-
1
-
-
0027953703
-
Banting lecture. Insulin action, diabetogenes, and the cause of type II diabetes
-
(1994)
Diabetes
, vol.43
, pp. 1066-1084
-
-
Kahn, C.R.1
-
4
-
-
0029920935
-
A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK is generated by alternative splicing of the p85a gene
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 5317-5320
-
-
Inukai, K.1
-
7
-
-
0030615068
-
p85a gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-kinase), p50a, p55a, and p85a, with different PI 3-kinase activity elevating responses to insulin
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 7873-7882
-
-
Inukai, K.1
-
8
-
-
0028982198
-
The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 4453-4465
-
-
Pons, S.1
-
10
-
-
0027981333
-
1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 7415-7419
-
-
Hara, K.1
-
11
-
-
0028308412
-
Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 4902-4911
-
-
Chearham, B.1
-
14
-
-
0030050975
-
Insulin regulation of phosphoenolpyruvate carboxykinase gene expression does not require activation of the Ras/mitogen-activated protein kinase signaling pathway
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 1890-1897
-
-
Gabbay, R.A.1
-
15
-
-
0032563201
-
Assessment of the roles of mitogen-activated protein kinase, phosphatidylinositol 3-kinase, protein kinase B, and protein kinase C in insulin inhibition of cAMP-induced phosphoenol pyruvate carboxykinase gene transcription
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 18751-18759
-
-
Agati, J.M.1
Yeagley, D.2
Quinn, P.G.3
-
17
-
-
0031984952
-
Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats
-
(1998)
Diabetes
, vol.47
, pp. 13-23
-
-
Anai, M.1
-
20
-
-
0032909703
-
Increased insulin sensitivity and hypoglycaemia in mice lacking the p85a subunit of phosphoinositide 3-kinase
-
(1999)
Nat. Genet.
, vol.21
, pp. 230-235
-
-
Terauchi, Y.1
-
21
-
-
0033556333
-
Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85a
-
(1999)
Science
, vol.283
, pp. 393-397
-
-
Fruman, D.A.1
-
22
-
-
0033757592
-
Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85a
-
(2000)
Nat. Genet.
, vol.26
, pp. 379-382
-
-
Fruman, D.A.1
-
23
-
-
0031887249
-
Regulation of the p85/p110 phosphatidylinositol 3′-kinase: Stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 1379-1387
-
-
Yu, J.1
-
26
-
-
0038155702
-
Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles
-
(1997)
Cell
, vol.88
, pp. 561-572
-
-
Bruning, J.C.1
-
27
-
-
0032214652
-
A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance
-
(1998)
Mol. Cell.
, vol.2
, pp. 559-569
-
-
Bruning, J.C.1
-
28
-
-
18544407572
-
Restored insulin-sensitivity in IRS-1-deficient mice treated by adenovirus-mediated gene therapy
-
(2000)
J. Clin. Invest.
, vol.105
, pp. 1437-1445
-
-
Ueki, K.1
-
29
-
-
0032570815
-
Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 5315-5322
-
-
Ueki, K.1
-
31
-
-
0031014830
-
Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
-
(1997)
Diabetes
, vol.46
, pp. 3-10
-
-
Boden, G.1
-
32
-
-
0035905772
-
Diabetes. The missing link with obesity?
-
(2001)
Nature
, vol.409
, pp. 292-293
-
-
Flier, J.S.1
-
33
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
(1994)
Nature
, vol.372
, pp. 425-432
-
-
Zhang, Y.1
-
36
-
-
2042533256
-
Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival
-
In press
-
(2001)
Mol. Cell. Biol.
-
-
Ueki, K.1
-
37
-
-
0033636523
-
Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
-
(2000)
Mol. Cell.
, vol.6
, pp. 87-97
-
-
Michael, M.D.1
|