The forkhead transcription factor Fox01 regulates adipocyte differentiation

Developmental Cell

Volumn 4, Issue 1, 2003, Pages 119-129

  Nakae, Jun ^a,c   Kitamura, Tadahiro ^a   Kitamura, Yukari ^a   Biggs III, William H ^b   Arden, Karen C ^b   Accili, Domenico ^a  

^a The New York Presbyterian Hospital   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ASAHIKAWA MEDICAL COLLEGE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; PROTEIN KINASE B; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; CELL DIFFERENTIATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EMBRYO; FIBROBLAST; GENETIC TRANSCRIPTION; HORMONAL REGULATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REVIEW; TRANSCRIPTION REGULATION;

ANIMALIA; MAMMALIA;

EID: 0037237279     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1534-5807(02)00401-X     Document Type: Article

References (32)

1. Accili, D., and Taylor, S.I. (1991). Targeted inactivation of the insulin receptor gene in mouse 3T3-L1 fibroblasts via homologous recombination. Proc. Natl. Acad. Sci. USA 88, 4708-4712.
2. Ahima, R.S., and Flier, J.S. (2000). Adipose tissue as an endocrine organ. Trends Endocrinol. Metab. 11, 327-332.
3. Batchvarova, N., Wang, X.Z., and Ron, D. (1995). Inhibition of adipogenesis by the stress-induced protein CHOP (Gadd153). EMBO J. 14, 4654-4661.
4. Chen, P.L., Riley, D.J., Chen, Y., and Lee, W.H. (1996). Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs. Genes Dev. 10, 2794-2804.
5. Cinti, S., Eberbach, S., Castellucci, M., and Accili, D. (1998). Lack of insulin receptors affects the formation of white adipose tissue in mice. A morphological and ultrastructural analysis. Diabetologia 41, 171-177.
6. Datta, S.R., Brunet, A., and Greenberg, M.E. (1999). Cellular survival: a play in three Akts. Genes Dev. 13, 2905-2927.
7. Fajas, L., Landsberg, R.L., Huss-Garcia, Y., Sardet, C., Lees, J.A., and Auwerx, J. (2002). E2Fs regulate adipocyte differentiation. Dev. Cell 3, 39-49.
8. Gerrish, K., Cissell, M.A., and Stein, R. (2001). The role of hepatic nuclear factor 1 alpha and PDX-1 in transcriptional regulation of the pdx-1 gene. J. Biol. Chem. 276, 47775-47784.
9. Gregoire, F.M., Smas, C.M., and Sul, H.S. (1998). Understanding adipocyte differentiation. Physiol. Rev. 78, 783-809.
10. Hansen, J.B., Petersen, R.K., Larsen, B.M., Bartkova, J., Alsner, J., and Kristiansen, K. (1999). Activation of peroxisome proliferator-activated receptor gamma bypasses the function of the retinoblastoma protein in adipocyte differentiation. J. Biol. Chem. 274, 2386-2393.
11. Hu, E., Kim, J.B., Sarraf, P., and Spiegelman, B.M. (1996). Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma. Science 274, 2100-2103.
12. Kaestner, K.H., Knochel, W., and Martinez, D.E. (2000). Unified nomenclature for the winged helix/forkhead transcription factors. Genes Dev. 14, 142-146.
13. Kido, Y., Burks, D.J., Withers, D., Bruning, J.C., Kahn, C.R., White, M.F., and Accili, D. (2000). Tissue-specific insulin resistance in mice with combined mutations of insulin receptor, IRS-1 and IRS-2. J. Clin. Invest. 105, 199-205.
14. Kitamura, T., Nakae, J., Kitamura, Y., Kido, Y., Biggs, W., Wright, C., White, M., Arden, K., and Accili, D. (2002). The transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β-cell growth. J. Clin. Invest. 110, 1839-1847.
15. Kohn, A.D., Summers, S.A., Birnbaum, M.J., and Roth, R.A. (1996). Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J. Biol. Chem. 271, 31372-31378.
16. Kops, G.J., and Burgering, B.M. (1999). Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling. J. Mol. Med. 77, 656-665.
17. Kops, G.J., Medema, R.H., Glassford, J., Essers, M.A., Dijkers, P.F., Coffer, P.J., Lam, E.W., and Burgering, B.M. (2002). Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors. Mol. Cell. Biol. 22, 2025-2036.
18. Medema, R.H., Kops, G.J., Bos, J.L., and Burgering, B.M. (2000). AFX-like forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 404, 782-787.
19. Miki, H., Yamauchi, T., Suzuki, R., Komeda, K., Tsuchida, A., Kubota, N., Terauchi, Y., Kamon, J., Kaburagi, Y., Matsui, J., et al. (2001). Essential role of insulin receptor substrate 1 (IRS-1) and IRS-2 in adipocyte differentiation. Mol. Cell. Biol. 21, 2521-2532.
20. Morrison, R.F., and Farmer, S.R. (1999). Role of PPARgamma in regulating a cascade expression of cyclin- dependent kinase inhibitors, p18(INK4c) and p21(Waf1/Cip1), during adipogenesis. J. Biol. Chem. 274, 17088-17097.
21. Nakae, J., Barr, V., and Accili, D. (2000). Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR. EMBO J. 19, 989-996.
22. Nakae, J., Biggs, W.I., Kitamura, T., Cavenee, W., Wright, C., Arden, K., and Accili, D. (2002). Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat. Genet. 32, 245-253.
23. Nakae, J., Kitamura, T., Silver, D.L., and Accili, D. (2001). The fork-head transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression. J. Clin. Invest. 108, 1359-1367.
24. Rosen, E.D., Walkey, C.J., Puigserver, P., and Spiegelman, B.M. (2000). Transcriptional regulation of adipogenesis. Genes Dev. 14, 1293-1307.
25. Ross, S.E., Erickson, R.L., Gerin, I., DeRose, P.M., Bajnok, L., Longo, K.A., Misek, D.E., Kuick, R., Hanash, S.M., Atkins, K.B., et al. (2002). Microarray analyses during adipogenesis: understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor alpha in adipocyte metabolism. Mol. Cell. Biol. 22, 5989-5999.
26. Rubin, C.S., Lai, E., and Rosen, O.M. (1977). Acquisition of increased hormone sensitivity during in vitro adipocyte development. J. Biol. Chem. 252, 3554-3557.
27. Sakaue, H., Ogawa, W., Matsumoto, M., Kuroda, S., Takata, M., Sugimoto, T., Spiegelman, B.M., and Kasuga, M. (1998). Posttranscriptional control of adipocyte differentiation through activation of phosphoinositide 3-kinase. J. Biol. Chem. 273, 28945-28952.
28. Schreiber, E., Matthias, P., Muller, M.M., and Schaffner, W. (1989). Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res. 17, 6419.
29. Spiegelman, B.M., and Flier, J.S. (2001). Obesity and the regulation of energy balance. Cell 104, 531-543.
30. Tang, Q.Q., and Lane, M.D. (2000). Role of C/EBP homologous protein (CHOP-10) in the programmed activation of CCAAT/enhancer-binding protein-beta during adipogenesis. Proc. Natl. Acad. Sci. USA 97, 12446-12450.
31. Wang, X.Z., and Ron, D. (1996). Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP kinase. Science 272, 1347-1349.
32. Wu, Z., Rosen, E.D., Brun, R., Hauser, S., Adelmant, G., Troy, A.E., McKeon, C., Darlington, G.J., and Spiegelman, B.M. (1999). Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity. Mol. Cell 3, 151-158.