Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

Nature Genetics

Volumn 38, Issue 3, 2006, Pages 320-323

  Grant, Struan F A ^a   Thorleifsson, Gudmar ^a   Reynisdottir, Inga ^a   Benediktsson, Rafn ^b,c   Manolescu, Andrei ^a   Sainz, Jesus ^a   Helgason, Agnar ^a   Stefansson, Hreinn ^a   Emilsson, Valur ^a   Helgadottir, Anna ^a   Styrkarsdottir, Unnur ^a   Magnusson, Kristinn P ^a   Walters, G Bragi ^a   Palsdottir, Ebba ^a   Jonsdottir, Thorbjorg ^a   Gudmundsdottir, Thorunn ^a   Gylfason, Arnaldur ^a   Saemundsdottir, Jona ^a   Wilensky, Robert L ^d   Reilly, Muredach P ^d   Rader, Daniel J ^d   Bagger, Yu ^e   Christiansen, Claus ^e   Gudnason, Vilmundur ^b   Sigurdsson, Gunnar ^b,c   Thorsteinsdottir, Unnur ^a   Gulcher, Jeffrey R ^a   Kong, Augustine ^a   Stefansson, Kari ^a   more..

^a DECODE GENETICS   (Iceland)

^b ICELANDIC HEART ASSOCIATION   (Iceland)

^c LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e CENTER FOR CLINICAL AND BASIC RESEARCH   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; HIGH MOBILITY GROUP B PROTEIN; PROGLUCAGON; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR 7 LIKE 2; UNCLASSIFIED DRUG; WNT PROTEIN;

ALLELE; ARTICLE; CHROMOSOME 10Q; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; ENDOCRINE CELL; FEMALE; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC LINKAGE; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HETEROZYGOTE; HIGH MOBILITY GROUP BOX DOMAIN; HOMOZYGOSITY; HUMAN; INTESTINE CELL; INTRON; MAJOR CLINICAL STUDY; MICROSATELLITE MARKER; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RISK ASSESSMENT; SIGNAL TRANSDUCTION;

CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 10; COHORT STUDIES; DENMARK; DIABETES MELLITUS, TYPE 2; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HETEROZYGOTE DETECTION; HUMANS; INTRONS; MICROSATELLITE REPEATS; MOLECULAR SEQUENCE DATA; REFERENCE VALUES; TCF TRANSCRIPTION FACTORS;

EID: 32544451924     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng1732     Document Type: Article

References (25)

1. Reynisdottir, I. et al. Localization of a susceptibility gene for type 2 diabetes to chromosome 5q34-q35.2. Am. J. Hum. Genet. 73, 323-335 (2003).
2. Yi, F., Brubaker, P.L. & Jin, T. TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta. J. Biol. Chem. 280, 1457-1464 (2005).
3. Zimmet, P., Alberti, K.G. & Shaw, J. Global and societal implications of the diabetes epidemic. Nature 414, 782-787 (2001).
4. Rich, S.S. Mapping genes in diabetes. Genetic epidemiological perspective. Diabetes 39, 1315-1319 (1990).
5. Altshuler, D. et al. The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat. Genet. 26, 76-80 (2000).
6. Horikawa, Y. et al. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat. Genet. 26, 163-175 (2000).
7. Gloyn, A.L. et al. Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. Diabetes 52, 568-572 (2003).
8. Duggirala, R. et al. Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans. Am. J. Hum. Genet. 64, 1127-1140 (1999).
9. Falk, C.T. & Rubinstein, P. Haplotype relative risks: an easy reliable way to construct a proper control sample for risk calculations. Ann. Hum. Genet. 51, 227-233 (1987).
10. The International HapMap Consortium. The International HapMap Project. Nature 426, 789-796 (2003).
11. Mantel, N. & Haenszel, W. Statistical aspects of the analysis of data from retrospective studies of disease. J. Natl. Cancer Inst. 22, 719-748 (1959).
12. Kong, A. & Cox, N.J. Allele-sharing models: LOD scores and accurate linkage tests. Am. J. Hum. Genet. 61, 1179-1188 (1997).
13. Prunier, C., Hocevar, B.A. & Howe, P.H. Wnt signaling: physiology and pathology. Growth Factors 22, 141-150 (2004).
14. Huelsken, J. & Birchmeier, W. New aspects of Wnt signaling pathways in higher vertebrates. Curr. Opin. Genet. Dev. 11, 547-553 (2001).
15. Nelson, W.J. & Nusse, R. Convergence of Wnt, beta-catenin, and cadherin pathways. Science 303, 1483-1487 (2004).
16. Duval, A. et al. The human T-cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines. Cancer Res. 60, 3872-3879 (2000).
17. Fajans, S.S., Bell, G.I. & Polonsky, K.S. Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young. N. Engl. J. Med. 345, 971-980 (2001).
18. Wolfrum, C., Asilmaz, E., Luca, E., Friedman, J.M. & Stoffel, M. Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes. Nature 432, 1027-1032 (2004).
19. Nakae, J. et al. Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat. Genet. 32, 245-253 (2002).
20. Noble, J.A. et al. A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes. Diabetes 52, 1579-1582 (2003).
21. Wong, N.A. & Pignatelli, M. Beta-catenin-a linchpin in colorectal carcinogenesis? Am. J. Pathol. 160, 389-401 (2002).
22. Lepourcelet, M. et al. Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. Cancer Cell 5, 91-102 (2004).
23. Korinek, V. et al. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat. Genet. 19, 379-383 (1998).
24. Tanko, L.B., Bagger, Y.Z., Nielsen, S.B. & Christiansen, C. Does serum cholesterol contribute to vertebral bone loss in postmenopausal women? Bone 32, 8-14 (2003).
25. Lewontin, R.C. The interaction of selection and linkage. II. Optimum models. Genetics 50, 757-782 (1964).