P., and R. P. Hill. 2003. The hypoxic tumour microenvironment and metastatic progression. Clin. Exp. Metastasis 20:237-250.
    • (2003) Clin. Exp. Metastasis , vol.20 , pp. 237-250
    • Subarsky, P.1    Hill, R.P.2
  • 38
    • 0037202608 scopus 로고    scopus 로고
    • Recombinational DNA repair and human disease
    • Thompson, L. H., and D. Schild. 2002. Recombinational DNA repair and human disease. Mutat. Res. 509:49-78.
    • (2002) Mutat. Res. , vol.509 , pp. 49-78
    • Thompson, L.H.1    Schild, D.2
  • 39
    • 0141757494 scopus 로고    scopus 로고
    • Regulation and mechanisms of mammalian double-strand break repair
    • Valerie, K., and L. F. Povirk. 2003. Regulation and mechanisms of mammalian double-strand break repair. Oncogene 22:5792-5812.
    • (2003) Oncogene , vol.22 , pp. 5792-5812
    • Valerie, K.1    Povirk, L.F.2
  • 41
    • 0037169354 scopus 로고    scopus 로고
    • Cancer susceptibility and the functions of BRCA1 and BRCA2
    • Venkitaraman, A. R. 2002. Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell 108:171-182.
    • (2002) Cell , vol.108 , pp. 171-182
    • Venkitaraman, A.R.1
  • 42
    • 0035887489 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1α is an intrinsic marker for hypoxia in cervical cancer xenografts
    • Vukovic, V., H. K. Haugland, T. Nicklee, A. J. Morrison, and D. W. Hedley. 2001. Hypoxia-inducible factor-1α is an intrinsic marker for hypoxia in cervical cancer xenografts. Cancer Res. 61:7394-7398.
    • (2001) Cancer Res. , vol.61 , pp. 7394-7398
    • Vukovic, V.1    Haugland, H.K.2    Nicklee, T.3    Morrison, A.J.4    Hedley, D.W.5
  • 43
    • 0027136260 scopus 로고
    • Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: Implications for models of hypoxia signal transduction
    • Wang, G. L., and G. L. Semenza. 1993. Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction. Blood 82:3610-3615.
    • (1993) Blood , vol.82 , pp. 3610-3615
    • Wang, G.L.1    Semenza, G.L.2
  • 44
    • 0037869270 scopus 로고    scopus 로고
    • The state of the art of mammalian promoter recognition
    • Werner, T. 2003. The state of the art of mammalian promoter recognition. Brief Bioinform. 4:22-30.
    • (2003) Brief Bioinform , vol.4 , pp. 22-30
    • Werner, T.1
  • 45
    • 0034842881 scopus 로고    scopus 로고
    • Hypoxia and oxidative stress. Tumour hypoxia-therapeutic considerations
    • Williams, K. J., R. L. Cowen, and I. J. Stratford. 2001. Hypoxia and oxidative stress. Tumour hypoxia-therapeutic considerations. Breast Cancer Res. 3:328-331.
    • (2001) Breast Cancer Res. , vol.3 , pp. 328-331
    • Williams, K.J.1    Cowen, R.L.2    Stratford, I.J.3
  • 46
    • 0010170555 scopus 로고
    • Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells
    • Young, S. D., R. S. Marshall, and R. P. Hill. 1988. Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells. Proc. Natl. Acad. Sci. USA 85:9533-9537.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 9533-9537
    • Young, S.D.1    Marshall, R.S.2    Hill, R.P.3
  • 47
    • 0032565578 scopus 로고    scopus 로고
    • Mutagenesis induced by the tumor microenvironment
    • Yuan, J., and P. M. Glazer. 1998. Mutagenesis induced by the tumor microenvironment. Mutat. Res. 400:439-446.
    • (1998) Mutat. Res. , vol.400 , pp. 439-446
    • Yuan, J.1    Glazer, P.M.2
  • 48
    • 0034662615 scopus 로고    scopus 로고
    • Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH
    • Yuan, J., L. Narayanan, S. Rockwell, and P. M. Glazer. 2000. Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH. Cancer Res. 60:4372-4376.
    • (2000) Cancer Res. , vol.60 , pp. 4372-4376
    • Yuan, J.1    Narayanan, L.2    Rockwell, S.3    Glazer, P.M.4
  • 50
    • 0036833897 scopus 로고    scopus 로고
    • Increased radiosensitivity with chronic hypoxia in four human tumor cell lines
    • Zolzer, F., and C. Streffer. 2002. Increased radiosensitivity with chronic hypoxia in four human tumor cell lines. Int. J. Radiat. Oncol. Biol. Phys. 54:910-920.
    • (2002) Int. J. Radiat. Oncol. Biol. Phys. , vol.54 , pp. 910-920
    • Zolzer, F.1    Streffer, C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.