A mutation in KCNJ11 causing human hyperinsulinism (Y12X) results in a glucose-intolerant phenotype in the mouse

Diabetologia

Volumn 53, Issue 11, 2010, Pages 2352-2356

  Hugill, A ^a   Shimomura, K ^b   Ashcroft, F M ^b   Cox, R D ^a  

^a MRC MAMMALIAN GENETICS UNIT   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

ENU; Hyperinsulinism; KATP channel; Kcnj11; Kir6.2

Indexed keywords

INCRETIN; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; HOMOZYGOSITY; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPERINSULINISM; IMPAIRED GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; INSULIN RELEASE; LOSS OF FUNCTION MUTATION; MALE; MOUSE; NONHUMAN; PANCREAS ISLET CELL; PHENOTYPE; PRIORITY JOURNAL;

ANIMALS; FEMALE; GENOTYPE; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; HUMANS; HYPERINSULINISM; MALE; MICE; MICE, MUTANT STRAINS; MUTATION; PHENOTYPE; POTASSIUM CHANNELS, INWARDLY RECTIFYING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 77957685298     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-010-1866-x     Document Type: Article

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