Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

Science

Volumn 316, Issue 5829, 2007, Pages 1336-1341

  Zeggini, Eleftheria ^a,b   Weedon, Michael N ^c   Lindgren, Cecilia M ^a,b   Frayling, Timothy M ^c   Elliott, Katherine S ^b   Lango, Hana ^c   Timpson, Nicholas J ^b,d   Perry, John R B ^c   Rayner, Nigel W ^a,b   Freathy, Rachel M ^c   Barrett, Jeffrey C ^b   Shields, Beverley ^c   Morris, Andrew P ^b   Ellard, Sian ^c,e   Groves, Christopher J ^a   Harries, Lorna W ^c   Marchini, Jonathan L ^f   Owen, Katharine R ^a   Knight, Beatrice ^c   Cardon, Lon R ^b   Walker, Mark ^g   Hitman, Graham A ^h   Morris, Andrew D ⁱ   Doney, Alex S F ⁱ   McCarthy, Mark I ^a,b   Hattersley, Andrew T ^c   Bruce, Ian N ^j   Donovan, Hannah ^j   Eyre, Steve ^j   Gilbert, Paul D ^j   Hider, Samantha L ^j   Hinks, Anne M ^j   John, Sally L ^j   Potter, Catherine ^j   Silman, Alan J ^j   Symmons, Deborah P M ^j   Thomson, Wendy ^j   Worthington, Jane ^j   more..

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c PENINSULA MEDICAL SCHOOL   (United Kingdom)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

^e ROYAL DEVON AND EXETER NHS FOUNDATION TRUST   (United Kingdom)

^f UNIVERSITY OF OXFORD   (United Kingdom)

^g NEWCASTLE UNIVERSITY   (United Kingdom)

^h ROYAL LONDON HOSPITAL   (United Kingdom)

ⁱ UNIVERSITY OF DUNDEE   (United Kingdom)

^j UNIVERSITY OF MANCHESTER   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

DETECTION METHOD; DIABETES; ETIOLOGY; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC MARKER; GENOMICS; GENOTYPE; HEALTH RISK; MOLECULAR ANALYSIS;

ARTICLE; CDKAL1 GENE; CDKN2A GENE; CDKN2B GENE; CHROMOSOME 6; CONTROLLED STUDY; DISEASE PREDISPOSITION; GENE; GENE FUNCTION; GENE LOCUS; GENE MAPPING; GENE REPLICATION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HHEX GENE; HUMAN; HUMAN GENOME; IDE GENE; IGF2BP2 GENE; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SLC3OA8 GENE; UNITED KINGDOM;

ADULT; AGED; CASE-CONTROL STUDIES; CHROMOSOME MAPPING; DIABETES MELLITUS, TYPE 2; FEMALE; GENES, P16; GENETIC PREDISPOSITION TO DISEASE; GENOME, HUMAN; GREAT BRITAIN; HOMEODOMAIN PROTEINS; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; INTRONS; MALE; META-ANALYSIS; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; TRANSCRIPTION FACTORS;

EURASIA; EUROPE; UNITED KINGDOM; WESTERN EUROPE;

EID: 34249895023     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1142364     Document Type: Article

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28. We are grateful to all the study participants. We acknowledge the support of Diabetes UK, British Diabetic Association Research, the UK Medical Research Council, the Wellcome Trust, European Commission (EURODIA LSHG-CT-2004-518153), and Peninsula Medical School. Personal funding comes from the Wellcome Trust (E.Z., A.T.H., and L.R.C.); UK Medical Research Council (J.R.B.P.); Diabetes UK (R.M.F.); Throne-Holst Foundation (C.M.L.); Leverhulme Trust (A.P.M.); Research Councils UK (L.W.H.); and the Scottish Executive Generations Scotland Initiative (C.N.A.P., A.D.M.). M.N.W. is Vandervell Foundation Research Fellow at the Peninsula Medical School. We are grateful to members of the DGI and FUSION teams for sharing data.