CHK2-dependent phosphorylation of BRCA1 in hypoxia

Radiation Research

Volumn 166, Issue 4, 2006, Pages 646-651

  Gibson, Shannon L ^a   Bindra, Ranjit S ^a   Glazer, Peter M ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; BRCA1 PROTEIN; CHECKPOINT KINASE 2; SERINE;

ARTICLE; CELL CYCLE REGULATION; CELL STRAIN MCF 7; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HYPOXIA; MAMMAL CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION;

BRCA1 PROTEIN; CELL HYPOXIA; CELL LINE; DOSE-RESPONSE RELATIONSHIP, RADIATION; HUMANS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RADIATION DOSAGE;

MAMMALIA;

EID: 33749163797     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR0660.1     Document Type: Article

References (19)

1. A. R. Venkitaraman, Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell 108, 171-182 (2002).
2. P. Arizti, L. Fang, I. Park, Y. Yin, E. Solomon, T. Ouchi, S. A. Aaronson and S. W. Lee, Tumor suppressor p53 is required to modulate BRCA1 expression. Mol. Cell. Biol. 20, 7450-7459 (2000).
3. D. Cortez, Y. Wang, J. Qin and S. J. Elledge, Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science 286, 1162-1166 (1999).
4. M. Gatei, S. P. Scott, I. Filippovitch, N. Soronika, M. F. Lavin, B. Weber and K. K. Khanna, Role for ATM in DNA damage-induced phosphorylation of BRCA1. Cancer Res. 60, 3299-3304 (2000).
5. J. Chen, Ataxia telangiectasia-related protein is involved in the phosphorylation of BRCA1 following deoxyribonucleic acid damage. Cancer Res. 60, 5037-5039 (2000).
6. R. S. Tibbetts, D. Cortez, K. M. Brumbaugh, R. Scully, D. Livingston, S. J. Elledge and R. T. Abraham, Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev. 14, 2989-3002 (2000).
7. J. S. Lee, K. M. Collins, A. L. Brown, C. H. Lee and J. H. Chung, hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature 404, 201-204 (2000).
8. J. Zhang, H. Willers, Z. Feng, J. C. Ghosh, S. Kim, D. T. Weaver, J. H. Chung, S. N. Powell and F. Xia, Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair. Mol. Cell. Biol. 24, 708-718 (2004).
9. H. C. Wang, W. C. Chou, S. Y. Shieh and C. Y. Shen, Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining. Cancer Res. 66, 1391-1400 (2006).
10. J. Zhuang, J. Zhang, H. Willers, H. Wang, J. H. Chung, D. C. van Gent, D. E. Hallahan, S. N. Powell and F. Xia, Checkpoint kinase 2-mediated phosphorylation of BRCA1 regulates the fidelity of nonhomologous end-joining. Cancer Res. 66, 1401-1408 (2006).
11. E. M. Hammond, M. J. Done and A. J. Giaccia, ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. J. Biol. Chem. 278, 12207-12213 (2003).
12. R. S. Bindra, P. J. Schaffer, A. Meng, J. Woo, K. Maseide, M. E. Roth, P. Lizardi, D. W. Hedley, R. G. Bristow and P. M. Glazer, Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells. Mol. Cell. Biol. 24, 8504-8518 (2004).
13. R. S. Bindra, S. L. Gibson, A. Meng, U. Westermark, M. Jasin, A. J. Pierce, R. G. Bristow, M. K. Classon and P. M. Glazer, Hypoxia-induced down-regulation of BRCA1 expression by E2Fs. Cancer Res. 65, 11597-11604 (2005).
14. A. X. Meng, F. Jalali, A. Cuddihy, N. Chan, R. S. Bindra, P. M. Glazer and R. G. Bristow, Hypoxia down-regulates DNA double strand break repair gene expression in prostate cancer cells. Radiother. Oncol. 76, 168-176 (2005).
15. R. A. Freiberg, E. M. Hammond, M. J. Doric, S. M. Welford and A. J. Giaccia, DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response. Mol. Cell. Biol. 26, 1598-1609 (2006).
16. S. L. Gibson, R. S. Bindra and P. M. Glazer, Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner. Cancer Res. 65, 10734-10741 (2005).
17. V. T. Mihaylova, R. S. Bindra, J. Yuan, D. Campisi, L. Narayanan, R. Jensen, F. Giordano, R. S. Johnson, S. Rockwell and P. M. Glazer, Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells. Mol. Cell. Biol. 23, 3265-3273 (2003).
18. E. M. Hammond, S. L. Green and A. J. Giaccia, Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest. Mutat. Res. 532, 205-213 (2003).
19. C. Stevens, L. Smith and N. B. La Thangue, Chk2 activates E2F-1 in response to DNA damage. Nat. Cell Biol. 5, 401-409 (2003).