Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle

Journal of Clinical Investigation

Volumn 105, Issue 12, 2000, Pages 1791-1797

  Kim, Jason K ^a   Michael, M Dodson ^b   Previs, Stephen F ^a   Peroni, Odile D ^b   Mauvais Jarvis, Franck ^b   Neschen, Susanne ^a   Kahn, Barbara B ^b   Kahn, C Ronald ^b   Shulman, Gerald I ^a,c  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLYCOGEN; INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; GENE INACTIVATION; GLUCOSE TRANSPORT; GLYCOGEN SYNTHESIS; HORMONE ACTION; HYPERINSULINEMIA; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL;

EID: 0033917321     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI8305     Document Type: Article

References (29)

1. DeFronzo, R.A., Simonson, D., and Ferrannini, E. 1982. Heparic and peripheral insulin resistance: a common feature of type 2 (non-insulin-dependent) and type 1 (insulin-dependent) diabetes mellitus. Diabetologia. 23:313-319.
2. Hollenbeck, C.B., Chen, Y.I., and Reaven, G.M. 1984. A comparison of the relative effects of obesity and non-insulin-dependent diabetes mellitus on in vivo insulin-stimulated glucose utilization. Diabetes. 33:622-626.
3. 13C nuclear magnetic resonance spectroscopy. N. Engl. J. Med. 322:223-228.
4. DeFronzo, R.A., et al. 1981. The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes. 30:1000-1007.
5. Beck-Nielsen, H., et al. 1992. Insulin resistance in skeletal muscles in patients with NIDDM. Diabetes Care. 15:418-429.
6. Bogardus, C., and Lillioja, S. 1990. Where all the glucose doesn't go in non-insulin-dependent diabetes mellitus. N. Engl. J. Med. 322:262-263.
7. Kahn, C.R. 1994. Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes. Diabetes. 43:1066-1084.
8. Bruning, J.C., et al. 1998. A muscle-specific insulin receptor knock-out exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol. Cell. 2:559-569.
9. Kim, J.K., Gavrilova, O., Chen, Y., Reitman, M.L., and Shulman, G.I. 2000. Mechanism of insulin resistance in A-ZIP/F-1 fatless mice. J. Biol. Chem. 275:8456-8460.
10. Ohshima, K., Shargill, N.S., Chan, T.M., and Bray, G.A. 1984. Adrenalectomy reverses insulin resistance in muscle from obese (ob/ob) mice. Am. J. Physiol. 246:E193-E197.
11. Kim, J.K., Wi, J.K., and Youn, J.H. 1996. Plasma free fatty acids decrease insulin-stimulated skeletal muscle glucose uptake by suppressing glycolysis in conscious rats. Diabetes. 45:446-453.
12. Tozzo, E., Shepherd, P.R., Gnudi, L., and Kahn, B.B. 1995. Transgenic GLUT-4 overexpression in fat enhances glucose metabolism: preferential effect on fatty acid synthesis. Am. J. Physiol. 268:956-964.
13. Rossetti, L., and Giaccari, A. 1990. Relative contribution of glycogen synthesis and glycolysis to insulin-mediated glucose uptake. J. Clin. Invest. 85:1785-1792.
14. Youn, J.H., and Buchanan, T.A. 1993. Fasting does not impair insulin-stimulated glucose uptake but alters intracellular glucose metabolism in conscious rats. Diabetes. 42:757-763.
15. Joshi, R.L., et al. 1996. Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality. EMBO J. 15:1542-1547.
16. Accili, D., et al. 1996. Early neonatal death in mice homozygous for a null allele of the insulin receptor gene. Nat. Genet. 12:106-109.
17. Folli, F., Saad, M.J.A., Backer, J.M., and Kahn, C.R. 1992. Insulin stimulation of phosphatidylinositol 3-kinase activity and association with IRS-1 in liver and muscle of the intact rar. J. Biol. Chem. 267:22171-22177.
18. Marette, A., Burdett, E., Douen, A., Vranic, M., and Klip, A. 1992. Insulin induces the translocation of GLUT4 from a unique intracellular organelle to transverse tubules in rat skeletal muscle. Diabetes. 41:1562-1569.
19. Le Marchand-Brustel, Y. 1999. Molecular mechanisms of insulin action in normal and insulin-resistant states. Exp. Clin. Endocrinol. Diabetes. 107:126-132.
20. Jullien, D., Heydrick, S.J., Gautier, N., Van Obberghen, E., and Le Marchand-Brustel, Y. 1996. Effect of IGF-I on phosphatidylinositol 3-kinase in soleus muscle of lean and insulin-resistant obese mice. Diabetes. 45:869-875.
21. Ren, J.-M., et al. 1993. Evidence from transgenic mice that glucose transport is rate-limiting for glycogen deposition and glycolysis in skeletal muscle. J. Biol. Chem. 268:16113-16115.
22. Cline, G.W., et al. 1999. Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes. N. Engl. J. Med. 341:240-246.
23. Goodman, M.N , Berger, M., and Ruderman, N.B. 1974. Glucose metabolism in rat skeletal muscle at rest. Effect of starvation, diabetes, ketone bodies, and free fatty acids. Diabetes. 23:881-888.
24. Richter, E.A., Garetto, L.P., Goodman, M.N., and Ruderman, N.B. 1982. Muscle glucose metabolism following exercise in the rat: increased sensitivity to insulin. J. Clin. Invest. 69:785-793.
25. Garvey, W.T., Huecksteadt, T.P., Matthaei, S., and Olefsky, J.M. 1988. Role of glucose transporters in the cellular insulin resistance of type II non-insulin-dependent diabetes mellitus. J. Clin. Invest. 81:1528-1536.
26. Garvey, W.T. 1992. Glucose transport and NIDDM. Diabetes Care. 15:396-417.
27. Pedersen, O., et al. 1990. Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM. Diabetes. 39:865-870.
28. Cusin, I., Terrettaz, J., Rohner-Jeanrenaud, F., and Jeanrenaud, B. 1990. Metabolic consequences of hyperinsulinemia imposed on normal rats on glucose handling by white adipose tissue, muscles, and liver. Biochem. J. 267:99-103.
29. Cusin, I., et al. 1990. Hyperinsulinemia increases the amount of GLUT4 mRNA in white adipose tissue and decreases that of muscles, a clue for increased fat depot and insulin resistance. Endocrinology. 127:3246-3248.